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公开(公告)号:US20110086834A1
公开(公告)日:2011-04-14
申请号:US12997868
申请日:2009-06-26
申请人: Guoqing Chen , Timothy D. Cushing , Paul Faulder , Benjamin Fisher , Xiao He , Kexue Li , Zhihong Li , Wen Liu , Lawrence R. Mcgee , Vatee Pattaropong , Jennifer L. Seganish , Youngshook Shin , Zhulun Wang
发明人: Guoqing Chen , Timothy D. Cushing , Paul Faulder , Benjamin Fisher , Xiao He , Kexue Li , Zhihong Li , Wen Liu , Lawrence R. Mcgee , Vatee Pattaropong , Jennifer L. Seganish , Youngshook Shin , Zhulun Wang
IPC分类号: A61K31/506 , C07D413/14 , C07D403/14 , C07D401/14 , C07D417/14 , C07D413/04 , C07D403/04 , C07D409/14 , C07D491/107 , C07D498/10 , C07D473/16 , C07D487/04 , C07D407/14 , C07D239/48 , C07D471/10 , C07D495/10 , C07D487/14 , A61K31/497 , A61K31/433 , A61K31/53 , A61K31/4439 , A61K31/427 , A61K31/52 , A61K31/5377 , A61K31/505 , A61K31/519 , A61K31/55 , A61P35/00 , A61P35/02 , A61P37/06 , A61P11/06 , A61P17/00 , A61P19/02 , A61P25/28 , A61P11/00 , A61P1/00 , A61P29/00
CPC分类号: C07D413/14 , C07D213/82 , C07D233/88 , C07D401/14 , C07D403/04 , C07D403/14 , C07D407/08 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/06 , C07D487/10 , C07D487/16 , C07D491/10 , C07D495/10
摘要: Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like.
摘要翻译: 选择的化合物对于预防和治疗炎症和炎症性疾病如NIK介导的病症是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗疾病和其它疾病或涉及炎症等的病症的药物组合物和方法。
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公开(公告)号:US08586739B2
公开(公告)日:2013-11-19
申请号:US13468212
申请日:2012-05-10
申请人: Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian S. Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer L. Seganish , Youngsook Shin , Dawei Zhang
发明人: Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian S. Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer L. Seganish , Youngsook Shin , Dawei Zhang
IPC分类号: C07D487/04 , C07D473/34 , C07D241/40 , C07D241/44 , C07D215/14 , C07D215/26 , C07D215/22 , C07D417/14 , C07D417/04 , A61K31/52 , A61P35/00 , A61P19/02 , A61P37/06 , A61P19/08
CPC分类号: C07D487/04 , C07D471/04 , C07D473/30 , C07D473/34
摘要: Substituted bicyclic heteroaryls having the general structure: and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid Leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译: 具有一般结构的取代的双环杂芳基和含有它们的组合物,用于治疗一般炎症,关节炎,风湿性疾病,骨关节炎,炎性肠病,炎症性眼病,炎性或不稳定性膀胱病,牛皮癣,皮肤炎症成分投诉,慢性 包括但不限于自身免疫性疾病如系统性红斑狼疮(SLE),重症肌无力,类风湿性关节炎,急性播散性脑脊髓炎,特发性血小板减少性紫癜,多发性硬化症,Sjoegren综合征和自身免疫性溶血性贫血,包括所有形式的超敏反应的过敏性疾病 。 本发明还使得能够治疗依赖于p110delta活性或与p110delta活性相关的癌症的方法,包括但不限于白血病,例如急性骨髓性白血病(AML)Myelo-dysplastic综合征(MDS)骨髓增生性疾病(MPD) 慢性骨髓性白血病(CML)T细胞急性淋巴细胞白血病(T-ALL)B细胞急性淋巴细胞白血病(B-ALL)非霍奇金淋巴瘤(NHL)B细胞淋巴瘤和实体瘤如乳腺癌。
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公开(公告)号:US20090137581A1
公开(公告)日:2009-05-28
申请号:US12079406
申请日:2008-03-24
申请人: Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
发明人: Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
IPC分类号: C07D473/34 , C07D487/04 , A61K31/52 , A61K31/519 , A61K31/5377 , A61P35/00 , A61P19/02 , A61P37/02 , A61P27/02 , A61P13/10
CPC分类号: C07D487/04 , C07D471/04 , C07D473/30 , C07D473/34
摘要: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
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公开(公告)号:US08901135B2
