-
公开(公告)号:US20110086842A1
公开(公告)日:2011-04-14
申请号:US12972976
申请日:2010-12-20
申请人: Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
发明人: Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
IPC分类号: A61K31/553 , A61K31/506 , A61K31/5355 , A61P35/00 , A61P31/00 , A61P37/00
CPC分类号: C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要: The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中A,W,X,Y,Z,Ra,Rb,Rc,R 1和R 3如权利要求1中所定义,其适用于治疗以过量 或异常细胞增殖,以及其用于制备具有上述性质的药物组合物的用途。
-
公开(公告)号:US20090149438A1
公开(公告)日:2009-06-11
申请号:US12366078
申请日:2009-02-05
申请人: Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
发明人: Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
IPC分类号: A61K31/5377 , C07D413/14 , C07D403/12 , A61K31/506 , A61K31/551 , C07D409/14 , A61K31/553
CPC分类号: C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要: The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
-
公开(公告)号:US20090163465A1
公开(公告)日:2009-06-25
申请号:US12366075
申请日:2009-02-05
申请人: Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
发明人: Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
IPC分类号: A61K31/506 , A61K31/55 , A61K31/553 , A61K31/551 , A61P35/00
CPC分类号: C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要: The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
-
公开(公告)号:US20100029642A1
公开(公告)日:2010-02-04
申请号:US12578737
申请日:2009-10-14
IPC分类号: A61K31/5377 , A61K31/4985 , A61P35/04
CPC分类号: C07D471/04
摘要: Disclosed are pyridodihydropyrazinone compounds, processes for preparing them and their use as pharmaceutical compositions. The compounds according to the invention correspond to general formula (I), while the groups L, R1, R2, R3, R4 and R5 may have the meanings given in the claims and specification.
摘要翻译: 公开了吡啶二氢吡嗪酮化合物,其制备方法及其作为药物组合物的用途。 根据本发明的化合物对应于通式(I),而基团L,R 1,R 2,R 3,R 4和R 5可以具有权利要求书和说明书中给出的含义。
-
公开(公告)号:US20090087405A1
公开(公告)日:2009-04-02
申请号:US12334323
申请日:2008-12-12
申请人: Gerald Juergen ROTH , Armin HECKEL , Rainer WALTER , Frank HILBERG , Rudolf HAUPTMANN , Martin Friedrich STEFANIC , Florian COLBATZKY , Steffen ERNST
发明人: Gerald Juergen ROTH , Armin HECKEL , Rainer WALTER , Frank HILBERG , Rudolf HAUPTMANN , Martin Friedrich STEFANIC , Florian COLBATZKY , Steffen ERNST
IPC分类号: A61K38/20 , A61K31/454 , A61K31/40 , A61K31/4025 , A61K31/4184 , A61K31/517 , A61K31/496 , A61K31/60 , A61K31/5415 , A61P37/00 , A61K31/56 , A61K31/4985 , A61K31/675 , A61K33/24 , A61K38/13 , A61K31/4353 , A61K38/21
CPC分类号: A61K45/06 , A61K31/404 , A61K31/454 , A61K31/517 , A61K2300/00
摘要: The invention relates to a method of treating immunologic diseases or pathological conditions involving an immunologic component using certain Lck inhibitors already known as kinase inhibitors for therapy in oncology, optionally in combination with one or more other drugs selected from NSAIDs, steroids, DMARDs, immunsuppressives, biologic response modifiers and antinfectives, pharmaceutical compositions comprising said Lck inhibitors together with said other drugs, and the use of the Lck inhibitors for the manufacture of a pharmaceutical composition for the treatment of immunologic diseases or pathological conditions involving an immunologic component.
摘要翻译: 本发明涉及一种治疗免疫学疾病或病理状态的方法,该方法使用已知的用作肿瘤学治疗的激酶抑制剂的某些Lck抑制剂,任选与一种或多种其它选自NSAID,类固醇,DMARD,免疫抑制剂, 生物反应调节剂和抗感染剂,包含所述Lck抑制剂与所述其它药物的药物组合物,以及使用Lck抑制剂制备用于治疗免疫学疾病或涉及免疫组分的病理状况的药物组合物。
-
-
-
-