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公开(公告)号:US08524722B2
公开(公告)日:2013-09-03
申请号:US12678288
申请日:2008-09-02
申请人: Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirstin Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffmann , Gerhard Siemeister , Ulf Bömer
发明人: Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirstin Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffmann , Gerhard Siemeister , Ulf Bömer
IPC分类号: A01N43/54 , A01N43/40 , A61K31/505 , A61K31/445 , C07D239/00 , C07D471/00 , C07D491/00 , C07D401/00 , C07D405/00 , C07D409/00
CPC分类号: C07D495/14 , C07D491/147 , C07D519/00
摘要: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
摘要翻译: 本发明涉及新化合物及其制备方法,治疗疾病,特别是癌症的方法,包括给药所述化合物,以及制备用于治疗或预防病症,特别是癌症的药物组合物的方法。
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公开(公告)号:US20110021493A1
公开(公告)日:2011-01-27
申请号:US12678288
申请日:2008-09-02
申请人: Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirsten Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffman , Gerhard Siemeister , Ulf Bömer
发明人: Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirsten Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffman , Gerhard Siemeister , Ulf Bömer
IPC分类号: C07D495/14 , A61K31/519 , A61K31/496 , A61K31/5377 , C07D491/147 , A61K31/4375 , A61K31/553 , A61K31/55 , A61P35/04 , A61P9/12 , A61P17/06 , A61P1/00
CPC分类号: C07D495/14 , C07D491/147 , C07D519/00
摘要: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
摘要翻译: 本发明涉及新化合物及其制备方法,治疗疾病,特别是癌症的方法,包括给药所述化合物,以及制备用于治疗或预防病症,特别是癌症的药物组合物的方法。
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3.
公开(公告)号:US09040691B2
公开(公告)日:2015-05-26
申请号:US14130586
申请日:2012-06-26
申请人: Jürgen Klar , Verena Vöhringer , Joachim Telser , Mario Lobell , Frank Süβmeier , Volkhart Min-Jian Li , Michael Böttger , Stefan Golz , Dieter Lang , Karl-Heinz Schlemmer , Thomas Schlange , Andreas Schall , Wenlang Fu
发明人: Jürgen Klar , Verena Vöhringer , Joachim Telser , Mario Lobell , Frank Süβmeier , Volkhart Min-Jian Li , Michael Böttger , Stefan Golz , Dieter Lang , Karl-Heinz Schlemmer , Thomas Schlange , Andreas Schall , Wenlang Fu
IPC分类号: C07D487/04 , C07D401/04 , A61K31/53 , A61K31/4427 , A61P25/02 , A61P27/02 , A61K31/5377
CPC分类号: A61K31/5377 , A61K31/4427 , A61K31/53 , C07D401/04 , C07D487/04
摘要: This invention relates to novel 5-[(hydroxymethyl)aryl]-substituted pyrrolo[2,1-f][1,2,4]triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.
摘要翻译: 本发明涉及式(I)的新的5 - [(羟甲基)芳基] - 取代的吡咯并[2,1-f] [1,2,4]三嗪-4-胺,用于制备这些化合物, 含有这些化合物的药物组合物,以及这些化合物或组合物用于治疗血管生成相关病症,特别是血管发生相关性眼部疾病的用途。
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4.
公开(公告)号:US20140256718A1
公开(公告)日:2014-09-11
申请号:US14130586
申请日:2012-06-26
申请人: Jürgen Klar , Verena Vöhringer , Joachim Telser , Mario Lobell , Frank Süssmeier , Volkhart Min-Jian Li , Michael Böttger , Stefan Golz , Dieter Lang , Karl-Heinz Schlemmer , Thomas Schlange , Andreas Schall , Wenlang Fu
发明人: Jürgen Klar , Verena Vöhringer , Joachim Telser , Mario Lobell , Frank Süssmeier , Volkhart Min-Jian Li , Michael Böttger , Stefan Golz , Dieter Lang , Karl-Heinz Schlemmer , Thomas Schlange , Andreas Schall , Wenlang Fu
IPC分类号: A61K31/5377 , C07D487/04 , A61K31/53
CPC分类号: A61K31/5377 , A61K31/4427 , A61K31/53 , C07D401/04 , C07D487/04
摘要: This invention relates to novel 5-[(hydroxymethyl)aryl]-substituted pyrrolo[2,1-f][1,2,4]triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.
