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    Reduced coenzyme Q10 crystal having excellent stability
    1.
    发明授权
    Reduced coenzyme Q10 crystal having excellent stability 有权
    还原型辅酶Q10晶体具有优异的稳定性

    公开(公告)号：US09388109B2

    公开(公告)日：2016-07-12

    申请号：US14129003

    申请日：2012-06-21

    申请人： Hideo Kawachi ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Hideo Kawachi ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： A61K31/12 ,  C07C49/577 ,  A23L2/52 ,  A23K1/16 ,  A23L1/30 ,  A61K8/34 ,  A61Q19/00 ,  C07C45/81 ,  C07C41/40 ,  C07C41/46 ,  C07C43/23

    CPC分类号： C07C49/577 ,  A23K20/111 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  A61K8/347 ,  A61K9/28 ,  A61K31/122 ,  A61Q19/00 ,  C07C41/40 ,  C07C41/46 ,  C07C43/23 ,  C07C45/81

    摘要： With respect to reduced coenzyme Q10, there has been no report about the presence of crystal polymorphism, and it has been considered that a conventionally obtained crystal form is only one form. The present invention relates to a reduced coenzyme Q10 crystal having an endothermic peak indicating melting at 54±2° C. during temperature rise at a rate of 5° C./min by differential scanning calorimetry (DSC), and/or to a reduced coenzyme Q10 crystal showing characteristic peaks at diffraction angles (2θ±0.2°) of 11.5°, 18.2°, 19.3°, 22.3°, 23.0° and 33.3° by powder X-ray (Cu—Kα) diffraction. The crystal form is a novel reduced coenzyme Q10 crystal which has a higher melting point and a lower solubility in a solvent, and is more excellent in stability than the conventionally known reduced coenzyme Q10 crystal.

    摘要翻译： 关于还原型辅酶Q10，没有关于晶体多晶型的存在的报道，已经认为常规获得的晶体形式仅是一种形式。 本发明涉及在通过差示扫描量热法（DSC）以5℃/ min的速率升温的温度升高期间具有指示在54±2℃熔化的吸热峰的还原型辅酶Q10晶体和/或还原型辅酶Q10晶体 通过粉末X射线（Cu-Kα）衍射，辅助Q10晶体在衍射角（2θ;±0.2°）为11.5°，18.2°，19.3°，22.3°，23.0°和33.3°处显示出特征峰。 晶体形式是在溶剂中具有较高熔点和较低溶解度的新型还原型辅酶Q10晶体，其稳定性优于常规已知的还原型辅酶Q10晶体。

    REDUCED COENZYME Q10 CRYSTAL HAVING EXCELLENT STABILITY
    2.
    发明申请
    REDUCED COENZYME Q10 CRYSTAL HAVING EXCELLENT STABILITY 有权
    降低COYZYME Q10水晶具有优异的稳定性

    公开(公告)号：US20140120073A1

    公开(公告)日：2014-05-01

    申请号：US14129003

    申请日：2012-06-21

    申请人： Hideo Kawachi ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Hideo Kawachi ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： C07C49/577 ,  C07C45/81

    CPC分类号： C07C49/577 ,  A23K20/111 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  A61K8/347 ,  A61K9/28 ,  A61K31/122 ,  A61Q19/00 ,  C07C41/40 ,  C07C41/46 ,  C07C43/23 ,  C07C45/81

    摘要： With respect to reduced coenzyme Q10, there has been no report about the presence of crystal polymorphism, and it has been considered that a conventionally obtained crystal form is only one form. The present invention relates to a reduced coenzyme Q10 crystal having an endothermic peak indicating melting at 54±2° C. during temperature rise at a rate of 5° C./min by differential scanning calorimetry (DSC), and/or to a reduced coenzyme Q10 crystal showing characteristic peaks at diffraction angles (2θ±0.2°) of 11.5°, 18.2°, 19.3°, 22.3°, 23.0° and 33.3° by powder X-ray (Cu—Kα) diffraction. The crystal form is a novel reduced coenzyme Q10 crystal which has a higher melting point and a lower solubility in a solvent, and is more excellent in stability than the conventionally known reduced coenzyme Q10 crystal.

