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    Anti-mesothelin immunoconjugates and uses therefor
    3.
    发明授权
    Anti-mesothelin immunoconjugates and uses therefor 有权
    抗间皮素免疫缀合物及其用途

    公开(公告)号：US09084829B2

    公开(公告)日：2015-07-21

    申请号：US13318138

    申请日：2010-04-16

    申请人： Antje Kahnert ,  Kerstin Berhörster ,  Iring Heisler ,  Charlotte Christine Kopitz ,  Joachim Schuhmacher

    发明人： Antje Kahnert ,  Kerstin Berhörster ,  Iring Heisler ,  Charlotte Christine Kopitz ,  Joachim Schuhmacher

    IPC分类号： C07K16/00 ,  A61K47/48

    CPC分类号： C07K16/30 ,  A61K47/6803 ,  A61K47/6851 ,  C07K2317/14 ,  C07K2317/56 ,  C07K2317/565

    摘要： The present invention provides immunoconjugates composed of antibodies, e.g., monoclonal antibodies, or antibody fragments that bind to mesothelin, that are conjugated to cytotoxic agents, e.g., maytansine, or derivatives thereof, and/or co-administered or formulated with one or more additional anti-cancer agents. The immunoconjugates of the invention can be used in the methods of the invention to treat and/or diagnose and/or monitor cancers, e.g. solid tumors. The immunoconjugates comprise antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells.

    摘要翻译： 本发明提供免疫缀合物，其由抗体组成，例如单克隆抗体或结合间皮素的抗体片段，其与细胞毒性剂例如美登素或其衍生物缀合，和/或与一种或多种另外的附加物共同施用或配制 抗癌剂。 本发明的免疫缀合物可以用于本发明的方法来治疗和/或诊断和/或监测癌症，例如， 实体瘤。 免疫缀合物包含抗体和功能片段，其含有对多个肿瘤例如胰腺和卵巢肿瘤，间皮瘤和肺癌细胞中过表达的膜锚定的40kDa间皮素多肽具有特异性的抗原结合区。

    ANTI-MESOTHELIN IMMUNOCONJUGATES AND USES THEREFOR
    4.
    发明申请
    ANTI-MESOTHELIN IMMUNOCONJUGATES AND USES THEREFOR 有权
    免疫球蛋白免疫球蛋白及其用途

    公开(公告)号：US20120189644A1

    公开(公告)日：2012-07-26

    申请号：US13318138

    申请日：2010-04-16

    申请人： Antje Kahnert ,  Kerstin Berhörster ,  Iring Heisler ,  Charlotte Christine Kopitz ,  Joachim Schuhmacher

    发明人： Antje Kahnert ,  Kerstin Berhörster ,  Iring Heisler ,  Charlotte Christine Kopitz ,  Joachim Schuhmacher

    IPC分类号： A61K39/395 ,  C07K17/02 ,  A61P35/00 ,  C07K17/00

    CPC分类号： C07K16/30 ,  A61K47/6803 ,  A61K47/6851 ,  C07K2317/14 ,  C07K2317/56 ,  C07K2317/565

    摘要： The present invention provides immunoconjugates composed of antibodies, e.g., monoclonal antibodies, or antibody fragments that bind to mesothelin, that are conjugated to cytotoxic agents, e.g., maytansine, or derivatives thereof, and/or co-administered or formulated with one or more additional anti-cancer agents. The immunoconjugates of the invention can be used in the methods of the invention to treat and/or diagnose and/or monitor cancers, e.g. solid tumors. The immunoconjugates comprise antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells.

    摘要翻译： 本发明提供免疫缀合物，其由抗体组成，例如单克隆抗体或结合间皮素的抗体片段，其与细胞毒性剂例如美登素或其衍生物缀合，和/或与一种或多种另外的附加物共同施用或配制 抗癌剂。 本发明的免疫缀合物可以用于本发明的方法来治疗和/或诊断和/或监测癌症，例如， 实体瘤。 免疫缀合物包含抗体和功能片段，其含有对多个肿瘤例如胰腺和卵巢肿瘤，间皮瘤和肺癌细胞中过表达的膜锚定的40kDa间皮素多肽具有特异性的抗原结合区。