公开(公告)号：US20060025425A1

公开(公告)日：2006-02-02

申请号：US11179458

申请日：2005-07-12

申请人： Guiying Li ,  Pamela Albaugh ,  Kevin Currie ,  Guolin Cai ,  Linda Gustavson ,  Kyungae Lee ,  Alan Hutchison ,  George Maynard ,  Jun Yuan ,  Ling Xie ,  Manuka Ghosh ,  Nian Liu ,  George Luke ,  Scott Mitchell ,  Martin Allen ,  Spiros Liras

发明人： Guiying Li ,  Pamela Albaugh ,  Kevin Currie ,  Guolin Cai ,  Linda Gustavson ,  Kyungae Lee ,  Alan Hutchison ,  George Maynard ,  Jun Yuan ,  Ling Xie ,  Manuka Ghosh ,  Nian Liu ,  George Luke ,  Scott Mitchell ,  Martin Allen ,  Spiros Liras

IPC分类号： A61K31/506 ,  A61K31/4745 ,  A61K31/427 ,  A61K31/4184 ,  C07D471/02 ,  C07D403/02 ,  C07D417/02 ,  C07D413/02

CPC分类号： C07D401/04 ,  C07D233/20 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D491/08 ,  C07D491/10

摘要： This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.

摘要翻译： 本发明涉及苯并咪唑，吡啶基咪唑和相关双环杂芳基化合物，所有这些可以由式I描述。本发明特别涉及以高选择性和高亲和力结合GABA A的苯并二氮杂部位的化合物， / SUB>受体。 本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗某些中枢神经系统（CNS）疾病中的用途。 公开了制备式I化合物的新方法。 本发明还涉及式I的苯并咪唑，吡啶基咪唑和相关的双环杂芳基化合物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。 此外，本发明涉及使用这些化合物作为组织切片中GABA A A受体定位的探针。

公开(公告)号：US20100267698A1

公开(公告)日：2010-10-21

申请号：US12652435

申请日：2010-01-05

申请人： Guiying Li ,  Pamela Albaugh ,  Kevin S. Currie ,  Guolin Cai ,  Linda M. Gustavson ,  Kyungae Lee ,  Alan Hutchison ,  George D. Maynard ,  Jun Yuan ,  Ling Hong Xie ,  Manuka Ghosh ,  Nian Liu ,  George P. Luke ,  Scott Mitchell ,  Martin Patrick Allen ,  Spiros Liras

发明人： Guiying Li ,  Pamela Albaugh ,  Kevin S. Currie ,  Guolin Cai ,  Linda M. Gustavson ,  Kyungae Lee ,  Alan Hutchison ,  George D. Maynard ,  Jun Yuan ,  Ling Hong Xie ,  Manuka Ghosh ,  Nian Liu ,  George P. Luke ,  Scott Mitchell ,  Martin Patrick Allen ,  Spiros Liras

IPC分类号： A61K31/55 ,  C07D401/14 ,  A61K31/4439 ,  C07D403/06 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/41 ,  C07D413/14 ,  A61K31/4245 ,  C07D471/04 ,  A61K31/437 ,  C07D417/14 ,  A61K31/427 ,  C07D473/00 ,  A61K31/52 ,  C07D403/14 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61P25/22 ,  A61P25/24 ,  A61P25/18 ,  A61P25/00 ,  C12N5/079 ,  C12Q1/02

CPC分类号： C07D401/04 ,  C07D233/20 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D491/08 ,  C07D491/10

摘要： This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed.This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.

摘要翻译： 本发明涉及苯并咪唑，吡啶基咪唑和相关双环杂芳基化合物，所有这些可以由式I描述。本发明特别涉及以高选择性和高亲和力结合GABA A受体的苯并二氮杂位点的化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗某些中枢神经系统（CNS）疾病中的用途。 公开了制备式I化合物的新方法。 本发明还涉及式I的苯并咪唑，吡啶基咪唑和相关的双环杂芳基化合物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。 此外，本发明涉及使用这些化合物作为组织切片中GABA A受体定位的探针。

公开(公告)号：US20080227793A1

公开(公告)日：2008-09-18

申请号：US11942480

申请日：2007-11-19

申请人： Guiying Li ,  Pamela Albaugh ,  Kevin S. Currie ,  Guolin Cai ,  Linda M. Gustavson ,  Kyungae Lee ,  Alan Hutchison ,  George D. Maynard ,  Jun Yuan ,  Ling Hong Xie ,  Manuka Ghosh ,  Nian Liu ,  George P. Luke ,  Scott Mitchell ,  Martin Patrick Allen ,  Spiros Liras

