Keratin-Binding Polypeptides
    1.
    发明申请
    Keratin-Binding Polypeptides 审中-公开
    角蛋白结合多肽

    公开(公告)号:US20080075684A1

    公开(公告)日:2008-03-27

    申请号:US11597815

    申请日:2005-05-24

    IPC分类号: A61K8/64 C07K14/475

    摘要: The invention relates to novel keratin-binding protein active substances, and also to the production and use thereof. Particularly suitable keratin-binding polypeptides are sequences which are contained in human desmoplakin or are derived therefrom by altering the human desmoplakin polypeptide sequences such as amino acid insertions, substitutions or deletions. The polypeptide sequences of the human desmoplakin is represented in SEQ ID NO: 1. A suitable keratin-binding domain (domain B) is the polypeptide sequence SEQ ID NO: 1, position 2193 2481, in addition to functional equivalents thereof. An additional keratin-binding domain (domain C) is the polypeptide sequence SEQ ID NO: 1, position 2606 2871 and the functional equivalents thereof.

    摘要翻译: 本发明涉及新型角蛋白结合蛋白活性物质,以及其生产和使用。 特别合适的角蛋白结合多肽是通过改变人类粘蛋白多肽序列例如氨基酸插入,取代或缺失而包含在人类丝氨酸蛋白酶中或通过其衍生的序列。 人类粘蛋白的多肽序列表示在SEQ ID NO:1中。合适的角蛋白结合结构域(结构域B)是除了其功能等同物之外的多肽序列SEQ ID NO:1,位置21932481。 另外的角蛋白结合结构域(结构域C)是多肽序列SEQ ID NO:1,位置2606 2871及其功能等同物。