利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

31 条记录 (耗时 0.028 秒)

    PROCESS FOR PREPARING INHIBITORS OF THE HEPATITIS C VIRUS
    8.
    发明申请
    PROCESS FOR PREPARING INHIBITORS OF THE HEPATITIS C VIRUS 审中-公开
    制备丙型肝炎病毒的抑制剂的方法

    公开(公告)号：US20140058116A1

    公开(公告)日：2014-02-27

    申请号：US14114251

    申请日：2012-05-02

    申请人： Ji Xie ,  George Wu ,  Joseph Lamberson ,  Marc Poirier ,  Frank Chen

    发明人： Ji Xie ,  George Wu ,  Joseph Lamberson ,  Marc Poirier ,  Frank Chen

    IPC分类号： C07D209/52

    CPC分类号： A61K9/00 ,  A61K38/005 ,  A61K38/06 ,  C07D209/52 ,  C07K1/36

    摘要： The present invention relates to synthetic processes useful in the preparation of compounds of Formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease and have application in the treatment of conditions caused by HCV. In particular, the present invention relates to novel oxidation processes useful for preparing compounds of Formula (I) and related compounds, including pharmaceutically acceptable salts, hydrates and solvates thereof, and including stereoisomers thereof.

    摘要翻译： 本发明涉及用于制备式（I）化合物的合成方法，其可用作丙型肝炎病毒（HCV）NS3蛋白酶的抑制剂，并且可用于治疗由HCV引起的病症。 特别地，本发明涉及可用于制备式（I）化合物和相关化合物的新型氧化方法，包括其药学上可接受的盐，水合物和溶剂合物，并包括它们的立体异构体。

    Synthesis of intermediates useful in preparing tricyclic compounds
    9.
    发明授权
    Synthesis of intermediates useful in preparing tricyclic compounds 有权
    可用于制备三环化合物的中间体的合成

    公开(公告)号：US06372909B1

    公开(公告)日：2002-04-16

    申请号：US09442512

    申请日：1999-11-18

    申请人： Charles F. Bernard ,  Michael Casey ,  Frank Xing Chen ,  Denise C. Grogan ,  Marc Poirier ,  Robert P. Williams ,  Yee-Shing Wong ,  George G. Wu

    发明人： Charles F. Bernard ,  Michael Casey ,  Frank Xing Chen ,  Denise C. Grogan ,  Marc Poirier ,  Robert P. Williams ,  Yee-Shing Wong ,  George G. Wu

    IPC分类号： C07F980

    CPC分类号： C07D221/16

    摘要： Disclosed is a process for preparing a compound having the formula: wherein R, R1, R2, R3, and R4 are independently selected from the group consisting of H, Br, Cl, F, alkyl, or alkoxy, by (A) reacting a compound having the formula  wherein RA, RC, RD, and RE are independently selected from the group consisting of H, halo, alkyl, or alkoxy, and R5 is aryl or heteroaryl, with a dehydrating agent to produce an imine having the formula: (B) hydrolyzing the imine produced in step (A) to produce the compound having formula (I). Also disclosed are novel intermediates having the formula:  wherein RA, RB, RC, RD, and RE are independently selected from the group consisting of H, halo, alkyl, or alkoxy, and R5 is aryl or heteroaryl. Also disclosed is a process for preparing a compound having the formula:  comprising: reacting a compound having the formula:  with NH2R5 in the presence of a palladium catalyst, carbon monoxide, a base, and an ether selected from the group consisting of: CH3OCH2CH2OCH3; CH3OCH2CH2OCH2CH2OCH3; and CH3OCH2CH2OCH2CH2OCH2CH2OCH3, wherein X is H, Br, Cl, or F, and R5 is aryl or heteroaryl. The compounds made by these processes are useful intermediates for preparing compounds that are antihistamines or inhibitors of farnesyl protein transferase.

    摘要翻译： 公开了一种制备具有下式的化合物的方法：其中R，R 1，R 2，R 3和R 4独立地选自H，Br，Cl，F，烷基或烷氧基，通过（A）使 具有下式的化合物其中RA，RC，RD和RE独立地选自H，卤素，烷基或烷氧基，R5是芳基或杂芳基，与脱水剂反应生成具有下式的亚胺：（B ）水解步骤（A）中产生的亚胺以制备具有式（I）的化合物。 还公开了具有下式的新型中间体：其中RA，RB，RC，RD和RE独立地选自H，卤素，烷基或烷氧基，R5是芳基或杂芳基。 还公开了制备具有下式的化合物的方法：包括：在钯催化剂，一氧化碳，碱和选自以下的醚的存在下使具有下式的化合物与NH 2 R 5反应：CH 3 OCH 2 CH 2 OCH 3; CH3OCH2CH2OCH2CH2OCH3; 和CH 3 OCH 2 CH 2 OCH 2 CH 2 OCH 2 CH 2 OCH 3，其中X是H，Br，Cl或F，R 5是芳基或杂芳基。 通过这些方法制备的化合物是制备抗组胺剂或法呢基蛋白转移酶抑制剂的化合物的有用中间体。