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公开(公告)号:US4358602A
公开(公告)日:1982-11-09
申请号:US240457
申请日:1981-03-04
申请人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Shinichi Kondo , Masaaki Ishizuka
发明人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Shinichi Kondo , Masaaki Ishizuka
IPC分类号: A61K31/335 , A61K31/337 , A61K31/365 , A61P37/04 , C07D305/12 , C12N9/99 , C12P17/02 , C12R1/465
CPC分类号: C12R1/465 , C07D305/12 , C12P17/02
摘要: New physiologically active substances, ebelactone A and ebelactone B which are generally termed ebelactone are produced from a new microorganism, Streptomyces MG7-G1 strain identified FERM-P 5363 or ATCC No. 31860 and ATCC No. 31880. Ebelactone is useful as a host defense stimulator having an activity to enhance cell-mediated immunity, and also as an anti-inflammatory agent.
摘要翻译: 通常称为内酯的新的生理活性物质Ebelactone A和ebelactone B由新的微生物,鉴定为FERM-P 5363的链霉菌MG7-G1菌株或ATCC No.31860和ATCC No.31880产生.Ebelactone可用作宿主防御 刺激剂具有增强细胞介导的免疫力的活性,并且还作为抗炎剂。
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2.
公开(公告)号:US4859593A
公开(公告)日:1989-08-22
申请号:US809215
申请日:1985-12-16
申请人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
发明人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
CPC分类号: C12P13/005 , C07C279/12 , C12R1/01 , Y10S435/822
摘要: New physiologically active substances, arphamenine A and arphamenine B which are generically termed arphamenine are produced from a new microorganism, BMG361-CF4 strain identified as FERM P-6521 or FERM BP-286 or ATCC No. 39373. Arphamenine is useful as a host defence stimulator having an activity to enhance cell-mediated immunity, and also as an anti-tumor agent.
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公开(公告)号:US4663342A
公开(公告)日:1987-05-05
申请号:US749456
申请日:1985-06-27
申请人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
发明人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
IPC分类号: C07D207/08 , A61K31/40 , A61K38/00 , A61P37/04
CPC分类号: A61K31/40
摘要: A compound of the formula (I) ##STR1## which is identified as an actinonin has now been found to potentiate the immune response in animals bearing Ascites Sarcoma 180 tumor cells.
摘要翻译: 现已发现被鉴定为放线诺宁的式(I)化合物(I)可增强携带腹水肉瘤180肿瘤细胞的动物的免疫应答。
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公开(公告)号:US4242453A
公开(公告)日:1980-12-30
申请号:US39094
申请日:1979-05-14
申请人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
发明人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
IPC分类号: A61K31/335 , A61K31/337 , A61K38/55 , A61P37/06 , C07D305/12 , C07G99/00 , C12N9/99 , C12P1/06 , C12P13/00 , C12P17/02 , C12R1/465
CPC分类号: C07D305/12 , C12P17/02 , Y10S435/899
摘要: A new physiologically active substance named esterastin is now provided, which inhibits the activity of esterase and is useful as an immunosuppressive drug. Esterastin is produced by cultivating a micro-organism Streptomyces MD4-C1 identified as FERM-P 3723 or ATCC. 31336 in a culture medium under aerobic conditions and recovering it from the resulting culture. Esterastin is the compound having the formula ##STR1##
摘要翻译: 现在提供一种名为酯酶的新的生理活性物质,其抑制酯酶的活性,并且可用作免疫抑制药物。 通过培养鉴定为FERM-P 3723或ATCC的微生物链霉菌属MD4-C1产生甾类化合物。 31336在有氧条件下在培养基中,并从所得培养物中回收。 甾类化合物是具有式CH 3(CH 2)4 CHCHCH 2 CH + TR
的化合物 -
公开(公告)号:US4189438A
公开(公告)日:1980-02-19
申请号:US873350
申请日:1978-01-30
申请人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
发明人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
IPC分类号: A61K31/335 , A61K31/337 , A61K38/55 , A61P37/06 , C07D305/12 , C07G99/00 , C12N9/99 , C12P1/06 , C12P13/00 , C12P17/02 , C12R1/465
CPC分类号: C07D305/12 , C12P17/02 , Y10S435/899
摘要: A new physiologically active substance named esterastin is now provided, which inhibits the activity of esterase and is useful as an immunosuppressive drug. Esterastin is produced by cultivating a microorganism Streptomyces MD4-C1 identified as FERM-P 3723 or ATCC. 31336 in a culture medium under aerobic conditions and recovering it from the resulting culture. Esterastin is the compound having the formula ##STR1##
摘要翻译: 现在提供一种名为酯酶的新的生理活性物质,其抑制酯酶的活性,并且可用作免疫抑制药物。 通过培养鉴定为FERM-P 3723或ATCC的微生物Streptomyces MD4-C1产生酯甾烷酮。 31336在有氧条件下在培养基中,并从所得培养物中回收。 酯甾体是具有式(IMAGE)的化合物
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6.
