公开(公告)号：US20080076138A1

公开(公告)日：2008-03-27

申请号：US11664422

申请日：2006-02-24

申请人： Hideaki Matsuoka ,  Yoshinori Ishii ,  Kaori Matsuda ,  Ichiro Aramori ,  Hiroaki Mori

发明人： Hideaki Matsuoka ,  Yoshinori Ishii ,  Kaori Matsuda ,  Ichiro Aramori ,  Hiroaki Mori

IPC分类号： G01N33/53 ,  C12Q1/02

CPC分类号： C12N9/99 ,  C12Q1/48 ,  G01N33/502

摘要： It is intended to provide a method for evaluating a pharmacological effect of a histone deacetylase (HDAC) inhibitor, comprising the steps of: (a) preparing a cell expressing CPSF5 protein; (b) contacting the cell with an HDAC inhibitor; (c) measuring the acetylation level of CPSF5 protein in the cell; and (d) comparing the acetylation level measured in the step (c) with the measured acetylation level of CPSF5 protein in a control cell that has not been contacted with the HDAC inhibitor.

摘要翻译： 本发明旨在提供一种评价组蛋白脱乙酰酶（HDAC）抑制剂的药理作用的方法，包括以下步骤：（a）制备表达CPSF5蛋白的细胞; （b）使细胞与HDAC抑制剂接触; （c）测量细胞中CPSF5蛋白的乙酰化水平; 和（d）将步骤（c）中测量的乙酰化水平与未与HDAC抑制剂接触的对照细胞中测量的CPSF5蛋白的乙酰化水平进行比较。

公开(公告)号：US08558267B2

公开(公告)日：2013-10-15

申请号：US13591674

申请日：2012-08-22

申请人： Kazuhiko Kai ,  Masahiro Tanaka ,  Yoshinori Ishii

发明人： Kazuhiko Kai ,  Masahiro Tanaka ,  Yoshinori Ishii

IPC分类号： H05B33/04

CPC分类号： H01L51/56 ,  H01L51/5246 ,  H01L2251/568

摘要： An organic EL display device manufacturing method that allows the reliability of the organic EL display device having undergone a defect repair process to be improved. Manufacturing method for organic EL display device, method including an organic EL element substrate formation step of forming at least one organic EL element on an organic EL element substrate, the organic EL element including an organic EL film, an anode electrode, reflection electrode that form a first conductive film provided below the organic EL film, a cathode electrode that forms a second conductive film provided above the to organic EL film, resin sealing step of providing a thermoplastic sealing resin to cover the upper side of the organic EL element, defect detection step of detecting a defect in the organic EL element, and defect elimination step of eliminating the defect detected in the defect detection step by irradiating the defect with a laser beam.

摘要翻译： 有机EL显示装置的制造方法能够提高经历了缺陷修复处理的有机EL显示装置的可靠性。 有机EL显示装置的制造方法，包括在有机EL元件基板上形成至少一个有机EL元件的有机EL元件基板形成工序的方法，所述有机EL元件包括有机EL膜，阳极电极，形成 设置在有机EL膜下方的第一导电膜，形成在有机EL膜上方设置的第二导电膜的阴极电极，提供热塑性密封树脂以覆盖有机EL元件的上侧的树脂密封步骤，缺陷检测 检测有机EL元件中的缺陷的步骤，以及通过用激光束照射缺陷来消除在缺陷检测步骤中检测到的缺陷的缺陷消除步骤。

公开(公告)号：US20120313514A1

公开(公告)日：2012-12-13

申请号：US13591674

申请日：2012-08-22

申请人： Kazuhiko Kai ,  Masahiro Tanaka ,  Yoshinori Ishii

发明人： Kazuhiko Kai ,  Masahiro Tanaka ,  Yoshinori Ishii

IPC分类号： H05B33/04

CPC分类号： H01L51/56 ,  H01L51/5246 ,  H01L2251/568

摘要： An organic EL display device manufacturing method that allows the reliability of the organic EL display device having undergone a defect repair process to be improved. Manufacturing method for organic EL display device, method including an organic EL element substrate formation step of forming at least one organic EL element on an organic EL element substrate, the organic EL element including an organic EL film, an anode electrode, reflection electrode that form a first conductive film provided below the organic EL film, a cathode electrode that forms a second conductive film provided above the to organic EL film, resin sealing step of providing a thermoplastic sealing resin to cover the upper side of the organic EL element, defect detection step of detecting a defect in the organic EL element, and defect elimination step of eliminating the defect detected in the defect detection step by irradiating the defect with a laser beam.

