公开(公告)号：US20080073817A1

公开(公告)日：2008-03-27

申请号：US11748387

申请日：2007-05-14

申请人： Gregory Hyde ,  Jane Sifuentes ,  Kim Hayenga ,  Erik Eli ,  Jim Phelan ,  Ellen Roche

发明人： Gregory Hyde ,  Jane Sifuentes ,  Kim Hayenga ,  Erik Eli ,  Jim Phelan ,  Ellen Roche

IPC分类号： B29C53/80 ,  C08F216/06

CPC分类号： B29C53/42 ,  B29C33/52 ,  B29C39/006 ,  B29C39/34 ,  B29L2031/7532

摘要： Embodiments provide for partially cured, preformed pieces of PVA capable of later being formed into more specific models. The partially cured, pre-made pieces of PVA can take on many forms and shapes. For example, the shape may be a flat, tubular, cone, spherical, or other similar shape. In fact, more complex shapes such as full organs are also contemplated herein. Nevertheless, such pre-molded components are considered common or general shaped in that the particular shape is produced using standard or common molds, and then later formed into a more specific or desired shape. As such, the preformed pieces of PVA are only partially cured or cross-linked such that they can later be formed into the more specific models that then have additional processing (e.g., freeze-thaw cycle) to retain the new shape.

摘要翻译： 实施例提供了可以稍后形成更具体的模型的部分固化的预成型的PVA片。 PVA的部分固化预制件可以具有许多形式和形状。 例如，该形状可以是扁平的，管状的，锥形的，球形的或其它类似的形状。 事实上，这里也考虑了更复杂的形状，例如全器官。 然而，这样的预成型部件被认为是普通的或一般的形状，因为特定的形状是使用标准的或共同的模具制造的，然后形成更具体或期望的形状。 因此，预成型的PVA片仅部分固化或交联，使得它们可以随后形成更具体的模型，然后具有额外的加工（例如冻融循环）以保持新的形状。

公开(公告)号：US20080076101A1

公开(公告)日：2008-03-27

申请号：US11748374

申请日：2007-05-14

申请人： Gregory Hyde ,  Jane Sifuentes ,  Kim Hayenga ,  Erik Eli ,  Jim Phelan ,  Ellen Roche

发明人： Gregory Hyde ,  Jane Sifuentes ,  Kim Hayenga ,  Erik Eli ,  Jim Phelan ,  Ellen Roche

IPC分类号： G09B23/30 ,  B28B7/34 ,  B29D31/505

CPC分类号： G09B23/30

摘要： Anatomical models are provided with simulated plaque, lesion, chronic total occlusion, as well as other vascular diseases that more accurately replicate these abnormalities. In such embodiment, the vascular disease may be formed separate from the structured anatomical model. The formed vascular disease material may then be bonded to or within a PVA material in a separate process from forming this simulated vascular disease, thus providing a replicated specific anatomy structure with an abnormality for demonstrating, testing, and/or developing medical functions and/or devices.

摘要翻译： 解剖模型提供模拟斑块，病变，慢性完全闭塞，以及更准确地复制这些异常的其他血管疾病。 在这样的实施例中，血管疾病可以与结构解剖模型分开形成。 形成的血管疾病材料然后可以在单独的过程中与PVA材料结合或在PVA材料内形成该模拟的血管疾病，从而提供具有用于展示，测试和/或开发医学功能的异常的复制的特定解剖结构和/或 设备。

公开(公告)号：US20080073022A1

公开(公告)日：2008-03-27

申请号：US11748378

申请日：2007-05-14

申请人： Gregory Hyde ,  Jane Sifuentes ,  Kim Hayenga ,  Eric Eli ,  Jim Phelan ,  Ellen Roche

发明人： Gregory Hyde ,  Jane Sifuentes ,  Kim Hayenga ,  Eric Eli ,  Jim Phelan ,  Ellen Roche

IPC分类号： B65H69/02 ,  C08L23/02

CPC分类号： C09J129/04

摘要： Models are made through a process that provides for a bonding mechanism of pre-made PVA parts to create more complex structures. The components are bonded together by wetting the surfaces to be connected with a PVA solution. The components are then adjoined together and bonded through an additional processing or curing, e.g., freeze-thaw cycle. This process can be repeated multiple times to create more complex structures or models. In another embodiment, a textile or fabric type material is used to increase the radial strength of the models. In such an embodiment, a usually thin piece of textile material, such as a nylon fabric, may be placed within the core molding. Liquid PVA then flows through the nylon hosiery or textile material and one or more curing process are then applied, which allows the PVA solution to bond or otherwise adhere with the material.

