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公开(公告)号：US20130172985A1
公开(公告)日：2013-07-04
申请号：US13522032
申请日：2011-01-13
IPC分类号： C07K14/435 , A61F2/06 , A61N5/06
CPC分类号： C07K14/435 , A61F2/06 , A61K41/0042 , A61L27/222 , A61L27/38 , A61L27/48 , A61L27/52 , A61N5/062 , C07K14/78 , C08H1/06 , C08J3/246 , C08J2305/08 , C08J2389/00 , C08K5/0025 , C08L89/06 , C08L2312/00 , C08L89/00
摘要： Described herein are modified gelatins or the pharmaceutically-acceptable salts or esters thereof comprising at least one actinically crosslinkable group covalently bonded to gelatin. The modified gelatins are useful in producing composites that ultimately can be used to produce three-dimensional engineered biological constructs. The composites are the polymerization product between the modified gelatin and at least one actinically crosslinkable macromolecule. Methods for making the modified gelatins are also described herein.
摘要翻译： 本文描述的是修饰明胶或其药学上可接受的盐或酯，其包含共价键合到明胶上的至少一种可光化交联的基团。 修饰的明胶可用于生产最终可用于生产三维工程生物构建体的复合材料。 复合材料是改性明胶与至少一种可光化交联的大分子之间的聚合产物。 本文还描述了制备改性明胶的方法。
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公开(公告)号：US20100330143A1
公开(公告)日：2010-12-30
申请号：US12764466
申请日：2010-04-21
IPC分类号： C07K14/78 , C08B37/00 , C08G63/91 , C08F120/10 , A61K31/728 , A61K38/39 , A61K31/74 , A61F2/00 , B05D5/00 , C12Q1/02 , C12N5/073
CPC分类号： C08B37/0072 , A61K31/728 , A61K31/74 , C08B15/10 , C08B37/003 , C08B37/0045 , C08B37/0069 , C08B37/0075 , C08B37/0084 , C08G63/91 , C08L2203/02 , C12N5/0068 , C12N2533/80 , C12N2537/10
摘要： Described herein are composites produced by reacting a first thiolated macromolecule with at least one compound having at least one thiol-reactive electrophilic functional group. The methods described herein permit the cross-linking of a variety of different thiolated macromolecules with one another. The composites described herein have a variety of biomedical and pharmaceutical applications, which are also described herein.
摘要翻译： 本文描述的是通过使第一硫醇化大分子与至少一种具有至少一个硫醇反应性亲电官能团的化合物反应制备的复合材料。 本文描述的方法允许各种不同硫醇化的大分子彼此交联。 本文描述的复合材料具有各种生物医学和药物应用，其也在本文中描述。
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3.发明申请ALKYLATED SEMI SYNTHETIC GLYCOSAMINOGLYCOSAN ETHERS, AND METHODS FOR MAKING AND USING THEREOF 有权烷基半胱氨酸合成谷氨酰胺聚糖酯及其制备及使用方法公开(公告)号：US20120058161A1
公开(公告)日：2012-03-08
申请号：US13304292
申请日：2011-11-23
IPC分类号： A61K31/728 , A61K9/00 , C08B37/08 , A61P27/02 , A61P27/04
CPC分类号： A61K31/728 , A61K45/06 , C08B37/0072 , C08L5/08 , Y02A50/387
摘要： Described herein are alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as “SAGEs.” The synthesis of sulfated and alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including use for ocular or ophthalmic treatment.
摘要翻译： 本文描述了烷基化和半合成的糖胺聚糖醚，在本文中称为“SAGE”。还描述了硫酸化和烷基化的SAGE的合成。 本文所述的化合物可用于许多应用，包括用于眼部或眼部治疗。
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4.发明申请公开(公告)号：US20100317616A1
公开(公告)日：2010-12-16
申请号：US12870763
申请日：2010-08-27
CPC分类号： A61K31/728 , A61K45/06 , C08B37/0072 , C08L5/08 , Y02A50/387
摘要： Described herein is the synthesis of alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as “SAGEs.” The synthesis of sulfated alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including wound healing, drug delivery, and the treatment of a number of inflammatory diseases and skin disorders.
