公开(公告)号：US5066817A

公开(公告)日：1991-11-19

申请号：US516304

申请日：1990-04-30

申请人： Hirofumi Nakano ,  Mitsunobu Hara ,  Tsuyoshi Mokudai ,  Isao Kawamoto ,  Mayumi Yoshida ,  Eiji Kobayashi

发明人： Hirofumi Nakano ,  Mitsunobu Hara ,  Tsuyoshi Mokudai ,  Isao Kawamoto ,  Mayumi Yoshida ,  Eiji Kobayashi

IPC分类号： C07D407/04 ,  C12P17/06

CPC分类号： C07D407/04 ,  C12P17/06 ,  Y10S435/886

摘要： Disclosed are DC115A compounds represented by the following general formula: ##STR1## wherein R represents ethyl, propyl or 1-propenyl, and which have antibacterial and anti-tumor activity. DC115A compounds are produced by culturing a microorganism belonging to the genus Streptomyces.

公开(公告)号：US4992570A

公开(公告)日：1991-02-12

申请号：US173174

申请日：1988-03-24

申请人： Hirofumi Nakano ,  Eiji Kobayashi ,  Isami Takahashi ,  Katsuhiko Ando ,  Mayumi Yoshida ,  Shiro Akinaga ,  Takao Iida

发明人： Hirofumi Nakano ,  Eiji Kobayashi ,  Isami Takahashi ,  Katsuhiko Ando ,  Mayumi Yoshida ,  Shiro Akinaga ,  Takao Iida

IPC分类号： C12P15/00

CPC分类号： C12P15/00 ,  Y10S435/911

摘要： UCN-1028A and UCN-1028C having an anti-tumor activity and a protein kinase C inhibitory activity are produced by culturing a microorganism belonging to the genus Cladosporium.

公开(公告)号：US5081264A

公开(公告)日：1992-01-14

申请号：US584278

申请日：1990-09-18

申请人： Shinichiro Toki ,  Mika Nozawa ,  Mayumi Yoshida ,  Hiroshi Sano ,  Katsuhiko Ando ,  Isao Kawamoto ,  Yuzuru Matsuda ,  Junichi Ikeda ,  Kazuhiro Kubo

发明人： Shinichiro Toki ,  Mika Nozawa ,  Mayumi Yoshida ,  Hiroshi Sano ,  Katsuhiko Ando ,  Isao Kawamoto ,  Yuzuru Matsuda ,  Junichi Ikeda ,  Kazuhiro Kubo

IPC分类号： C12P17/06 ,  A61K31/35 ,  A61K31/352 ,  A61P9/10 ,  A61P25/18 ,  A61P25/28 ,  C07D311/92 ,  C12P17/16 ,  C12R1/645

CPC分类号： C12P17/162 ,  C07D311/92

摘要： A compound of formula (I): ##STR1## wherein R.sub.1 represents hydrogen, hydroxy or acetoxy and R.sub.2 represents hydroxy or acetoxy.The compounds are capable of protecting the nerve cells and also antagonistic activity against N-methyl-D-aspartic acid receptors.They may be prepared by fermentation of a microorganism of the genus Verticillium or a mutant thereof.

公开(公告)号：US06642355B2

公开(公告)日：2003-11-04

申请号：US09750754

申请日：2001-01-02

申请人： Takeo Tanaka ,  Yoshikazu Morishita ,  Mika Makino ,  Shigeru Chiba ,  Isao Kawamoto ,  Eiji Tsukuda ,  Mayumi Yoshida ,  Chieko Bando ,  Kazuo Yamaguchi ,  Yuzuru Matsuda ,  Shigeto Kitamura ,  Toshihide Ikemura ,  Tatsuhiro Ogawa ,  Keiichi Yano ,  Toshiyuki Suzawa ,  Kenji Shibata ,  Motoo Yamasaki

发明人： Takeo Tanaka ,  Yoshikazu Morishita ,  Mika Makino ,  Shigeru Chiba ,  Isao Kawamoto ,  Eiji Tsukuda ,  Mayumi Yoshida ,  Chieko Bando ,  Kazuo Yamaguchi ,  Yuzuru Matsuda ,  Shigeto Kitamura ,  Toshihide Ikemura ,  Tatsuhiro Ogawa ,  Keiichi Yano ,  Toshiyuki Suzawa ,  Kenji Shibata ,  Motoo Yamasaki

