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    Spray Drying Process
    1.
    发明申请
    Spray Drying Process 审中-公开
    喷雾干燥过程

    公开(公告)号：US20120309664A1

    公开(公告)日：2012-12-06

    申请号：US13491106

    申请日：2012-06-07

    申请人： Herbert B. Scher ,  Deborah S. Winetzky ,  Nathaniel T. Becker ,  Kathleen A. Clarkson ,  Mark S. Gebert ,  Troels N. Gravesen ,  Michael Partsuf

    发明人： Herbert B. Scher ,  Deborah S. Winetzky ,  Nathaniel T. Becker ,  Kathleen A. Clarkson ,  Mark S. Gebert ,  Troels N. Gravesen ,  Michael Partsuf

    IPC分类号： B29B9/00 ,  C11D3/386

    CPC分类号： C11D3/38672 ,  C11D3/225 ,  C11D3/3707

    摘要： The present invention generally relates to particulate compositions and methods for making the compositions. It specifically relates to improved spray drying methods that substantially reduce the production of small particles that pose industrial hygiene concerns for factory workers and product consumers. In a composition aspect, the present invention provides an atomized aqueous composition. The composition is formed using a spray-drying apparatus. It includes 0.001 to 0.10 weight percent of a polymer, which is selected from a group consisting of a cellulose-based polymer, a gum, and a synthetic polymer. It further includes at least one polypeptide, which is present in the aqueous composition at a concentration greater than 0.01 weight percent.

    摘要翻译： 本发明一般涉及制备组合物的颗粒组合物和方法。 它具体涉及改进的喷雾干燥方法，其显着降低了造成工厂工人和产品消费者的工业卫生问题的小颗粒的生产。 在组合物方面，本发明提供雾化的水性组合物。 使用喷雾干燥装置形成组合物。 它包括0.001至0.10重量％的聚合物，其选自纤维素基聚合物，胶和合成聚合物。 它还包括至少一种多肽，其以大于0.01重量％的浓度存在于水性组合物中。

    Purified galactomannan as an improved pharmaceutical excipient
    9.
    发明授权
    Purified galactomannan as an improved pharmaceutical excipient 失效
    纯化的半乳甘露聚糖作为改进的药物赋形剂

    公开(公告)号：US6063402A

    公开(公告)日：2000-05-16

    申请号：US487605

    申请日：1995-06-07

    申请人： Mark S. Gebert ,  David R. Friend ,  David Wong ,  Jagdish Parasrampuria

    发明人： Mark S. Gebert ,  David R. Friend ,  David Wong ,  Jagdish Parasrampuria

    IPC分类号： A61K47/36 ,  A61K9/20 ,  C08B37/00 ,  C08L5/14 ,  C07M1/00

    CPC分类号： A61K9/205 ,  C08B37/0087 ,  C08L5/14

    摘要： Disclosed is a substantially anhydrous, powdered, galactomannan composition consisting essentially of a galactomannan hydrocolloid exhibiting about 50% to about 90% by weight of anhydromannose residues and about 10% to about 50% by weight anhydrogalactose residues; less than about 1% by weight of protein material and less than about 3% of other nonaqueous impurities. This material is useful for preparing pharmaceutical compositions both in the substantially anhydrous form but preferably in an anhydrated form which includes about 5-15% by weight water. The pharmaceutical compositions comprise a therapeutically effective amount of a drug, the hydrated powered gallactomannan composition and optionally other pharmaceutically-acceptable excipients. When the hydrated powdered purified glactomannan of the invention is used to form a tablet, one sees improved hardness in the tablet formed. The pharmaceutical composition of the invention is particularly valuable for delivering a therapeutically effective drug to the colon without significant release of the drug in the upper GI tract after oral administration of the composition. Unique means to prepare the purified galactomannan in large quantities is provided.

    摘要翻译： 公开了基本上无水的，粉状的半乳甘露聚糖组合物，其基本上由显示约50重量％至约90重量％的脱水甘露糖残基和约10重量％至约50重量％的半脱水半乳糖残基的半乳甘露聚糖水胶体组成; 小于约1重量％的蛋白质材料和小于约3％的其它非水性杂质。 该材料可用于制备基本上无水形式的药物组合物，但优选以包含约5-15重量％水的脱水形式。 药物组合物包含治疗有效量的药物，水合动力的甘蔗聚糖组合物和任选的其它药学上可接受的赋形剂。 当使用本发明的水合粉末状纯化甘蓝聚糖来形成片剂时，可以看出形成的片剂的硬度提高。 本发明的药物组合物对于在口服给药组合物之后将治疗有效的药物递送至结肠而不会在上GI道中显着释放药物是特别有价值的。 提供了大量制备纯化的半乳甘露聚糖的独特手段。