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    Method of constructing spinal injury model monkey and utilization thereof
    1.
    发明授权
    Method of constructing spinal injury model monkey and utilization thereof 有权
    构建脊髓损伤模型猴的方法及其应用

    公开(公告)号：US07753054B2

    公开(公告)日：2010-07-13

    申请号：US10496993

    申请日：2002-11-26

    申请人： Hideyuki Okano ,  Yoshiaki Toyama ,  Masaya Nakamura ,  Tatsuji Nomura ,  Yoshikuni Tanioka ,  Kiyoshi Ando ,  Yonehiro Kanemura

    发明人： Hideyuki Okano ,  Yoshiaki Toyama ,  Masaya Nakamura ,  Tatsuji Nomura ,  Yoshikuni Tanioka ,  Kiyoshi Ando ,  Yonehiro Kanemura

    IPC分类号： A61B19/00

    CPC分类号： A01K67/027 ,  A01K2227/106 ,  A01K2267/03 ,  A01K2267/0356

    摘要： A method for creating a monkey model of spinal cord injury, which includes exposing the dura mater of the cervical cord of a monkey and applying a load on the dura mater; the thus-created monkey model of spinal cord injury; and a method for evaluating a therapeutic drug for spinal cord injury by use of this model.According to the present invention, it is possible to create a monkey which is close to the human and thus useful as a model of human spinal cord injury. This model enables proper evaluation of therapeutic effects of various drugs on spinal cord injury. Through use of this model, it has been confirmed for the first time that transplantation therapy of human neural stem cells is efficacious against spinal cord injury.

    摘要翻译： 一种创建脊髓损伤猴模型的方法，其包括暴露猴子的颈椎硬脑膜并在硬脑膜上施加负荷; 由此造成的脊髓损伤猴模型; 以及使用该模型评价脊髓损伤治疗药物的方法。 根据本发明，可以产生靠近人类的猴，因此可用作人脊髓损伤的模型。 该模型能够适当评估各种药物对脊髓损伤的治疗效果。 通过使用该模型，人类神经干细胞的移植治疗首次对脊髓损伤有效。

    Method of inducing growth of nerve stem cells
    4.
    发明申请
    Method of inducing growth of nerve stem cells 审中-公开
    诱导神经干细胞生长的方法

    公开(公告)号：US20050226852A1

    公开(公告)日：2005-10-13

    申请号：US10509529

    申请日：2003-03-27

    申请人： Masahiro Toda ,  Hideyuki Okano ,  Yutaka Kawakami ,  Yoshiaki Toyama ,  Yuji Mikami ,  Masanori Sakaguchi

    发明人： Masahiro Toda ,  Hideyuki Okano ,  Yutaka Kawakami ,  Yoshiaki Toyama ,  Yuji Mikami ,  Masanori Sakaguchi

    IPC分类号： A61P25/00 ,  C12N5/02 ,  C12N5/0797 ,  A61K45/00 ,  C12N5/08

    CPC分类号： C12N5/0623 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/22 ,  C12N2506/11

    摘要： It is intended to provide a method of efficiently inducing the growth of nerve stem cells, which are most important in transplantation therapy for nerve damage and neurological dysfunction, either in vitro or in vivo, a method of using the nerve stem cells obtained by the above growth induction method, etc. A mammalian nerve tissue containing nerve stem cells is separated and the nerve stem cells are selectively cultured in a medium containing growth factors such as EGF and FGF. Next, the nerve stem cells are co-cultured with dendritic cell such as an immature dendritic cell subset having a CD11c surface marker on the cell surface, spleen cells or blood cell-type cells such as CD8-positive T cells. Alternatively, the nerve stem cells after the culture are further cultured in the presence of GM-CSF or the nerve stem cells after the culture are further cultured in a culture supernatant of dendritic cells or a culture supernatant of blood cell-type cells.

    摘要翻译： 旨在提供一种有效诱导神经干细胞生长的方法，其在体外或体内用于神经损伤和神经功能障碍的移植治疗中是最重要的，使用由上述获得的神经干细胞的方法 生长诱导方法等。分离含有神经干细胞的哺乳动物神经组织，并在含有生长因子如EGF和FGF的培养基中选择性培养神经干细胞。 接下来，将神经干细胞与树突状细胞共同培养，例如在细胞表面上具有CD11c表面标志物的未成熟树突状细胞亚群，脾细胞或血液细胞型细胞如CD8阳性T细胞。 或者，培养后的神经干细胞在GM-CSF存在下进一步培养，或者培养后的神经干细胞进一步在树突状细胞的培养上清液或血细胞型细胞的培养上清液中培养。

    Vertebral surgery instrument
    5.
    发明授权
    Vertebral surgery instrument 有权

    公开(公告)号：US10130398B2

    公开(公告)日：2018-11-20

    申请号：US15329740

    申请日：2015-06-29

    申请人： KYOCERA Medical Corporation ,  Ken Ishii ,  Morio Matsumoto ,  Yoshiaki Toyama

