公开(公告)号：US20100168082A1

公开(公告)日：2010-07-01

申请号：US12632396

申请日：2009-12-07

申请人： Gerald David Artmann, III ,  Jason Matthew Elliott ,  Nan Ji ,  Donglei Liu ,  Fupeng Ma ,  Nello Mainolfi ,  Erik Meredith ,  Karl Miranda ,  James J. Powers ,  Chang Rao

发明人： Gerald David Artmann, III ,  Jason Matthew Elliott ,  Nan Ji ,  Donglei Liu ,  Fupeng Ma ,  Nello Mainolfi ,  Erik Meredith ,  Karl Miranda ,  James J. Powers ,  Chang Rao

IPC分类号： A61K31/55 ,  C07D403/14 ,  A61K31/506 ,  A61K31/4439 ,  C07D413/14 ,  C07D471/04 ,  A61K31/519 ,  C07D487/04 ,  C07D261/14 ,  A61K31/42 ,  A61K31/4155 ,  C07D403/04

CPC分类号： C07D403/12 ,  A61K31/18 ,  A61K31/404 ,  A61K45/06 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  A61K2300/00

摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.

摘要翻译： 本发明涉及式（I）的新型有机化合物及其在治疗动物或人体中的用途，包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病，特别是增殖性疾病，例如治疗肿瘤疾病和眼睛新生血管疾病。

公开(公告)号：US08431584B2

公开(公告)日：2013-04-30

申请号：US13488760

申请日：2012-06-05

申请人： Gerald David Artman, III ,  Jason Matthew Elliott ,  Nan Ji ,  Donglei Liu ,  Fupeng Ma ,  Nello Mainolfi ,  Erik Meredith ,  Karl Miranda ,  James J. Powers ,  Chang Rao

发明人： Gerald David Artman, III ,  Jason Matthew Elliott ,  Nan Ji ,  Donglei Liu ,  Fupeng Ma ,  Nello Mainolfi ,  Erik Meredith ,  Karl Miranda ,  James J. Powers ,  Chang Rao

IPC分类号： C07D487/04 ,  C07D487/08 ,  A61K31/404

CPC分类号： C07D403/12 ,  A61K31/18 ,  A61K31/404 ,  A61K45/06 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  A61K2300/00

摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.

公开(公告)号：US08486954B2

公开(公告)日：2013-07-16

申请号：US13613034

申请日：2012-09-13

申请人： Gerald David Artman, III ,  Jason Matthew Elliott ,  Nan Ji ,  Donglei Liu ,  Fupeng Ma ,  Nello Mainolfi ,  Erik Meredith ,  Karl Miranda ,  James J. Powers ,  Chang Rao

发明人： Gerald David Artman, III ,  Jason Matthew Elliott ,  Nan Ji ,  Donglei Liu ,  Fupeng Ma ,  Nello Mainolfi ,  Erik Meredith ,  Karl Miranda ,  James J. Powers ,  Chang Rao

IPC分类号： C07D487/04 ,  C07D487/08 ,  A61K31/404 ,  A61P27/02

CPC分类号： C07D403/12 ,  A61K31/18 ,  A61K31/404 ,  A61K45/06 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  A61K2300/00

摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.

摘要翻译： 本发明涉及式（I）的新型有机化合物及其在治疗动物或人体中的用途，包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病，特别是增殖性疾病，例如治疗肿瘤疾病和眼睛新生血管疾病。

公开(公告)号：US08501756B2

公开(公告)日：2013-08-06

申请号：US13613062

申请日：2012-09-13

申请人： Gerald David Artman, III ,  Jason Matthew Elliott ,  Nan Ji ,  Donglei Liu ,  Fupeng Ma ,  Nello Mainolfi ,  Erik Meredith ,  Karl Miranda ,  James J. Powers ,  Chang Rao

发明人： Gerald David Artman, III ,  Jason Matthew Elliott ,  Nan Ji ,  Donglei Liu ,  Fupeng Ma ,  Nello Mainolfi ,  Erik Meredith ,  Karl Miranda ,  James J. Powers ,  Chang Rao

IPC分类号： C07D487/04 ,  C07D487/08 ,  A61K31/404 ,  A61P27/02

CPC分类号： C07D403/12 ,  A61K31/18 ,  A61K31/404 ,  A61K45/06 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  A61K2300/00

摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.

公开(公告)号：US08541432B2

公开(公告)日：2013-09-24

申请号：US13613053

申请日：2012-09-13

申请人： Gerald David Artman, III ,  Jason Matthew Elliott ,  Nan Ji ,  Donglei Liu ,  Fupeng Ma ,  Nello Mainolfi ,  Erik Meredith ,  Karl Miranda ,  James J. Powers ,  Chang Rao

发明人： Gerald David Artman, III ,  Jason Matthew Elliott ,  Nan Ji ,  Donglei Liu ,  Fupeng Ma ,  Nello Mainolfi ,  Erik Meredith ,  Karl Miranda ,  James J. Powers ,  Chang Rao

IPC分类号： C07D487/04 ,  C07D487/08 ,  A61K31/404 ,  A61P27/02

CPC分类号： C07D403/12 ,  A61K31/18 ,  A61K31/404 ,  A61K45/06 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  A61K2300/00

摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.