公开(公告)日:2014-12-02
申请号:US13468234
申请日:2012-05-10
申请人: Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
发明人: Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
IPC分类号: C07D487/04 , C07D473/34 , C07D473/30
CPC分类号: C07D487/04 , C07D471/04 , C07D473/30 , C07D473/34
摘要: Substituted bicyclic heteroaryls having the following formula where the variables are as defined herein, and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110□ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译: 具有下式的取代的双环杂芳基,其中变量如本文所定义,以及含有它们的组合物,用于治疗一般炎症,关节炎,风湿性疾病,骨关节炎,炎性肠病,炎症性眼病,炎性或不稳定性膀胱病,牛皮癣, 包括但不限于自身免疫性疾病如系统性红斑狼疮(SLE),重症肌无力,类风湿关节炎,急性播散性脑脊髓炎,特发性血小板减少性紫癜,多发性硬化症,Sjoegren综合征和自身免疫性溶血性贫血, 包括所有形式的超敏反应的过敏症状本发明还使得能够治疗依赖于p110□活性或与p110□活性相关的癌症的方法,包括但不限于白血病,例如急性骨髓性白血病(AML)Myelo-dysplastic sy (MDS)骨髓增生性疾病(MPD)慢性骨髓性白血病(CML)T细胞急性淋巴细胞性白血病(T-ALL)B细胞急性淋巴细胞性白血病(B-ALL)非霍奇金淋巴瘤(NHL)B细胞淋巴瘤和 实体肿瘤,如乳腺癌。
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公开(公告)号:US20120220586A1
公开(公告)日:2012-08-30
申请号:US13468234
申请日:2012-05-10
申请人: Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
发明人: Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
IPC分类号: A61K31/52 , C07D473/30 , C07D473/38 , A61K31/5377 , A61P19/02 , A61P37/00 , A61P17/06 , A61P29/00 , A61P1/00 , A61P27/02 , A61P13/10 , A61P17/00 , A61P21/04 , A61P7/00 , A61P25/00 , A61P7/06 , A61P37/08 , A61P27/00 , A61P35/00 , A61P19/00 , C07D473/34
CPC分类号: C07D487/04 , C07D471/04 , C07D473/30 , C07D473/34
摘要: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
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公开(公告)号:US20120220585A1
公开(公告)日:2012-08-30
申请号:US13468212
申请日:2012-05-10
申请人: Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
发明人: Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
IPC分类号: A61K31/5377 , A61K31/52 , C07D487/04 , A61K31/519 , C07D473/40 , C07D473/30 , C07D473/38 , C07D473/16 , C07D471/04 , A61K31/4709 , A61P29/00 , A61P19/02 , A61P17/06 , A61P37/00 , A61P1/00 , A61P27/02 , A61P13/10 , A61P17/00 , A61P21/04 , A61P25/00 , A61P7/00 , A61P7/06 , A61P37/08 , A61P35/00 , C07D473/34
CPC分类号: C07D487/04 , C07D471/04 , C07D473/30 , C07D473/34
摘要: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译: 取代的双环杂芳基和含有它们的组合物,用于治疗一般炎症,关节炎,风湿性疾病,骨关节炎,炎性肠病,炎症性眼病,炎症性或不稳定性膀胱病,牛皮癣,皮肤炎症成分的投诉,慢性炎性病症 不限于自身免疫性疾病如系统性红斑狼疮(SLE),重症肌无力,类风湿性关节炎,急性播散性脑脊髓炎,特发性血小板减少性紫癜,多发性硬化症,Sjoegren综合征和自身免疫性溶血性贫血,包括所有形式的超敏反应的过敏症状 包括但不限于白血病,如急性骨髓性白血病(AML)骨髓增生异常综合征(MDS)骨髓增生性疾病(MPD)慢性骨髓性白血病(MPD),介导,依赖或与p110δ活性相关的癌症的方法 (CML)T细胞急性淋巴细胞白血病(T-ALL)B细胞急性淋巴细胞白血病(B-ALL)非霍奇金淋巴瘤(NHL)B细胞淋巴瘤和实体瘤如乳腺癌。
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公开(公告)号:US08193199B2
公开(公告)日:2012-06-05
申请号:US12079406
申请日:2008-03-24
申请人: Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
发明人: Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
IPC分类号: C07D473/34 , A61K31/52 , A61P35/00 , A61P19/02 , A61P37/06 , A61P19/08 , C07D487/04 , C07D241/40 , C07D241/44 , C07D215/14 , C07D215/26 , C07D215/22 , C07D417/14 , C07D417/04
CPC分类号: C07D487/04 , C07D471/04 , C07D473/30 , C07D473/34
