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公开(公告)号：US08808984B2
公开(公告)日：2014-08-19
申请号：US12179323
申请日：2008-07-24
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H21/00 , C07H21/04 , C12Q1/6816 , C40B40/06 , C40B40/14
摘要： The invention relates to a method for synthesizing templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.
摘要翻译： 本发明涉及一种合成连接于模板的模板分子的方法，其指导其合成。 该方法涉及模板，脚手架功能实体和连接到构件块的功能实体，其又附接模板。 支架功能实体和构建单元的功能实体都具有互补的二聚化结构域，使得当互补结构域彼此相互作用时，功能实体能够接近。 该方法可以用于产生可以选择用于生物活性的模板分子的文库。
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公开(公告)号：US09109248B2
公开(公告)日：2015-08-18
申请号：US13455223
申请日：2012-04-25
申请人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
发明人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
CPC分类号： C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifuntional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
摘要翻译： 公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法，其中包含化学反应位点的初生双功能复合物和用于酶标记添加的引发位点在化学反应位点与一个或多个 反应物，并且提供标识起始位点处的反应物的各个标签是使用一种或多种酶。
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公开(公告)号：US20090264300A1
公开(公告)日：2009-10-22
申请号：US12095778
申请日：2006-12-01
申请人： Thomas Franch , Mikkel Dybro Lundorf , Soren Nyboe Jacobsen , Eva Kampmann Olsen , Anne Lee Andersen , Anette Holtmann , Anders Holm Hansen , Anders Malling Sorensen , Anne Goldbech , Daen de Leon , Ditte Kievsmose Kaldor , Frank Abildgaard Slok , Gitte Nystrup Husemoen , Johannes Dolberg , Kim Birkebaek Jensen , Lene Pedersen , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Sore Neve , Thomas Thisted , Tine Titilola Akinleminu Kronborg , Christian Klarner Sams , Jakob Felding , Per-Ola Freskgard , Alex Haahr Gouliaev , Henrik Pedersen
发明人： Thomas Franch , Mikkel Dybro Lundorf , Soren Nyboe Jacobsen , Eva Kampmann Olsen , Anne Lee Andersen , Anette Holtmann , Anders Holm Hansen , Anders Malling Sorensen , Anne Goldbech , Daen de Leon , Ditte Kievsmose Kaldor , Frank Abildgaard Slok , Gitte Nystrup Husemoen , Johannes Dolberg , Kim Birkebaek Jensen , Lene Pedersen , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Sore Neve , Thomas Thisted , Tine Titilola Akinleminu Kronborg , Christian Klarner Sams , Jakob Felding , Per-Ola Freskgard , Alex Haahr Gouliaev , Henrik Pedersen
CPC分类号： C12N15/1068 , C12N15/1089 , C40B40/08 , C40B50/04 , C40B50/06
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
摘要翻译： 公开了一种获得包含与单链标识符寡核苷酸连接的分子的双功能复合物的方法，其中包含化学反应位点的新生双功能复合物和用于酶标记添加的引发位点是a）在化学反应位点与 一种或多种反应物，和b）在起始位点用一种或多种标记反应物的标签进行酶促反应。
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公开(公告)号：US09574189B2
公开(公告)日：2017-02-21
申请号：US12095778
申请日：2006-12-01
申请人： Thomas Franch , Mikkel Dybro Lundorf , Søren Nyboe Jacobsen , Eva Kampmann Olsen , Anne Lee Andersen , Anette Holtmann , Anders Holm Hansen , Anders Malling Sørensen , Anne Goldbech , Daen de Leon , Ditte Kievsmose Kaldor , Frank Abildgaard Sløk , Gitte Nystrup Husemoen , Johannes Dolberg , Kim Birkebæ Jensen , Lene Pedersen , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Søren Neve , Thomas Thisted , Tine Titilola Akinleminu Kronborg , Christian Klarner Sams , Jakob Felding , Per-Ola Freskgård , Alex Haahr Gouliaev , Henrik Pedersen
发明人： Thomas Franch , Mikkel Dybro Lundorf , Søren Nyboe Jacobsen , Eva Kampmann Olsen , Anne Lee Andersen , Anette Holtmann , Anders Holm Hansen , Anders Malling Sørensen , Anne Goldbech , Daen de Leon , Ditte Kievsmose Kaldor , Frank Abildgaard Sløk , Gitte Nystrup Husemoen , Johannes Dolberg , Kim Birkebæ Jensen , Lene Pedersen , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Søren Neve , Thomas Thisted , Tine Titilola Akinleminu Kronborg , Christian Klarner Sams , Jakob Felding , Per-Ola Freskgård , Alex Haahr Gouliaev , Henrik Pedersen
CPC分类号： C12N15/1068 , C12N15/1089 , C40B40/08 , C40B50/04 , C40B50/06
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
摘要翻译： 公开了一种获得包含与单链标识符寡核苷酸连接的分子的双功能复合物的方法，其中包含化学反应位点的新生双功能复合物和用于酶标记添加的引发位点是a）在化学反应位点与 一种或多种反应物，和b）在起始位点用一种或多种标记反应物的标签进行酶促反应。
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公开(公告)号：US08206901B2
公开(公告)日：2012-06-26
申请号：US10525817
申请日：2003-10-30
申请人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
发明人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
CPC分类号： C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactants(s) at the priming site using one or more enzymes.
