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公开(公告)号：US5981570A
公开(公告)日：1999-11-09
申请号：US935374
申请日：1997-09-22
IPC分类号： C07D333/16 , A61K31/38 , A61K31/381 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4433 , A61P3/06 , A61P19/10 , A61P43/00 , C07D277/20 , C07D277/24 , C07D277/34 , C07D333/32 , C07D333/56 , C07D333/64 , C07D409/12 , C07D417/12
CPC分类号： C07D409/12 , C07D333/56 , C07D417/12
摘要： The invention provides benzothiophene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, cardiovascular-related pathological conditions, including hyperlipidemia.
摘要翻译： 本发明提供苯并噻吩化合物，制剂和抑制骨丢失或骨吸收的方法，特别是骨质疏松症，心血管相关的病理状况，包括高脂血症。
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2.发明授权Methods for inhibiting detrimental side-effects due to GnRH of GnRH agonist administration 失效抑制GnRH激动剂施用GnRH引起的有害副作用的方法
公开(公告)号：US6096764A
公开(公告)日：2000-08-01
申请号：US134316
申请日：1998-08-14
IPC分类号： C07D333/56 , A61K31/4025 , A61K31/44 , A61K31/4535 , A61K31/55 , A61K38/09 , A61P43/00 , A61K31/445 , A61K31/38 , A61K31/40
CPC分类号： A61K31/44 , A61K31/4535 , A61K38/09
摘要： A method of inhibiting detrimental side-effects of GnRH or GnRH agonist administration in a mammal which comprises the administration to a mannal in need thereof of an effective amount of a compound of formula I ##STR1## wherein R.sup.1 and R.sup.3 are, independently, --H, --CH.sub.3, --CO(C.sub.1 -C.sub.6 alkyl), or --COAr, where Ar is optionally substituted phenyl;R.sup.3 is selected from the group consisting of pyrrolidine, piperidine, and hexamethyleneimino; ora pharmaceutically acceptable salt or solvate thereof.
摘要翻译： 一种抑制哺乳动物GnRH或GnRH激动剂施用的有害副作用的方法，其包括向需要其的甘露醇施用有效量的式I化合物，其中R 1和R 3独立地为-H，-CH 3 ，-CO（C 1 -C 6烷基）或-COAr，其中Ar是任选取代的苯基; R3选自吡咯烷，哌啶和六亚甲基亚氨基; 或其药学上可接受的盐或溶剂合物。
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公开(公告)号：US5821253A
公开(公告)日：1998-10-13
申请号：US937646
申请日：1997-09-24
IPC分类号： C07D295/08 , A61K31/135 , A61K31/40 , A61K31/445 , A61K31/55 , A61K31/565 , A61K31/57 , A61P3/06 , A61P9/00 , A61P19/10 , A61P43/00 , C07C217/18 , C07C309/65 , C07D207/06 , C07D295/092 , C07J69/00 , C07D211/08
CPC分类号： C07D295/088 , A61K31/565 , A61K31/57 , C07C217/18 , C07C2103/40
摘要： The invention provides tetrahydrobenzo�a!fluorene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions, including hyperlipidemia.
摘要翻译： 本发明提供四氢苯并[a]芴化合物，制剂和抑制骨丢失或骨吸收，特别是骨质疏松症和心血管相关病理状况（包括高脂血症）的方法。
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公开(公告)号：US5760030A
公开(公告)日：1998-06-02
申请号：US886575
申请日：1997-06-30
IPC分类号： C07D333/22 , A61K31/38 , A61K31/44 , C07D409/00 , C07D411/00
CPC分类号： C07D333/22
摘要： The instant invention provides novel benzothiophene compounds, pharmaceutical formulations, and methods of use.
摘要翻译： 本发明提供新的苯并噻吩化合物，药物制剂和使用方法。
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公开(公告)号：US6110942A
公开(公告)日：2000-08-29
申请号：US867058
申请日：1997-06-02
IPC分类号： C07D333/56 , A61K31/445 , A61K31/4535 , A61K31/135
CPC分类号： A61K31/4535 , A61K31/445
摘要： The present invention provides a method of minimizing the uterotrophic effect of a compound of formula II ##STR1## or a pharmaceutically acceptable salt or solvate thereof, comprising concurrently or sequentially administering a compound of formula I ##STR2## or pharmaceutically acceptable salt or solvate thereof.