公开(公告)号:US4595698A
公开(公告)日:1986-06-17
申请号:US500396
申请日:1983-06-02
申请人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
发明人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
IPC分类号: A61K31/195 , A61K31/19 , A61P37/04 , C12N9/99 , C12P7/40 , C12P13/00 , C12R1/01 , C07C119/00
CPC分类号: C12P13/005 , C07C279/12 , C12R1/01 , Y10S435/822
摘要: New physiologically active substances, arphamenine A and arphamenine B which are generically termed arphamenine are produced from a new microorganism, BMG361-CF4 strain identified as FERM P-6521 or FERM BP-286 or ATCC No. 39373. Arphamenine is useful as a host defence stimulator having an activity to enhance cell-mediated immunity, and also as an anti-tumor agent.
摘要翻译: 新生物活性物质,一般被称为阿芬太尼的阿芬太尼A和阿芬太尼B由新的微生物,鉴定为FERM P-6521或FERM BP-286或ATCC No. 39373的BMG361-CF4菌株产生。阿德美宁作为宿主防御 刺激剂具有增强细胞介导的免疫的活性,并且还作为抗肿瘤剂。
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公开(公告)号:US4049497A
公开(公告)日:1977-09-20
申请号:US747470
申请日:1976-12-06
申请人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Shinichi Kondo , Masaaki Ishizuka , Hiroshi Naganawa
发明人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Shinichi Kondo , Masaaki Ishizuka , Hiroshi Naganawa
IPC分类号: C07G11/00
CPC分类号: A61K36/06 , C07G11/00 , Y10S435/886
摘要: There are disclosed two new antibiotics formerly denominated MC916-A and MC916-B and now called neothramycin A and neothramycin B which are potent inhibitors of the growth of leukemia cells, e.g. Leukema L-1210 cells in mice. They are produced by controlled fermentation of Streptomyces FERM-P 2452 (A.T.C.C. 31123).
摘要翻译: 已经公开了两种以前称为MC916-A和MC916-B的新抗生素,现在称为新西霉素A和新霉素B,其是白血病细胞生长的有效抑制剂,例如。 白血病L-1210细胞在小鼠中。 它们通过Frep-P 2452链霉菌(A.T.C.C. 31123)的对照发酵生产。
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公开(公告)号:US4105658A
公开(公告)日:1978-08-08
申请号:US659319
申请日:1976-02-19
申请人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Shinichi Kondo , Masaaki Ishizuka , Hiroshi Naganawa
发明人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Shinichi Kondo , Masaaki Ishizuka , Hiroshi Naganawa
IPC分类号: C07G11/00
CPC分类号: A61K36/06 , C07G11/00 , Y10S435/886
摘要: There are disclosed two new antibiotics formerly denominated MC916-A and MC916-B and now called neothramycin A and neothramycin B which are potent inhibitors of the growth of leukemia cells, e.g. Leukemia L-1210 cells in mice. They are produced by controlled fermentation of Streptomyces FERM-P 2452 (A.T.C.C. 31123).
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公开(公告)号:US4192915A
公开(公告)日:1980-03-11
申请号:US898065
申请日:1978-04-20
申请人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
发明人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
IPC分类号: C07H15/252 , C12P19/56 , C12D9/14
CPC分类号: C12R1/465 , C07H15/252 , C12P19/56 , C12R1/48 , Y10S435/886 , Y10S435/888
摘要: New antitumor agents designated rhodirubin A and B, which are anthracycline glycosides and inhibit the growth of gram-positive bacteria and mammalian tumors, are produced by fermentation of rhodirubin-producing strains of Streptomyces, e.g. Streptomyces sp. ME 505-HEI (ATCC 31273).
摘要翻译: 通过发酵罗丹明生产菌株Streptomyces,例如,通过发酵来产生称为罗丹霉素A和B的新型抗肿瘤药物,其是蒽环类苷并抑制革兰氏阳性细菌和哺乳动物肿瘤的生长。 链霉菌属 ME 505-HEI(ATCC 31273)。
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公开(公告)号:US4127714A
公开(公告)日:1978-11-28
申请号:US823052
申请日:1977-08-09
申请人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
发明人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
IPC分类号: C12P19/56 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , A61P35/00 , C07H15/252 , C07H15/24
CPC分类号: C07H15/252 , Y10S435/886
摘要: New antitumor agents designated rhodirubin A and B, which are anthracycline glycosides and inhibit the growth of gram-positive bacteria and mammalian tumors, are produced by fermentation of rhodirubin-producing strains of Streptomyces, e.g. Streptomyces sp. ME 505-HEI (ATCC 31273).
摘要翻译: 通过发酵罗丹明生产菌株Streptomyces,例如,通过发酵来产生称为罗丹霉素A和B的新型抗肿瘤药物,其是蒽环类苷并抑制革兰氏阳性细菌和哺乳动物肿瘤的生长。 链霉菌属 ME 505-HEI(ATCC 31273)。
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