专利检索 ap:("Gilbert Besong" OR "Christopher Thomas Brain" OR "Clinton A Brooks" OR "Miles Stuart Congreve" OR "Claudio Dagostin" OR "Guo He" OR "Ying Hou" OR "Steven Howard" OR "Yue Li" OR "Yipin Lu" OR "Paul Mortenson" OR "Troy Smith" OR "Moo Je Sung" OR "Steven Woodhead" OR "Wojciech Wrona" OR "Bharat Lagu") AND inv:"Wojciech Wrona" 第 1 页

1.

发明授权
Pyrrolopyrimidine compounds and their uses 有权

公开(公告)号：US09416136B2

公开(公告)日：2016-08-16

申请号：US14158358

申请日：2014-01-17

申请人： Gilbert Besong , Christopher Thomas Brain , Clinton A Brooks , Miles Stuart Congreve , Claudio Dagostin , Guo He , Ying Hou , Steven Howard , Yue Li , Yipin Lu , Paul Mortenson , Troy Smith , Moo Je Sung , Steven Woodhead , Wojciech Wrona , Bharat Lagu

发明人： Gilbert Besong , Christopher Thomas Brain , Clinton A Brooks , Miles Stuart Congreve , Claudio Dagostin , Guo He , Ying Hou , Steven Howard , Yue Li , Yipin Lu , Paul Mortenson , Troy Smith , Moo Je Sung , Steven Woodhead , Wojciech Wrona , Bharat Lagu

IPC分类号： A61K31/519 , A61P35/04 , C07D487/04 , C07D487/08

CPC分类号： C07D487/04 , A61K31/519 , C07D487/08

摘要： The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

2.

发明申请
PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES 有权
标题翻译：吡咯啉化合物及其用途

公开(公告)号：US20100105653A1

公开(公告)日：2010-04-29

申请号：US12545322

申请日：2009-08-21

申请人： Gilbert Besong , Christopher Thomas Brain , Clinton A. Brooks , Miles Stuart Congreve , Claudio Dagostin , Guo He , Ying Huo , Steven Howard , Yue Li , Yipin Lu , Paul Mortenson , Troy Smith , Moo Je Sung , Steven Woodhead , Wojciech Wrona

发明人： Gilbert Besong , Christopher Thomas Brain , Clinton A. Brooks , Miles Stuart Congreve , Claudio Dagostin , Guo He , Ying Huo , Steven Howard , Yue Li , Yipin Lu , Paul Mortenson , Troy Smith , Moo Je Sung , Steven Woodhead , Wojciech Wrona

IPC分类号： A61K31/519 , C07D487/04 , A61K31/551 , C12N5/00

CPC分类号： C07D487/04 , A61K31/519 , C07D487/08

摘要： The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

摘要翻译： 所公开的化合物涉及蛋白激酶相关病症的治疗和疗法。还需要可用于治疗或预防或改善癌症，移植排斥和自身免疫性疾病的一种或多种症状的化合物。此外，需要使用本文提供的化合物调节蛋白激酶如CDK1，CDK2，CDK4，CDK5，CDK6，CDK7，CDK8和CDK9的活性的方法。

3.

发明申请
PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES 有权
标题翻译：吡咯啉化合物及其用途

公开(公告)号：US20140135312A1

公开(公告)日：2014-05-15

申请号：US14158358

申请日：2014-01-17

申请人： Gilbert BESONG , Christopher Thomas Brain , Clinton A. Brooks , Miles Stuart Congreve , Claudio Dagostin , Guo He , Ying Huo , Steven Howard , Yue Ll , Yipin Lu , Paul Mortenston , Troy Smith , Moo Je Sung , Steven Woodhead , Wojciech Wrona , Bharat Lagu

发明人： Gilbert BESONG , Christopher Thomas Brain , Clinton A. Brooks , Miles Stuart Congreve , Claudio Dagostin , Guo He , Ying Huo , Steven Howard , Yue Ll , Yipin Lu , Paul Mortenston , Troy Smith , Moo Je Sung , Steven Woodhead , Wojciech Wrona , Bharat Lagu

IPC分类号： C07D487/08 , C07D487/04

CPC分类号： C07D487/04 , A61K31/519 , C07D487/08

摘要： The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

摘要翻译： 所公开的化合物涉及蛋白激酶相关病症的治疗和疗法。还需要可用于治疗或预防或改善癌症，移植排斥和自身免疫性疾病的一种或多种症状的化合物。此外，需要使用本文提供的化合物调节蛋白激酶如CDK1，CDK2，CDK4，CDK5，CDK6，CDK7，CDK8和CDK9的活性的方法。

4.

