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公开(公告)号：US20080261294A1
公开(公告)日：2008-10-23
申请号：US12034880
申请日：2008-02-21
申请人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
摘要翻译： 一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。 该装置包括：第一遮光盒，其具有样品容器保持器和其中的快门单元，所述快门单元包括顶板，该顶板部分地通过板构件的运动和在其中具有光电检测器的第二遮光箱而形成。 虽然没有实现测量，但是关闭快门单元以阻止杂散光入射到光电检测器，并且在实施测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入通孔 使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。
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公开(公告)号：US08334144B2
公开(公告)日：2012-12-18
申请号：US13478527
申请日：2012-05-23
申请人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member, and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
摘要翻译： 一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。 该装置包括：第一遮光箱，其具有样本容器保持器和其中的快门单元，所述快门单元包括部分地由板构件的运动形成的顶板和在其中具有光电检测器的第二遮光箱。 虽然没有实现测量，但是快门单元被关闭以阻止杂散光入射到光电检测器，并且在实现测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入到 通孔形成在顶板中，使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。
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公开(公告)号：US08197751B2
公开(公告)日：2012-06-12
申请号：US12976031
申请日：2010-12-22
申请人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member, and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
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公开(公告)号：US20110091355A1
公开(公告)日：2011-04-21
申请号：US12976031
申请日：2010-12-22
申请人： Hideyuki NODA , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki NODA , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
IPC分类号： G01N21/76
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member, and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
摘要翻译： 一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。 该装置包括：第一遮光箱，其具有样本容器保持器和其中的快门单元，所述快门单元包括部分地由板构件的运动形成的顶板和在其中具有光电检测器的第二遮光箱。 虽然没有实现测量，但是快门单元被关闭以阻止杂散光入射到光电检测器，并且在实现测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入到 通孔形成在顶板中，使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。
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公开(公告)号：US07879290B2
公开(公告)日：2011-02-01
申请号：US12034880
申请日：2008-02-21
申请人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
摘要翻译： 一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。 该装置包括：第一遮光盒，其具有样品容器保持器和其中的快门单元，所述快门单元包括顶板，该顶板部分地通过板构件的运动和在其中具有光电检测器的第二遮光箱而形成。 虽然没有实现测量，但是快门单元被关闭以阻止杂散光入射到光电检测器，并且在实现测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入到 通孔形成在顶板中，使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。
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6.发明授权Capturing carrier, capturing device, analysis system using the same, and method for capturing and testing microorganisms 有权捕获载体，捕获装置，使用其的分析系统以及捕获和测试微生物的方法公开(公告)号：US08628953B2
公开(公告)日：2014-01-14
申请号：US12292626
申请日：2008-11-21
申请人： Noe Osato , Ryusuke Gotoda , Satoshi Ozawa , Hideyuki Noda , Masahiro Okanojo
发明人： Noe Osato , Ryusuke Gotoda , Satoshi Ozawa , Hideyuki Noda , Masahiro Okanojo
IPC分类号： C12M1/00
CPC分类号： C12Q1/04 , G01N1/2208 , G01N1/2214 , G01N2001/4088
摘要： In order to make a process of capturing and testing air-borne microorganisms more convenient and quick, a capturing device which comprises the capturing carrier comprising a polymer which is in a gel phase at the time of capturing the microorganisms but undergoes a phase transition under heating to a sol phase at the temperature at or less than 40° C. (especially in the temperature range between 15° C. and 37° C.), and a vessel to contain the capturing carrier is used. Further, by comprising a test reagent in the polymer, the test reagent can be eluted upon said phase transition from a gel phase to a sol phase. By heating the capturing carrier, a phase transition to a sol phase can occur at or less than 40° C. As such, since recovery of microorganisms and addition of a test reagent to the microorganisms can be carried out simultaneously, the process can be simplified and the process time can be shortened.
