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公开(公告)号：US07125968B2
公开(公告)日：2006-10-24
申请号：US10819490
申请日：2004-04-07
申请人： Hirofumi Yura , Yoshio Saito , Masayuki Ishihara , Katsuaki Ono , Shiro Saeki
发明人： Hirofumi Yura , Yoshio Saito , Masayuki Ishihara , Katsuaki Ono , Shiro Saeki
CPC分类号： A61Q19/00 , A61K8/736 , A61K2800/57 , A61L15/28 , A61L33/08 , A61Q5/00 , A61Q17/04 , A61Q19/08 , C08B37/003 , C08L5/08
摘要： A functional chitosan derivative which comprises a chitin/chitosan, which is a natural polysaccharide, and incorporated therein at least one of a carbohydrate, a photo-reactive functional group, an amphipathic group, e.g. a polyoxyethylene alkyl ether, and a glycosaminoglycan and which, due to the incorporation, has solubility in a neutral medium, self-crosslinking ability, the property of highly containing water or healing wounds, and antithrombotic properties. Namely, the derivative has various properties required of health care materials such as medical products and cosmetics.
摘要翻译： 一种功能性壳聚糖衍生物，其包含几丁质/壳聚糖，其为天然多糖，并且其中并入至少一种碳水化合物，光反应性官能团，两亲性基团等。 聚氧乙烯烷基醚和糖胺聚糖，由于其结合，在中性介质中具有溶解性，自交联能力，高含水或愈合伤口的性质以及抗血栓性质。 即，该衍生物具有医疗用品，化妆品等保健品所需的各种特性。
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2.发明授权Functionalized glycosaminoglycan polymer and medical instruments and drugs by using the same 有权官能化的糖胺聚糖和医疗仪器和药物使用相同公开(公告)号：US07005513B1
公开(公告)日：2006-02-28
申请号：US09937991
申请日：2000-03-30
CPC分类号： C08F246/00 , C08B37/0063
摘要： The present invention provides a functionalized polymer which can be used extensively in the field of medical drugs as well as medical devices and which is obtainable in an organic synthetic manner from glycosaminoglycan controlling adhesion, migration and proliferation of cells via linkage to various cellular growth factors or cytokines or direct interactions with the cells. The functionalized polymer of the present invention is characterized in that it comprises a carbohydrate corresponding to at least a part of the basic structure of glycosaminoglycan introduced into a vinyl-type polymer chain.
摘要翻译： 本发明提供了可广泛用于医疗药物以及医疗器械领域的官能化聚合物，其可以通过与各种细胞生长因子的连接控制细胞粘附，迁移和增殖的糖胺聚糖以有机合成方式获得，或 细胞因子或与细胞的直接相互作用。 本发明的官能化聚合物的特征在于，其包含对应于导入乙烯基型聚合物链的糖胺聚糖的至少一部分碱性结构的碳水化合物。
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公开(公告)号：US07226611B2
公开(公告)日：2007-06-05
申请号：US10472347
申请日：2002-04-02
申请人： Hirofumi Yura , Masayuki Ishihara , Yoshio Saito , Katsuaki Ono , Masato Sato
发明人： Hirofumi Yura , Masayuki Ishihara , Yoshio Saito , Katsuaki Ono , Masato Sato
CPC分类号： C12N5/0068 , A61K31/726 , A61K31/727 , A61K38/39 , A61K47/36 , A61K47/42 , A61L27/26 , A61L27/48 , C08B37/0063 , C08H1/06 , C08L5/08 , C08L5/10 , C12N2533/54 , C12N2533/70 , C08L5/00 , C08L89/06 , C08L2666/04
摘要： The present invention is intended to offer a novel material which combines cell-adhesive proteins such as collagen with GAG polymers to construct an environment similar to an extracellular matrix, capable of controlling differentiation and proliferation of cells. The present invention offers a glycosaminoglycan-functionalized polymer protein composite produced by combining a cell-adhesive protein with a glycosaminoglycan-functionalized polymer obtained by incorporating a carbohydrate chain containing a structure corresponding to at least a portion of a glycosaminoglycan backbone into a vinyl polymer main chain, as well as a cell culture substrate and a material for tissue reconstruction treatments comprising the composite.
