公开(公告)号：US07381568B2

公开(公告)日：2008-06-03

申请号：US10858738

申请日：2004-06-02

申请人： Haiying Zhang ,  Kenneth L. Ray ,  Donglu Zhang

发明人： Haiying Zhang ,  Kenneth L. Ray ,  Donglu Zhang

IPC分类号： G01N24/00

CPC分类号： H01J49/0027 ,  Y10T436/24

摘要： A method for detecting and identifying metabolites in biological samples includes subjecting the samples to high resolution mass spectrometry (MS) analysis to detect ions of the molecular species. Mass defect values for the detected ions are determined. The method also includes specifying a predetermined range for mass defect values. Detected ions having mass defect values falling outside the specified range are discarded and those with mass defect values falling within the predetermined range are retained. Species of interest are determined from the retained values. The species of interest include drug metabolites or impurities and/or degradants of a known pharmaceutical sample.

摘要翻译： 用于检测和鉴定生物样品中代谢物的方法包括对样品进行高分辨质谱（MS）分析以检测分子种类的离子。 确定检测离子的质量缺陷值。 该方法还包括指定质量缺陷值的预定范围。 质量缺陷值超出规定范围的检测离子被丢弃，质量缺陷值落在预定范围内的检测离子被保留。 感兴趣的物种是根据保留值确定的。 感兴趣的物种包括已知药物样品的药物代谢物或杂质和/或降解物。