发明人： Guiying Li ,  Pamela Albaugh ,  Kevin S. Currie ,  Guolin Cai ,  Linda M. Gustavson ,  Kyungae Lee ,  Alan Hutchison ,  George D. Maynard ,  Jun Yuan ,  Ling Hong Xie ,  Manuka Ghosh ,  Nian Liu ,  George P. Luke ,  Scott Mitchell ,  Martin Patrick Allen ,  Spiros Liras

IPC分类号： A61K31/496 ,  C07D403/06 ,  A61K31/4184 ,  C07D471/04 ,  G01N33/566 ,  A61P25/18 ,  A61P25/24 ,  C12N5/06 ,  A61K31/437 ,  C07D403/14

CPC分类号： C07D401/04 ,  C07D233/20 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D491/08 ,  C07D491/10

摘要： This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed.This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.

摘要翻译： 本发明涉及苯并咪唑，吡啶基咪唑和相关双环杂芳基化合物，所有这些可以由式I描述。本发明特别涉及以高选择性和高亲和力结合GABA A的苯并二氮杂部位的化合物， / SUB>受体。 本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗某些中枢神经系统（CNS）疾病中的用途。 公开了制备式I化合物的新方法。 本发明还涉及式I的苯并咪唑，吡啶基咪唑和相关的双环杂芳基化合物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。 此外，本发明涉及使用这些化合物作为组织切片中GABA A A受体定位的探针。

公开(公告)号：US07642267B2

公开(公告)日：2010-01-05

申请号：US11942480

申请日：2007-11-19

申请人： Guiying Li ,  Pamela Albaugh ,  Kevin S. Currie ,  Guolin Cai ,  Linda M. Gustavson ,  Kyungae Lee ,  Alan Hutchison ,  George D. Maynard ,  Jun Yuan ,  Ling Hong Xie ,  Manuka Ghosh ,  Nian Liu ,  George P. Luke ,  Scott Mitchell ,  Martin Patrick Allen ,  Spiros Liras

发明人： Guiying Li ,  Pamela Albaugh ,  Kevin S. Currie ,  Guolin Cai ,  Linda M. Gustavson ,  Kyungae Lee ,  Alan Hutchison ,  George D. Maynard ,  Jun Yuan ,  Ling Hong Xie ,  Manuka Ghosh ,  Nian Liu ,  George P. Luke ,  Scott Mitchell ,  Martin Patrick Allen ,  Spiros Liras

IPC分类号： C07D471/04 ,  A61K31/437

CPC分类号： C07D401/04 ,  C07D233/20 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D491/08 ,  C07D491/10

摘要： This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I. The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.

摘要翻译： 本发明涉及苯并咪唑，吡啶基咪唑和相关的双环杂芳基化合物，所有这些可以由式I描述。本发明特别涉及以高选择性和高亲和力结合GABA A受体的苯并二氮杂位点的化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗某些中枢神经系统（CNS）疾病中的用途。 公开了制备式I化合物的新方法。 本发明还涉及式I的苯并咪唑，吡啶基咪唑和相关的双环杂芳基化合物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。 此外，本发明涉及使用这些化合物作为组织切片中GABA A受体定位的探针。

公开(公告)号：US07300945B2

公开(公告)日：2007-11-27

申请号：US11179458

申请日：2005-07-12

申请人： Guiying Li ,  Pamela Albaugh ,  Kevin S. Currie ,  Guolin Cai ,  Linda M. Gustavson ,  Kyungae Lee ,  Alan Hutchison ,  George D. Maynard ,  Jun Yuan ,  Ling Hong Xie ,  Manuka Ghosh ,  Nian Liu ,  George P. Luke ,  Scott Mitchell ,  Martin Patrick Allen ,  Spiros Liras

发明人： Guiying Li ,  Pamela Albaugh ,  Kevin S. Currie ,  Guolin Cai ,  Linda M. Gustavson ,  Kyungae Lee ,  Alan Hutchison ,  George D. Maynard ,  Jun Yuan ,  Ling Hong Xie ,  Manuka Ghosh ,  Nian Liu ,  George P. Luke ,  Scott Mitchell ,  Martin Patrick Allen ,  Spiros Liras

IPC分类号： C07D471/04 ,  A61K31/437

CPC分类号： C07D401/04 ,  C07D233/20 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D491/08 ,  C07D491/10

摘要： This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed.This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.

