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公开(公告)号:US08513282B2
公开(公告)日:2013-08-20
申请号:US12605053
申请日:2009-10-23
申请人: Hayley Binch , Lev T. D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D. J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
发明人: Hayley Binch , Lev T. D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D. J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
IPC分类号: A61K31/04
CPC分类号: A61K31/4709 , A61K45/06 , C07D215/56 , C07D221/22 , C07D451/02 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07F7/1804 , G01N33/5041 , G01N33/6872 , G01N2800/382
摘要: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
摘要翻译: 本发明涉及囊性纤维化跨膜传导调节剂(“CFTR”)的调节剂,其组合物及其方法。 本发明还涉及使用CFTR的调节剂治疗疾病的方法。
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公开(公告)号:US08598205B2
公开(公告)日:2013-12-03
申请号:US13439379
申请日:2012-04-04
申请人: Hayley Binch , Lev T. D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D. J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
发明人: Hayley Binch , Lev T. D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D. J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
IPC分类号: C07D215/38 , A61K31/04
CPC分类号: A61K31/4709 , A61K45/06 , C07D215/56 , C07D221/22 , C07D451/02 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07F7/1804 , G01N33/5041 , G01N33/6872 , G01N2800/382
摘要: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
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公开(公告)号:US20100113508A1
公开(公告)日:2010-05-06
申请号:US12605053
申请日:2009-10-23
申请人: Hayley Binch , Lev T.D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D.J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
发明人: Hayley Binch , Lev T.D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D.J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
IPC分类号: A61K31/439 , C07D453/04 , C12Q1/02
CPC分类号: A61K31/4709 , A61K45/06 , C07D215/56 , C07D221/22 , C07D451/02 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07F7/1804 , G01N33/5041 , G01N33/6872 , G01N2800/382
摘要: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
摘要翻译: 本发明涉及囊性纤维化跨膜传导调节剂(“CFTR”)的调节剂,其组合物及其方法。 本发明还涉及使用CFTR的调节剂治疗疾病的方法。
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公开(公告)号:US20120208841A1
公开(公告)日:2012-08-16
申请号:US13439379
申请日:2012-04-04
申请人: Hayley Binch , Lev T.D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D.J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
发明人: Hayley Binch , Lev T.D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D.J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
IPC分类号: A61K31/4709 , C07D487/08 , C07F7/10 , A61P11/06 , A61P11/00 , A61P1/10 , A61P1/18 , A61P1/16 , A61P35/00 , A61P3/10 , A61P25/28 , A61P25/16 , A61P25/14 , C12N5/071 , C07D451/02
CPC分类号: A61K31/4709 , A61K45/06 , C07D215/56 , C07D221/22 , C07D451/02 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07F7/1804 , G01N33/5041 , G01N33/6872 , G01N2800/382
摘要: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
摘要翻译: 本发明涉及囊性纤维化跨膜传导调节剂(“CFTR”)的调节剂,其组合物及其方法。 本发明还涉及使用CFTR的调节剂治疗疾病的方法。
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5.
公开(公告)号:US20110257223A1
公开(公告)日:2011-10-20
申请号:US13092838
申请日:2011-04-22
申请人: Fredrick Van Goor , Hayley Binch , Martyn Botfield , Lev T.D. Fanning , Peter D.J. Grootenhuis , Dennis Hurley , Medhi Michel Djamel Numa , Urvi Sheth , Alina Silina , Xiaoqing Yang , Gregor Zlokarnik
发明人: Fredrick Van Goor , Hayley Binch , Martyn Botfield , Lev T.D. Fanning , Peter D.J. Grootenhuis , Dennis Hurley , Medhi Michel Djamel Numa , Urvi Sheth , Alina Silina , Xiaoqing Yang , Gregor Zlokarnik
IPC分类号: A61K31/4709 , A61P11/06 , A61P11/08 , A61P1/10 , A61P11/00 , A61P15/00 , A61P1/16 , A61P1/18 , A61P3/10 , A61P35/00 , A61P21/00 , A61P25/28 , A61P25/16 , A61P25/00 , A61P27/02 , A61P19/10 , A61P19/08 , A61P25/08 , G01N33/567
CPC分类号: A61K31/4709 , A61K31/404 , A61K31/443 , G01N2800/382
摘要: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to pharmaceutical compositions comprising a compound of Formula I with one or both of a Compound of Formula II and/or a Compound of Formula III. Further, the present invention relates to methods of treating CFTR mediated diseases, particularly cystic fibrosis, using modulators of CFTR, and compositions and combinations thereof.