摘要: Substituted bicyclic heteroaryls having the structures: and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译: 具有以下结构的取代的双环杂芳基:和含有它们的组合物,用于治疗一般炎症,关节炎,风湿性疾病,骨关节炎,炎性肠病,炎症性眼病,炎性或不稳定性膀胱病,牛皮癣,皮肤炎症成分的投诉,慢性炎症 包括但不限于自身免疫疾病如系统性红斑狼疮(SLE),重症肌无力,类风湿性关节炎,急性播散性脑脊髓炎,特发性血小板减少性紫癜,多发性硬化症,Sjoegren综合征和自身免疫性溶血性贫血,包括所有形式的超敏反应的过敏性疾病, 本发明还使得能够治疗依赖于p110δ活性或与p110δ活性相关的癌症的方法,包括但不限于白血病,例如急性骨髓性白血病(AML)Myelo-dysplastic综合征(MDS)骨髓增殖性疾病(MPD) Ch 骨髓性白血病(CML)T细胞急性淋巴细胞白血病(T-ALL)B细胞急性淋巴细胞白血病(B-ALL)非霍奇金淋巴瘤(NHL)B细胞淋巴瘤和实体瘤如乳腺癌。
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公开(公告)号:US20120094972A1
公开(公告)日:2012-04-19
申请号:US13377210
申请日:2010-06-25
申请人: Matthew Brown , Yi Chen , Timothy David Cushing , Felix Gonzalez Lopez De Turiso , Xiao He , Todd J. Kohn , Julia Winslow Lohman , Vatee Pattaropong , Jennifer Seganish , Youngsook Shin , Jillian L. Simard
发明人: Matthew Brown , Yi Chen , Timothy David Cushing , Felix Gonzalez Lopez De Turiso , Xiao He , Todd J. Kohn , Julia Winslow Lohman , Vatee Pattaropong , Jennifer Seganish , Youngsook Shin , Jillian L. Simard
IPC分类号: A61K31/5415 , C07D491/107 , C07D471/04 , C07D401/14 , C07D491/20 , C07D473/00 , C07D417/14 , C07D513/04 , A61K31/5377 , A61K31/506 , A61K31/4709 , A61K31/52 , A61K31/538 , A61P19/08 , A61P19/02 , A61P27/02 , A61P29/00 , A61P17/06 , A61P1/00 , A61P13/10 , A61P17/00 , A61P35/00 , C07D413/14
CPC分类号: C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/107 , C07D491/113 , C07D491/20 , C07D495/10 , C07D513/04
摘要: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
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公开(公告)号:US08765940B2
公开(公告)日:2014-07-01
申请号:US13377210
申请日:2010-06-25
申请人: Matthew Brown , Yi Chen , Timothy David Cushing , Felix Gonzalez Lopez De Turiso , Xiao He , Todd J. Kohn , Julia Winslow Lohman , Vatee Pattaropong , Jennifer Seganish , Youngsook Shin , Jillian L. Simard
发明人: Matthew Brown , Yi Chen , Timothy David Cushing , Felix Gonzalez Lopez De Turiso , Xiao He , Todd J. Kohn , Julia Winslow Lohman , Vatee Pattaropong , Jennifer Seganish , Youngsook Shin , Jillian L. Simard
IPC分类号: C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/107 , C07D491/20 , C07D513/04
CPC分类号: C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/107 , C07D491/113 , C07D491/20 , C07D495/10 , C07D513/04
摘要: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
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公开(公告)号:US20100179177A1
公开(公告)日:2010-07-15
申请号:US12713360
申请日:2010-02-26
申请人: Yi Chen , Timothy D. Cushing , Xiaolin Hao , Xiao He , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
发明人: Yi Chen , Timothy D. Cushing , Xiaolin Hao , Xiao He , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
IPC分类号: A61K31/506 , C07D239/42 , C07D215/36 , A61K31/4709 , C07D215/12 , A61P19/02 , A61P19/00 , A61P29/00 , A61P37/00 , A61P27/02 , A61P13/10 , A61P17/00 , A61P1/00 , A61P35/00
CPC分类号: C07D401/12 , C07D401/14
摘要: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译: 取代的双环杂芳基和含有它们的组合物,用于治疗一般炎症,关节炎,风湿性疾病,骨关节炎,炎性肠病,炎症性眼病,炎症性或不稳定性膀胱病,牛皮癣,皮肤炎症成分的投诉,慢性炎性病症 不限于自身免疫性疾病如系统性红斑狼疮(SLE),重症肌无力,类风湿性关节炎,急性播散性脑脊髓炎,特发性血小板减少性紫癜,多发性硬化症,Sjoegren综合征和自身免疫性溶血性贫血,包括所有形式的超敏反应的过敏症状 包括但不限于白血病,如急性骨髓性白血病(AML)骨髓增生异常综合征(MDS)骨髓增生性疾病(MPD)慢性骨髓性白血病(MPD),介导,依赖或与p110δ活性相关的癌症的方法 (CML)T细胞急性淋巴细胞白血病(T-ALL)B细胞急性淋巴细胞白血病(B-ALL)非霍奇金淋巴瘤(NHL)B细胞淋巴瘤和实体瘤如乳腺癌。
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