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公开(公告)号：US08334125B2
公开(公告)日：2012-12-18
申请号：US13169853
申请日：2011-06-27
申请人： Grace DeSantis , Ellen Chi , Jennifer Ann Chaplin , Aileen Milan , Jay Short , David Weiner , Mark Madden , Darcy Madden, legal representative , Mark Burk , Dan Robertson
发明人： Grace DeSantis , Ellen Chi , Jennifer Ann Chaplin , Aileen Milan , Jay Short , David Weiner , Mark Madden , Mark Burk , Dan Robertson
IPC分类号： C12N9/78 , C12N15/00 , C12N1/20 , C12P21/04 , C12Q1/00 , C12Q1/68 , A61K38/00 , C07H21/04 , C07H21/02
CPC分类号： C12P7/42 , C12N9/78 , C12N15/00 , C12N15/70 , C12N15/74 , C12N15/81 , C12N15/815 , C12P7/40 , C12P13/004 , C12P13/04 , C12P21/00 , C12P41/006
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 另外还提供了设计新腈水解酶的方法及其使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。
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公开(公告)号：US07651849B2
公开(公告)日：2010-01-26
申请号：US12397204
申请日：2009-03-03
申请人： Grace DeSantis , Ellen Chi , Jennifer Ann Chaplin , Aileen Milan , Jay M. Short , David Paul Weiner , Mark Madden , Darcy Madden, legal representative , Mark J. Burk , Dan E. Robertson
发明人： Grace DeSantis , Ellen Chi , Jennifer Ann Chaplin , Aileen Milan , Jay M. Short , David Paul Weiner , Mark Madden , Mark J. Burk , Dan E. Robertson
IPC分类号： C12N9/78 , C12N15/00 , C12N1/20 , C12P21/04 , C12Q1/00 , A61K38/00 , C07H21/04 , C12Q1/68 , C07H21/02
CPC分类号： C12P7/42 , C12N9/78 , C12N15/00 , C12N15/70 , C12N15/74 , C12N15/81 , C12N15/815 , C12P7/40 , C12P13/004 , C12P13/04 , C12P21/00 , C12P41/006
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 另外还提供了设计新腈水解酶的方法及其使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。
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公开(公告)号：US20100273659A1
公开(公告)日：2010-10-28
申请号：US12529340
申请日：2008-02-29
申请人： Grace DeSantis , Jennifer Chaplin , Ellen Chi , Aileen Milan , Jay Short , David Weiner , Mark Madden , Darcy Madden , Dan Robertson
发明人： Grace DeSantis , Jennifer Chaplin , Ellen Chi , Aileen Milan , Jay Short , David Weiner , Mark Madden , Darcy Madden , Dan Robertson
IPC分类号： C40B20/00 , C12N15/55 , C12N15/63 , C12N9/78 , C12P7/40 , C12P7/42 , C12P13/00 , C12P7/54 , C12P7/56 , C12P19/34 , C12Q1/68 , C12P1/00 , C12Q1/34
CPC分类号： C12P7/42 , C12N9/78 , C12P13/002 , C12P13/004 , C12P13/005 , C12P13/04 , C12P41/007
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
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公开(公告)号：US09217164B2
公开(公告)日：2015-12-22
申请号：US12529340
申请日：2008-02-29
申请人： Jennifer A. Chaplin , Ellen Chi , Grace DeSantis , Mark Madden , Darcy Madden , Aileen Milan , Dan E. Robertson , Jay M. Short , David P. Weiner
发明人： Jennifer A. Chaplin , Ellen Chi , Grace DeSantis , Mark Madden , Aileen Milan , Dan E. Robertson , Jay M. Short , David P. Weiner
CPC分类号： C12P7/42 , C12N9/78 , C12P13/002 , C12P13/004 , C12P13/005 , C12P13/04 , C12P41/007
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
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5.发明授权Nitrilases, nucleic acids encoding them and methods for making and using them 有权腈水解酶，编码它们的核酸和制备和使用它们的方法公开(公告)号：US07811804B2
公开(公告)日：2010-10-12
申请号：US12556528
申请日：2009-09-09
申请人： Grace DeSantis , Jay Short , Mark Burk , Kelvin Wong , Kelly Chatman , Bob Farwell
发明人： Grace DeSantis , Jay Short , Mark Burk , Kelvin Wong , Kelly Chatman , Bob Farwell
CPC分类号： C12N9/78 , C12N15/00 , C12P7/42 , C12P13/002 , C12P13/04 , C12P41/006 , C12Y305/05001 , Y02P20/52
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 另外还提供了设计新腈水解酶的方法及其使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。
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公开(公告)号：US08377670B2
公开(公告)日：2013-02-19
申请号：US12439459
申请日：2007-08-31
申请人： Janne S. Kerovuo , Sylke Haremza , Oliver Koch , Tilo Habicher , Dan Robertson , Grace DeSantis , Ryan McCann , Peter Luginbühl
发明人： Janne S. Kerovuo , Sylke Haremza , Oliver Koch , Tilo Habicher , Dan Robertson , Grace DeSantis , Ryan McCann , Peter Luginbühl
CPC分类号： C12N9/0061 , C12N15/09 , C12P5/00 , C12P7/00 , C12P19/00 , C12Y110/03002 , D21C5/005 , D21C9/005 , D21C9/1063
摘要： Provided herein are isolated laccase enzymes and nucleic acids encoding them. Also provided are mediators for laccase reactions. Also provided herein are methods for using laccases to oxidize lignins and other phenolic and aromatic compounds, such as for bio-bleaching and decolorization of wood pulp under high temperature and pH conditions to facilitate a substantial reduction in use of bleaching chemicals, as well as for treatment of fibers.
