公开(公告)号：US5618830A

公开(公告)日：1997-04-08

申请号：US536294

申请日：1995-09-29

申请人： Harold G. Selnick ,  John J. Baldwin ,  Gerald S. Ponticello ,  Joanne E. Tomassini

发明人： Harold G. Selnick ,  John J. Baldwin ,  Gerald S. Ponticello ,  Joanne E. Tomassini

IPC分类号： C07D211/32 ,  C07D211/34 ,  C07D211/96 ,  A61K31/44 ,  A61K31/445

CPC分类号： C07D211/32 ,  C07D211/34 ,  C07D211/96

摘要： Dioxobutanoic acids substituted with piperidine or similar N-substituted saturated cycloalkyls are found to inhibit the cap-dependent endonuclease of influenza virus. These compounds are useful in the prevention or treatment of infection by influenza virus and the treatment of influenza, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating influenza and methods of preventing or treating infection by influenza virus are also described.

摘要翻译： 被哌啶或类似的N-取代的饱和环烷基取代的二氧代丁酸被发现抑制流感病毒的帽依赖性内切核酸酶。 这些化合物可用于预防或治疗流感病毒的感染和治疗流感，作为化合物，药学上可接受的盐，药物组合物成分，无论是否与其它抗病毒剂，免疫调节剂，抗生素或疫苗结合使用。 还描述了治疗流感的方法和预防或治疗流感病毒感染的方法。

公开(公告)号：US5475109A

公开(公告)日：1995-12-12

申请号：US324190

申请日：1994-10-17

申请人： Harold G. Selnick ,  Gerald S. Ponticello ,  John J. Baldwin ,  Joanne E. Tomassini

发明人： Harold G. Selnick ,  Gerald S. Ponticello ,  John J. Baldwin ,  Joanne E. Tomassini

IPC分类号： C07D211/32 ,  C07D211/34 ,  C07D211/96 ,  C07D401/06

CPC分类号： C07D211/32 ,  C07D211/34 ,  C07D211/96

摘要： Dioxobutanoic acids substituted with piperidine or similar N-substituted saturated cycloalkyls are found to inhibit the cap-dependent endonuclease of influenza virus. These compounds are useful in the prevention or treatment of infection by influenza virus and the treatment of influenza, either as compound, pharmaceutically acceptable salts,. pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating influenza and methods of preventing or treating infection by influenza virus are also described.

摘要翻译： 被哌啶或类似的N-取代的饱和环烷基取代的二氧代丁酸被发现抑制流感病毒的帽依赖性内切核酸酶。 这些化合物可用于预防或治疗流感病毒的感染和治疗流感，作为化合物，药学上可接受的盐。 药物组合物成分，无论是否与其他抗病毒药，免疫调节剂，抗生素或疫苗结合使用。 还描述了治疗流感的方法和预防或治疗流感病毒感染的方法。

公开(公告)号：US4614793A

公开(公告)日：1986-09-30

申请号：US585942

申请日：1984-03-02

申请人： Joseph V. Hughes ,  Edward M. Scolnick ,  Joanne E. Tomassini

发明人： Joseph V. Hughes ,  Edward M. Scolnick ,  Joanne E. Tomassini

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/10 ,  C07K16/10 ,  C07K15/04

CPC分类号： C07K14/005 ,  C07K16/1009 ,  A61K38/00 ,  A61K39/00 ,  C12N2770/32422 ,  C12N2770/32434 ,  Y10S530/806 ,  Y10S530/826 ,  Y10S930/223

摘要： A surface structural protein of Hepatitis A Virus (HAV) has been isolated and characterized from virus grown in tissue culture. This 33,000 dalton viral protein (VP-1) reacts with immune HAV sera and monoclonal antibodies that neutralize HAV infectivity. The VP-1 is usable for the preparation of a polypeptide subunit vaccine for HAV.Hybridoma cells were made which produced monoclonal antibodies to HAV or VP-1. These monoclonal antibodies were found to neutralize the infectivity of HAV and to compete with polyclonal antibody derived from human HAV immune sera. The monoclonal antibodies are useful for the neutralization of infectious HAV, the detection of antibodies to neutralizing sites on HAV, and the diagnoses of HAV disease in humans and other susceptible hosts.

摘要翻译： 甲型肝炎病毒（HAV）的表面结构蛋白已经从在组织培养物中生长的病毒分离并表征。 该33,000道顿病毒蛋白（VP-1）与免疫HAV血清和中和HAV感染性的单克隆抗体反应。 VP-1可用于制备HAV的多肽亚单位疫苗。 制备产生单克隆抗体HAV或VP-1的杂交瘤细胞。 发现这些单克隆抗体中和HAV的感染性并与来自人HAV免疫血清的多克隆抗体竞争。 单克隆抗体可用于感染性HAV的中和，HAV中和位点的抗体检测以及人类和其他敏感宿主中HAV病的诊断。