摘要翻译： 本文描述的是合成烷基化和半合成的糖胺聚糖醚，本文称为“SAGE”。还描述了硫酸化烷基化SAGE的合成。 本文所述的化合物可用于许多应用，包括伤口愈合，药物递送以及治疗许多炎性疾病和皮肤病症。
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5.发明授权Alkylated semi synthetic glycosaminoglycosan ethers, and methods for making and using thereof 有权烷基化半合成糖胺聚糖醚，及其制备和使用方法公开(公告)号：US08399430B2
公开(公告)日：2013-03-19
申请号：US12870774
申请日：2010-08-27
IPC分类号： A61K31/175 , A61K31/70 , A01N43/04 , C07H5/04
CPC分类号： A61K31/728 , A61K45/06 , C08B37/0072 , C08L5/08 , Y02A50/387
摘要： Described herein is the synthesis of alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as “SAGEs.” The synthesis of sulfated alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including wound healing, drug delivery, and the treatment of a number of inflammatory diseases and skin disorders.
摘要翻译： 本文描述的是合成烷基化和半合成的糖胺聚糖醚，本文称为SAGE。 还描述了硫酸化烷基化SAGE的合成。 本文所述的化合物可用于许多应用，包括伤口愈合，药物递送以及治疗许多炎性疾病和皮肤病症。
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6.发明授权Alkylated semi synthetic glycosaminoglycosan ethers, and methods for making and using thereof 有权烷基化半合成糖胺聚糖醚，及其制备和使用方法公开(公告)号：US08329673B2
公开(公告)日：2012-12-11
申请号：US13304292
申请日：2011-11-23
IPC分类号： A61K31/728 , A61K9/00 , C08B37/08 , A61P27/02 , A61P27/04
CPC分类号： A61K31/728 , A61K45/06 , C08B37/0072 , C08L5/08 , Y02A50/387
摘要： Described herein are alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as “SAGEs.” The synthesis of sulfated and alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including use for ocular or ophthalmic treatment.
摘要翻译： 本文所述的是烷基化和半合成的糖胺聚糖醚，在本文中称为SAGE。 还描述了硫酸化和烷基化SAGE的合成。 本文所述的化合物可用于许多应用，包括用于眼部或眼部治疗。
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7.发明申请HYDROGELS CROSSLINKED WITH GOLD NANOPARTICLES AND METHODS OF MAKING AND USING THEREOF 审中-公开与金纳米颗粒交联的水凝胶及其制备和使用方法公开(公告)号：US20110280914A1
公开(公告)日：2011-11-17
申请号：US13146564
申请日：2009-12-17
IPC分类号： A61K9/00 , C07K14/435 , A61K47/36 , A61K47/38 , A61K47/42 , A61K35/12 , A61K35/30 , A61K35/34 , A61K35/407 , A61K35/36 , A61K35/14 , A61K35/39 , C12N5/071 , C12N5/077 , C12N5/0793 , C12N5/078 , C12Q1/02 , C12P21/08 , C12P21/00 , C07H23/00 , B82Y5/00
CPC分类号： G01N33/585 , A61L27/38 , A61L27/446 , B22F1/0062 , B22F1/0096 , B82Y5/00 , C12N5/0068 , C12N2533/10 , C12N2533/80 , G01N33/532 , G01N2400/10
摘要： Described herein are composites useful in tissue and organ engineering. In one aspect, the composite comprises the reaction product between a macromolecule comprising at least one thiol group and a gold nanoparticle. The thiolated macro-molecule crosslinks with the gold nanoparticle to produce a composite that is useful in anchoring cells. The composites can be used to form multi-layer 3-D structures, where the cells in each layer can aggregate and fuse with one another to form tissues and organs.