摘要翻译： 为了更方便快捷地捕获和测试空气传播的微生物的过程，捕获装置包括捕获载体，捕获载体包含在捕获微生物时处于凝胶相的聚合物，但在加热下经历相变 在等于或低于40℃的温度下（特别是在15℃至37℃的温度范围内）的溶胶相，并且使用容纳捕获载体的容器。 此外，通过在聚合物中包含测试试剂，在从凝胶相到溶胶相的所述相转变时，可以洗脱测试试剂。 通过加热捕获载体，可以在40℃以下发生溶胶相的相变。因此，由于可以同时进行微生物的回收和微生物的添加试验，因此可以简化该过程 并且可以缩短处理时间。
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7.发明申请Capturing carrier, capturing device, analysis system using the same, and method for capturing and testing microorganisms 有权捕获载体，捕获装置，使用其的分析系统以及捕获和测试微生物的方法公开(公告)号：US20090142785A1
公开(公告)日：2009-06-04
申请号：US12292626
申请日：2008-11-21
申请人： Noe Osato , Ryusuke Gotoda , Satoshi Ozawa , Hideyuki Noda , Masahiro Okanojo
发明人： Noe Osato , Ryusuke Gotoda , Satoshi Ozawa , Hideyuki Noda , Masahiro Okanojo
CPC分类号： C12Q1/04 , G01N1/2208 , G01N1/2214 , G01N2001/4088
摘要： In order to make a process of capturing and testing air-borne microorganisms more convenient and quick, a capturing device which comprises the capturing carrier comprising a polymer which is in a gel phase at the time of capturing the microorganisms but undergoes a phase transition under heating to a sol phase at the temperature at or less than 40° C. (especially in the temperature range between 15° C. and 37° C.), and a vessel to contain the capturing carrier is used. Further, by comprising a test reagent in the polymer, the test reagent can be eluted upon said phase transition from a gel phase to a sol phase. By heating the capturing carrier, a phase transition to a sol phase can occur at or less than 40° C. As such, since recovery of microorganisms and addition of a test reagent to the microorganisms can be carried out simultaneously, the process can be simplified and the process time can be shortened.
摘要翻译： 为了更方便快捷地捕获和测试空气传播的微生物的过程，捕获装置包括捕获载体，捕获载体包含在捕获微生物时处于凝胶相的聚合物，但在加热下经历相变 在等于或低于40℃的温度下（特别是在15℃至37℃的温度范围内）的溶胶相，并且使用容纳捕获载体的容器。 此外，通过在聚合物中包含测试试剂，在从凝胶相到溶胶相的所述相转变时，可以洗脱测试试剂。 通过加热捕获载体，可以在40℃以下发生溶胶相的相变。因此，由于可以同时进行微生物的回收和微生物的添加试验，因此可以简化该过程 并且可以缩短处理时间。
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公开(公告)号：US20080241871A1
公开(公告)日：2008-10-02
申请号：US12010497
申请日：2008-01-25
申请人： Masahiro Okanojo , Satoshi Ozawa , Hideyuki Noda , Masaaki Hirano
发明人： Masahiro Okanojo , Satoshi Ozawa , Hideyuki Noda , Masaaki Hirano
CPC分类号： G01N21/11 , G01N21/274 , G01N21/6428 , G01N2021/7786
摘要： The present invention provides a luminescence measuring method that can be accurately and quickly carried out while inhibiting a possible background associated with viable bacteria adhering to a nozzle or Adenosine Tri Phosphate remaining in the nozzle, and an apparatus for the method. The present invention uses a washing apparatus characterized by including a nozzle, a lysys solution, a luminescence reagent solution, and a detection section, as well as a relevant washing method and a relevant luminescence measuring method. To remove viable bacteria adhering to the nozzle, the nozzle is immersed in the lysys solution and then in the luminescence reagent solution. The detection section monitors luminescence occurring during a washing process.
