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9 条记录 (耗时 0.027 秒)

    Radiolabeled farnesyl-protein transferase inhibitors
    2.
    发明授权
    Radiolabeled farnesyl-protein transferase inhibitors 失效
    放射标记的法呢基蛋白转移酶抑制剂

    公开(公告)号：US06458935B1

    公开(公告)日：2002-10-01

    申请号：US09668637

    申请日：2000-06-12

    申请人： H. Donald Burns ,  Terence G. Hamill ,  Raymond E. Gibson

    发明人： H. Donald Burns ,  Terence G. Hamill ,  Raymond E. Gibson

    IPC分类号： C07D40304

    CPC分类号： C12Q1/48 ,  A61K51/0459 ,  C07D233/64

    摘要： The present invention is directed toward radiolabeled farnesyl-protein transferase inhibitor compounds which are useful to label FPTase in assays, whether cell-based, tissue-based or in whole animal. The tracers can also be used in competitive binding assays to obtain information on the interaction of unlabeled FTIs with FPTase.

    摘要翻译： 本发明涉及放射性标记的法呢基 - 蛋白转移酶抑制剂化合物，其用于在测定中标记FPTase，无论是基于细胞的，基于组织的还是在整个动物中。 示踪剂也可用于竞争性结合测定中以获得关于未标记的FTI与FPTase的相互作用的信息。

    Imidazole derivatives useful as modulators of FAAH and as FAAH imaging agents
    8.
    发明授权
    Imidazole derivatives useful as modulators of FAAH and as FAAH imaging agents 有权
    咪唑衍生物可用作FAAH和FAAH显像剂的调节剂

    公开(公告)号：US08664253B2

    公开(公告)日：2014-03-04

    申请号：US13254363

    申请日：2010-02-22

    申请人： Ping Liu ,  Robert J. DeVita ,  Linus S. Lin ,  Marc D. Chioda ,  Terence G. Hamill ,  Wenping Li

    发明人： Ping Liu ,  Robert J. DeVita ,  Linus S. Lin ,  Marc D. Chioda ,  Terence G. Hamill ,  Wenping Li

    IPC分类号： A61K31/4178 ,  A61K31/4439 ,  C07D401/10

    CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D413/10 ,  C07D413/14

    摘要： The present invention is directed to certain Inidazole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease.

    摘要翻译： 本发明涉及可用作脂肪酸酰胺水解酶（FAAH）和FAAH显像剂的调节剂的某些咪唑衍生物。 本发明还涉及包含这些化合物作为活性成分的药物制剂，以及这些化合物及其制剂在治疗某些疾病，包括骨关节炎，类风湿性关节炎，糖尿病性神经病变，带状疱疹后神经痛，ke肉肌痛和纤维肌痛等方面的用途。 作为急性疼痛，偏头痛，睡眠障碍，阿尔茨海默病和帕金森病。