摘要翻译： 有机EL显示装置的制造方法能够提高经历了缺陷修复处理的有机EL显示装置的可靠性。 有机EL显示装置的制造方法，包括在有机EL元件基板上形成至少一个有机EL元件的有机EL元件基板形成工序的方法，所述有机EL元件包括有机EL膜，阳极电极，形成 设置在有机EL膜下方的第一导电膜，形成在有机EL膜上方设置的第二导电膜的阴极电极，提供热塑性密封树脂以覆盖有机EL元件的上侧的树脂密封步骤，缺陷检测 检测有机EL元件中的缺陷的步骤，以及通过用激光束照射缺陷来消除在缺陷检测步骤中检测到的缺陷的缺陷消除步骤。

公开(公告)号：US20100321779A1

公开(公告)日：2010-12-23

申请号：US12521365

申请日：2007-12-27

申请人： Tomoko Hane ,  Yoshinori Ishii

发明人： Tomoko Hane ,  Yoshinori Ishii

IPC分类号： G02B5/30 ,  B32B27/06

CPC分类号： G02B1/14 ,  C08J7/065 ,  C08J2365/00 ,  G02B1/105 ,  G02B5/3025 ,  G06F3/045 ,  Y10T428/31663

摘要： The present invention provides a polarizing plate protective film obtained by forming a silane coupling agent layer on one side of a cyclic olefin-based resin film; a polarizing plate wherein the protective film is laminated on one side or both sides of a polarizer through the isocyanate-based silane coupling agent layer; and a resistive touch panel using the polarizing plate.

摘要翻译： 本发明提供通过在环状烯烃系树脂膜的一面上形成硅烷偶联剂而得到的偏振片保护膜; 偏振片，其中所述保护膜通过所述异氰酸酯基硅烷偶联剂层层压在偏振片的一侧或两侧; 以及使用该偏振片的电阻式触摸面板。

公开(公告)号：US20090115325A1

公开(公告)日：2009-05-07

申请号：US12264942

申请日：2008-11-05

申请人： Eiji Matsuzaki ,  Yoshinori Ishii ,  Satoru Kase

发明人： Eiji Matsuzaki ,  Yoshinori Ishii ,  Satoru Kase

IPC分类号： H01J1/62 ,  H01J9/22

CPC分类号： H01L51/5256 ,  H01L51/524 ,  H01L2251/5315

摘要： An organic EL element section (1000) is formed on a circuit formation section (102) formed on a circuit board (101). The organic EL element section (1000) is covered with a protective layer (113) including an SiNxOy film. The SiNxOy film has infrared absorption characteristics including: an Si—O—Si stretching vibration absorption peak appearing at energy lower than 1,000 cm−1; an absorption intensity of an Si—N stretching vibration absorption peak appearing in the vicinity of around 870 cm−1 which is 0.75 or more times an absorption intensity of the Si—O—Si stretching vibration absorption peak; and an absorption peak intensity in a range of 2,000 to 4,000 cm−1, which is 5% or less of the absorption intensity of the Si—N stretching vibration absorption peak. Thus, the protective film having an excellent moisture-blocking property may be obtained, and life property of an organic EL display device may be improved.

摘要翻译： 有机EL元件部（1000）形成在电路基板（101）上形成的电路形成部（102）上。 有机EL元件部分（1000）被包括SiN x O y膜的保护层（113）覆盖。 SiN x O y膜具有红外吸收特性，包括：以低于1000cm -1的能量出现的Si-O-Si伸缩振动吸收峰; 在约870cm -1附近出现的Si-N伸缩振动吸收峰的吸收强度是Si-O-Si伸缩振动吸收峰的吸收强度的0.75倍以上; 以及在2,000〜4000cm -1的范围内的吸收峰强度，其为Si-N伸缩振动吸收峰的吸收强度的5％以下。 因此，可以获得具有优异的防湿性的保护膜，并且可以提高有机EL显示装置的寿命。

公开(公告)号：US07014221B2

公开(公告)日：2006-03-21

申请号：US10745052

申请日：2003-12-22

申请人： Kazuo Iwasaki ,  Takamitsu Kobayashi ,  Yusushi Tsuchiya ,  Yoshinori Ishii ,  Kazuya Suzuki ,  Nagahisa Amano

发明人： Kazuo Iwasaki ,  Takamitsu Kobayashi ,  Yusushi Tsuchiya ,  Yoshinori Ishii ,  Kazuya Suzuki ,  Nagahisa Amano

IPC分类号： F16L39/00

CPC分类号： F16L37/0987 ,  F16L37/0985

摘要： A joint for piping includes a pipe with an annular swelling wall and a connector body with a socket that includes locking pieces. The locking pieces hold the annular swelling wall when the pipe is inserted through the connector body to connector the pipe to the connector body. A projected member on the pipe fits in a recess on the connector body to prevent rotation between the pipe and the connector body.

