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公开(公告)号：US20110144119A1
公开(公告)日：2011-06-16
申请号：US13057415
申请日：2009-07-30
申请人： Harry Chobanian , Linus S. Lin , Ping Liu , Marc D. Chioda , Robert J. DeVita , Ravi P. Nargund , Yan Guo
发明人： Harry Chobanian , Linus S. Lin , Ping Liu , Marc D. Chioda , Robert J. DeVita , Ravi P. Nargund , Yan Guo
IPC分类号： A61K31/501 , C07D413/14 , A61K31/497 , C07D413/04 , A61K31/444 , A61K31/4439 , A61K31/506 , C07D263/46 , A61K31/421 , C07D413/10 , A61K31/4245 , C07D413/12 , A61K31/4545 , C07D417/14 , A61K31/4725 , A61K31/4709 , A61P19/02 , A61P29/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/20 , A61P25/28 , A61P25/16
CPC分类号： C07D413/14 , C07D263/46 , C07D271/06 , C07D271/10 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/14
摘要： The present invention is directed to certain oxazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease.
摘要翻译： 本发明涉及可用作脂肪酸酰胺水解酶（FAAH）抑制剂的某些恶唑衍生物。 本发明还涉及包含这些化合物作为活性成分的药物制剂，以及这些化合物及其制剂在治疗某些疾病，包括骨关节炎，类风湿性关节炎，糖尿病性神经病变，带状疱疹后神经痛，ke肉肌痛和纤维肌痛等方面的用途。 作为急性疼痛，偏头痛，睡眠障碍，阿尔茨海默病和帕金森病。
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公开(公告)号：US08673941B2
公开(公告)日：2014-03-18
申请号：US13057415
申请日：2009-07-30
申请人： Harry Chobanian , Linus S. Lin , Ping Liu , Marc D. Chioda , Robert J. DeVita , Ravi P. Nargund , Yan Guo
发明人： Harry Chobanian , Linus S. Lin , Ping Liu , Marc D. Chioda , Robert J. DeVita , Ravi P. Nargund , Yan Guo
CPC分类号： C07D413/14 , C07D263/46 , C07D271/06 , C07D271/10 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/14
摘要： The present invention is directed to certain oxazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer Disease, and Parkinson's Disease.
摘要翻译： 本发明涉及可用作脂肪酸酰胺水解酶（FAAH）抑制剂的某些恶唑衍生物。 本发明还涉及包含这些化合物作为活性成分的药物制剂，以及这些化合物及其制剂在治疗某些疾病，包括骨关节炎，类风湿性关节炎，糖尿病性神经病变，带状疱疹后神经痛，ke肉肌痛和纤维肌痛等方面的用途。 作为急性疼痛，偏头痛，睡眠障碍，阿尔茨海默病和帕金森病。
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公开(公告)号：US20110021531A1
公开(公告)日：2011-01-27
申请号：US12509542
申请日：2009-07-27
申请人： Harry CHOBANIAN , Linus S. Lin , Ping Liu , Marc D. Chioda , Robert J. DeVita , Ravi P. Nargund , Yan Guo
发明人： Harry CHOBANIAN , Linus S. Lin , Ping Liu , Marc D. Chioda , Robert J. DeVita , Ravi P. Nargund , Yan Guo
IPC分类号： A61K31/497 , C07D413/14 , A61K31/444 , A61K31/501 , A61P25/00 , A61P19/00
CPC分类号： A61K31/444 , A61K31/497 , A61K31/501 , C07D413/14
摘要： The present invention is directed to certain oxazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer Disease, and Parkinson's Disease.