摘要翻译： 本发明涉及苯并咪唑，吡啶基咪唑和相关双环杂芳基化合物，所有这些可以由式I描述。本发明特别涉及以高选择性和高亲和力结合GABA A的苯并二氮杂部位的化合物， / SUB>受体。 本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗某些中枢神经系统（CNS）疾病中的用途。 公开了制备式I化合物的新方法。 本发明还涉及式I的苯并咪唑，吡啶基咪唑和相关的双环杂芳基化合物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。 此外，本发明涉及使用这些化合物作为组织切片中GABA A A受体定位的探针。

公开(公告)号：US06916819B2

公开(公告)日：2005-07-12

申请号：US10038069

申请日：2001-12-21

申请人： Guiying Li ,  John M. Peterson ,  Pamela Albaugh ,  Kevin S. Currie ,  Guolin Cai ,  Linda M. Gustavson ,  Kyungae Lee ,  Alan Hutchison ,  Vinod Singh ,  George D. Maynard ,  Jun Yuan ,  Ling Hong Xie ,  Manuka Ghosh ,  Nian Liu

发明人： Guiying Li ,  John M. Peterson ,  Pamela Albaugh ,  Kevin S. Currie ,  Guolin Cai ,  Linda M. Gustavson ,  Kyungae Lee ,  Alan Hutchison ,  Vinod Singh ,  George D. Maynard ,  Jun Yuan ,  Ling Hong Xie ,  Manuka Ghosh ,  Nian Liu

IPC分类号： A61K31/415 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/435 ,  A61K31/437 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61P25/00 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  C07D233/20 ,  C07D233/54 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D491/08 ,  C07D491/10 ,  C07D491/113 ,  C07D403/12

CPC分类号： C07D401/04 ,  C07D233/20 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D491/08 ,  C07D491/10

摘要： This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed.This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.

摘要翻译： 本发明涉及苯并咪唑，吡啶基咪唑和相关双环杂芳基化合物，所有这些可以由式I描述。本发明特别涉及以高选择性和高亲和力结合GABA A的苯并二氮杂部位的化合物， / SUB>受体。 本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗某些中枢神经系统（CNS）疾病中的用途。 公开了制备式I化合物的新方法。 本发明还涉及式I的苯并咪唑，吡啶基咪唑和相关的双环杂芳基化合物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。 此外，本发明涉及使用这些化合物作为组织切片中GABA A A受体定位的探针。

公开(公告)号：US20060014746A1

公开(公告)日：2006-01-19

申请号：US11214345

申请日：2005-08-29

申请人： Alan Hutchison ,  George Maynard ,  Pamela Albaugh ,  Linghong Xie ,  Jun Yuan ,  Scott Mitchell ,  Vinod Singh ,  Manuka Ghosh ,  Guiying Li ,  Nian Liu

发明人： Alan Hutchison ,  George Maynard ,  Pamela Albaugh ,  Linghong Xie ,  Jun Yuan ,  Scott Mitchell ,  Vinod Singh ,  Manuka Ghosh ,  Guiying Li ,  Nian Liu

IPC分类号： C07D487/04 ,  C07D471/02 ,  A61K31/519 ,  A61K31/503 ,  A61K31/4745

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D513/04

摘要： This invention relates to heteroaryl substituted fused bicyclic heteroaryl compounds, such as heteroaryl substituted imidazopyridines, imidazopyrazines, imidazopyridizines, imidazopyrimidines, and imidazothiazoles, which may be described by Formula I or Formula II: The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Processes for preparing compounds of Formula I and Formula II are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I or Formula II in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.