摘要翻译： 本发明旨在提供一种将细胞粘附蛋白如胶原与GAG聚合物结合以构建类似细胞外基质的环境，能够控制细胞分化和增殖的新型材料。 本发明提供了通过将细胞粘附蛋白与通过将含有至少一部分糖胺聚糖主链的结构的碳水化合物链并入乙烯基聚合物主链而获得的糖胺聚糖官能化聚合物而制备的糖胺聚糖官能化聚合物蛋白复合物 ，以及细胞培养基质和用于组织重建处理的材料，其包含该复合物。
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4.发明申请公开(公告)号：US20050238702A1
公开(公告)日：2005-10-27
申请号：US10512384
申请日：2003-04-21
IPC分类号： A61K31/722 , A61K31/727 , A61K38/18 , A61K45/06 , A61L15/28 , A61L15/44 , A61L26/00 , A61L27/20 , A61L27/54 , A61L27/60 , A61P17/02 , C08B37/08 , A61K9/14 , A61L15/00
CPC分类号： A61K45/06 , A61K31/722 , A61K31/727 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61L15/28 , A61L15/44 , A61L26/0023 , A61L26/0066 , A61L27/20 , A61L27/54 , A61L27/60 , A61L2300/414 , A61L2300/602 , A61K2300/00 , C08L5/08
摘要： A medical composition is provided which is advantageous as a sealant for wound openings as well as have a function promoting healing of intractable wound or incision wound, and which accelerate tissue regeneration but does not cause any side effect such as canceration. The present invention relates to a medical composition comprising a photo-crosslinkable chitosan derivative and a wound healing promoter. The photo-crosslinkable chitosan derivative is preferably a polymer obtainable by incorporating a carbohydrate chain containing a reducing terminal to at least one portion of amino groups of chitosan back bone and incorporating a photoreactive group to at least another part of the amino groups. The wound healing promoter is preferably a growth factor.
摘要翻译： 提供作为伤口的密封剂有利的医疗组合物，具有促进难治性伤口或切口伤口愈合的功能，并且加速组织再生，但不引起任何副作用，例如癌变。 本发明涉及包含光交联性壳聚糖衍生物和伤口愈合促进剂的医药组合物。 光交联性壳聚糖衍生物优选为通过将含有还原末端的碳水化合物链引入壳聚糖背骨的至少一部分氨基并将光反应性基团并入至少另一部分氨基而得到的聚合物。 伤口愈合促进剂优选为生长因子。
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公开(公告)号：US20100056462A1
公开(公告)日：2010-03-04
申请号：US11913995
申请日：2006-05-12
申请人： Yasuhiro Kanatani , Tetsuro Kiyozumi , Yoshiaki Okada , Daizoh Saitoh , Masayuki Ishihara , Hirofumi Yura , Yoshinori Misawa
发明人： Yasuhiro Kanatani , Tetsuro Kiyozumi , Yoshiaki Okada , Daizoh Saitoh , Masayuki Ishihara , Hirofumi Yura , Yoshinori Misawa
IPC分类号： A61K31/70 , A61K31/197 , A61P17/00
CPC分类号： A61L27/60 , A61K31/198 , A61K31/405 , A61K31/4172 , A61K31/7004 , A61L27/20 , C08L5/08
摘要： The present invention provides a medical composition which, in autotransplantation which is the only method that can induce the epithelialization even in a widespread full-thickness skin defect, enables the fixation of an autotransplantation skin graft in a simple manner and can increase the efficiency of epithelialization to promote the regeneration of the skin. The present invention elates to a medical composition comprising a photo-crosslinkable chitosan derivative and an amino acid and/or a saccharide. The amino acid is preferably an essential amino acid, and the saccharide is preferably a neutral saccharide selected from glucose, galactose, mannose and fucose.
摘要翻译： 本发明提供了一种医用组合物，其在自体移植中，即使在广泛的全层皮肤缺损中也是能够诱导上皮形成的唯一方法，能够以简单的方式固定自体移植皮肤移植物并且可以提高上皮化的效率 促进皮肤的再生。 本发明涉及包含光交联性壳聚糖衍生物和氨基酸和/或糖类的医药组合物。 氨基酸优选为必需氨基酸，并且糖优选为选自葡萄糖，半乳糖，甘露糖和岩藻糖的中性糖。
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6.发明授权Liquid composition for bulging mucous membrane for use in endoscopic surgery comprising a chitosan derivative containing carbohydrate chains 失效用于内窥镜手术中用于膨胀粘膜的液体组合物，其包含含有碳水化合物链的壳聚糖衍生物公开(公告)号：US07476659B2
公开(公告)日：2009-01-13
申请号：US10576745
申请日：2004-10-21
申请人： Takuya Hayashi , Masayuki Ishihara , Hirofumi Yura
发明人： Takuya Hayashi , Masayuki Ishihara , Hirofumi Yura
IPC分类号： A61K31/715 , A61B17/94 , C07B37/08 , A61F13/00
CPC分类号： A61K31/70 , A61K41/0042 , A61K49/00
摘要： The present invention provides a liquid composition to make the mucous membrane bulge during endoscopic surgery characterized in that it comprises a chitosan derivative containing carbohydrate chains. The use of the composition of the present invention as a liquid for bulging the mucous membrane during endoscopic surgery, maintain the bulge of the mucous membrane for a long period, and prevent perforation, resulting in the improved reliability of endoscopic surgery. The composition of the present invention also demonstrates prevention and inhibition of bleeding from the incised portion. The introduction of a photo-reactive group to the above chitosan derivative with carbohydrate chains allows the easy formation of a hydrogel through photo-crosslinking, leading to the further improvement in retention of the bulge and prevention of bleeding.
