公开(公告)号：US07306815B2

公开(公告)日：2007-12-11

申请号：US10764231

申请日：2004-01-23

申请人： Gerald T. Gourdin ,  Steven L. Richheimer ,  Michael S. Tempesta ,  David T. Bailey ,  Rebecca L. Nichols ,  F. Joseph Daugherty ,  Delano R. Freeberg

发明人： Gerald T. Gourdin ,  Steven L. Richheimer ,  Michael S. Tempesta ,  David T. Bailey ,  Rebecca L. Nichols ,  F. Joseph Daugherty ,  Delano R. Freeberg

IPC分类号： A61K36/00 ,  A61K36/45 ,  C07H17/00 ,  C07D311/00

CPC分类号： C07H17/00 ,  A61K31/352 ,  A61K31/70 ,  A61K36/185 ,  A61K36/35 ,  A61K36/38 ,  A61K36/45 ,  A61K36/48 ,  A61K36/63 ,  A61K36/73 ,  A61K36/734 ,  A61K36/752 ,  A61K36/81 ,  A61K36/87 ,  C07D311/62 ,  Y02A50/393 ,  A61K2300/00

摘要： Provided are processes for the preparation of compositions enriched in phenolic compounds from a crude plant extract. One process includes a novel column purification step using a polymer resin that releasably adsorbs the phenolic compounds but does not retain polar non-phenolic compounds, wherein the resin comprises aromatic rings substituted with one or more electron-withdrawing groups. This invention also includes compositions enriched in phenolic compounds. This invention encompasses methods of using the phenolic-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease. The compositions are also useful as meat additives to inhibit food-borne pathogens.

摘要翻译： 提供了从粗植物提取物制备富含酚类化合物的组合物的方法。 一种方法包括使用可释放地吸附酚类化合物但不保留极性非酚类化合物的聚合物树脂的新型柱纯化步骤，其中树脂包含被一个或多个吸电子基团取代的芳环。 本发明还包括富含酚类化合物的组合物。 本发明包括使用富含酚的组合物治疗感染副粘病毒例如呼吸道合胞病毒，正义霉病如甲型流感A，乙型和丙型流感病毒，副流感病毒，疱疹病毒如HSV-1的温血动物包括人的方法 和HSV-2和黄病毒如西尼罗病毒，并用于治疗由关节炎，压力和消化疾病引起的炎症。 组合物还可用作抑制食源性病原体的肉添加剂。

公开(公告)号：US20080199548A1

公开(公告)日：2008-08-21

申请号：US11890788

申请日：2007-08-07

申请人： Gerald T. Gourdin ,  Steven L. Richheimer ,  Michael S. Tempesta ,  David T. Bailey ,  Rebecca L. Nichols ,  F. Joseph Daugherty ,  Delano R. Freeberg

发明人： Gerald T. Gourdin ,  Steven L. Richheimer ,  Michael S. Tempesta ,  David T. Bailey ,  Rebecca L. Nichols ,  F. Joseph Daugherty ,  Delano R. Freeberg

IPC分类号： A61K36/45 ,  A61K36/00 ,  A61K36/73

CPC分类号： A61K31/352 ,  A61K31/70 ,  A61K36/185 ,  A61K36/35 ,  A61K36/45 ,  A61K36/73 ,  A61K36/736 ,  A61K36/87 ,  C07D311/62 ,  Y02A50/393 ,  A61K2300/00

摘要： A product made by a process which results in compositions enriched in total phenols includes purification steps not involving the addition of bisulfite ions. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols, total phenol concentration >12% and exhibiting in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 μg/mL.

摘要翻译： 通过产生富含总酚的组合物的方法制备的产品包括不涉及加入亚硫酸氢盐离子的纯化步骤。 富集的组合物的特征在于含有单体，低聚和聚合物酚，总苯酚浓度> 12％，体外COX-2抑制活性比标准阿司匹林剂量为660mug / mL增加至少2.5倍。

公开(公告)号：US20080207770A1

公开(公告)日：2008-08-28

申请号：US11948622

申请日：2007-11-30

申请人： Gerald T. GOURDIN ,  Steven L. Richheimer ,  Michael S. Tempesta ,  David T. Bailey ,  Rebecca L. Nichols ,  F. Joseph Daugherty ,  Delano R. Freeberg

发明人： Gerald T. GOURDIN ,  Steven L. Richheimer ,  Michael S. Tempesta ,  David T. Bailey ,  Rebecca L. Nichols ,  F. Joseph Daugherty ,  Delano R. Freeberg

