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公开(公告)号:US20170183352A1
公开(公告)日:2017-06-29
申请号:US15231005
申请日:2016-08-08
申请人: Gilbert BESONG , Christopher Thomas BRAIN , Clinton A. BROOKS , Miles Stuart CONGREVE , Claudio DAGOSTIN , Guo HE , Ying HOU , Steven HOWARD , Yue LI , Yipin LU , Paul MORTENSON , Troy SMITH , Moo Je SUNG , Steven WOODHEAD , Wojciech WRONA , Bharat LAGU
发明人: Gilbert BESONG , Christopher Thomas BRAIN , Clinton A. BROOKS , Miles Stuart CONGREVE , Claudio DAGOSTIN , Guo HE , Ying HOU , Steven HOWARD , Yue LI , Yipin LU , Paul MORTENSON , Troy SMITH , Moo Je SUNG , Steven WOODHEAD , Wojciech WRONA , Bharat LAGU
IPC分类号: C07D487/04 , A61K31/519
CPC分类号: C07D487/04 , A61K31/519 , C07D487/08
摘要: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.