摘要翻译： 模型通过提供预制PVA部件的粘结机制以产生更复杂结构的方法制成。 通过润湿与PVA溶液连接的表面将组分粘合在一起。 然后将这些部件连接在一起，并通过额外的加工或固化（例如冷冻 - 融化循环）粘合。 该过程可以重复多次以创建更复杂的结构或模型。 在另一个实施例中，使用织物或织物类型的材料来增加模型的径向强度。 在这样的实施例中，通常薄的织物材料例如尼龙织物可以放置在芯模制品内。 然后液体PVA流过尼龙袜子或纺织材料，然后施加一个或多个固化过程，这允许PVA溶液粘合或以其他方式粘附材料。

公开(公告)号：US07591199B2

公开(公告)日：2009-09-22

申请号：US11758548

申请日：2007-06-05

申请人： Lisa Weldon ,  Greg Hyde ,  Ellen Roche ,  Maithili Shrivastava

发明人： Lisa Weldon ,  Greg Hyde ,  Ellen Roche ,  Maithili Shrivastava

IPC分类号： G01N19/00

CPC分类号： G01N15/06

摘要： An apparatus for measuring particles generated from a medical device includes a platform configured for retaining at least one medical device and at least one simulated body lumen tubing. The platform includes: a medical device receptacle dimensioned to retain a medical device; a pretest receptacle dimensioned to retain pretest tubing; and a test receptacle dimensioned to retain test tubing. The apparatus can be used for measuring particles generated from a medical device during a simulated clinical application by the following: introducing the medical device into the test tubing; causing fluid to flow through the pretest tubing, past the medical device, and through the test tubing; and counting the particles in the fluid downstream from the medical device.

摘要翻译： 一种用于测量由医疗装置产生的颗粒的装置包括：一个平台，其被配置用于保持至少一个医疗装置和至少一个模拟的体腔管。 该平台包括：尺寸设计成保持医疗装置的医疗装置插座; 预先测试的容器的尺寸用于保留预测试管; 以及尺寸设计用于保持测试管的测试插座。 该装置可用于在模拟临床应用期间通过以下方式测量由医疗装置产生的颗粒：将医疗装置引入测试管中; 使流体流过预测试管，经过医疗装置，并通过试管; 并计数来自医疗装置下游的流体中的颗粒。

公开(公告)号：US20080006081A1

公开(公告)日：2008-01-10

申请号：US11758548

申请日：2007-06-05

申请人： Lisa Weldon ,  Greg Hyde ,  Ellen Roche ,  Maithili Shrivastava

发明人： Lisa Weldon ,  Greg Hyde ,  Ellen Roche ,  Maithili Shrivastava

IPC分类号： G01N33/00

CPC分类号： G01N15/06

摘要： An apparatus for measuring particles generated from a medical device includes a platform configured for retaining at least one medical device and at least one simulated body lumen tubing. The platform includes: a medical device receptacle dimensioned to retain a medical device; a pretest receptacle dimensioned to retain pretest tubing; and a test receptacle dimensioned to retain test tubing. The apparatus can be used for measuring particles generated from a medical device during a simulated clinical application by the following: introducing the medical device into the test tubing; causing fluid to flow through the pretest tubing, past the medical device, and through the test tubing; and counting the particles in the fluid downstream from the medical device.