IPC分类号： C07K700

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K5/1021 ,  C07K5/1024 ,  C07K7/08 ,  C07K14/36 ,  C07K14/57536 ,  C12R1/465

摘要： The invention relates to an endothelin antagonistic peptide of the formula (I): X-A-Trp-B-Gly-Thr-E-G-Y   (I) SEQ ID NO: 2 wherein represents Asn or Asp; B represents His or Lys; E represents Ala or Ser; G represents Ala or Pro; X represents X1-Gly or  and Y represents hydroxy, lower alkoxy, amino, wherein X1, X3, Y1, Y2 and Z are further defined, or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明涉及式（I）的内皮素拮抗肽：其中代表Asn或Asp; B代表His或Lys; E表示Ala或Ser; G表示Ala或Pro; X表示X 1 -Gly或Y表示羟基，低级烷氧基，氨基，其中X 1，X 3，Y 1，Y 2和Z进一步定义，或 其药学上可接受的盐。

公开(公告)号：US06194195B1

公开(公告)日：2001-02-27

申请号：US09181083

申请日：1998-10-27

申请人： Takeo Tanaka ,  Yoshikazu Morishita ,  Mika Makino ,  Shigeru Chiba ,  Isao Kawamoto ,  Eiji Tsukuda ,  Mayumi Yoshida ,  Chieko Bando ,  Kazuo Yamaguchi ,  Yuzuru Matsuda ,  Shigeto Kitamura ,  Toshihide Ikemura ,  Tatsuhiro Ogawa ,  Keiichi Yano ,  Toshiyuki Suzawa ,  Kenji Shibata ,  Motoo Yamasaki

发明人： Takeo Tanaka ,  Yoshikazu Morishita ,  Mika Makino ,  Shigeru Chiba ,  Isao Kawamoto ,  Eiji Tsukuda ,  Mayumi Yoshida ,  Chieko Bando ,  Kazuo Yamaguchi ,  Yuzuru Matsuda ,  Shigeto Kitamura ,  Toshihide Ikemura ,  Tatsuhiro Ogawa ,  Keiichi Yano ,  Toshiyuki Suzawa ,  Kenji Shibata ,  Motoo Yamasaki

IPC分类号： C12N120

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K5/1021 ,  C07K5/1024 ,  C07K7/08 ,  C07K14/36 ,  C07K14/57536 ,  C12R1/465

摘要： The invention relates to biologically pure cultures of Streptomyces sp. RE-701 (FERM BP-3624) and Streptomyces sp. RE-629 (FERM BP-4126) that produce endothelin antagonistic peptides.

摘要翻译： 本发明涉及链霉菌属的生物纯培养物。 RE-701（FERM BP-3624）和Streptomyces sp。 产生内皮素拮抗肽的RE-629（FERM BP-4126）。

公开(公告)号：US5639860A

公开(公告)日：1997-06-17

申请号：US321625

申请日：1994-10-12

申请人： Takeo Tanaka ,  Yoshikazu Morishita ,  Mika Makino ,  Shigeru Chiba ,  Isao Kawamoto ,  Eiji Tsukuda ,  Mayumi Yoshida ,  Chieko Bando ,  Kazuo Yamaguchi ,  Yuzuru Matsuda ,  Shigeto Kitamura ,  Toshihide Ikemura ,  Tatsuhiro Ogawa ,  Keiichi Yano ,  Toshiyuki Suzawa ,  Kenji Shibata ,  Motoo Yamasaki

发明人： Takeo Tanaka ,  Yoshikazu Morishita ,  Mika Makino ,  Shigeru Chiba ,  Isao Kawamoto ,  Eiji Tsukuda ,  Mayumi Yoshida ,  Chieko Bando ,  Kazuo Yamaguchi ,  Yuzuru Matsuda ,  Shigeto Kitamura ,  Toshihide Ikemura ,  Tatsuhiro Ogawa ,  Keiichi Yano ,  Toshiyuki Suzawa ,  Kenji Shibata ,  Motoo Yamasaki

