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公开(公告)号:US20070049588A1
公开(公告)日:2007-03-01
申请号:US11468315
申请日:2006-08-30
申请人: Graeme Smith , Niall Martin , Andrew Slade , Keith Menear , Marc Hummersone , Xiao-Ling Cockcroft , Ian Matthews , Laurent Rigoreau , Roger Griffin , David Newell , Nicola Curtin
发明人: Graeme Smith , Niall Martin , Andrew Slade , Keith Menear , Marc Hummersone , Xiao-Ling Cockcroft , Ian Matthews , Laurent Rigoreau , Roger Griffin , David Newell , Nicola Curtin
IPC分类号: A61K31/5377 , C07D413/14
CPC分类号: C07D409/04
摘要: A compound of formula (I): and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, and their use in treating diseases ameliorated by the inhibition of ATM.
摘要翻译: 式(I)的化合物及其异构体,盐,溶剂化物,化学保护形式及其前药,以及它们在治疗通过抑制ATM而改善的疾病中的用途。
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公开(公告)号:US5919648A
公开(公告)日:1999-07-06
申请号:US817900
申请日:1997-04-25
申请人: Keith William Burr , Martin Ramsden , Graham Timothy Illing , Leslie Ann Harrison , Nicholas John Maishman , David Wilson Spence , Andrew Slade
发明人: Keith William Burr , Martin Ramsden , Graham Timothy Illing , Leslie Ann Harrison , Nicholas John Maishman , David Wilson Spence , Andrew Slade
IPC分类号: C12N15/09 , C12N1/21 , C12N9/80 , C12N15/00 , C12N15/55 , C12P35/02 , C12R1/19 , C12R1/38 , C12P35/00 , C12N1/20 , C12N9/14
CPC分类号: C12N9/80 , C12P35/02 , Y10S435/874
摘要: The present invention relates to an enzyme process for the one-step conversion of cephalosporin C or a derivative thereof into 7-aminocephalosporanic acid or a corresponding derivative thereof. The one step conversion is effected using a cephalosphorin C amidohydrolase derived from Pseudomonas Vesicularis B965, or from any cephalosporin C amidolydrolase producing or potentially producing descendants thereof, or from expression of DNA derived from Pseudomonas Vesicularis B965 or any cephalosporin C amidohydrolase producing or potentially producing descendants thereof
摘要翻译: PCT No.PCT / EP95 / 04487第 371日期1997年04月25日 102(e)日期1997年4月25日PCT提交1995年11月15日PCT公布。 公开号WO96 / 16174 日期:1996年5月30日本发明涉及一种将头孢菌素C或其衍生物一步转化为7-氨基头孢烷酸或其相应衍生物的酶方法。 使用来自Pseudomonas Vesicularis B965的头孢菌素C酰氨基水解酶或产生或潜在产生其后代的任何头孢菌素C酰氨基转移酶,或来自Pseudomonas Vesicularis B965或产生或潜在产生后代的任何头孢菌素C酰氨基水解酶的DNA的表达来实现一步转化 其中
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公开(公告)号:US06984729B1
公开(公告)日:2006-01-10
申请号:US08901612
申请日:1997-07-28
申请人: Bruce L. Frank , Peter C. Roberts , John Goodchild , J. Charles Craig , John S. Mills , Andrew Slade , Robert E. Kilkuskie , Noel A. Roberts , Raymond Jupp
发明人: Bruce L. Frank , Peter C. Roberts , John Goodchild , J. Charles Craig , John S. Mills , Andrew Slade , Robert E. Kilkuskie , Noel A. Roberts , Raymond Jupp
IPC分类号: C07H21/04
CPC分类号: C12N15/1131 , C12N2310/313 , C12N2310/314 , C12N2310/315
摘要: The present invention discloses synthetic oligonucleotides complementary to contiguous and noncontiguous regions of the HBV RNA. Also disclosed are methods and kits for inhibiting the replication and expression of HBV, and for treating HBV infections and associated conditions.
摘要翻译: 本发明公开了与HBV RNA的连续和非连续区域互补的合成寡核苷酸。 还公开了用于抑制HBV的复制和表达以及用于治疗HBV感染和相关病症的方法和试剂盒。
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公开(公告)号:US20070281898A1
公开(公告)日:2007-12-06
申请号:US11692846
申请日:2007-03-28
申请人: Andrew Slade , Susan Kingsman
发明人: Andrew Slade , Susan Kingsman
IPC分类号: A61K31/711 , A61K31/7105 , A61K35/76 , A61P35/00
CPC分类号: C12N9/0077
摘要: The present invention relates to a retroviral vector system comprising a therapeutic gene wherein said retroviral vector system is pseudotyped with at least part of a heterologous envelope protein or a mutant, variant or homologue thereof and wherein said therapeutic gene is downstream of an internal promoter.
摘要翻译: 本发明涉及包含治疗基因的逆转录病毒载体系统,其中所述逆转录病毒载体系统用至少部分异源包膜蛋白或其突变体,变体或同源物进行假型化,并且其中所述治疗基因位于内部启动子的下游。
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