摘要翻译： 一种用于测量由医疗装置产生的颗粒的装置包括：一个平台，其被配置用于保持至少一个医疗装置和至少一个模拟的体腔管。 该平台包括：尺寸设计成保持医疗装置的医疗装置插座; 预先测试的容器的尺寸用于保留预测试管; 以及尺寸设计用于保持测试管的测试插座。 该装置可用于在模拟临床应用期间通过以下方式测量由医疗装置产生的颗粒：将医疗装置引入测试管中; 使流体流过预测试管，经过医疗装置，并通过试管; 并计数来自医疗装置下游的流体中的颗粒。

公开(公告)号：US20120226303A1

公开(公告)日：2012-09-06

申请号：US13040729

申请日：2011-03-04

申请人： Ellen Roche ,  Kevin O'Sullivan

发明人： Ellen Roche ,  Kevin O'Sullivan

IPC分类号： A61M29/02

CPC分类号： A61M25/1002 ,  A61M25/104 ,  A61M2025/1093 ,  A61M2025/1095

摘要： A system includes an elongate catheter having a self-expanding frame disposed at the distal end of the catheter. The frame includes a plurality of longitudinal struts defined by parallel slots. The frame may be constrained into a radially compressed configuration for delivery to a treatment site. A helical balloon is mounted about the frame. Upon release from the constraining mechanism, the frame returns to a heat-set radially expanded configuration to initiate dilation of a treatment site in a patient. Inflating the balloon around the expanded frame further expands the initial radial dilation of the site. Proximal and distal ends of the slots are unobstructed by the balloon to permit flow of a fluid through the slots and through a lumen defined by an interior surface of the balloon when the frame is in the radially expanded configuration.

摘要翻译： 系统包括细长导管，其具有设置在导管远端的自扩张框架。 框架包括由平行狭槽限定的多个纵向支柱。 框架可以被约束成径向压缩的构造以便递送到治疗部位。 围绕框架安装螺旋形气球。 当从约束机构释放时，框架返回到热定形径向膨胀的构造以引发患者中的治疗部位的扩张。 气球在扩张的框架周围膨胀，进一步扩大了现场的初始径向扩张。 狭槽的近端和远端通过气囊不被阻挡，以允许流体通过狭槽流动并且当框架处于径向扩张构型时通过由球囊的内表面限定的内腔。

公开(公告)号：US09480823B2

公开(公告)日：2016-11-01

申请号：US13040729

申请日：2011-03-04

申请人： Ellen Roche ,  Kevin O'Sullivan

发明人： Ellen Roche ,  Kevin O'Sullivan

IPC分类号： A61M29/00 ,  A61M25/10

CPC分类号： A61M25/1002 ,  A61M25/104 ,  A61M2025/1093 ,  A61M2025/1095

摘要： A system includes an elongate catheter having a self-expanding frame disposed at the distal end of the catheter. The frame includes a plurality of longitudinal struts defined by parallel slots. The frame may be constrained into a radially compressed configuration for delivery to a treatment site. A helical balloon is mounted about the frame. Upon release from the constraining mechanism, the frame returns to a heat-set radially expanded configuration to initiate dilation of a treatment site in a patient. Inflating the balloon around the expanded frame further expands the initial radial dilation of the site. Proximal and distal ends of the slots are unobstructed by the balloon to permit flow of a fluid through the slots and through a lumen defined by an interior surface of the balloon when the frame is in the radially expanded configuration.

摘要翻译： 系统包括细长导管，其具有设置在导管远端的自扩张框架。 框架包括由平行狭槽限定的多个纵向支柱。 框架可以被约束成径向压缩的构造以便递送到治疗部位。 围绕框架安装螺旋形气球。 当从约束机构释放时，框架返回到热定形径向膨胀的构造以引发患者中的治疗部位的扩张。 气球在扩张的框架周围膨胀，进一步扩大了现场的初始径向扩张。 狭槽的近端和远端通过气囊不被阻挡，以允许流体通过狭槽流动并且当框架处于径向扩张构型时通过由球囊的内表面限定的内腔。