摘要翻译： 本发明提供了一种在内窥镜手术中使粘膜膨胀的液体组合物，其特征在于其包含含有碳水化合物链的壳聚糖衍生物。 在内窥镜手术中使用本发明的组合物作为液体膨胀粘膜，长时间保持粘膜的隆起，防止穿孔，从而提高内窥镜手术的可靠性。 本发明的组合物还表现出预防和抑制切开部分的渗色。 用碳水化合物链向上述壳聚糖衍生物引入光反应性基团可以通过光交联容易地形成水凝胶，从而进一步改进了凸起的保留和防止出血。
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7.发明申请公开(公告)号：US20100093660A1
公开(公告)日：2010-04-15
申请号：US12525809
申请日：2008-02-07
IPC分类号： A61K31/722 , A61P17/02
CPC分类号： A61K31/722 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K31/726 , A61K47/183 , A61K47/26 , A61K47/61 , A61K47/6903 , C08B37/003 , C08L5/08
摘要： The present invention is achieved based on a novel finding that chitosan gel having retentivity in tissue has an antitumor activity and provides an antitumor composition containing chitosan gel having retentivity in tissue. The chitosan gel having retentivity in tissue of the present invention is preferably chitosan gel formed of a chitosan derivative having a carbohydrate chain introduced thereto as a base, to which a photoreactive group is further introduced to form crosslink with photo-irradiation; or chitosan gel formed of a polyion complex, which is formed of a carbohydrate chain-containing chitosan derivative and another substance, for example, an acidic polysaccharide. The antitumor composition of the present invention can suppress growth of a tumor without bringing it into contact with the tumor but by simply arranging it near the tumor.
摘要翻译： 基于在组织中具有保留性的壳聚糖凝胶具有抗肿瘤活性并提供含有在组织中具有保留性的壳聚糖凝胶的抗肿瘤组合物的新发现来实现本发明。 在本发明的组织中具有保持性的壳聚糖凝胶优选为壳聚糖凝胶，其由导入有碳水化合物链的壳聚糖衍生物形成，作为基底，进一步引入光反应性基团以通过光照射形成交联; 或由聚糖配合物形成的壳聚糖凝胶，其由含碳水化合物链的壳聚糖衍生物和另一种物质例如酸性多糖形成。 本发明的抗肿瘤成分可以抑制肿瘤的生长而不使其与肿瘤接触，而是简单地将其设置在肿瘤附近。
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8.发明申请Liquid composition for bulging mucous membrane for use in endoscopic surgery comprising a chitosan derivative containing carbohydrate chains 失效用于内窥镜手术中用于膨胀粘膜的液体组合物，其包含含有碳水化合物链的壳聚糖衍生物公开(公告)号：US20070078108A1
公开(公告)日：2007-04-05
申请号：US10576745
申请日：2004-10-21
申请人： Takuya Hayashi , Masayuki Ishihara , Hirofumi Yura
发明人： Takuya Hayashi , Masayuki Ishihara , Hirofumi Yura
IPC分类号： A61K31/722
CPC分类号： A61K31/70 , A61K41/0042 , A61K49/00
摘要： The present invention provides a liquid composition to make the mucous membrane bulge during endoscopic surgery characterized in that it comprises a chitosan derivative containing carbohydrate chains. The use of the composition of the present invention as a liquid for bulging the mucous membrane during endoscopic surgery, maintain the bulge of the mucous membrane for a long period, and prevent perforation, resulting in the improved reliability of endoscopic surgery. The composition of the present invention also demonstrates prevention and inhibition of bleeding from the incised portion. The introduction of a photo-reactive group to the above chitosan derivative with carbohydrate chains allows the easy formation of a hydrogel through photo-crosslinking, leading to the further improvement in retention of the bulge and prevention of bleeding.