摘要翻译： 本发明提供了使式II化合物或其药学上可接受的盐或溶剂合物的子宫营养作用最小化的方法，其包括同时或依次施用式I化合物或其药学上可接受的盐或溶剂化物。
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公开(公告)号：US6090843A
公开(公告)日：2000-07-18
申请号：US128873
申请日：1998-08-04
IPC分类号： A61K31/381 , A61K31/4025 , A61K31/4433 , A61K31/4535 , A61K31/55 , A61P5/30 , A61P19/10 , A61P35/00 , C07D333/56 , C07D409/12 , C07D333/52 , A61K31/38
CPC分类号： C07D409/12 , C07D333/56
摘要： This invention provides novel benzothiophene compounds of the formula I: ##STR1## which are useful for the treatment of the various medical conditions associated with postmenopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus, and cervix. The present invention further relates to pharmaceutical formulations of compounds of formula I.
摘要翻译： 本发明提供了式I的新型苯并噻吩化合物：其可用于治疗与绝经后综合征相关的各种医学病症，以及雌激素依赖性疾病，包括乳腺癌，子宫癌和子宫颈癌。 本发明还涉及式I化合物的药物制剂。
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公开(公告)号：US5889000A
公开(公告)日：1999-03-30
申请号：US934988
申请日：1997-09-22
IPC分类号： C07D295/08 , A61K31/135 , A61K31/445 , A61K31/55 , A61P3/06 , A61P9/00 , A61P19/10 , C07C39/23 , C07C49/84 , C07C217/18 , C07C309/65 , C07D207/06 , C07D295/092 , A61K31/45
CPC分类号： C07D295/088 , C07C2103/52 , Y02P20/55
摘要： The invention provides naphthofluorene compounds, intermediates, formulations, processes, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, cardiovascular-related pathological conditions, including hyperlipidemia, and estrogen-dependent cancer.
摘要翻译： 本发明提供萘并芴化合物，中间体，制剂，方法和抑制骨丢失或骨吸收的方法，特别是骨质疏松症，心血管相关的病理状况，包括高脂血症和雌激素依赖性癌症。
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公开(公告)号：US06992097B2
公开(公告)日：2006-01-31
申请号：US10453833
申请日：2003-06-03
申请人： Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , Jeffrey Daniel Cohen , James Densmore Copp , Kennan Joseph Fahey , William Harlan Gritton , Louis Nickolaus Jungheim , Joseph Henry Kennedy , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , David Edward Seyler , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
发明人： Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , Jeffrey Daniel Cohen , James Densmore Copp , Kennan Joseph Fahey , William Harlan Gritton , Louis Nickolaus Jungheim , Joseph Henry Kennedy , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , David Edward Seyler , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
IPC分类号： A61K31/415 , C07D233/44
CPC分类号： C07D207/416 , A61K45/06 , C07D207/16 , C07D207/42 , C07D231/40 , C07D233/88 , C07D401/06 , C07D403/06 , C07D403/12 , C07D409/12 , C07D417/06 , C07D487/08
摘要： This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
摘要翻译： 本发明涉及可用于调节哺乳动物内源性生长激素水平的新化合物。 本发明还涉及用于合成所述化合物的新中间体，以及在这些合成中使用的新方法。 还包括治疗哺乳动物的方法，其包括施用所述化合物。
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公开(公告)号：US06639076B1
公开(公告)日：2003-10-28
申请号：US09762529
申请日：2001-04-17
申请人： Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , James Densmore Copp , William Harlan Gritton , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
发明人： Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , James Densmore Copp , William Harlan Gritton , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
IPC分类号： C07D40112
CPC分类号： C07D207/416 , A61K45/06 , C07D207/16 , C07D207/42 , C07D231/40 , C07D233/88 , C07D401/06 , C07D403/06 , C07D403/12 , C07D409/12 , C07D417/06 , C07D487/08
摘要： This invention relates to novel compounds of formula I wherein A, B, D, E, G, J, L, X, V are as defined in the specification, and the compounds are useful in the modulation of endogenous growth hormone levels in a mammal.
摘要翻译： 本发明涉及式I的新化合物，其中A，B，D，E，G，J，L，X，V如说明书中所定义，并且该化合物可用于调节哺乳动物内源性生长激素水平。
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公开(公告)号：US06291484B1
公开(公告)日：2001-09-18
申请号：US09482432
申请日：2000-01-13
IPC分类号： A61K31445
CPC分类号： C07D409/12 , C07D333/56
摘要： This invention provides novel benzothiophene compounds of the formula I: which are useful for the treatment of the various medical conditions associated with postmenopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus, and cervix. The present invention further relates to pharmaceutical formulations of compounds of formula I.
摘要翻译： 本发明提供了式I的新型苯并噻吩化合物：其可用于治疗与绝经后综合征相关的各种医学病症，以及雌激素依赖性疾病，包括乳腺癌，子宫癌和子宫颈癌。 本发明还涉及式I化合物的药物制剂。
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