公开(公告)号：US07591198B2

公开(公告)日：2009-09-22

申请号：US11758544

申请日：2007-06-05

申请人： Lisa Weldon ,  Greg Hyde ,  Ellen Roche ,  Maithili Shrivastava

发明人： Lisa Weldon ,  Greg Hyde ,  Ellen Roche ,  Maithili Shrivastava

IPC分类号： G01N19/00

CPC分类号： A61B5/06 ,  A61F2/00 ,  A61F2/2472 ,  A61F2240/008 ,  A61M25/00 ,  G01N15/12

摘要： An apparatus for measuring particles generated from a medical device during a simulated clinical application includes a platform configured for retaining at least one medical device and at least one simulated body lumen tubing. The platform includes the following: a medical device receptacle dimensioned to retain the at least one medical device; a pretest receptacle dimensioned to retain pretest tubing; and a test receptacle dimensioned to retain test tubing, said test receptacle having at least one substantially straight portion configured for straightening said test tubing when disposed therein and at least one tortuous portion configured for bending said test tubing into a tortuous pathway when disposed therein. Additionally, the platform includes a junction that interconnects the medical device receptacle, pretest receptacle, and test receptacle.

摘要翻译： 用于在模拟的临床应用期间测量由医疗装置产生的颗粒的装置包括被配置为保持至少一个医疗装置和至少一个模拟的体腔管的平台。 该平台包括以下内容：医疗设备接收器，其尺寸设计成保持至少一个医疗设备; 预先测试的容器的尺寸用于保留预测试管; 所述测试容器具有至少一个基本上直的部分，所述至少一个基本上直的部分被配置用于当设置在其中时矫直所述测试管道;以及至少一个曲折部分，其构造成用于当所述测试管道设置在弯曲路径中时弯曲成曲折的路径。 此外，平台包括将医疗设备插座，预测试插座和测试插座互连的连接点。

公开(公告)号：US20080084959A1

公开(公告)日：2008-04-10

申请号：US11758544

申请日：2007-06-05

申请人： Lisa Weldon ,  Greg Hyde ,  Ellen Roche ,  Maithili Shrivastava

发明人： Lisa Weldon ,  Greg Hyde ,  Ellen Roche ,  Maithili Shrivastava

IPC分类号： G06M11/02

CPC分类号： A61B5/06 ,  A61F2/00 ,  A61F2/2472 ,  A61F2240/008 ,  A61M25/00 ,  G01N15/12

摘要： An apparatus for measuring particles generated from a medical device during a simulated clinical application includes a platform configured for retaining at least one medical device and at least one simulated body lumen tubing. The platform includes the following: a medical device receptacle dimensioned to retain the at least one medical device; a pretest receptacle dimensioned to retain pretest tubing; and a test receptacle dimensioned to retain test tubing, said test receptacle having at least one substantially straight portion configured for straightening said test tubing when disposed therein and at least one tortuous portion configured for bending said test tubing into a tortuous pathway when disposed therein. Additionally, the platform includes a junction that interconnects the medical device receptacle, pretest receptacle, and test receptacle.

摘要翻译： 用于在模拟的临床应用期间测量由医疗装置产生的颗粒的装置包括被配置为保持至少一个医疗装置和至少一个模拟的体腔管的平台。 该平台包括以下内容：医疗设备接收器，其尺寸设计成保持至少一个医疗设备; 预先测试的容器的尺寸用于保留预测试管; 所述测试容器具有至少一个基本上直的部分，所述至少一个基本上直的部分被配置用于当设置在其中时矫直所述测试管道;以及至少一个曲折部分，其构造成用于当所述测试管道设置在弯曲路径中时弯曲成曲折的路径。 此外，平台包括将医疗设备插座，预测试插座和测试插座互连的连接点。

公开(公告)号：US20070110280A1

公开(公告)日：2007-05-17

申请号：US11464436

申请日：2006-08-14

申请人： Lisa Weldon ,  Ellen Roche ,  Eoin Banville

发明人： Lisa Weldon ,  Ellen Roche ,  Eoin Banville

IPC分类号： G06K9/00

CPC分类号： G01B11/0675

摘要： A method for determining the thickness of a coating or a plurality of coatings applied to medical devices. In particular, determining coating thickness of a medical device including an endoprosthesis.

摘要翻译： 用于确定施加到医疗装置的涂层或多个涂层的厚度的方法。 特别地，确定包括内置假体的医疗装置的涂层厚度。