摘要翻译： 本发明提供一种能够准确，快速地进行发光测定的方法，同时抑制与残留在喷嘴中的喷嘴或三磷酸腺苷的活菌相关的可能背景，以及该方法的装置。 本发明使用一种洗涤装置，其特征在于包括喷嘴，溶解液，发光试剂溶液和检测部分，以及相关的洗涤方法和相关的发光测量方法。 为了除去附着在喷嘴上的活细菌，将喷嘴浸入溶解液中，然后浸入发光试剂溶液中。 检测部分监视在洗涤过程中发生的发光。
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9.发明申请Substrate with Photo-Controllable Cell Adhesion Property, Method for Analyzing and Fractionating Cells, and Device for Analysis and Fractionation of Cells 审中-公开具有光可控细胞粘附性质的基质，分析细胞分离方法和分离细胞分离装置公开(公告)号：US20120225448A1
公开(公告)日：2012-09-06
申请号：US13509338
申请日：2010-11-04
摘要： When cells are analyzed, fractionated, and incubated while keeping the cells alive, real-time operations can be performed more easily and the cells can be incubated while removing unnecessary cells from the incubated cells to purify the cells being incubated. Furthermore, desired cells are separated through analysis from the incubated cells, and the purity, recovery, and viability of the cells are heightened. Use is made of a substrate having photo-controllable cell adhesion properties, the substrate comprising a transparent base and, formed thereon, a film of a material which has photo-controllable cell adhesion properties and has been obtained by bonding a cell-adhesive material to a cell-non-adhesive material through photo-dissociable groups. Cell images are detected and analyzed to obtain information about the location of desired cells. On the basis of the information, a space is formed between cells and the material having photo-controllable cell adhesion properties is cut, by means of second light irradiation. Meanwhile, by means of first light irradiation, the surface of the substrate is changed from a cell-adhesive surface to a cell-non-adhesive surface, thereby separating the cell(s) from the substrate. Thus, cells can be analyzed and fractionated while keeping the cells alive.
摘要翻译： 当细胞分析，分级和孵育同时保持细胞活着时，可以更容易地进行实时操作，并且可以孵育细胞，同时从培养的细胞中除去不需要的细胞以纯化待孵育的细胞。 此外，通过从培养的细胞的分析分离所需的细胞，并且提高细胞的纯度，回收率和存活力。 使用具有光可控细胞粘附性质的基材，所述基材包括透明基材，并且在其上形成具有光可控细胞粘附性的材料的膜，并且通过将细胞粘合剂材料粘合到 通过光解离基团的细胞非粘合材料。 检测和分析细胞图像以获得关于所需细胞位置的信息。 基于该信息，在单元之间形成空间，通过第二次光照射切断具有光可控细胞粘附性的材料。 同时，通过第一光照射，将基板的表面从电池 - 粘合剂表面改变为电池非粘合剂表面，从而将电池与基板分离。 因此，可以在保持细胞活着的同时分析和分级细胞。
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10.发明申请BIOPOLYMER ANALYSIS METHOD, BIOPOLYMER ANALYZER, AND BIOPOLYMER ANALYSIS CHIP 审中-公开生物聚合物分析方法，生物聚合物分析仪和生物分析仪分析公开(公告)号：US20120312083A1
公开(公告)日：2012-12-13
申请号：US13579329
申请日：2011-02-23
申请人： Rena Akahori , Takashi Anazawa , Satoshi Ozawa , Yoshiaki Yazawa , Tomoyuki Sakai , Hideyuki Noda
发明人： Rena Akahori , Takashi Anazawa , Satoshi Ozawa , Yoshiaki Yazawa , Tomoyuki Sakai , Hideyuki Noda
IPC分类号： G01N33/48
CPC分类号： C12Q1/6869 , G01N21/6428 , G01N33/48721 , C12Q2565/631
摘要： There have been the following problems with sequence analysis using multiple nanopores: trapping a sample in the nanopores is not always 100% efficient and unnecessary time is spent to measure pores in which no sample has been trapped, resulting in low measurement efficiency. To address the problems, a labeling substance is boned to a sample, and the sample to which the labeling substance has been bonded is trapped in the nanopores. An apparatus for observing the labeling substance is used to observe the labeling substance and monitor whether or not the sample has been trapped in the nanopores. Measuring only nanopores in which the sample has been trapped allows the measurement efficiency to be improved.
摘要翻译： 使用多个纳米孔的序列分析存在以下问题：在纳米孔中捕获样品并不总是100％的有效性，并且花费不需要的时间来测量没有样品被捕获的孔隙，导致低的测量效率。 为了解决这些问题，将标记物质结合到样品中，并且标记物质已经结合的样品被捕获在纳米孔中。 用于观察标记物质的装置用于观察标记物质并监测样品是否已被捕获在纳米孔中。 仅测量样品已被捕获的纳米孔，可以提高测量效率。
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