发明申请
PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES 有权
标题翻译：吡咯啉化合物及其用途

公开(公告)号：US20110152244A1

公开(公告)日：2011-06-23

申请号：US13060154

申请日：2009-08-20

申请人： Gilbert Besong , Christopher Thomas Brain , Clinton A. Brooks , Miles Stuart Congreve , Claudio Dagostin , Guo He , Ying Huo , Steven Howard , Yue Li , Yipin Lu , Paul Morteson , Troy Smith , Moo Sung , Steven Woodhead , Wojciech Wrona

发明人： Gilbert Besong , Christopher Thomas Brain , Clinton A. Brooks , Miles Stuart Congreve , Claudio Dagostin , Guo He , Ying Huo , Steven Howard , Yue Li , Yipin Lu , Paul Morteson , Troy Smith , Moo Sung , Steven Woodhead , Wojciech Wrona

IPC分类号： C07D487/04 , A61K31/497 , A61K31/519 , A61K31/551 , A61K31/5377 , A61K31/501 , C12N9/99 , A61P35/04 , A61P29/00

CPC分类号： C07D487/04 , A61K31/519 , C07D487/08

摘要： The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

摘要翻译： 所公开的化合物涉及蛋白激酶相关病症的治疗和疗法。还需要可用于治疗或预防或改善癌症，移植排斥和自身免疫性疾病的一种或多种症状的化合物。此外，需要使用本文提供的化合物调节蛋白激酶如CDK1，CDK2，CDK4，CDK5，CDK6，CDK7，CDK8和CDK9的活性的方法。

5.

发明授权
Pyrrolopyrimidine compounds and their uses 有权
标题翻译：吡咯并嘧啶化合物及其用途

公开(公告)号：US08685980B2

公开(公告)日：2014-04-01

申请号：US13060154

申请日：2009-08-20

申请人： Gilbert Ebai Besong , Christopher Thomas Brain , Clinton Alan Brooks , Miles Stuart Congreve , Claudio Dagostin , Guo He , Ying Hou , Steven Howard , Yue Li , Yipin Lu , Paul Neil Mortenson , Troy D. Smith , Moo Je Sung , Steven John Woodhead , Wojciech Wrona , Bharat Lagu

发明人： Gilbert Ebai Besong , Christopher Thomas Brain , Clinton Alan Brooks , Miles Stuart Congreve , Claudio Dagostin , Guo He , Ying Hou , Steven Howard , Yue Li , Yipin Lu , Paul Neil Mortenson , Troy D. Smith , Moo Je Sung , Steven John Woodhead , Wojciech Wrona , Bharat Lagu

IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P29/00

CPC分类号： C07D487/04 , A61K31/519 , C07D487/08

摘要： The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

摘要翻译： 所公开的化合物涉及蛋白激酶相关病症的治疗和疗法。还需要可用于治疗或预防或改善癌症，移植排斥和自身免疫性疾病的一种或多种症状的化合物。此外，需要使用本文提供的化合物调节蛋白激酶如CDK1，CDK2，CDK4，CDK5，CDK6，CDK7，CDK8和CDK9的活性的方法。

6.

发明申请
Organic compounds 有权
标题翻译：有机化合物

公开(公告)号：US20050234042A1

公开(公告)日：2005-10-20

申请号：US11099941

申请日：2005-04-06

申请人： Mark Palermo , Sushil Sharma , Christopher Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark Charest , Feng He

发明人： Mark Palermo , Sushil Sharma , Christopher Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark Charest , Feng He

IPC分类号： A61K31/40 , A61K31/4025 , A61K31/437 , A61K31/4745 , A61K31/55 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/16 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/04

CPC分类号： C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04

摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I

摘要翻译： 抑制Smac蛋白与抑制凋亡蛋白抑制剂（IAP）的新型化合物

7.

