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    Method of constructing spinal injury model monkey and utilization thereof
    1.
    发明授权
    Method of constructing spinal injury model monkey and utilization thereof 有权
    构建脊髓损伤模型猴的方法及其应用

    公开(公告)号：US07753054B2

    公开(公告)日：2010-07-13

    申请号：US10496993

    申请日：2002-11-26

    申请人： Hideyuki Okano ,  Yoshiaki Toyama ,  Masaya Nakamura ,  Tatsuji Nomura ,  Yoshikuni Tanioka ,  Kiyoshi Ando ,  Yonehiro Kanemura

    发明人： Hideyuki Okano ,  Yoshiaki Toyama ,  Masaya Nakamura ,  Tatsuji Nomura ,  Yoshikuni Tanioka ,  Kiyoshi Ando ,  Yonehiro Kanemura

    IPC分类号： A61B19/00

    CPC分类号： A01K67/027 ,  A01K2227/106 ,  A01K2267/03 ,  A01K2267/0356

    摘要： A method for creating a monkey model of spinal cord injury, which includes exposing the dura mater of the cervical cord of a monkey and applying a load on the dura mater; the thus-created monkey model of spinal cord injury; and a method for evaluating a therapeutic drug for spinal cord injury by use of this model.According to the present invention, it is possible to create a monkey which is close to the human and thus useful as a model of human spinal cord injury. This model enables proper evaluation of therapeutic effects of various drugs on spinal cord injury. Through use of this model, it has been confirmed for the first time that transplantation therapy of human neural stem cells is efficacious against spinal cord injury.

    摘要翻译： 一种创建脊髓损伤猴模型的方法，其包括暴露猴子的颈椎硬脑膜并在硬脑膜上施加负荷; 由此造成的脊髓损伤猴模型; 以及使用该模型评价脊髓损伤治疗药物的方法。 根据本发明，可以产生靠近人类的猴，因此可用作人脊髓损伤的模型。 该模型能够适当评估各种药物对脊髓损伤的治疗效果。 通过使用该模型，人类神经干细胞的移植治疗首次对脊髓损伤有效。

    Novel nerve stem cell marker
    3.
    发明申请
    Novel nerve stem cell marker 审中-公开
    新型神经干细胞标记

    公开(公告)号：US20070031894A1

    公开(公告)日：2007-02-08

    申请号：US10571268

    申请日：2004-09-10

    申请人： Tomoko Syofuda ,  Yonehiro Kanemura ,  Jun Miyake ,  Hideo Niwa ,  Kenji Yamashita

    发明人： Tomoko Syofuda ,  Yonehiro Kanemura ,  Jun Miyake ,  Hideo Niwa ,  Kenji Yamashita

    IPC分类号： G01N33/567 ,  C07K14/475 ,  C07K16/22 ,  C07H21/04

    CPC分类号： G01N33/5058 ,  C12Q1/6876 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5073 ,  G01N2500/00

    摘要： It is an object of the present invention to provide a method for detecting nerve stem cells/progenitor cells among a tissue or a mass of cells as constituted of a plurality of cell species, and a method for screening for a drug functioning as a nerve differentiation factor or the like by using the above-mentioned detection method. It was found in this invention that the expression of the NC1 gene was high in undifferentiated nerve stem cells and said expression decreased with an advance of differentiation. Furthermore in this invention, by using the NC1 gene, the product thereof (NC1 protein) and the base sequences or the amino acid sequences thereof, antibodies or the like, it became possible to detect nerve stem cells/progenitor cells by way of various methods, so that a novel method for screening for a drug functioning as a nerve differentiation factor or the like was provided.

    摘要翻译： 本发明的目的是提供一种由多种细胞种组成的组织或大量细胞中的神经干细胞/祖细胞的检测方法，以及筛选作为神经分化的药物的方法 因子等通过使用上述检测方法。 在本发明中发现NC1基因的表达在未分化神经干细胞中高，并且所述表达随着分化的进展而降低。 此外，在本发明中，通过使用NC1基因，其产物（NC1蛋白）及其碱基序列或其氨基酸序列，抗体等，可以通过各种方法检测神经干细胞/祖细胞 ，因此提供了筛选用作神经分化因子等的药物的新方法。