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公开(公告)号：US20070015260A1
公开(公告)日：2007-01-18
申请号：US11481653
申请日：2006-07-05
申请人： Chi-Huey Wong , Junjie Liu , Grace DeSantis , Mark Burk
发明人： Chi-Huey Wong , Junjie Liu , Grace DeSantis , Mark Burk
摘要： The present invention is based on the discovery that 2-deoxyribose-5-phosphate aldolase (DERA, EC 4.1.2.4) and variants thereof can be used to catalyze sequential asymmetric aldol reactions between a wide variety of donor and acceptor aldehydes. The reaction products typically contain at least two new stereogenic centers and can be produced in enantiomerically pure form. As such, DERA catalyzed asymmetric aldol chemistry can be exploited to produce synthons for the synthesis of a variety of bioactive molecules.
摘要翻译： 本发明基于以下发现：2-脱氧核糖-5-磷酸醛缩酶（DERA，EC 4.1.2.4）及其变体可用于催化多种供体和受体醛之间的顺序不对称醛醇反应。 反应产物通常含有至少两个新的立体中心并且可以以对映体纯的形式制备。 因此，DERA催化的不对称醛醇化学可以被利用来产生用于合成各种生物活性分子的合成物。
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公开(公告)号：US20100009426A1
公开(公告)日：2010-01-14
申请号：US12556528
申请日：2009-09-09
申请人： Grace DeSantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Kelly Chatman , Robert Farwell
发明人： Grace DeSantis , Jay M. Short , Mark J. Burk , Kelvin Wong , Kelly Chatman , Robert Farwell
IPC分类号： C12N9/78
CPC分类号： C12N9/78 , C12N15/00 , C12P7/42 , C12P13/002 , C12P13/04 , C12P41/006 , C12Y305/05001 , Y02P20/52
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
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![Processes for making [R]-ethyl 4-cyano-3 hydroxybutyric acid](/abs-image/US/2013/02/12/US08372608B2/abs.jpg.150x150.jpg)
公开(公告)号：US08372608B2
公开(公告)日：2013-02-12
申请号：US13053404
申请日：2011-03-22
申请人： Mark J. Burk , Grace DeSantis , Brian Morgan , Zuolin Zhu
发明人： Mark J. Burk , Grace DeSantis , Brian Morgan , Zuolin Zhu
CPC分类号： C12P13/004 , C07C253/14 , C07C253/30 , C12P13/002 , C12P13/02 , C12P17/10 , C07C255/16
摘要： The invention provides novel processes for making ethyl-4-cyano-3-hydroxybutyrate, e.g., (R)-ethyl 4-cyano-3-hydroxybutyric acid, and 4-cyano-3-hydroxybutyric acid. The invention provides protocols for making and 4-cyano-3-hydroxybutyric acid and ethyl-4-cyano-3-hydroxybutyrate by whole cell processes, cell lysate processes, “one pot processes” and “multi-pot” processes using a variety of parameters.
摘要翻译： 本发明提供了制备4-氰基-3-羟基丁酸乙酯的新方法，例如（R）-4-氰基-3-羟基丁酸乙酯和4-氰基-3-羟基丁酸。 本发明提供了通过全细胞过程，细胞裂解物过程，一锅法和多锅法使用各种参数制备4-氰基-3-羟基丁酸和4-氰基-3-羟基丁酸乙酯的方案。
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