公开(公告)号：US6093715A

公开(公告)日：2000-07-25

申请号：US275107

申请日：1999-03-24

申请人： Hans-Peter Harz ,  Loni Schweikert ,  Douglas Norbert Schmidt

发明人： Hans-Peter Harz ,  Loni Schweikert ,  Douglas Norbert Schmidt

IPC分类号： A61K9/16 ,  A61K9/20 ,  A61K31/525 ,  A61K47/02 ,  A61K47/32 ,  A61K47/38 ,  A61P3/02 ,  C07D475/14

CPC分类号： A61K31/525 ,  A61K9/2018 ,  A61K9/1611 ,  A61K9/1635

摘要： Process for producing riboflavin granules or riboflavin microgranules with a riboflavin content of from 90 to 99.5% by weight and with a particle size range from 50 to 450 .mu.m, which entails adding during the granulation at least one auxiliary selected from the group consisting of alkali metal and alkaline earth metal halides, alkali metal and alkaline earth metal carbonates, alkali metal and alkaline earth metal bicarbonates, alkali metal and alkaline earth metal phosphates, crosslinked cellulose and cellulose derivatives and crosslinked polyvinylpyrrolidone in amounts of from 0.5 to 10% by weight, all % by weight data being based in each case on the dry product.

摘要翻译： 生产核黄素颗粒或核黄素微粒的方法，其中核黄素含量为90-99.5重量％，粒度范围为50-450μm，这需要在造粒过程中加入至少一种选自碱 金属和碱土金属卤化物，碱金属和碱土金属碳酸盐，碱金属和碱土金属碳酸氢盐，碱金属和碱土金属磷酸盐，交联纤维素和纤维素衍生物和交联聚乙烯吡咯烷酮，其量为0.5-10重量％ 在每种情况下，所有重量％的数据都是基于干燥产品。