摘要翻译： 本发明涉及可以由式I或式II描述的杂芳基取代的稠合双环杂芳基化合物，例如杂芳基取代的咪唑并吡啶，咪唑并吡嗪，咪唑并吡啶，咪唑并嘧啶和咪唑并噻唑。本发明特别涉及以高选择性结合的这些化合物 并且对GABA A A受体的苯并二氮杂位点具有高亲和力。 本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗某些中枢神经系统（CNS）疾病中的用途。 公开了制备式I和式II化合物的方法。 本发明还涉及式I或式II的苯并咪唑，吡啶基咪唑和相关双环杂芳基化合物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。 此外，本发明涉及使用这些化合物作为组织切片中GABA A A受体定位的探针。

公开(公告)号：US06936617B2

公开(公告)日：2005-08-30

申请号：US10194852

申请日：2002-07-12

申请人： Alan Hutchison ,  George Maynard ,  Pamela Albaugh ,  Linghong Xie ,  Jun Yuan ,  Scott Mitchell ,  Vinod Singh ,  Manuka Ghosh ,  Guiying Li ,  Nian Liu

发明人： Alan Hutchison ,  George Maynard ,  Pamela Albaugh ,  Linghong Xie ,  Jun Yuan ,  Scott Mitchell ,  Vinod Singh ,  Manuka Ghosh ,  Guiying Li ,  Nian Liu

IPC分类号： G01N33/48 ,  A61K31/4355 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  A61P25/00 ,  A61P25/14 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C12N15/09 ,  C12Q1/02 ,  G01N33/58 ,  G01N33/60 ,  A61K31/437

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D513/04

摘要： This invention relates to heteroaryl substituted fused bicyclic heteroaryl compounds, such as heteroaryl substituted imidazopyridines, imidazopyrazines, imidazopyridizines, imidazopyrimidines, and imidazothiazoles, which may be described by Formula I or Formula II: The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Processes for preparing compounds of Formula I and Formula II are disclosed.This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I or Formula II in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.

摘要翻译： 本发明涉及可以由式I或式II描述的杂芳基取代的稠合双环杂芳基化合物，例如杂芳基取代的咪唑并吡啶，咪唑并吡嗪，咪唑并吡啶，咪唑并嘧啶和咪唑并噻唑。本发明特别涉及以高选择性结合的这些化合物 并且对GABA A A受体的苯并二氮杂位点具有高亲和力。 本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗某些中枢神经系统（CNS）疾病中的用途。 公开了制备式I和式II化合物的方法。 本发明还涉及式I或式II的苯并咪唑，吡啶基咪唑和相关双环杂芳基化合物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。 此外，本发明涉及使用这些化合物作为组织切片中GABA A A受体定位的探针。

公开(公告)号：US20070249616A1

公开(公告)日：2007-10-25

申请号：US11763926

申请日：2007-06-15

申请人： Alan Hutchison ,  Bertrand Chenard ,  James Tarrant ,  Guiying Li ,  Manuka Ghosh ,  George Luke ,  John Peterson ,  Wallace Pringle ,  Mary-Margaret O'Donnell ,  Kyungae Lee ,  Linda Gustavson ,  Dario Doller

发明人： Alan Hutchison ,  Bertrand Chenard ,  James Tarrant ,  Guiying Li ,  Manuka Ghosh ,  George Luke ,  John Peterson ,  Wallace Pringle ,  Mary-Margaret O'Donnell ,  Kyungae Lee ,  Linda Gustavson ,  Dario Doller

IPC分类号： A61K31/496 ,  A61K31/498 ,  A61P3/04

CPC分类号： C07D213/74 ,  C07D213/82 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08

摘要： Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).

摘要翻译： 提供了式I化合物，其中变量如本文所述：这样的化合物可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗各种代谢，进食和性障碍 在人类，驯养的伴侣动物和家畜中。 还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。

公开(公告)号：US20060142301A1

公开(公告)日：2006-06-29

申请号：US11100355

申请日：2005-04-06

申请人： Alan Hutchison ,  Bertrand Chenard ,  James Tarrant ,  Guiying Li ,  Manuka Ghosh ,  George Luke ,  John Peterson ,  Wallace Pringle ,  Mary-Margaret O'Donnell ,  Kyungae Lee ,  Linda Gustavson ,  Dario Doller

发明人： Alan Hutchison ,  Bertrand Chenard ,  James Tarrant ,  Guiying Li ,  Manuka Ghosh ,  George Luke ,  John Peterson ,  Wallace Pringle ,  Mary-Margaret O'Donnell ,  Kyungae Lee ,  Linda Gustavson ,  Dario Doller

IPC分类号： A61K31/496 ,  A61K31/497 ,  C07D403/02

CPC分类号： C07D213/74 ,  C07D213/82 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08

摘要： Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).

摘要翻译： 提供了式I化合物，其中变量如本文所述：这样的化合物可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗各种代谢，进食和性障碍 在人类，驯养的伴侣动物和家畜中。 还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。