摘要翻译： 本发明涉及可用作脂肪酸酰胺水解酶（FAAH）抑制剂的某些恶唑衍生物。 本发明还涉及包含这些化合物作为活性成分的药物制剂，以及这些化合物及其制剂在治疗某些疾病，包括骨关节炎，类风湿性关节炎，糖尿病性神经病变，带状疱疹后神经痛，ke肉肌痛和纤维肌痛等方面的用途。 作为急性疼痛，偏头痛，睡眠障碍，阿尔茨海默病和帕金森病。
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4.发明申请公开(公告)号：US20130030000A1
公开(公告)日：2013-01-31
申请号：US13574303
申请日：2011-01-25
申请人： Harry R. Chobanian , Linus S. Lin , Ping Liu , Marc D. Chioda , Robert J. DeVita , Ravi P. Nargund , Yan Guo , Terence G. Hamill , Wenping Li , Darrell Arthur Henze
发明人： Harry R. Chobanian , Linus S. Lin , Ping Liu , Marc D. Chioda , Robert J. DeVita , Ravi P. Nargund , Yan Guo , Terence G. Hamill , Wenping Li , Darrell Arthur Henze
IPC分类号： A61K31/497 , A61K31/506 , A61K31/513 , A61K31/4439 , A61K31/421 , A61K31/4245 , A61K31/4545 , A61K31/501 , A61K31/4725 , A61K31/4709 , A61P29/00 , A61P25/22 , A61P3/04 , A61P27/02 , A61P11/06 , A61P27/06 , A61P9/00 , A61P25/24 , A61P43/00 , A61P19/02 , A61P25/28 , A61P25/18 , A61P25/30 , A61P25/16 , A61P25/08 , A61P11/00 , A61P35/00 , A61P1/00 , A61P1/04 , A61P1/12 , A61P17/04 , A61P1/16 , A61P25/06 , A61P25/02 , A61K31/444
CPC分类号： A61K31/422 , A61K31/4178
摘要： The present invention is directed to a composition useful for the treatment of a FAAH mediated disease, disorder or conditions comprising a FAAH inhibitor and a second activation, comprising a selected imidazole or oxazole FAAH inhibitor and a second active agent. The compositions will be useful in the treatment of a wide range of disease, disorder, or conditions including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer disease, and Parkinson's disease. In another aspect the invention discloses herein is directed to compositions useful in the treatment of neuropathic and nociceptive pain, said compositions comprising etoricoxib.
摘要翻译： 本发明涉及可用于治疗包含选择的咪唑或恶唑FAAH抑制剂和第二活性剂的FAAH介导的疾病，病症或包含FAAH抑制剂和第二活化的病症的组合物。 该组合物可用于治疗广泛的疾病，病症或病症，包括骨关节炎，类风湿性关节炎，糖尿病性神经病，带状疱疹后神经痛，肌肉痛和纤维肌痛，以及急性疼痛，偏头痛，睡眠障碍，阿尔茨海默病 ，和帕金森病。 另一方面，本发明公开了本发明涉及用于治疗神经性疼痛和伤害性疼痛的组合物，所述组合物包含埃托考昔。
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5.发明授权Imidazole derivatives useful as modulators of FAAH and as FAAH imaging agents 有权咪唑衍生物可用作FAAH和FAAH显像剂的调节剂公开(公告)号：US08664253B2
公开(公告)日：2014-03-04
申请号：US13254363
申请日：2010-02-22
申请人： Ping Liu , Robert J. DeVita , Linus S. Lin , Marc D. Chioda , Terence G. Hamill , Wenping Li
发明人： Ping Liu , Robert J. DeVita , Linus S. Lin , Marc D. Chioda , Terence G. Hamill , Wenping Li
IPC分类号： A61K31/4178 , A61K31/4439 , C07D401/10
CPC分类号： C07D401/12 , C07D401/14 , C07D413/10 , C07D413/14
摘要： The present invention is directed to certain Inidazole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease.
摘要翻译： 本发明涉及可用作脂肪酸酰胺水解酶（FAAH）和FAAH显像剂的调节剂的某些咪唑衍生物。 本发明还涉及包含这些化合物作为活性成分的药物制剂，以及这些化合物及其制剂在治疗某些疾病，包括骨关节炎，类风湿性关节炎，糖尿病性神经病变，带状疱疹后神经痛，ke肉肌痛和纤维肌痛等方面的用途。 作为急性疼痛，偏头痛，睡眠障碍，阿尔茨海默病和帕金森病。
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6.发明申请IMIDAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH AND AS FAAH IMAGING AGENTS 有权作为FAAH和FAAH成像剂的调节剂的咪唑衍生物公开(公告)号：US20120115894A1
公开(公告)日：2012-05-10
申请号：US13254363
申请日：2010-02-22
申请人： Ping Liu , Robert J. DeVita , Linus S. Lin , Marc D. Chioda , Terence G Hamill , Wenping Li
发明人： Ping Liu , Robert J. DeVita , Linus S. Lin , Marc D. Chioda , Terence G Hamill , Wenping Li
IPC分类号： A61K31/506 , A61K31/4439 , C07D233/84 , A61K31/4164 , C07D413/14 , C07D401/14 , C07D413/10 , A61K31/4245 , A61P19/02 , A61P29/00 , A61P25/00 , A61P25/06 , A61P25/20 , A61P25/28 , A61P25/16 , C07D401/12
CPC分类号： C07D401/12 , C07D401/14 , C07D413/10 , C07D413/14
摘要： The present invention is directed to certain Inidazole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease.