IPC分类号： A61K31/05 ,  A01N31/08 ,  A61P31/12 ,  A01P1/00

CPC分类号： C07H17/00 ,  A61K31/352 ,  A61K31/70 ,  A61K36/185 ,  A61K36/35 ,  A61K36/38 ,  A61K36/45 ,  A61K36/48 ,  A61K36/63 ,  A61K36/73 ,  A61K36/734 ,  A61K36/752 ,  A61K36/81 ,  A61K36/87 ,  C07D311/62 ,  Y02A50/393 ,  A61K2300/00

摘要： Provided are processes for the preparation of compositions enriched in phenolic compounds from a crude plant extract. One process includes a novel column purification step using a polymer resin that releasably adsorbs the phenolic compounds but does not retain polar non-phenolic compounds, wherein the resin comprises aromatic rings substituted with one or more electron-withdrawing groups. This invention also includes compositions enriched in phenolic compounds. This invention encompasses methods of using the phenolic-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease. The compositions are also useful as meat additives to inhibit food-borne pathogens.

摘要翻译： 提供了从粗植物提取物制备富含酚类化合物的组合物的方法。 一种方法包括使用可释放地吸附酚类化合物但不保留极性非酚类化合物的聚合物树脂的新型柱纯化步骤，其中树脂包含被一个或多个吸电子基团取代的芳环。 本发明还包括富含酚类化合物的组合物。 本发明包括使用富含酚的组合物治疗感染副粘病毒例如呼吸道合胞病毒，正义霉病如甲型流感A，乙型和丙型流感病毒，副流感病毒，疱疹病毒如HSV-1的温血动物包括人的方法 和HSV-2和黄病毒如西尼罗病毒，并用于治疗由关节炎，压力和消化疾病引起的炎症。 组合物还可用作抑制食源性病原体的肉添加剂。

公开(公告)号：US06960360B2

公开(公告)日：2005-11-01

申请号：US10302264

申请日：2002-11-22

申请人： Gerald T. Gourdin ,  Steven L. Richheimer ,  Michael S. Tempesta ,  David T. Bailey ,  Rebecca L. Nichols ,  F. Joseph Daugherty ,  Delano R. Freeberg

发明人： Gerald T. Gourdin ,  Steven L. Richheimer ,  Michael S. Tempesta ,  David T. Bailey ,  Rebecca L. Nichols ,  F. Joseph Daugherty ,  Delano R. Freeberg

IPC分类号： A61K31/352 ,  A61K31/70 ,  A61K36/185 ,  A61K36/35 ,  A61K36/45 ,  A61K36/73 ,  A61K36/736 ,  A61K36/87 ,  C07D311/62 ,  A61K35/78 ,  A61K47/00 ,  C07H17/00 ,  C07D311/04

CPC分类号： A61K31/352 ,  A61K31/70 ,  A61K36/185 ,  A61K36/35 ,  A61K36/45 ,  A61K36/73 ,  A61K36/736 ,  A61K36/87 ,  C07D311/62 ,  Y02A50/393 ,  A61K2300/00

摘要： This invention provides a process for the preparation of compositions enriched in total phenols from a crude plant extract. The process includes a novel column purification step using a brominated polystyrene resin. This invention also includes compositions enriched in total phenols. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols and having HPLC chromatograms substantially as set forth in FIGS. 10-13. This invention encompasses methods of using the total phenol-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease.

摘要翻译： 本发明提供了一种从粗植物提取物制备富含总酚的组合物的方法。 该方法包括使用溴化聚苯乙烯树脂的新型柱纯化步骤。 本发明还包括富含总酚的组合物。 富集的组合物的特征在于含有单体，低聚和聚合酚，并且具有基本如图1和2所述的HPLC色谱图。 10-13。 本发明包括使用全氟酚组合物治疗感染副粘病毒如呼吸道合胞病毒，正义霉菌科如A，B和C型流感的副流感病毒，疱疹病毒如HSV- 1和HSV-2，以及黄病毒如西尼罗病毒，并用于治疗由关节炎，应激和消化疾病引起的炎症。

公开(公告)号：US07682637B2

公开(公告)日：2010-03-23

申请号：US11890788

申请日：2007-08-07

申请人： Gerald T. Gourdin ,  Steven L. Richheimer ,  Michael S. Tempesta ,  David T. Bailey ,  Rebecca L. Nichols ,  F. Joseph Daugherty ,  Delano R. Freeberg

发明人： Gerald T. Gourdin ,  Steven L. Richheimer ,  Michael S. Tempesta ,  David T. Bailey ,  Rebecca L. Nichols ,  F. Joseph Daugherty ,  Delano R. Freeberg

IPC分类号： A61K36/45 ,  A61K31/70 ,  A61K31/35

CPC分类号： A61K31/352 ,  A61K31/70 ,  A61K36/185 ,  A61K36/35 ,  A61K36/45 ,  A61K36/73 ,  A61K36/736 ,  A61K36/87 ,  C07D311/62 ,  Y02A50/393 ,  A61K2300/00

摘要： A product made by a process which results in compositions enriched in total phenols includes purification steps not involving the addition of bisulfite ions. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols, total phenol concentration >12% and exhibiting in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 μg/mL.

