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    THERAPY USING PERTURBATION AND EFFECT OF PHYSIOLOGICAL SYSTEMS
    1.
    发明申请
    THERAPY USING PERTURBATION AND EFFECT OF PHYSIOLOGICAL SYSTEMS 有权
    使用生理系统的治疗和效果的治疗

    公开(公告)号：US20110270343A1

    公开(公告)日：2011-11-03

    申请号：US13094327

    申请日：2011-04-26

    申请人： Hendrik Peter Johan Buschman ,  Richard N.M. Cornelussen ,  Michael Roland Scott Hill ,  Lilian Kornet ,  Simone Cornelia Maria Anna Ordelman ,  Petrus Hermanus Veltink

    发明人： Hendrik Peter Johan Buschman ,  Richard N.M. Cornelussen ,  Michael Roland Scott Hill ,  Lilian Kornet ,  Simone Cornelia Maria Anna Ordelman ,  Petrus Hermanus Veltink

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36114 ,  A61N1/365

    摘要： Methods for treating a patient and further to devices for performing such treatment, e.g., methods and devices to perturb at least one physiological system and deliver therapy to the patient based on the effects of such perturbation. For example, a method for using an implantable medical device is disclosed that involves a method for using an implantable medical device delivering electrical stimuli to an afferent nerve associated with the selected organ. The efferent electrical activity is monitored in an efferent nerve responsive to delivering electrical stimuli to the afferent nerve, the monitored efferent electrical activity includes an indirect component of a compound action potential (CAP). A status of the selected organ is assessed based upon the indirect component.

    摘要翻译： 用于治疗患者和进一步进行这种治疗的装置的方法，例如用于扰乱至少一个生理系统的方法和装置，并且基于这种扰动的影响向患者递送治疗。 例如，公开了一种使用可植入医疗装置的方法，该方法涉及使用将植入式医疗装置向与所选择的器官相关的传入神经递送电刺激的方法。 响应于传递对传入神经的电刺激，传出的神经中监测传出的电活动，所监测的传出电活动包括复合动作电位（CAP）的间接成分。 所选器官的状态根据间接成分进行评估。

    ATRIAL NERVE STIMULATION WITH VENTRICULAR PACING
    5.
    发明申请
    ATRIAL NERVE STIMULATION WITH VENTRICULAR PACING 有权
    心脏神经刺激与静脉瓣

    公开(公告)号：US20120239105A1

    公开(公告)日：2012-09-20

    申请号：US13047928

    申请日：2011-03-15

    申请人： Vinayakrishnan Rajan ,  Richard N.M. Cornelussen ,  Berthold Stegemann ,  Lilian Kornet

    发明人： Vinayakrishnan Rajan ,  Richard N.M. Cornelussen ,  Berthold Stegemann ,  Lilian Kornet

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： An implantable medical device senses atrial depolarizations having associated refractory periods thereafter and delivers electrical stimulation pulses during the associated refractory periods to stimulate the atrioventricular (AV) node to cause a prolonged conduction time of an atrial depolarization to a ventricular chamber. The device delivers a pacing pulse to a first ventricular chamber during the prolonged conduction time to cause a contraction and associated refractory period of the first ventricular chamber, the first ventricular chamber contraction occurring earlier than a contraction of a second ventricular chamber.

    摘要翻译： 植入式医疗装置感测其后具有相关不应期的心房去极化，并且在相关联的不应期期间传递电刺激脉冲以刺激房室（AV）节点，从而导致心室去极化延长到心室的传导时间。 该设备在延长的传导时间期间将起搏脉冲递送到第一心室，以引起第一心室的收缩和相关联的不应期，第一心室的收缩早于第二心室的收缩。