摘要翻译： 本发明涉及可用作脂肪酸酰胺水解酶（FAAH）和FAAH显像剂的调节剂的某些咪唑衍生物。 本发明还涉及包含这些化合物作为活性成分的药物制剂，以及这些化合物及其制剂在治疗某些疾病，包括骨关节炎，类风湿性关节炎，糖尿病性神经病变，带状疱疹后神经痛，ke肉肌痛和纤维肌痛等方面的用途。 作为急性疼痛，偏头痛，睡眠障碍，阿尔茨海默病和帕金森病。
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公开(公告)号：US08933113B2
公开(公告)日：2015-01-13
申请号：US13979875
申请日：2012-01-19
申请人： Alejandro Crespo , Ping Lan , Rudrajit Mal , Anthony Ogawa , Hong Shen , Peter J. Sinclair , Zhongxiang Sun , Ellen K. Vande Bunte , Zhicai Wu , Kun Liu , Robert J. DeVita , Dong-Ming Shen , Min Shu , John Qiang Tan , Changhe Qi , Yuguang Wang , Richard Beresis
发明人： Alejandro Crespo , Ping Lan , Rudrajit Mal , Anthony Ogawa , Hong Shen , Peter J. Sinclair , Zhongxiang Sun , Ellen K. Vande Bunte , Zhicai Wu , Kun Liu , Robert J. DeVita , Dong-Ming Shen , Min Shu , John Qiang Tan , Changhe Qi , Yuguang Wang , Richard Beresis
IPC分类号： A61K31/416 , C07D231/56 , A61K31/405 , A61K31/404 , C07D403/06 , C07D209/08 , C07D209/10 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K45/06 , C07D413/06
CPC分类号： C07D413/06 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/416 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K45/06 , C07D209/08 , C07D209/10 , C07D231/56 , C07D403/04 , C07D403/06 , C07D405/06
摘要： Disclosed are the compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, which are useful for treating aldosterone-mediated diseases. The processes for preparing compounds of the Formula (I), the use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and the pharmaceutical compositions which comprise compounds of the formula (I) are disclosed too.
摘要翻译： 公开了式（I）化合物及其药学上可接受的盐，其可用于治疗醛固酮介导的疾病。 还公开了制备式（I）化合物，用于治疗和预防上述疾病和用于制备用于此目的的药物的方法和包含式（I）化合物的药物组合物。
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公开(公告)号：US08124633B2
公开(公告)日：2012-02-28
申请号：US12593168
申请日：2008-04-07
IPC分类号： A61K31/422 , C07D209/02
CPC分类号： C07D209/44 , C07D413/04
摘要： The present invention is directed to certain hydroxymethyl ether hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, LUTS, depression, and anxiety.
摘要翻译： 本发明涉及某些可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的羟甲基醚异二氢吲哚化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂 以及化合物及其制剂在治疗某些疾病（包括呕吐，尿失禁，LUTS，抑郁和焦虑）中的用途。
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公开(公告)号：US20090221611A1
公开(公告)日：2009-09-03
申请号：US12087187
申请日：2007-01-05
IPC分类号： A61K31/4196 , C07D249/08 , C07D471/04 , C07D401/14 , A61K31/4353 , A61K31/4427 , A61P21/00
CPC分类号： C07D471/04
摘要： The present invention is directed to certain fused triazole compounds which are useful as neurokinin-1 (NK-I) receptor antagonists, and inhibitors of tachykinin and in particular substance P- The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P-的某些稠合三唑化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂和 化合物及其制剂在治疗某些疾病中的应用，包括呕吐，尿失禁，抑郁和焦虑。
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公开(公告)号：US20100197724A1
公开(公告)日：2010-08-05
申请号：US12665088
申请日：2008-06-18
申请人： Jianming Bao , Robert J. DeVita , Huagang Lu
发明人： Jianming Bao , Robert J. DeVita , Huagang Lu
IPC分类号： A61K31/437 , C07D471/04 , A61P25/00 , A61P29/00 , A61P25/06 , A61P1/08 , A61P25/24 , A61P25/22
CPC分类号： C07D471/04
摘要： The present invention is directed to certain hydroxymethyl ether hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, LUTS, depression, and anxiety.
摘要翻译： 本发明涉及某些可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的羟甲基醚异二氢吲哚化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂 以及化合物及其制剂在治疗某些疾病（包括呕吐，尿失禁，LUTS，抑郁和焦虑）中的用途。
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