    发明人： Ken Ishii ,  Morio Matsumoto ,  Yoshiaki Toyama ,  Masaki Atarashi ,  Junji Ito

    IPC分类号： A61B17/70 ,  A61B17/86 ,  A61B17/88

    摘要： A vertebral surgery instrument includes: an engagement part for engaging with a pair of opposing parts provided on or attached to a vertebral implant in a state in which the vertebral implant is fixed to a vertebra, the pair of opposing parts forming a slit into which a fixation rod for fixing a plurality of vertebrae to each other is to be inserted; and a pair of guide parts that are provided integrally with or attached to the engagement part. The pair of guide parts are formed extending so as to separate from each other toward a side on which the fixation rod is to be inserted, in a state in which the engagement part is engaged with the pair of opposing parts, and the slit and a guide passage that is formed between the pair of guide parts are in communication with each other.

    Vertebra correcting and fixing device
    7.
    发明授权
    Vertebra correcting and fixing device 失效

    公开(公告)号：US06660005B2

    公开(公告)日：2003-12-09

    申请号：US10034211

    申请日：2001-12-26

    申请人： Yoshiaki Toyama ,  Morio Matsumoto ,  Takashi Nishizawa ,  Hirokazu Amino

    发明人： Yoshiaki Toyama ,  Morio Matsumoto ,  Takashi Nishizawa ,  Hirokazu Amino

    IPC分类号： A61B1756

    CPC分类号： A61B17/7032

    摘要： A vertebra correcting and fixing device including: a vertebra fixing screw to be threadedly connected to a vertebra; A movable spherical body which can be combined with this vertebra fixing screw; and a clamping screw threadedly connected to the movable spherical body. The movable spherical body is substantially spherical, has a split through-hole formed in the diametrical direction thereof, and also has a screw hole extending at right angles to tho split through hole and communicating therewith. Provision is made such that the clamping screw is threadedly connected to this screw hole. The vertebra fixing screw is provided at one end thereof with a threaded portion and at the other end thereof with a groove-shape scat portion for receiving and holding the movable spherical body. The seat portion is capable of rotatably holding the spherical body.

    REMEDIES FOR NERVE DAMAGES
    8.
    发明申请
    REMEDIES FOR NERVE DAMAGES 审中-公开
    对神经损害的补救措施

    公开(公告)号：US20070243160A1

    公开(公告)日：2007-10-18

    申请号：US11539476

    申请日：2006-10-06

    申请人： Masahiro Toda ,  Yutaka Kawakami ,  Yoshiaki Toyama ,  Yuji Mikami

    发明人： Masahiro Toda ,  Yutaka Kawakami ,  Yoshiaki Toyama ,  Yuji Mikami

    IPC分类号： A61K45/00 ,  A61P25/00

    CPC分类号： A61K38/193 ,  A61K35/16 ,  A61K38/1808 ,  A61K38/1841 ,  A61K38/185 ,  A61K38/204 ,  A61K38/208

    摘要： The present invention provides a remedy for a nerve dysfunctional disorder such as a central nervous system damage including a spinal cord injury and a cerebral infarction and the like having an excellent nerve regeneration promoting action which can be administered not only by injecting into a injured site but also by various administration methods including intravenous administration, which can be easily handled and stored over a long time, and can be prepared in a large amount at any time. Said remedy for a nerve dysfunctional disorder such as a central nervous system damage including a spinal cord injury and a cerebral infarction and the like are prepared by using the following as active ingredients: one or more substances selected from a substance secreted from dendritic cells such as IL-12, GM-CSF and the like, a substance inducing and proliferating dendritic cells, a substance activating dendritic cells; a substance inducing the expression of a neurotrophic factor in nerve tissues, a substance inducing and proliferating microglias and macrophages in nerve tissues; and a vector which can expresses the aforementioned substances; or dendritic cell subsets secreting a neurotrophic factor such as NT-3, CNTF, TGF-β1, IL-6, and EGF.

    摘要翻译： 本发明提供了神经功能障碍性疾病的补救措施，例如包括脊髓损伤和脑梗死等的中枢神经系统损伤，其具有优异的神经再生促进作用，其不仅可以通过注射到受伤部位而被施用， 也可以通过静脉内给药等各种施用方法，能够容易地长时间处理和储存，并且可以在任何时间大量制备。 通过使用以下作为活性成分，可以制备神经功能障碍障碍如中枢神经系统损伤（包括脊髓损伤和脑梗塞等）的一种或多种物质：​​选自树突状细胞分泌的物质，例如 IL-12，GM-CSF等，诱导和增殖树突状细胞的物质，激活树突状细胞的物质; 诱导神经组织中神经营养因子表达的物质，在神经组织中诱导和增殖微小神经细胞和巨噬细胞的物质; 和可以表达上述物质的载体; 或分泌神经营养因子如NT-3，CNTF，TGF-β1，IL-6和EGF的树突状细胞亚群。