公开(公告)号：US20050058649A1

公开(公告)日：2005-03-17

申请号：US10726332

申请日：2003-12-02

申请人： Gregory Landes ,  Mary Haak-Frendscho ,  Ling Chen ,  Yen-Wah Lee ,  Meina Liang ,  Xiao Feng ,  Xiao-Chi Jia ,  Mark Nocerini

发明人： Gregory Landes ,  Mary Haak-Frendscho ,  Ling Chen ,  Yen-Wah Lee ,  Meina Liang ,  Xiao Feng ,  Xiao-Chi Jia ,  Mark Nocerini

IPC分类号： C07K16/40 ,  A61K39/395

CPC分类号： C07K16/40 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565

摘要： The invention described herein relates to antibodies directed to the antigen phospholipase A2 (PLA2) and uses of such antibodies. In particular, in accordance with some embodiments of the invention, there are provided fully human monoclonal antibodies directed to the antigen PLA2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

摘要翻译： 本文描述的本发明涉及针对抗原磷脂酶A2（PLA2）的抗体和这种抗体的用途。 特别地，根据本发明的一些实施方案，提供了针对抗原PLA2的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 ，提供。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

公开(公告)号：US08101178B2

公开(公告)日：2012-01-24

申请号：US11876669

申请日：2007-10-22

申请人： John S. Babcook ,  Jaspal S. Kang ,  Orit Foord ,  Larry Green ,  Xiao Feng ,  Scott Klakamp ,  Mary Haak-Frendscho ,  Palaniswami Rathanaswami ,  Craig Pigott ,  Meina Liang ,  Yen-Wah Lee ,  Kathy Manchulenko ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Qiaojuan Jane Su

发明人： John S. Babcook ,  Jaspal S. Kang ,  Orit Foord ,  Larry Green ,  Xiao Feng ,  Scott Klakamp ,  Mary Haak-Frendscho ,  Palaniswami Rathanaswami ,  Craig Pigott ,  Meina Liang ,  Yen-Wah Lee ,  Kathy Manchulenko ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Qiaojuan Jane Su

IPC分类号： A61K39/395

CPC分类号： C07K16/241 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

摘要： Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

摘要翻译： 针对抗原TNFα的抗体和这种抗体的用途。 特别是针对抗原TNFα的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

公开(公告)号：US07285269B2

公开(公告)日：2007-10-23

申请号：US10727155

申请日：2003-12-02

申请人： John S. Babcook ,  Jaspal S. Kang ,  Orit Foord ,  Larry Green ,  Xiao Feng ,  Scott Klakamp ,  Mary Haak-Frendscho ,  Palaniswami Rathanaswami ,  Craig Pigott ,  Meina Liang ,  Yen-Wah Lee ,  Kathy Manchulenko ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Qiaojuan Jane Su

发明人： John S. Babcook ,  Jaspal S. Kang ,  Orit Foord ,  Larry Green ,  Xiao Feng ,  Scott Klakamp ,  Mary Haak-Frendscho ,  Palaniswami Rathanaswami ,  Craig Pigott ,  Meina Liang ,  Yen-Wah Lee ,  Kathy Manchulenko ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Qiaojuan Jane Su

IPC分类号： A61K39/395 ,  C07K16/24

CPC分类号： C07K16/241 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

摘要： Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

摘要翻译： 针对抗原TNFα的抗体和这种抗体的用途。 特别是针对抗原TNFα的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

公开(公告)号：US20050049402A1

公开(公告)日：2005-03-03

申请号：US10727155

申请日：2003-12-02

申请人： John Babcook ,  Jaspal Kang ,  Orit Foord ,  Larry Green ,  Xiao Feng ,  Scott Klakamp ,  Mary Haak-Frendscho ,  Palaniswami Rathanaswami ,  Craig Pigott ,  Meina Liang ,  Yen-Wah Lee ,  Kathy Manchulencko ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Qiaojuan Su

发明人： John Babcook ,  Jaspal Kang ,  Orit Foord ,  Larry Green ,  Xiao Feng ,  Scott Klakamp ,  Mary Haak-Frendscho ,  Palaniswami Rathanaswami ,  Craig Pigott ,  Meina Liang ,  Yen-Wah Lee ,  Kathy Manchulencko ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Qiaojuan Su

IPC分类号： C07K16/24

CPC分类号： C07K16/241 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

摘要： Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

摘要翻译： 针对抗原TNFα的抗体和这种抗体的用途。 特别是针对抗原TNFα的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。