摘要翻译： 本发明提供了一种在内窥镜手术中使粘膜膨胀的液体组合物，其特征在于其包含含有碳水化合物链的壳聚糖衍生物。 在内窥镜手术中使用本发明的组合物作为液体膨胀粘膜，长时间保持粘膜的隆起，防止穿孔，从而提高内窥镜手术的可靠性。 本发明的组合物还表现出预防和抑制切开部分的渗色。 用碳水化合物链向上述壳聚糖衍生物引入光反应性基团可以通过光交联容易地形成水凝胶，从而进一步改进了凸起的保留和防止出血。
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公开(公告)号：US20050032201A1
公开(公告)日：2005-02-10
申请号：US10936937
申请日：2004-09-09
IPC分类号： C12N5/00 , C12N5/078 , G01N33/569 , C12M1/34
CPC分类号： G01N33/56972 , C12N5/0634 , G01N33/56966 , G01N2333/4724
摘要： The present invention provides a method for selective and high-yield separation, concentration, and recovery of desired cells from a blood sample. The method of the present invention is characterized in that the blood sample is caused to interact with lectins under conditions in which the cell membranes are inactive and cell-lectin complexes/non-complexes are formed, the sample containing these cell-lectin complexes/non-complexes is incubated together with a substrate, the surface of which is covered with polymers having carbohydrate chains which are specifically recognized by the lectins, and the cells are immobilized on the surface of the substrate via the lectins, and subsequently, the liquid layer and the solid phase are separated, and the desired blood cells are recovered from the liquid phase and/or the solid phase, and these lectins are present in such an amount that although the cells to be recovered from the solid phase bind to the solid phase with the polymer, the cells to be recovered from the liquid phase do not bind to the solid phase with the polymer.
摘要翻译： 本发明提供从血液样品中选择性和高产率分离，浓缩和回收所需细胞的方法。 本发明的方法的特征在于使血液样品与细胞膜无活性且细胞凝集素复合物/非复合物形成的条件下的凝集素相互作用，含有这些细胞凝集素复合物/非 - - 复合物与底物一起孵育，其表面被聚合物覆盖，所述聚合物具有由凝集素特异性识别的碳水化合物链，并且细胞通过凝集素固定在基质的表面上，随后将液体层和 分离固相，从液相和/或固相中回收所需的血细胞，这些凝集素的存在量，即使从固相中回收的细胞与固相相结合， 聚合物，从液相中回收的细胞不与聚合物结合固相。
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公开(公告)号：US20050214758A1
公开(公告)日：2005-09-29
申请号：US10498579
申请日：2002-12-09
申请人： Hirofumi Yura , Yoshio Saito , Michihiro Kitagawa
发明人： Hirofumi Yura , Yoshio Saito , Michihiro Kitagawa
IPC分类号： G01N33/537 , G01N33/569 , G01N33/68 , C12Q1/68 , C12M1/34 , G01N33/567
CPC分类号： G01N33/689 , G01N33/537 , G01N33/56966 , G01N2400/00 , G01N2800/368
摘要： A blood cell separating system is offered for precisely separating and concentrating rare fetal nucleated cells intermixed in the blood of a pregnant woman, to conveniently obtain test preparations capable of being used for prenatal chromosomal/genetic diagnosis. A blood cell separating system is characterized by comprising (1) a primary separating device for removing mainly non-nucleated erythrocytes, leukocytes and platelets from blood samples taken from a pregnant woman to obtain a primary separated sample, (2) a secondary separating device for using a carbohydrate-lectin method to remove residual non-nucleated erythrocytes and leukocytes from the primary separated sample obtained by the primary separating device to obtain a secondary separated sample with concentrated fetal nucleated cells, and (3) preparing device for preparing the secondary separated sample obtained by the secondary separating device.
摘要翻译： 提供血细胞分离系统，用于精确分离和浓缩在孕妇血液中混合的稀有胎儿有核细胞，以方便地获得能够用于产前染色体/遗传学诊断的测试制剂。 血细胞分离系统的特征在于包括：（1）主要分离装置，用于从孕妇取血的样品中主要去除未成核的红细胞，白细胞和血小板，以获得初级分离的样品;（2）二次分离装置， 使用碳水化合物凝集素方法从初级分离装置获得的主要分离样品中除去残留的未成核红细胞和白细胞，以获得具有浓缩胎儿有核细胞的二次分离样品，和（3）制备二次分离样品的制备装置 通过二次分离装置获得。
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