摘要翻译： 用于管道的接头包括具有环形膨胀壁的管道和具有包括锁定件的插座的连接器主体。 当管道插入连接器主体以将管道连接到连接器主体时，锁定件保持环形膨胀壁。 管上的突出部件装配在连接器主体上的凹部中，以防止管道和连接器主体之间的旋转。

公开(公告)号：US06726995B2

公开(公告)日：2004-04-27

申请号：US10149447

申请日：2002-10-23

申请人： Yoshinori Ishii ,  Takeshi Yamamoto ,  Takao Uesugi ,  Koichi Watanabe

发明人： Yoshinori Ishii ,  Takeshi Yamamoto ,  Takao Uesugi ,  Koichi Watanabe

IPC分类号： G02B530

CPC分类号： G02B5/3033 ,  G02B1/105 ,  G02B1/14 ,  Y10T428/24364 ,  Y10T428/31573 ,  Y10T428/31576 ,  Y10T428/31587 ,  Y10T428/31855 ,  Y10T428/31928 ,  Y10T428/31931

摘要： A polarizing plate with which a drop in polarization efficiency, hue shift, and light leakage do not substantially arise, under a high humidity/high temperature environment is provided. The polarizing plate of the present invention comprises a polyvinyl-alcohol-based polarizing film, a protective film having thereon two anchor coat agent layers, mainly composed of a cyclic-olefin-based resin, laminated on at least one side of the polarizing film, with an adhesive. The amount of change in optical in-plane retardation of the protective film is 5 nm or less after 24 hours in an atmosphere of 80° C., and the wetting tension of the anchor coated surface of the protective film is 500 &mgr;N/cm (23° C.) or more. The anchor coat agent layers include a first layer made of polyisocyanate and polyester polyol and/or polyether polyol, and a second layer made of polyvinyl alcohol. The adhesive is made of polyvinyl alcohol.

摘要翻译： 提供了在高湿度/高温环境下基本上不出现极化效率下降，色相偏移和漏光的偏振片。 本发明的偏光板包括聚偏二氟乙烯系偏振膜，在偏振膜的至少一侧层叠有主要由环状烯烃系树脂构成的两个保护涂层剂的保护膜， 用粘合剂。 保护膜的光学面内延迟的变化量在80℃的气氛中24小时后为5nm以下，保护膜的涂布表面的润湿张力为500μN/ cm（ 23℃）以上。 锚固剂层包括由聚异氰酸酯和聚酯多元醇和/或聚醚多元醇制成的第一层和由聚乙烯醇制成的第二层。 粘合剂由聚乙烯醇制成。

公开(公告)号：US06403336B1

公开(公告)日：2002-06-11

申请号：US08370356

申请日：1995-01-09

申请人： Ikuo Ueda ,  Mineo Niwa ,  Yoshimasa Saito ,  Hisashi Yamada ,  Yoshinori Ishii

发明人： Ikuo Ueda ,  Mineo Niwa ,  Yoshimasa Saito ,  Hisashi Yamada ,  Yoshinori Ishii

IPC分类号： C12P2102

CPC分类号： C12N15/70 ,  C07K14/58 ,  C07K2319/00 ,  C07K2319/32 ,  C07K2319/50 ,  C07K2319/75

摘要： DNA fragments which contain a sequence of DNA which encodes a protective peptide-fused &agr;-hANP in which the protective peptide has a C-terminus lysine residue which is directly fused to the N-terminus of the &agr;-hANP, vectors which contain such a DNA sequence, and microorganisms transformed which such a vector are useful for the production of &agr;-hANP.

