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公开(公告)号:US20100168082A1
公开(公告)日:2010-07-01
申请号:US12632396
申请日:2009-12-07
申请人: Gerald David Artmann, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人: Gerald David Artmann, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号: A61K31/55 , C07D403/14 , A61K31/506 , A61K31/4439 , C07D413/14 , C07D471/04 , A61K31/519 , C07D487/04 , C07D261/14 , A61K31/42 , A61K31/4155 , C07D403/04
CPC分类号: C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要: The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.
摘要翻译: 本发明涉及式(I)的新型有机化合物及其在治疗动物或人体中的用途,包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病,特别是增殖性疾病,例如治疗肿瘤疾病和眼睛新生血管疾病。
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公开(公告)号:US08431584B2
公开(公告)日:2013-04-30
申请号:US13488760
申请日:2012-06-05
申请人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号: C07D487/04 , C07D487/08 , A61K31/404
CPC分类号: C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要: The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.
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公开(公告)号:US08486954B2
公开(公告)日:2013-07-16
申请号:US13613034
申请日:2012-09-13
申请人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号: C07D487/04 , C07D487/08 , A61K31/404 , A61P27/02
CPC分类号: C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要: The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.
摘要翻译: 本发明涉及式(I)的新型有机化合物及其在治疗动物或人体中的用途,包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病,特别是增殖性疾病,例如治疗肿瘤疾病和眼睛新生血管疾病。
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公开(公告)号:US08242125B2
公开(公告)日:2012-08-14
申请号:US12632396
申请日:2009-12-07
申请人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号: C07D403/12 , C07D403/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K31/404
CPC分类号: C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要: The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.
摘要翻译: 本发明涉及式(I)的新型有机化合物及其在治疗动物或人体中的用途,包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病,特别是增殖性疾病,例如治疗肿瘤疾病和眼睛新生血管疾病。
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公开(公告)号:US08501756B2
公开(公告)日:2013-08-06
申请号:US13613062
申请日:2012-09-13
申请人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号: C07D487/04 , C07D487/08 , A61K31/404 , A61P27/02
CPC分类号: C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要: The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.
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公开(公告)号:US08541432B2
公开(公告)日:2013-09-24
申请号:US13613053
申请日:2012-09-13
申请人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号: C07D487/04 , C07D487/08 , A61K31/404 , A61P27/02
CPC分类号: C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要: The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.
摘要翻译: 本发明涉及式(I)的新型有机化合物及其在治疗动物或人体中的用途,包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病,特别是增殖性疾病,例如治疗肿瘤疾病和眼睛新生血管疾病。
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公开(公告)号:US08492393B2
公开(公告)日:2013-07-23
申请号:US13613019
申请日:2012-09-13
申请人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号: C07D487/04 , C07D487/08 , A61K31/404
CPC分类号: C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要: The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.
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8.
公开(公告)号:US10208018B2
公开(公告)日:2019-02-19
申请号:US15320810
申请日:2015-07-02
申请人: Christopher M. Adams , Doug Bevan , Michael Paul Capparelli , Takeru Ehara , Luciana Ferrara , Nan Ji , Mitsunori Kato , Nello Mainolfi , Erik Meredith , Muneto Mogi , James J. Powers , Ganesh Prasanna
发明人: Christopher M. Adams , Doug Bevan , Michael Paul Capparelli , Takeru Ehara , Luciana Ferrara , Nan Ji , Mitsunori Kato , Nello Mainolfi , Erik Meredith , Muneto Mogi , James J. Powers , Ganesh Prasanna
IPC分类号: C07D401/04 , C07D401/14 , C07D413/14 , C07D401/10 , C07D401/12 , A61K9/00 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , C07D405/14
摘要: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号:US09765067B2
公开(公告)日:2017-09-19
申请号:US15320813
申请日:2015-07-02
申请人: Christopher M. Adams , David B. Belanger , Doug Bevan , Takeru Ehara , Luciana Ferrara , Nan Ji , Donglei Liu , Erik Meredith , Muneto Mogi , James Powers , Ganesh Prasanna , Mitsunori Kato
发明人: Christopher M. Adams , David B. Belanger , Doug Bevan , Takeru Ehara , Luciana Ferrara , Nan Ji , Donglei Liu , Erik Meredith , Muneto Mogi , James Powers , Ganesh Prasanna , Mitsunori Kato
IPC分类号: A61K31/4545 , A61K31/4725 , A61K31/4439 , C07D409/14 , A61K9/00
CPC分类号: C07D409/14 , A61K9/0048 , A61K31/4439 , A61K31/4545 , A61K31/4725
摘要: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号:US09957254B2
公开(公告)日:2018-05-01
申请号:US15320815
申请日:2015-07-02
申请人: Christopher M. Adams , David B. Belanger , Doug Bevan , Philippe Bolduc , Takeru Ehara , Luciana Ferrara , Nan Ji , Mitsunori Kato , Erik Meredith , Muneto Mogi , James J. Powers , Ganesh Prasanna
发明人: Christopher M. Adams , David B. Belanger , Doug Bevan , Philippe Bolduc , Takeru Ehara , Luciana Ferrara , Nan Ji , Mitsunori Kato , Erik Meredith , Muneto Mogi , James J. Powers , Ganesh Prasanna
IPC分类号: C07D401/14 , C07D401/04
CPC分类号: C07D401/14 , A61K31/4545 , A61K31/4985 , A61K31/519 , A61K31/53 , A61K45/06 , C07D401/04 , C07D401/12 , A61K2300/00
摘要: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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