摘要翻译: 本发明涉及式(I)的新的5 - [(羟甲基)芳基] - 取代的吡咯并[2,1-f] [1,2,4]三嗪-4-胺,用于制备这些化合物, 含有这些化合物的药物组合物,以及这些化合物或组合物用于治疗血管生成相关病症,特别是血管发生相关性眼部疾病的用途。
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公开(公告)号:US20080214533A1
公开(公告)日:2008-09-04
申请号:US11792108
申请日:2005-11-22
申请人: Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Arounarith Tuch , Mario Lobell , Peter Nell , Nils Burkhardt
发明人: Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Arounarith Tuch , Mario Lobell , Peter Nell , Nils Burkhardt
IPC分类号: A61K31/5355 , C07D401/14 , C07D413/14 , A61K31/4439 , C07D417/14 , A61K31/497 , A61P7/00
CPC分类号: C07D413/14
摘要: The invention relates to novel cyclic iminocarbamates of formula (I), wherein R1, R2, R3, A, Z, and n have the meanings recited in the description, to a method for the production thereof, to pharmaceutical compositions containing such materials, and to methods for the treatment and/or prophylaxis of thromboembolic diseases using them.
摘要翻译: 本发明涉及式(I)的新型环状亚氨基化物,其中R 1,R 2,R 3,A,Z和n 具有本说明书中所述的含义,其制备方法,含有这些材料的药物组合物,以及使用它们治疗和/或预防血栓栓塞性疾病的方法。
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公开(公告)号:US20060287315A1
公开(公告)日:2006-12-21
申请号:US11299342
申请日:2005-12-08
申请人: Susanne Rohrig , Mario Jeske , Metin Akbaba , Ulrich Rosentreter , Stephen Boyer , Karin Fischer , Jens Pohlmann , Arounarith Tuch , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Nils Burkhardt , Swen Allerheiligen , Peter Nell , Sabine Arndt , Mario Lobell
发明人: Susanne Rohrig , Mario Jeske , Metin Akbaba , Ulrich Rosentreter , Stephen Boyer , Karin Fischer , Jens Pohlmann , Arounarith Tuch , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Nils Burkhardt , Swen Allerheiligen , Peter Nell , Sabine Arndt , Mario Lobell
IPC分类号: A61K31/5377 , A61K31/497 , C07D413/02 , C07D403/02
CPC分类号: C07D491/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14
摘要: The present invention relates to novel pyridinedicarboxamides, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
摘要翻译: 本发明涉及新的吡啶二酰胺,其制备方法,其用于治疗和/或预防疾病的用途,以及其用于制备用于治疗和/或预防疾病,特别是血栓栓塞性疾病的药物的用途。
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7.Substituted phenylamino-benzene derivatives useful for treating hyper-proliferative disorders and diseases associated with mitogen extracellular kinase activity 审中-公开
标题翻译: 用于治疗高增殖性疾病和与丝裂原细胞外激酶活性相关的疾病的取代的苯基氨基苯衍生物公开(公告)号:US20090082328A1
公开(公告)日:2009-03-26
申请号:US12151855
申请日:2008-05-09
申请人: Yingfu Li , Joachim Rudolph , Jacques P. Dumas , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther
发明人: Yingfu Li , Joachim Rudolph , Jacques P. Dumas , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther
IPC分类号: A61K31/445 , C07C205/45 , C07D211/32 , C07C255/58 , C07D317/30 , C07C237/28 , A61K31/397 , A61K31/40 , A61K31/27 , A61P35/00 , A61K31/44 , A61K31/166 , C07D295/14 , C07D279/12 , C07D265/30 , A61K31/54 , A61K31/5375
CPC分类号: C07D233/60 , C07C217/92 , C07C237/30 , C07C237/44 , C07C243/38 , C07C255/58 , C07C255/59 , C07C271/16 , C07C271/28 , C07C271/44 , C07C275/28 , C07C275/36 , C07C307/02 , C07C307/10 , C07C309/66 , C07C311/08 , C07C311/09 , C07C311/17 , C07C311/48 , C07C2601/08 , C07C2601/10 , C07D205/04 , C07D207/08 , C07D207/27 , C07D207/48 , C07D209/08 , C07D211/22 , C07D211/46 , C07D211/96 , C07D213/30 , C07D213/34 , C07D213/68 , C07D231/18 , C07D233/84 , C07D265/30 , C07D277/22 , C07D295/088 , C07D295/185 , C07D295/26 , C07D317/22 , C07D317/64 , C07D327/04 , C07D403/12
