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公开(公告)号:US20050267170A1
公开(公告)日:2005-12-01
申请号:US11118497
申请日:2005-04-29
申请人: Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
发明人: Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
IPC分类号: A61K31/195 , A61K31/455 , C07C235/42 , C07C235/46 , C07C235/70 , C07D213/56 , C07D213/65 , C07D213/74 , C07D213/82 , C07D213/89
CPC分类号: C07D213/74 , C07C235/42 , C07C235/46 , C07C2601/08 , C07C2601/14 , C07D213/65 , C07D213/82 , C07D213/89
摘要: This invention provides a compound of the formula (I): wherein X represents a carbon atom or the like: Y represents imino, or the like: R1 represents an alkyl group having from 1 to 6 carbon atoms or the like: R2 and R3 independently represents a hydrogen atom or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译: 本发明提供式(I)的化合物:其中X表示碳原子等:Y表示亚氨基等:R 1表示具有1至6个碳原子的烷基 R 2,R 3和R 3独立地表示氢原子等。 这些化合物可用于治疗由前列腺素介导的疾病状况,例如哺乳动物中的疼痛等。 本发明还提供了包含上述化合物的药物组合物。
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公开(公告)号:US08084476B2
公开(公告)日:2011-12-27
申请号:US12368778
申请日:2009-02-10
申请人: Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
发明人: Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
IPC分类号: A61K31/44 , C07D211/72
CPC分类号: C07D213/74 , C07C235/42 , C07C235/46 , C07C2601/08 , C07C2601/14 , C07D213/65 , C07D213/82 , C07D213/89
摘要: This invention provides a compound of the formula (I): wherein X represents a carbon atom or the like: Y represents imino, or the like: R1 represents an alkyl group having from 1 to 6 carbon atoms or the like: R2 and R3 independently represents a hydrogen atom or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译: 本发明提供式(I)的化合物:其中X表示碳原子等:Y表示亚氨基等:R 1表示具有1至6个碳原子的烷基等:R 2和R 3独立地 表示氢原子等。 这些化合物可用于治疗由前列腺素介导的疾病状况,例如哺乳动物中的疼痛等。 本发明还提供了包含上述化合物的药物组合物。
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公开(公告)号:US20090163558A1
公开(公告)日:2009-06-25
申请号:US12368778
申请日:2009-02-10
申请人: Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
发明人: Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
IPC分类号: A61K31/44 , C07D213/56
CPC分类号: C07D213/74 , C07C235/42 , C07C235/46 , C07C2601/08 , C07C2601/14 , C07D213/65 , C07D213/82 , C07D213/89
摘要: This invention provides a compound of the formula (I): wherein X represents a carbon atom or the like: Y represents imino, or the like: R1 represents an alkyl group having from 1 to 6 carbon atoms or the like: R2 and R3 independently represents a hydrogen atom or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译: 本发明提供式(I)的化合物:其中X表示碳原子等:Y表示亚氨基等:R 1表示具有1至6个碳原子的烷基等:R 2和R 3独立地 表示氢原子等。 这些化合物可用于治疗由前列腺素介导的疾病状况,例如哺乳动物中的疼痛等。 本发明还提供了包含上述化合物的药物组合物。
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公开(公告)号:US07534914B2
公开(公告)日:2009-05-19
申请号:US11118497
申请日:2005-04-29
申请人: Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
发明人: Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
IPC分类号: C07C229/00
CPC分类号: C07D213/74 , C07C235/42 , C07C235/46 , C07C2601/08 , C07C2601/14 , C07D213/65 , C07D213/82 , C07D213/89
摘要: This invention provides a compound of the formula (I): wherein X represents a carbon atom or the like: Y represents imino, or the like: R1 represents an alkyl group having from 1 to 6 carbon atoms or the like: R2 and R3 independently represents a hydrogen atom or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译: 本发明提供式(I)的化合物:其中X表示碳原子等:Y表示亚氨基等:R 1表示具有1至6个碳原子的烷基等:R 2和R 3独立地 表示氢原子等。 这些化合物可用于治疗由前列腺素介导的疾病状况,例如哺乳动物中的疼痛等。 本发明还提供了包含上述化合物的药物组合物。
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