摘要翻译: 本发明涉及囊性纤维化跨膜传导调节剂(“CFTR”)的调节剂,其组合物及其方法。 本发明还涉及包含式I化合物与式II化合物和/或式III化合物中的一种或两种的药物组合物。 此外,本发明涉及使用CFTR的调节剂治疗CFTR介导的疾病,特别是囊性纤维化的方法及其组合物及其组合。
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公开(公告)号:US20100184739A1
公开(公告)日:2010-07-22
申请号:US12635927
申请日:2009-12-11
申请人: Urvi Sheth , Lev T.D. Fanning , Mehdi Michael Djamel Numa , Hayley Binch , Dennis Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick van Goor , Peter D.J. Grootenhuis , Martyn Botfield
发明人: Urvi Sheth , Lev T.D. Fanning , Mehdi Michael Djamel Numa , Hayley Binch , Dennis Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick van Goor , Peter D.J. Grootenhuis , Martyn Botfield
IPC分类号: A61K31/4709 , C07D215/56 , A61K31/47 , C07D413/12 , A61K31/5377 , A61K31/496 , C07D401/12 , A61P11/06 , A61P1/10 , A61P1/18 , A61P1/16 , A61P3/10 , A61P5/18 , A61P35/00 , A61P5/16 , A61P25/16 , A61P25/28 , A61P27/02 , A61P19/10 , A61P25/08 , A61P25/14 , C12Q1/02
CPC分类号: C07C215/76 , C07D209/08 , C07D209/14 , C07D209/18 , C07D209/42 , C07D209/94 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/38 , C07D215/56 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/10
摘要: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译: 本发明涉及ATP结合盒(“ABC”)转运蛋白或其片段的调节剂,包括囊性纤维化跨膜电导调节剂,其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号:US08802700B2
公开(公告)日:2014-08-12
申请号:US13492164
申请日:2012-06-08
申请人: Urvi Sheth , Lev T. D. Fanning , Mehdi Numa , Hayley Binch , Dennis James Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna R. Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick F. Van Goor , Peter Diederik Jan Grootenhuis , Martyn C. Botfield
发明人: Urvi Sheth , Lev T. D. Fanning , Mehdi Numa , Hayley Binch , Dennis James Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna R. Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick F. Van Goor , Peter Diederik Jan Grootenhuis , Martyn C. Botfield
IPC分类号: A61K31/04 , A61K31/4725 , A61K31/4709
CPC分类号: A61K31/4725 , A61K31/47 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D215/56 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K2300/00
摘要: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译: 本发明涉及ATP结合盒(“ABC”)转运蛋白或其片段的调节剂,包括囊性纤维化跨膜电导调节剂,其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号:US20120309758A1
公开(公告)日:2012-12-06
申请号:US13492164
申请日:2012-06-08
申请人: Urvi Sheth , Lev T.D. Fanning , Mehdi Numa , Hayley Binch , Dennis James Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna R. Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick F. Van Goor , Peter Diederik Jan Grootenhuis , Martyn C. Botfield
发明人: Urvi Sheth , Lev T.D. Fanning , Mehdi Numa , Hayley Binch , Dennis James Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna R. Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick F. Van Goor , Peter Diederik Jan Grootenhuis , Martyn C. Botfield
IPC分类号: A61K31/47 , A61K31/4709 , C12N5/071 , C07D215/56 , C07D413/12 , A61K31/5377 , A61P29/00 , A61P25/08 , A61P25/16 , A61P25/28 , A61P25/00 , A61P3/00 , A61P11/00 , A61P1/18 , A61P19/10 , A61P3/10 , A61P27/02 , A61P11/06 , A61P15/08 , C07D401/12
CPC分类号: A61K31/4725 , A61K31/47 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D215/56 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K2300/00
摘要: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译: 本发明涉及ATP结合盒(ABC)转运蛋白或其片段的调节剂,包括囊性纤维化跨膜电导调节剂,其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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9.
公开(公告)号:US08163720B2
公开(公告)日:2012-04-24
申请号:US12844047
申请日:2010-07-27
申请人: Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人: Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号: A01N51/00 , A61N31/655
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译: 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病(包括例如治疗疼痛)的方法。
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10.
公开(公告)号:US08809353B2
公开(公告)日:2014-08-19
申请号:US12050289
申请日:2008-03-18
申请人: Dean Wilson , Lev T. D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
发明人: Dean Wilson , Lev T. D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
IPC分类号: A61K31/517 , C07D239/72
CPC分类号: C07D403/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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