-
公开(公告)号:US10654892B2
公开(公告)日:2020-05-19
申请号:US13877768
申请日:2011-10-04
申请人: Haruo Sugiyama , Shinji Sogo , Masayoshi Sato , Ryuki Kitamoto , Yoshihiro Goto
发明人: Haruo Sugiyama , Shinji Sogo , Masayoshi Sato , Ryuki Kitamoto , Yoshihiro Goto
IPC分类号: A61K39/00 , C12N5/0783 , C07K7/08 , C07K14/82 , A61K35/17
摘要: The present invention relates to a method for activating helper T cells, which includes the step of activating helper T cells by adding a WT1 peptide to antigen presenting cells, wherein the WT1 peptide has the ability to bind to any MHC class II molecule of an HLA-DRB1*0101 molecule, an HLA-DRB1*0401 molecule, an HLA-DRB1*0403 molecule, an HLA-DRB1*0406 molecule, an HLA-DRB1*0803 molecule, an HLA-DRB1*0901 molecule, an HLA-DRB1*1101 molecule, an HLA-DRB3*0202 molecule, an HLA-DRB4*0101 molecule, an HLA-DPB1*0201 molecule or an HLA-DPB1*0301 molecule, and the like.
-
公开(公告)号:US20130266958A1
公开(公告)日:2013-10-10
申请号:US13877768
申请日:2011-10-04
申请人: Haruo Sugiyama , Shinji Sogo , Masayoshi Sato , Ryuki Kitamoto , Yoshihiro Goto
发明人: Haruo Sugiyama , Shinji Sogo , Masayoshi Sato , Ryuki Kitamoto , Yoshihiro Goto
IPC分类号: C07K7/08
CPC分类号: C07K7/08 , A61K35/17 , A61K39/0011 , A61K2039/5158 , A61K2039/57 , C07K14/82 , C12N5/0636 , C12N5/0638 , C12N2501/2302 , C12N2501/2307
摘要: The present invention relates to a method for activating helper T cells, which includes the step of activating helper T cells by adding a WT1 peptide to antigen presenting cells, wherein the WT1 peptide has the ability to bind to any MHC class II molecule of an HLA-DRB1* 0101 molecule, an HLA-DRB1* 0401 molecule, an HLA-DRB1* 0403 molecule, an HLA-DRB1* 0406 molecule, an HLA-DRB1* 0803 molecule, an HLA-DRB1* 0901 molecule, an HLA-DRB1* 1101 molecule, an HLA-DRB3* 0202 molecule, an HLA-DRB4* 0101 molecule, an HLA-DPB1* 0201 molecule or an HLA-DPB1* 0301 molecule, and the like.
摘要翻译: 本发明涉及一种用于激活辅助性T细胞的方法,其包括通过向抗原呈递细胞添加WT1肽来激活辅助T细胞的步骤,其中WT1肽具有结合HLA的任何MHC II类分子的能力 -DRB1 * 0101分子,HLA-DRB1 * 0401分子,HLA-DRB1 * 0403分子,HLA-DRB1 * 0406分子,HLA-DRB1 * 0803分子,HLA-DRB1 * 0901分子,HLA-DRB1 HLA-DRB3 * 0202分子,HLA-DRB4 * 0101分子,HLA-DPB1 * 0201分子或HLA-DPB1 * 0301分子等。
-