摘要翻译： 通过产生富含总酚的组合物的方法制备的产品包括不涉及加入亚硫酸氢盐离子的纯化步骤。 富集的组合物的特征在于含有单体，低聚和聚合物酚，总苯酚浓度> 12％，体外COX-2抑制活性比标准阿司匹林剂量为660μg/ mL增加至少2.5倍。

公开(公告)号：US07462370B2

公开(公告)日：2008-12-09

申请号：US11750906

申请日：2007-05-18

申请人： David T. Bailey ,  Delano R. Freeberg ,  Dennis Gertenbach ,  Gerald T. Gourdin ,  Steven L. Richheimer ,  Michael S. Tempesta ,  F. Joseph Daugherty

发明人： David T. Bailey ,  Delano R. Freeberg ,  Dennis Gertenbach ,  Gerald T. Gourdin ,  Steven L. Richheimer ,  Michael S. Tempesta ,  F. Joseph Daugherty

IPC分类号： A61K36/45

CPC分类号： C07D311/62 ,  A23L33/105 ,  A61K31/352 ,  A61K36/074 ,  A61K36/185 ,  A61K36/29 ,  A61K36/31 ,  A61K36/35 ,  A61K36/39 ,  A61K36/45 ,  A61K36/73 ,  A61K36/736 ,  A61K36/81 ,  A61K36/87 ,  A61K36/899 ,  A61K2300/00

摘要： This invention provides compositions enriched for anthocyanins and methods of preparation thereof from a crude plant extract. The method of preparation includes a novel column purification step using a brominated polystyrene resin.

摘要翻译： 本发明提供富含花青素的组合物及其制备方法。 制备方法包括使用溴化聚苯乙烯树脂的新型柱纯化步骤。

公开(公告)号：US06780442B2

公开(公告)日：2004-08-24

申请号：US09943158

申请日：2001-08-30

申请人： David T. Bailey ,  Delano R. Freeberg ,  Dennis Gertenbach ,  Gerald T. Gourdin ,  Steven L. Richheimer ,  Michael S. Tempesta ,  F. Joseph Daugherty

发明人： David T. Bailey ,  Delano R. Freeberg ,  Dennis Gertenbach ,  Gerald T. Gourdin ,  Steven L. Richheimer ,  Michael S. Tempesta ,  F. Joseph Daugherty

IPC分类号： A61K3578

CPC分类号： C07D311/62 ,  A23L33/105 ,  A61K31/352 ,  A61K36/074 ,  A61K36/185 ,  A61K36/29 ,  A61K36/31 ,  A61K36/35 ,  A61K36/39 ,  A61K36/45 ,  A61K36/73 ,  A61K36/736 ,  A61K36/81 ,  A61K36/87 ,  A61K36/899 ,  A61K2300/00

摘要： This invention includes both a one-column process and a two-column process for the preparation of compositions enriched for anthocyanins from a crude plant extract. Both processes include a novel column purification step using a brominated polystyrene resin. This invention also includes extracts enriched for anthocyanins.

摘要翻译： 本发明包括用于从粗植物提取物制备富含花青素的组合物的单柱方法和双柱方法。 两种方法都包括使用溴化聚苯乙烯树脂的新型柱纯化步骤。 本发明还包括富含花青素的提取物。

公开(公告)号：US20090099373A1

公开(公告)日：2009-04-16

申请号：US12262000

申请日：2008-10-30

申请人： David T. BAILEY ,  Delano R. Freeberg ,  Dennis Gertenbach ,  Gerald T. Gourdin ,  Steven L. Richheimer ,  Michael S. Tempesta ,  F. Joseph Daugherty

发明人： David T. BAILEY ,  Delano R. Freeberg ,  Dennis Gertenbach ,  Gerald T. Gourdin ,  Steven L. Richheimer ,  Michael S. Tempesta ,  F. Joseph Daugherty

IPC分类号： C07D311/00

CPC分类号： C07D311/62 ,  A23L33/105 ,  A61K31/352 ,  A61K36/074 ,  A61K36/185 ,  A61K36/29 ,  A61K36/31 ,  A61K36/35 ,  A61K36/39 ,  A61K36/45 ,  A61K36/73 ,  A61K36/736 ,  A61K36/81 ,  A61K36/87 ,  A61K36/899 ,  A61K2300/00

摘要： This invention provides compositions enriched for anthocyanins and methods of preparation thereof from a crude plant extract. The method of preparation includes a novel column purification step using a brominated polystyrene resin.