    摘要翻译： 关于还原型辅酶Q10，没有关于晶体多晶型的存在的报道，已经认为常规获得的晶体形式仅是一种形式。 本发明涉及在通过差示扫描量热法（DSC）以5℃/ min的速率升温的温度升高期间具有指示在54±2℃熔化的吸热峰的还原型辅酶Q10晶体和/或还原型辅酶Q10晶体 通过粉末X射线（Cu-Kα）衍射，辅助Q10晶体在衍射角（2θ;±0.2°）为11.5°，18.2°，19.3°，22.3°，23.0°和33.3°处显示出特征峰。 晶体形式是在溶剂中具有较高熔点和较低溶解度的新型还原型辅酶Q10晶体，其稳定性优于常规已知的还原型辅酶Q10晶体。

    Processes for producing coenzyme Q10
    3.
    发明授权
    Processes for producing coenzyme Q10 有权
    生产辅酶Q10的方法

    公开(公告)号：US09315839B2

    公开(公告)日：2016-04-19

    申请号：US13020500

    申请日：2011-02-03

    申请人： Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： C12P7/66 ,  C12P7/22

    CPC分类号： C12P7/66 ,  C12P7/22

    摘要： The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally disrupting the cells and recovering thus produced reduced coenzyme Q10. The present invention also relates to a process for producing oxidized coenzyme Q10 which comprises either recovering oxidized coenzyme Q10 after oxidizing the above-mentioned microbial cells or disrupted product thereof, or recovering reduced coenzyme Q10 from the above-mentioned microbial cells or disrupted product thereof to oxidize thus-obtained reduced coenzyme Q10 thereafter. According to the processes of the present invention, reduced coenzyme Q10 and oxidized coenzyme Q10 can be produced simply on the industrial scale.

    摘要翻译： 本发明涉及一种还原型辅酶Q10的制备方法，其包括在整个辅酶Q10中获得含有还原型辅酶Q10比例不小于70摩尔％的微生物细胞，任选地破坏细胞并回收所生成的还原型辅酶Q10。 本发明还涉及氧化型辅酶Q10的制造方法，该方法包括在氧化上述微生物细胞或其破坏的产物后回收氧化型辅酶Q10，或将还原型辅酶Q10从上述微生物细胞或其破坏性产物回收至 此后氧化由此得到的还原型辅酶Q10。 根据本发明的方法，可以简单地在工业规模上制备还原型辅酶Q10和氧化型辅酶Q10。

    Method for preserving reduced coenzyme Q10
    4.
    发明授权
    Method for preserving reduced coenzyme Q10 有权
    保留还原型辅酶Q10的方法

    公开(公告)号：US08067217B2

    公开(公告)日：2011-11-29

    申请号：US11315161

    申请日：2005-12-23

    申请人： Takahiro Ueda ,  Tadao Ono ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Takahiro Ueda ,  Tadao Ono ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： C12N9/98

    CPC分类号： A61K9/4816

    摘要： The present invention has its object to provide a method for stably preserving a capsule containing reduced coenzyme Q10, which is useful as foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. The present invention relates to a method for preserving reduced coenzyme Q10 which comprises producing or obtaining a capsule containing reduced coenzyme Q10, and controlling environment surrounding the capsule to a relative humidity of not less than 0% but not more than 60%. According to this method, reduced coenzyme Q10 can be preserved stably, without requiring huge cost and labor, or special equipment.

    摘要翻译： 本发明的目的是提供一种用于稳定保存含有还原型辅酶Q10的胶囊的方法，所述还原型辅酶Q10可用作食品，功能营养食品，特定保健食品，营养补充剂，营养物质，动物药物，饮料，饲料，化妆品，药​​物， 补救剂，预防药物等。本发明涉及一种保存还原型辅酶Q10的方法，其包括制备或获得含有还原型辅酶Q10的胶囊，并且将胶囊周围的环境控制在相对湿度不小于0％但不超过 超过60％。 根据该方法，可以稳定地保持还原型辅酶Q10，而不需要巨大的成本和劳动力，或特殊设备。

    METHOD OF PRODUCING REDUCED COENZYME Q10 CRYSTALS WITH EXCELLENT HANDLING PROPERTIES
    5.
    发明申请
    METHOD OF PRODUCING REDUCED COENZYME Q10 CRYSTALS WITH EXCELLENT HANDLING PROPERTIES 有权
    生产具有优异处理性能的还原型COYZYME Q10水晶的方法

    公开(公告)号：US20110263906A1

    公开(公告)日：2011-10-27

    申请号：US13176479

    申请日：2011-07-05

    申请人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： C07C41/40

    CPC分类号： C07C41/40 ,  C07C43/23

    摘要： The present invention provides a method of producing reduced coenzyme Q10 crystals suitable for commercial scale production thereof.According to a method of the present invention of producing a reduced coenzyme Q10 crystal which comprises a crystallization of reduced coenzyme Q10 in a solution of alcohols and/or ketones, reduced coenzyme Q10 crystal excellent in slurry properties and crystalline properties maybe obtained. Moreover, an isolation process including a crystal separation or the whole process including the isolation process maybe minimized and simplified. Thus, highly pure reduced coenzyme Q10 may be obtained in a high yield.