摘要翻译： 本发明涉及式（I）的新型有机化合物及其在治疗动物或人体中的用途，包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病，特别是增殖性疾病，例如治疗肿瘤疾病和眼睛新生血管疾病。

公开(公告)号：US08492393B2

公开(公告)日：2013-07-23

申请号：US13613019

申请日：2012-09-13

申请人： Gerald David Artman, III ,  Jason Matthew Elliott ,  Nan Ji ,  Donglei Liu ,  Fupeng Ma ,  Nello Mainolfi ,  Erik Meredith ,  Karl Miranda ,  James J. Powers ,  Chang Rao

发明人： Gerald David Artman, III ,  Jason Matthew Elliott ,  Nan Ji ,  Donglei Liu ,  Fupeng Ma ,  Nello Mainolfi ,  Erik Meredith ,  Karl Miranda ,  James J. Powers ,  Chang Rao

IPC分类号： C07D487/04 ,  C07D487/08 ,  A61K31/404

CPC分类号： C07D403/12 ,  A61K31/18 ,  A61K31/404 ,  A61K45/06 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  A61K2300/00

摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.

公开(公告)号：US08242125B2

公开(公告)日：2012-08-14

申请号：US12632396

申请日：2009-12-07

申请人： Gerald David Artman, III ,  Jason Matthew Elliott ,  Nan Ji ,  Donglei Liu ,  Fupeng Ma ,  Nello Mainolfi ,  Erik Meredith ,  Karl Miranda ,  James J. Powers ,  Chang Rao

发明人： Gerald David Artman, III ,  Jason Matthew Elliott ,  Nan Ji ,  Donglei Liu ,  Fupeng Ma ,  Nello Mainolfi ,  Erik Meredith ,  Karl Miranda ,  James J. Powers ,  Chang Rao

IPC分类号： C07D403/12 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  A61K31/404

CPC分类号： C07D403/12 ,  A61K31/18 ,  A61K31/404 ,  A61K45/06 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  A61K2300/00

摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.

摘要翻译： 本发明涉及式（I）的新型有机化合物及其在治疗动物或人体中的用途，包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病，特别是增殖性疾病，例如治疗肿瘤疾病和眼睛新生血管疾病。

公开(公告)号：US20110092505A1

公开(公告)日：2011-04-21

申请号：US12996901

申请日：2009-06-12

申请人： Robin Burgis ,  Michael Paul Capparelli ,  Lucian Dipietro ,  Gabriel G. Gamber ,  Charles Francis Jewell, JR. ,  Erik Meredith ,  Karl Miranda ,  Lauren G. Monovich ,  Chang Rao ,  Nicolas Soldermann ,  Taeyoung Yoon ,  Qingming Zhu

发明人： Robin Burgis ,  Michael Paul Capparelli ,  Lucian Dipietro ,  Gabriel G. Gamber ,  Charles Francis Jewell, JR. ,  Erik Meredith ,  Karl Miranda ,  Lauren G. Monovich ,  Chang Rao ,  Nicolas Soldermann ,  Taeyoung Yoon ,  Qingming Zhu

IPC分类号： A61K31/535 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/497 ,  A61K31/437 ,  A61K31/4545 ,  C07D417/14 ,  C07D487/04 ,  C07D413/14 ,  C07D471/04 ,  C07D401/14 ,  A61P17/00 ,  A61P9/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

摘要： The present invention provides novel organic compounds of Formula I: methods of use, and pharmaceutical compositions thereof.

公开(公告)号：US08580798B2

公开(公告)日：2013-11-12

申请号：US12158524

申请日：2006-12-20

申请人： Roger Smith ,  Jacques Dumas ,  Gan Wang ,  Wendy Lee ,  Karl Miranda

发明人： Roger Smith ,  Jacques Dumas ,  Gan Wang ,  Wendy Lee ,  Karl Miranda

IPC分类号： C07D401/12 ,  A61K31/506

CPC分类号： C07D401/12

摘要： Substituted pyrimidine derivatives of formula (I), salts, metabolites, prodrugs and diastereoisomeric forms (both isolated stereoisomers and mixtures of stereoisomers) thereof (wherein A=pyrimidine) pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with other active ingredients, e.g., cytotoxic therapies.

摘要翻译： 式（I）的取代的嘧啶衍生物，其盐，代谢物，前药和非对映异构体形式（分离的立体异构体和立体异构体的混合物）（其中A =嘧啶）含有这些化合物的药物组合物以及这些化合物或组合物用于治疗 增殖和血管生成障碍，作为唯一的药剂或与其它活性成分组合，例如细胞毒性疗法。

公开(公告)号：US07563791B2

公开(公告)日：2009-07-21

申请号：US11596913

申请日：2005-06-03

申请人： Julie A. Dixon ,  Catherine Brennan ,  Karl Miranda ,  Brent Chandler ,  Barton Phillips ,  Jianmei Fan ,  Michael Brands ,  Andrea McClure ,  Benjamin Jones ,  Wenlang Fu ,  Donald Bierer ,  Steven Magnuson ,  Harold C. E. Kluender

发明人： Julie A. Dixon ,  Catherine Brennan ,  Karl Miranda ,  Brent Chandler ,  Barton Phillips ,  Jianmei Fan ,  Michael Brands ,  Andrea McClure ,  Benjamin Jones ,  Wenlang Fu ,  Donald Bierer ,  Steven Magnuson ,  Harold C. E. Kluender

IPC分类号： C07D487/04 ,  C07D417/02 ,  C07D413/02 ,  A61K31/53 ,  A61K35/00

CPC分类号： C07D491/113 ,  C07D487/04

摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.

摘要翻译： 本发明涉及新颖的吡唑并三嗪化合物，含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性障碍和疾病的用途。