摘要翻译： 本发明提供富含花青素的组合物及其制备方法。 制备方法包括使用溴化聚苯乙烯树脂的新型柱纯化步骤。

公开(公告)号：US06596776B2

公开(公告)日：2003-07-22

申请号：US10133986

申请日：2002-04-25

申请人： William R. Gamble ,  Zhengjie Liu ,  David T. Bailey ,  Pedro P. Perez ,  Dean P. Stull ,  Steven L. Richheimer ,  Rebecca L. Nichols ,  Rod Lenoble

发明人： William R. Gamble ,  Zhengjie Liu ,  David T. Bailey ,  Pedro P. Perez ,  Dean P. Stull ,  Steven L. Richheimer ,  Rebecca L. Nichols ,  Rod Lenoble

IPC分类号： A61K31045

CPC分类号： C07C29/76 ,  C07C29/86 ,  C07C31/125 ,  C07C33/025

摘要： The present invention relates to a naturally obtained mixture of higher molecular weight primary aliphatic alcohols which contain 20 to 34 carbon atoms. This invention also relates to the process for obtaining the alcohol mixture by extraction and purification with organic solvents from a natural product, such as beeswax with and without saponification of the natural product. The alcohol mixture obtained from beeswax has enhanced purity and contains a mixture of alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering cholesterol and LDL-cholesterol and increasing HDL-cholesterol levels so that it is effective in treating hypercholesterolemia. Consequently the composition may be used to reduce the risk of coronary heart disease, to inhibit the atherosclerotic process (platelet hyperaggregability, ischemia and thrombosis) and also to act as an anti-inflammatory and anti-thrombotic agent. The composition also possesses neurotrophic properties and is useful for improving male sexual activity.

公开(公告)号：US07141611B2

公开(公告)日：2006-11-28

申请号：US10622249

申请日：2003-07-18

申请人： William R. Gamble ,  Zhengjie Liu ,  David T. Bailey ,  Pedro P. Perez ,  Dean P. Stull ,  Steven L. Richheimer ,  Rebecca L. Nichols ,  Rod Lenoble

发明人： William R. Gamble ,  Zhengjie Liu ,  David T. Bailey ,  Pedro P. Perez ,  Dean P. Stull ,  Steven L. Richheimer ,  Rebecca L. Nichols ,  Rod Lenoble

IPC分类号： A61K31/045 ,  C07C29/76 ,  C07C29/28 ,  C07C29/86

CPC分类号： C07C29/76 ,  C07C29/86 ,  C07C31/125 ,  C07C33/025

摘要： This invention provides an isolated mixture of higher molecular weight primary aliphatic alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms and having enhanced purity. This invention also provides a process for obtaining the alcohol mixture by extracting a natural product with organic solvents with or without saponification of the natural product. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering total cholesterol and LDL-cholesterol and increasing HDL-cholesterol levels and therefore is effective in treating hypercholesterolemia. The composition may be used to reduce the risk of coronary heart disease, to inhibit the atherosclerotic process (platelet hyperaggregability, ischemia and thrombosis), and can be used as an anti-inflammatory and anti-thrombotic agent. The composition also possesses neurotrophic properties and is useful for improving male sexual activity.

摘要翻译： 本发明提供了具有20,22,24,26,27,28,30,32和34个碳原子的较高分子量伯脂肪醇的分离混合物，并且具有增强的纯度。 本发明还提供了一种通过在天然产物皂化或不皂化的情况下用有机溶剂萃取天然产物来获得醇混合物的方法。 酒精混合物可用于药物组合物，食品和膳食补充剂中，并有效降低总胆固醇和低密度脂蛋白胆固醇并增加HDL-胆固醇水平，因此有效治疗高胆固醇血症。 该组合物可用于降低冠心病的风险，抑制动脉粥样硬化过程（血小板超聚集，缺血和血栓形成），并可用作抗炎和抗血栓形成剂。 该组合物还具有神经营养性质，可用于改善男性的性活动。