摘要翻译： 含有编码保护性肽融合的α-hANP的DNA序列的DNA片段，其中保护性肽具有与α-hANP的N末端直接融合的C-末端赖氨酸残基，其含有这样的 DNA序列和转化的微生物，这种载体可用于生产α-hANP。

公开(公告)号：US5834263A

公开(公告)日：1998-11-10

申请号：US696834

申请日：1996-09-24

申请人： Mineo Niwa ,  Yoshimasa Saito ,  Yoshinori Ishii ,  Masaru Yoshida ,  Hiromi Hayashi

发明人： Mineo Niwa ,  Yoshimasa Saito ,  Yoshinori Ishii ,  Masaru Yoshida ,  Hiromi Hayashi

IPC分类号： C12N9/02 ,  C12N9/04 ,  C12N15/53 ,  C12P7/60 ,  C12N1/00 ,  C12N15/00

CPC分类号： C12N9/0008 ,  C12N9/0006 ,  C12P7/60 ,  Y10S435/822

摘要： An expression vector containing both a DNA encoding an L-sorbose dehydrogenase and a DNA encoding an L-sorbosone dehydrogenase; a transformant having an ability to produce 2-keto-L-gulonic acid (hereinafter 2KLGA) at high yields from D-sorbitol, which is prepared by transforming, with said expression vector, a microorganism capable of producing L-sorbose at high yields from D-sorbitol, which has no or low 2KLGA-decomposing activity or a host microorganism having, in addition to the above-mentioned properties, no or low L-idonic acid-producing activity; and a process for producing 2KLGA, which comprises culturing said transformant in a medium containing D-sorbitol. According to the present invention, 2KLGA useful for the production of L-ascorbic acid can be produced with ease and in larger amounts by a single operation of culture.

摘要翻译： PCT No.PCT / JP95 / 00285 Sec。 371日期：1996年9月24日 102（e）1996年9月24日PCT提交1995年2月24日PCT公布。 WO95 / 23220 PCT出版物 日期1995年8月31日含有编码L-山梨糖脱氢酶的DNA和编码L-山梨糖酮脱氢酶的DNA的表达载体; 具有从D-山梨醇以高产率生产2-酮-L-古洛糖酸（以下称为2KLGA）的能力的转化体，其通过用所述表达载体转化能以高产率生产L-山梨糖的微生物制备 没有或低的2KLGA分解活性的D-山梨糖醇或除了上述性质之外，没有或低的L-天冬糖酸生产活性的宿主微生物; 以及生产2KLGA的方法，其包括在含有D-山梨糖醇的培养基中培养所述转化体。 根据本发明，用于生产L-抗坏血酸的2KLGA可以通过单次的培养操作容易地和大量地生产。

公开(公告)号：US5753481A

公开(公告)日：1998-05-19

申请号：US513841

申请日：1995-11-01

申请人： Mineo Niwa ,  Yoshimasa Saito ,  Yoshinori Ishii ,  Masaru Yoshida ,  Hiromi Suzuki

发明人： Mineo Niwa ,  Yoshimasa Saito ,  Yoshinori Ishii ,  Masaru Yoshida ,  Hiromi Suzuki

IPC分类号： C12N9/04 ,  C12N9/02 ,  C07H21/04 ,  C12N1/00

CPC分类号： C12N9/0006 ,  Y10S435/822

摘要： A novel L-sorbose dehydrogenase (SDH) and a novel L-sorbosone dehydrogenase both derived from Gluconobacter oxydans T-100, a DNA which encodes the SDH and/or SNDH, an expression vector which contains the DNA, a host cell transformed by the expression vector and a process for producing the SDH and/or SNDH, which comprises culturing the host cell in a medium and recovering the SDH and/or SNDH from the resulting culture. The SDH and SNDH of the present invention are useful enzymes having preferable properties for the production of 2-keto-L-gulonic acid, as well as L-ascorbic acid. According to the production method of the present invention, the SDH and SNDH having such preferable properties can be produced in large amounts by genetic engineering.

摘要翻译： PCT No.PCT / JP94 / 00369 Sec。 371日期：1995年11月1日 102（e）日期1995年11月1日PCT 1994年3月8日PCT公布。 公开号WO94 / 20609 日期1994年9月15日新型L-山梨糖脱氢酶（SDH）和新型L-山梨糖酮脱氢酶均来自氧化葡糖杆菌T-100，编码SDH和/或SNDH的DNA，含有DNA的表达载体， 由表达载体转化的宿主细胞和产生SDH和/或SNDH的方法，其包括在培养基中培养宿主细胞并从所得培养物中回收SDH和/或SNDH。 本发明的SDH和SNDH是生产2-酮-L-古洛糖酸以及L-抗坏血酸的优选性质的有用的酶。 根据本发明的制造方法，可以通过遗传工程大量生产具有优选性质的SDH和SNDH。