摘要翻译： 这里描述的是在组织和器官工程中有用的复合材料。 在一个方面，复合物包含包含至少一个硫醇基的大分子和金纳米颗粒之间的反应产物。 硫醇化的大分子与金纳米颗粒交联以产生可用于锚定细胞的复合物。 复合材料可用于形成多层3-D结构，其中每层中的细胞可以彼此聚集并融合以形成组织和器官。
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8.发明授权Alkylated semi-synthetic glycosaminoglycosan ethers, and methods of making and using thereof 有权烷基化半合成糖胺聚糖醚，及其制备和使用方法公开(公告)号：US07855187B1
公开(公告)日：2010-12-21
申请号：US12870763
申请日：2010-08-27
IPC分类号： A61K31/715
CPC分类号： A61K31/728 , A61K45/06 , C08B37/0072 , C08L5/08 , Y02A50/387
摘要： Described herein is the synthesis of alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as “SAGEs.” The synthesis of sulfated alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including wound healing, drug delivery, and the treatment of a number of inflammatory diseases and skin disorders.
摘要翻译： 本文描述的是合成烷基化和半合成的糖胺聚糖醚，本文称为“SAGE”。还描述了硫酸化烷基化SAGE的合成。 本文所述的化合物可用于许多应用，包括伤口愈合，药物递送以及治疗许多炎性疾病和皮肤病症。
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9.发明申请PROCESSING METHOD FOR FRACTIONALLY CONVERTING PENNISETUM HYDRIDUM INTO FUEL ETHANOL WITH CO-PRODUCTION OF ELECTRICITY GENERATION AND PAPER PULP 审中-公开用于将电解质和纸浆共同生产的硫酸氢铵转化为燃料乙醇的处理方法公开(公告)号：US20110104773A1
公开(公告)日：2011-05-05
申请号：US12312201
申请日：2008-02-15
申请人： Hongzhang Chen , Jianxing Zhang , Cheuk Lam Leung , Yong Li
发明人： Hongzhang Chen , Jianxing Zhang , Cheuk Lam Leung , Yong Li
IPC分类号： C12P7/06
CPC分类号： C12P7/10 , C12M21/12 , C12M43/02 , C12M43/08 , C12M45/02 , C12M45/20 , D21C1/02 , D21C5/00 , D21C9/00 , D21H11/12 , Y02E50/16 , Y02E50/17
摘要： The invention relates to a method for fractionally converting pennisetum hydridum into fuel ethanol with co-production of electricity generation and paper pulp, which comprises subjecting the pennisetum hydridum having been cut into segments to steam explosion treatment by utilizing a steam explosion device to obtain a steam explosion product, and said method is characterized in that it comprises the steps of: washing the steam explosion product with water to obtain fibers and water washing liquid containing a degraded hemicellulose, and separating and purifying the water washing liquid to obtain an xylo-oligosaccharide; fractionally teasing the fibers, and subjecting the obtained long fibers to an ethanol self-catalyzed pulping and then a bleaching treatment to obtain a paper pulp, and after recovering ethanol, obtaining an alcohol-soluble lignin by separation; preparing cellulase by a solid state fermentation, that is, taking the short fibers obtained by fractionally teasing as a fermentation substrate of Trichoderma viride to prepare a solid cellulase; mixing the short fibers, the solid cellulase and yeast to perform a simultaneous saccharification fermentation for obtaining the fuel ethanol and a fermentation residue, and producing CO2 by the fermentation; and drying the fermentation residue to prepare a biomass fuel for electricity generation. The method of the invention can realize a high efficient comprehensive utilization of the pennisetum hydridum resource.
摘要翻译： 本发明涉及一种利用蒸汽爆炸装置共同生产发电和纸浆将狼尾草分为转化为燃料乙醇的方法，其中包括将经切割的狼尾草进行蒸汽爆炸处理，以获得蒸汽 所述方法的特征在于包括以下步骤：用水洗涤蒸汽爆炸产物以获得含有降解的半纤维素的纤维和水洗液，并分离和纯化水洗液以获得低聚木糖; 将所得长纤维进行乙醇自催化制浆，然后进行漂白处理以获得纸浆，并在回收乙醇后通过分离获得醇可溶性木质素; 通过固态发酵制备纤维素酶，即通过将通过分层挑选获得的短纤维作为绿色木霉的发酵底物制备固体纤维素酶; 混合短纤维，固体纤维素酶和酵母以进行同时糖化发酵以获得燃料乙醇和发酵残渣，并通过发酵产生CO 2; 并干燥发酵残渣以制备用于发电的生物质燃料。 本发明方法可以实现狼尾草资源的高效综合利用。
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