摘要: This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要翻译: 本发明涉及新的取代的苯基氨基苯化合物,含有这些化合物的药物组合物,以及这些化合物或组合物用于治疗高增殖和/或血管生成障碍,作为唯一试剂或与其它活性成分组合的用途。
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8.SUBSTITUTED PHENYLAMINO-BENZENE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH MITOGEN EXTRACELLULAR KINASE ACTIVITY 审中-公开
标题翻译: 用于治疗与增殖细胞激酶活性相关的超增殖性疾病和疾病的替代苯甲酰苯胺衍生物公开(公告)号:US20110071125A1
公开(公告)日:2011-03-24
申请号:US12599641
申请日:2008-05-09
申请人: Joachim Rudolph , Jaques Dumas , Li Yingfu , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther , Benjamin Bader
发明人: Joachim Rudolph , Jaques Dumas , Li Yingfu , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther , Benjamin Bader
IPC分类号: A61K31/4178 , C12N9/99 , A61K31/397 , A61K31/535 , A61K31/4965 , A61K31/445 , A61K31/425 , A61K31/385 , A61K31/17 , A61K31/165 , C07D295/12 , C07D241/04 , C07D211/30 , C07D277/04 , C07D403/12 , C07D327/04 , C07C273/00 , C07C233/00 , A61P35/00 , A61P27/12
CPC分类号: C07D233/60 , C07C217/92 , C07C237/30 , C07C237/44 , C07C243/38 , C07C255/58 , C07C255/59 , C07C271/16 , C07C271/28 , C07C271/44 , C07C275/28 , C07C275/36 , C07C307/02 , C07C307/10 , C07C309/66 , C07C311/08 , C07C311/09 , C07C311/17 , C07C311/48 , C07C2601/08 , C07C2601/10 , C07D205/04 , C07D207/08 , C07D207/27 , C07D207/48 , C07D209/08 , C07D211/22 , C07D211/46 , C07D211/96 , C07D213/30 , C07D213/34 , C07D213/68 , C07D231/18 , C07D233/84 , C07D265/30 , C07D277/22 , C07D295/088 , C07D295/185 , C07D295/26 , C07D317/22 , C07D317/64 , C07D327/04 , C07D403/12
摘要: This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要翻译: 本发明涉及新的取代的苯基氨基苯化合物,含有这些化合物的药物组合物,以及这些化合物或组合物用于治疗高增殖和/或血管生成障碍,作为唯一试剂或与其它活性成分组合的用途。
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9.Indazolyl-substituted dihydroisoxa-zolopyridines and methods of use thereof 有权
标题翻译: 吲唑基取代的二氢异恶唑并吡咯嗪及其使用方法公开(公告)号:US09073939B2
公开(公告)日:2015-07-07
申请号:US13383223
申请日:2010-07-07
申请人: Martin Michels , Markus Follmann , Alexandros Vakalopoulos , Katja Zimmermann , Nicole Teusch , Mario Lobell
发明人: Martin Michels , Markus Follmann , Alexandros Vakalopoulos , Katja Zimmermann , Nicole Teusch , Mario Lobell
IPC分类号: C07D498/04 , A61K31/437
CPC分类号: C07D498/04 , A61K31/437
摘要: This invention relates to novel 4-(indazol-5-yl)-4,7-dihydroisoxazolo[5,4-b]pyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.
摘要翻译: 本发明涉及具有蛋白酪氨酸激酶抑制活性的新型4-(吲唑-5-基)-4,7-二氢异恶唑并[5,4-b]吡啶衍生物及其制备方法及其用途 治疗c-Met介导的疾病或c-Met介导的病症,特别是癌症和其他增殖性疾病。
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10.Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases 失效
标题翻译: 吡咯并[2,1-f] [1,2,4]三嗪-4-基胺治疗癌症和其他过度增生性疾病的IGF-1R激酶抑制剂公开(公告)号:US08431695B2
公开(公告)日:2013-04-30
申请号:US12084411
申请日:2006-11-02
申请人: Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
发明人: Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
IPC分类号: C07D487/04 , C07D413/02 , C07D417/02 , A61K31/53 , A61P35/00
CPC分类号: C07D487/04
摘要: This invention relates to novel compounds of formula (I). Formula (I) in which the variable groups are as defined in the specification and claims, to pharmaceutical compositions containing them, and to a method of treatment using them for treatment of cancer.
摘要翻译: 本发明涉及新的式(I)化合物。 式(I)其中可变基团如说明书和权利要求中所定义,含有它们的药物组合物,以及使用它们治疗癌症的方法。
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