发明授权
Bioreductive cytotoxic agents 失效
标题翻译：生物还原性细胞毒素

公开(公告)号：US5969133A

公开(公告)日：1999-10-19

申请号：US83652

申请日：1998-05-22

申请人： Mitsunori Ono , Keizo Koya , Lijun Sun , Yumiko Wada , Wojciech Wrona , Natalie Dales , Xueliang Tao , Sylvia Holden

发明人： Mitsunori Ono , Keizo Koya , Lijun Sun , Yumiko Wada , Wojciech Wrona , Natalie Dales , Xueliang Tao , Sylvia Holden

IPC分类号： C07C229/56 , C07C229/60 , C07C229/64 , C07D209/08 , C07D209/12 , C07D235/12 , C07D295/112 , C07D307/42 , C07D307/79 , C07D265/30 , C07D235/02 , C07Z229/60 , C07Z261/00

CPC分类号： C07D295/112 , C07C229/56 , C07C229/60 , C07C229/64 , C07D209/08 , C07D209/12 , C07D235/12 , C07D307/42 , C07D307/79 , C07C2101/02 , C07C2101/04 , C07C2101/16

摘要： A compound which consists of a proactive alkylating moiety containing an electron-withdrawing group, a bioreductive moiety containing at least two double bonds, and a linker joining the proactive alkylating moiety and the bioreductive moiety.

摘要翻译： 由包含吸电子基团的主动烷基化部分，含有至少两个双键的生物还原部分和连接主动烷基化部分和生物还原部分的连接体组成的化合物。

8.

发明授权
Bis (haloethyl) aminobenzene derivatives 失效
标题翻译：双（卤代乙基）氨基苯衍生物

公开(公告)号：US6137003A

公开(公告)日：2000-10-24

申请号：US181436

申请日：1998-10-28

申请人： Mitsunori Ono , Keizo Koya , Lijun Sun , Wojciech Wrona , Sylvia Holden , Noriaki Tatsuta

发明人： Mitsunori Ono , Keizo Koya , Lijun Sun , Wojciech Wrona , Sylvia Holden , Noriaki Tatsuta

IPC分类号： C07D307/58 , A61K31/196 , A61K31/245 , A61K31/341 , A61K31/343 , A61P35/00 , C07C229/60 , C07C229/64 , C07D307/42 , C07C229/00

CPC分类号： C07D307/42 , C07C229/60 , C07C229/64 , C07C2101/02 , C07C2101/04

摘要： The present invention relates to bis(haloethyl)aminobenzene derivatives featured by having carboxyl-containing moiety and one other moiety at the ortho position with respect to the bis(haloethyl)amino substituent of the benzene ring. The moiety at the ortho position can be alkyl, cycloalkyl, heterocycloalkyl, aryl heteroaryl, alkyl(cycloalkyl), alkyl(heterocycloalkyl), alkyl(heteroaryl), alkyl(aryl), --(--O-alkyl).sub.2-5 or --Y.sup.1 --Y.sup.2 in which Y.sup.1 is O, S, or N(R.sup.5) wherein R.sup.5 is hydrogen or alkyl, and Y.sup.2 is alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, heteroacryl, alkyl(cycloalkyl), alkyl(hetero-cycloalkyl), alkyl(aryl), or alkyl(heteroaryl).

摘要翻译： 本发明涉及通过在相对于苯环的双（卤代乙基）氨基取代基的邻位具有含羧基的部分和一个其它部分而特征的双（卤代乙基）氨基苯衍生物。邻位的部分可以是烷基，环烷基，杂环烷基，芳基杂芳基，烷基（环烷基），烷基（杂环烷基），烷基（杂芳基），烷基（芳基）， - （ - O-烷基）2-5或-Y1 -Y 2，其中Y 1是O，S或N（R 5），其中R 5是氢或烷基，并且Y 2是烷基，烯基，环烷基，杂环烷基，芳基，异丙基丙烯酰基，烷基（环烷基），烷基（杂环烷基）（芳基）或烷基（杂芳基）。