    摘要翻译： 本发明提供了适合于商业规模生产的还原型辅酶Q10晶体的制造方法。 根据本发明的制备还原型辅酶Q10晶体的方法，所述还原型辅酶Q10晶体包括在醇和/或酮溶液中结晶还原型辅酶Q10，可得到浆料性能和结晶性能优异的还原型辅酶Q10晶体。 此外，包括晶体分离的分离过程或包括隔离过程的整个过程可以被最小化和简化。 因此，可以高产率获得高纯度还原型辅酶Q10。

    Method of producing reduced coenzyme Q10 as oily product
    8.
    发明申请
    Method of producing reduced coenzyme Q10 as oily product 有权

    公开(公告)号：US20070161825A1

    公开(公告)日：2007-07-12

    申请号：US11716828

    申请日：2007-03-12

    申请人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： C07C43/20

    CPC分类号： C07C41/26 ,  C07C41/34 ,  C07C43/23

    摘要： The present invention provides a method for obtaining reduced coenzyme Q10 which is useful as an ingredient in foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. suited for a commercial scale production in high quality and efficiently. The high-quality oily reduced coenzyme Q10 which has low viscosity and thereby easily handled may be produced by separating an aqueous phase from the reaction mixture obtainable by oily reacting oxidized coenzyme Q10 with a reducing agent in water, or by distilling off an coexisting organic solvent at or above the melting temperature of reduced coenzyme Q10 in concentrating the organic phase containing reduced coenzyme Q10. Moreover, a solution or slurry of reduced coenzyme Q10 may be obtained by adding a desired solvent to the obtained oily product, or a solid of reduced coenzyme Q10 may be produced by contacting the oily product with a seed crystal.

    Method for producing high-quality hydropbic licorice extract
    9.
    发明申请
    Method for producing high-quality hydropbic licorice extract 审中-公开
    生产高品质Hydropbic甘草提取物的方法

    公开(公告)号：US20050118288A1

    公开(公告)日：2005-06-02

    申请号：US10504256

    申请日：2003-02-20

    申请人： Koki Yamashita ,  Tadao Ono ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Koki Yamashita ,  Tadao Ono ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： A23K1/14 ,  A23K1/16 ,  A23L1/236 ,  A23L1/30 ,  A61K9/20 ,  A61K31/352 ,  A61K31/37 ,  A61K31/56 ,  A61K36/484 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00 ,  C07J63/00 ,  A61K35/78

    CPC分类号： C07J63/00 ,  A23K10/30 ,  A23K20/10 ,  A23L27/30 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/352 ,  A61K31/37 ,  A61K31/56 ,  A61K36/484 ,  A23V2250/252

    摘要： It is an object of the present invention to provide a method for producing a hydrophobic licorice extract which is useful for applications, such as food, food additives, functional nutritive food, food for specified health uses, dietary supplements, drink, feedstuff, drugs, and quasi-drugs, and which has satisfactory powder characteristics. This invention relates to a method for producing a hydrophobic licorice extract comprises performing extraction from licorice with a water-soluble organic solvent, the area of the bark of the licorice occupying at least 30% of the total surface area of the licorice. This invention also relates to a method for producing a hydrophobic licorice extract comprises crystallizing an extract extracted from licorice, or an extraction residue of the licorice, with a water-soluble organic solvent in a mixed solvent comprising water and the water-soluble organic solvent, the weight ratio, water/(water-soluble organic solvent+water), being ⅓ or more.

    摘要翻译： 本发明的目的是提供一种制备疏水性甘草提取物的方法，其可用于食品，食品添加剂，功能性营养食品，特定健康用途食品，膳食补充剂，饮料，饲料，药物， 和准药，具有令人满意的粉末特性。 本发明涉及一种生产疏水甘草提取物的方法，包括用水溶性有机溶剂从甘草中提取甘草的皮肤面积占甘草总表面积的至少30％。 本发明还涉及一种疏水性甘草提取物的制造方法，其特征在于，包括使水溶性有机溶剂在水和水溶性有机溶剂的混合溶剂中结晶从甘草提取的提取物或甘草的提取残渣， 重量比，水/（水溶性有机溶剂+水）为1/3以上。