-
公开(公告)号:US20100168082A1
公开(公告)日:2010-07-01
申请号:US12632396
申请日:2009-12-07
申请人: Gerald David Artmann, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人: Gerald David Artmann, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号: A61K31/55 , C07D403/14 , A61K31/506 , A61K31/4439 , C07D413/14 , C07D471/04 , A61K31/519 , C07D487/04 , C07D261/14 , A61K31/42 , A61K31/4155 , C07D403/04
CPC分类号: C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要: The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.
摘要翻译: 本发明涉及式(I)的新型有机化合物及其在治疗动物或人体中的用途,包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病,特别是增殖性疾病,例如治疗肿瘤疾病和眼睛新生血管疾病。
-
公开(公告)号:US08431584B2
公开(公告)日:2013-04-30
申请号:US13488760
申请日:2012-06-05
申请人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号: C07D487/04 , C07D487/08 , A61K31/404
CPC分类号: C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要: The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.
-
公开(公告)号:US08486954B2
公开(公告)日:2013-07-16
申请号:US13613034
申请日:2012-09-13
申请人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号: C07D487/04 , C07D487/08 , A61K31/404 , A61P27/02
CPC分类号: C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要: The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.
摘要翻译: 本发明涉及式(I)的新型有机化合物及其在治疗动物或人体中的用途,包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病,特别是增殖性疾病,例如治疗肿瘤疾病和眼睛新生血管疾病。
-
公开(公告)号:US08541432B2
公开(公告)日:2013-09-24
申请号:US13613053
申请日:2012-09-13
申请人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号: C07D487/04 , C07D487/08 , A61K31/404 , A61P27/02
CPC分类号: C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要: The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.
摘要翻译: 本发明涉及式(I)的新型有机化合物及其在治疗动物或人体中的用途,包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病,特别是增殖性疾病,例如治疗肿瘤疾病和眼睛新生血管疾病。
-
公开(公告)号:US08492393B2
公开(公告)日:2013-07-23
申请号:US13613019
申请日:2012-09-13
申请人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号: C07D487/04 , C07D487/08 , A61K31/404
CPC分类号: C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要: The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.
-
公开(公告)号:US08501756B2
公开(公告)日:2013-08-06
申请号:US13613062
申请日:2012-09-13
申请人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号: C07D487/04 , C07D487/08 , A61K31/404 , A61P27/02
CPC分类号: C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要: The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.
-
公开(公告)号:US08242125B2
公开(公告)日:2012-08-14
申请号:US12632396
申请日:2009-12-07
申请人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人: Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号: C07D403/12 , C07D403/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K31/404
CPC分类号: C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要: The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.
摘要翻译: 本发明涉及式(I)的新型有机化合物及其在治疗动物或人体中的用途,包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病,特别是增殖性疾病,例如治疗肿瘤疾病和眼睛新生血管疾病。
-
公开(公告)号:US06518273B1
公开(公告)日:2003-02-11
申请号:US09914893
申请日:2001-09-04
申请人: Kevin Tyler Chapman , Kevin Dinnell , Jason Matthew Elliott , Gregory John Hollingworth , Steven Michael Hutchins , Duncan Edward Shaw , Christopher Alan Willoughby
发明人: Kevin Tyler Chapman , Kevin Dinnell , Jason Matthew Elliott , Gregory John Hollingworth , Steven Michael Hutchins , Duncan Edward Shaw , Christopher Alan Willoughby
IPC分类号: A61K31496
CPC分类号: C07D401/12 , C07D209/18 , C07D403/06 , C07D403/12 , C07D405/12 , C07D487/08
摘要: The present invention relates to compounds of the formula (I): wherein R1a, R1b, R2, R3, R4, R5, X and n are defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis and postherpetic neuralgia.
摘要翻译: 本发明涉及式(I)化合物:其中R1a,R1b,R2,R3,R4,R5,X和n如本文所定义。 该化合物特别用于治疗或预防抑郁,焦虑,疼痛,炎症,偏头痛,呕吐和带状疱疹后神经痛。
-
公开(公告)号:US6096766A
公开(公告)日:2000-08-01
申请号:US91086
申请日:1998-06-09
IPC分类号: C07D401/10 , A61K31/00 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/454 , A61P1/00 , A61P9/00 , A61P11/00 , A61P17/00 , A61P25/00 , A61P25/04 , A61P29/00 , A61P35/00 , A61P43/00 , C07D401/12 , C07D403/12
CPC分类号: C07D401/12 , C07D403/12
摘要: The present invention relates to certain 3-benzylaminopiperidines which are tachykinin receptor antagonists and are useful in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia.
摘要翻译: PCT No.PCT / GB96 / 02998 Sec。 371日期1998年6月9日第 102(e)1998年6月9日PCT PCT 1996年12月6日PCT公布。 公开号WO97 / 21702 日期:1997年6月19日本发明涉及某些作为速激肽受体拮抗剂的3-苄基氨基哌啶,可用于治疗或预防疼痛,炎症,偏头痛,呕吐和带状疱疹后神经痛。
-
公开(公告)号:US6087348A
公开(公告)日:2000-07-11
申请号:US328743
申请日:1999-06-09
申请人: Raymond Baker , Neil Roy Curtis , Jason Matthew Elliott , Timothy Harrison , Gregory John Hollingworth , Philip Stephen Jackson , Janusz Jozef Kulagowski , Nadia Melanie Rupniak , Eileen Mary Seward , Christopher John Swain , Brian John Williams
发明人: Raymond Baker , Neil Roy Curtis , Jason Matthew Elliott , Timothy Harrison , Gregory John Hollingworth , Philip Stephen Jackson , Janusz Jozef Kulagowski , Nadia Melanie Rupniak , Eileen Mary Seward , Christopher John Swain , Brian John Williams
IPC分类号: A61K31/44 , A61K31/535 , A61K31/675 , A61K31/4445
CPC分类号: A61K31/44 , A61K31/535 , A61K31/675
摘要: The present invention provides the use of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist for the manufacture of a medicament adapted for oral administration for the treatment or prevention of stress disorders without concomitant therapy with other anti-stress agents, methods of treatment using such a NK-1 receptor antagonist and pharmaceutical compositions comprising it.
摘要翻译: 本发明提供口服活性的长效CNS渗透剂NK-1受体拮抗剂在制备适于口服给药以治疗或预防应激障碍的药物中的用途,而不与其它抗应激剂同时治疗, 使用这样的NK-1受体拮抗剂的药物组合物的方法和包含它的药物组合物。
-
-
-
-
-
-
-
-
-