摘要翻译： 公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法，其中包含化学反应位点的初生双功能复合物和用于酶标记添加的引发位点在化学反应位点与一个或多个 并且使用一种或多种酶提供标识启动位点处的反应物的各个标签。
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公开(公告)号：US20090143232A1
公开(公告)日：2009-06-04
申请号：US12179323
申请日：2008-07-24
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H21/00 , C07H21/04 , C12Q1/6816 , C40B40/06 , C40B40/14
摘要： The invention relates to a method for synthesizing templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.
摘要翻译： 本发明涉及一种合成连接于模板的模板分子的方法，其指导其合成。 该方法涉及模板，脚手架功能实体和连接到构件块的功能实体，其又附接模板。 支架功能实体和构建单元的功能实体都具有互补的二聚化结构域，使得当互补结构域彼此相互作用时，功能实体能够接近。 该方法可以用于产生可以选择用于生物活性的模板分子的文库。
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公开(公告)号：US07413854B2
公开(公告)日：2008-08-19
申请号：US10507121
申请日：2003-03-14
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H21/00 , C07H21/04 , C12Q1/6816 , C40B40/06 , C40B40/14
摘要： The invention relates to a method for synthesizing templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.
摘要翻译： 本发明涉及一种合成连接于模板的模板分子的方法，其指导其合成。 该方法涉及模板，脚手架功能实体和连接到构件块的功能实体，其又附接模板。 支架功能实体和构建单元的功能实体都具有互补的二聚化结构域，使得当互补结构域彼此相互作用时，功能实体能够接近。 该方法可以用于产生可以选择用于生物活性的模板分子的文库。
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公开(公告)号：US08932992B2
公开(公告)日：2015-01-13
申请号：US12330709
申请日：2008-12-09
申请人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
发明人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要： The present invention relates to a method for synthesizing templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
摘要翻译： 本发明涉及一种合成模板分子的方法。 在本发明的一个方面，模板分子连接到模板，其模板化其合成。 该内容允许生成可以被筛选的文库。 治疗活动。
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公开(公告)号：US07727713B2
公开(公告)日：2010-06-01
申请号：US10175539
申请日：2002-06-20
申请人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
发明人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要： The present invention relates to a method for synthesizing templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
摘要翻译： 本发明涉及一种合成模板分子的方法。 在本发明的一个方面，模板分子连接到模板，其模板化其合成。 该内容允许生成可以被筛选的文库。 治疗活动。
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公开(公告)号：US20060099592A1
公开(公告)日：2006-05-11
申请号：US10525817
申请日：2003-10-30
申请人： Per-Ola Freskgard , Thomas Franch , Alex Gouliaev , Mikkel Lundorf , Jakob Felding , Eva Olsen , Anette Holtmann , Soeren Jakobsen , Christian Sams , Sanne Glad , Kim Jensen , Henrik Pedersen
发明人： Per-Ola Freskgard , Thomas Franch , Alex Gouliaev , Mikkel Lundorf , Jakob Felding , Eva Olsen , Anette Holtmann , Soeren Jakobsen , Christian Sams , Sanne Glad , Kim Jensen , Henrik Pedersen
CPC分类号： C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactants(s) at the priming site using one or more enzymes.
摘要翻译： 公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法，其中包含化学反应位点的初生双功能复合物和用于酶标记添加的引发位点在化学反应位点与一个或多个 并且使用一种或多种酶提供标识启动位点处的反应物的各个标签。
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