IPC分类号： C07K5/113 ,  C07K5/117 ,  C07K7/06 ,  C07K7/08 ,  C07K14/575 ,  A61K38/10

CPC分类号： C07K7/06 ,  C07K14/57536 ,  C07K5/1021 ,  C07K5/1024 ,  C07K7/08

摘要： Peptides represented by the following formula (I): ##STR1## wherein A represents Asn or Asp; B represents His or Lys; and E represents Ala or Ser;(1) X.sup.1 and Y.sup.1 are combined together to form a single bond as X.sup.1 --Y1, or (2) X.sup.1 represents hydrogen and Y.sup.1 represents hydroxy;and Z represents, in case of (1),Trp-Phe-Phe-Asn-Tyr-Tyr-7Hyt-Z.sup.1Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1,Trp-Phe-Phe-Asn-Tyr-R-T-Z.sup.1wherein Z.sup.1 is an organic moiety,wherein R is Tyr or a covalent bond,T is Trp, Ala, Phe, Tyr, Trp-Trp, Asn-Tyr-Tyr-Trp, Trp-Asn-Tyr-Tyr-Trp, Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp,or in case of (2), Z representsTrp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1.These peptides have endothelin-antagonizing activity, and are useful for treating hypertension, asthma, cerebral apoplexy, angina pectoris, acute renal failure, cardiac infarction and cerebral vasospasm.

摘要翻译： 由下式（I）表示的肽：其中A表示Asn或Asp; B代表His或Lys; E表示Ala或Ser; （1）将X1和Y1组合在一起形成单键作为X1-Y1，或（2）X1表示氢，Y1表示羟基; 而在（1）的情况下，Z表示Trp-Phe-Phe-Asn-Tyr-Tyr-7Hyt-Z1 Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z1， Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z1，Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z1，Trp- Phe-Phe-Asn-Tyr-RT-Z1，其中Z1是有机部分，其中R是Tyr或共价键，T是Trp，Ala，Phe，Tyr，Trp-Trp，Asn-Tyr-Tyr-Trp，Trp -Tn-Tyr-Tyr-Trp，Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp，或在（2）的情况下，Z表示Trp-Val-Tyr-Phe-Ala -His-Leu-Asp-Ile-Ile-Trp-Z1 Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z1 Trp-Leu-Tyr-Phe-Ala-His-Gln -Asp-Val-Ile-Trp-Z1。 这些肽具有内皮素拮抗作用，可用于治疗高血压，哮喘，脑中风，心绞痛，急性肾功能衰竭，心肌梗死和脑血管痉挛。

公开(公告)号：US5843955A

公开(公告)日：1998-12-01

申请号：US723149

申请日：1996-09-30

申请人： Tatsuya Tamaoki ,  Hiroyuki Nagata ,  Isami Takahashi ,  Mayumi Yoshida ,  Yumiko Aotani ,  Katsuhiko Ando ,  Keiko Ochiai

发明人： Tatsuya Tamaoki ,  Hiroyuki Nagata ,  Isami Takahashi ,  Mayumi Yoshida ,  Yumiko Aotani ,  Katsuhiko Ando ,  Keiko Ochiai

IPC分类号： C07D471/06 ,  A61K31/475 ,  C07D471/16

CPC分类号： C07D471/06

摘要： The present invention relates to compound LK6-A represented by the formula: ##STR1## which has immunosuppressive activity, and pharmaceutically acceptable salts thereof.

摘要翻译： 本发明涉及由下式表示的化合物LK6-A：具有免疫抑制活性的及其药学上可接受的盐。

公开(公告)号：US07112571B2

公开(公告)日：2006-09-26

申请号：US10266609

申请日：2002-10-09

申请人： Katsuhiro Osajima ,  Eiji Seki ,  Mayumi Yoshida

发明人： Katsuhiro Osajima ,  Eiji Seki ,  Mayumi Yoshida

IPC分类号： A61K38/05

CPC分类号： A23J1/04 ,  A23L2/66 ,  A23L33/18 ,  A61K38/00 ,  C07K14/461

摘要： Peptide which is obtained by treating fish meat such as sardine with an alkaline protease is adsorbed with a peptide-adsorbing resin (such as ODS resin) and eluted with 10 aqueous ethanol to obtain a peptide (Y-2 fraction). The resulting novel peptide has an excellent hypotensive action and can be used as a nutrient and a specific health food and, in addition, it can be advantageously used as a hypotensive agent.

摘要翻译： 通过用碱性蛋白酶处理鱼肉如沙丁鱼获得的肽被肽吸附树脂（例如ODS树脂）吸附并用10％乙醇水溶液洗脱，得到肽（Y-2级分）。 所得的新型肽具有优异的降血压作用，可用作营养物质和特定保健食品，另外还可有利地用作降血压剂。

公开(公告)号：US6064470A

公开(公告)日：2000-05-16

申请号：US537352

申请日：1995-10-02

申请人： Kenji Karashima ,  Hisashi Fuzisaki ,  Mayumi Yoshida

发明人： Kenji Karashima ,  Hisashi Fuzisaki ,  Mayumi Yoshida

IPC分类号： G03G15/00 ,  G03G15/16

CPC分类号： G03G15/602 ,  G03G15/168 ,  G03G2215/1614 ,  G03G2215/1652

摘要： A contact type image transferring device and method incorporated in an image forming apparatus for cleaning a residual toner on a transfer roller. The transfer roller is in contact with a photoconductive drum at a first force and forms nip between the roller and the drum. A sheet of paper passes through the nip and a toner image on the drum is transferred to the sheet of paper. When the sheet of paper is not at the nip, the transfer roller is moved such that the force of the roller against the drum is a second force which is different from the first force. A cleaning bias voltage is applied to the roller and toner on the roller is transferred to the drum.

摘要翻译： 一种结合在用于清洁转印辊上的残留调色剂的图像形成装置中的接触型图像转印装置和方法。 转印辊以第一力与感光鼓接触并在辊和滚筒之间形成辊隙。 一张纸通过辊隙，鼓上的调色剂图像被转印到纸张上。 当纸张不在辊隙处时，转印辊被移动，使得辊抵靠鼓的力是与第一力不同的第二力。 将清洁偏压施加到辊上，并将辊上的调色剂转印到滚筒上。

公开(公告)号：US5887224A

公开(公告)日：1999-03-23

申请号：US862695

申请日：1997-05-23

申请人： Haruji Mizuishi ,  Masaru Tanaka ,  Shigeru Watanabe ,  Kenzo Tatsumi ,  Toshitaka Yamaguchi ,  Takeo Suda ,  Hiroshi Yoshinaga ,  Ken Amemiya ,  Mayumi Yoshida

发明人： Haruji Mizuishi ,  Masaru Tanaka ,  Shigeru Watanabe ,  Kenzo Tatsumi ,  Toshitaka Yamaguchi ,  Takeo Suda ,  Hiroshi Yoshinaga ,  Ken Amemiya ,  Mayumi Yoshida

IPC分类号： G03G15/08 ,  G03G21/10

CPC分类号： G03G15/0822 ,  G03G21/105 ,  G03G2215/0822

摘要： There is provided an image forming device capable of preventing smudges on the background of an image due to excess toner replenishment caused by a failure in stirring developer and toner enough to charge the toner or scattering of replenished toner without being charged. A toner conveying member for conveying replenished toner from a toner replenishing portion through a toner replenishing port to a developer stirring and conveying member is constructed by a screw member unitarily formed with the developer stirring and conveying member. The screw member has a spiral conveying fin capable of conveying the replenished toner at relatively high speed. The replenished toner is delivered to a toner replenishing portion provided in the upstream of a developer receiving portion of the screw member.

摘要翻译： 提供了一种图像形成装置，其能够防止由于搅拌显影剂的故障引起的多余的调色剂补充以及足以使调色剂充电或补充调色剂的飞散而不被充电而导致的图像背景上的污迹。 通过与显影剂搅拌和传送部件一体地形成的螺钉部件构成用于将补充调色剂从调色剂补充部分通过调色剂补充口输送到显影剂搅拌和传送部件的调色剂传送部件。 螺杆构件具有螺旋输送翅片，能够以相对高的速度输送补充的调色剂。 补充的调色剂被输送到设置在螺杆构件的显影剂接收部分的上游的调色剂补充部分。