公开(公告)号：US4659709A

公开(公告)日：1987-04-21

申请号：US764785

申请日：1985-08-12

申请人： Hiroshi Harada ,  Yoshihiro Matsushita ,  Masuhisa Nakamura ,  Yukio Yonetani

发明人： Hiroshi Harada ,  Yoshihiro Matsushita ,  Masuhisa Nakamura ,  Yukio Yonetani

IPC分类号： A61K31/34 ,  A61K31/343 ,  A61K31/365 ,  A61K31/40 ,  A61K31/535 ,  A61P7/10 ,  A61P9/12 ,  C07D307/79 ,  C07D307/80 ,  C07D307/85 ,  C07D307/88

CPC分类号： C07D307/79 ,  C07D307/80 ,  C07D307/85 ,  C07D307/88

摘要： Highly effective diuretic antihypertensives, i.e., 2,3-dihydrobenzofuran-5-sulfonamide derivatives which is classified to loop diuretics with less adverse side-effects and can be administered orally at a daily dosage of 0.5-200 mg or parenterally of 0.01-50 mg.

摘要翻译： 高效利尿抗高血压药，即2,3-二氢苯并呋喃-5-磺酰胺衍生物，其被分类为具有较少不良副作用的循环利尿剂，并且可以以0.5-200mg的日剂量口服或0.01-50mg肠胃外给药 。

公开(公告)号：US4918206A

公开(公告)日：1990-04-17

申请号：US245294

申请日：1988-09-16

申请人： Hiroshi Harada ,  Yoshihiro Matsushita ,  Masuhisa Nakamura ,  Yukio Yonetani

发明人： Hiroshi Harada ,  Yoshihiro Matsushita ,  Masuhisa Nakamura ,  Yukio Yonetani

IPC分类号： A61K31/34 ,  A61K31/343 ,  A61P7/10 ,  A61P9/12 ,  C07D307/85

CPC分类号： C07D307/85 ,  Y02P20/55

摘要： Highly effective diuretic antihypertensives, i.e., sulfamoyl-2-benzofurancarboxylic acid derivatives which are classified as loop diuretics with less adverse side-effects and can be administered orally at a daily dosage of 0.5 mg to 200 mg or parenterally at 0.01 mg to 50 mg.

公开(公告)号：US4595767A

公开(公告)日：1986-06-17

申请号：US791160

申请日：1985-10-22

申请人： Hiroshi Itazaki ,  Kunio Hayashi ,  Munenori Matsuura ,  Yukio Yonetani ,  Masuhisa Nakamura

发明人： Hiroshi Itazaki ,  Kunio Hayashi ,  Munenori Matsuura ,  Yukio Yonetani ,  Masuhisa Nakamura

IPC分类号： A61K31/335 ,  A61K31/357 ,  A61K31/38 ,  A61K31/381 ,  A61P7/10 ,  A61P9/12 ,  C07D319/00 ,  C07D319/20 ,  C07D333/00 ,  C07D407/06 ,  C07D409/06 ,  C07D409/00 ,  C07D319/14

CPC分类号： C07D407/06 ,  C07D319/20 ,  C07D409/06

摘要： Highly safe new diuretics, i.e., 1,4-benzodioxane and 1,4-benzodioxine derivatives having potent antihypertensive activity but no or little uricesuric activity, which can be administered to human orally, intravenously, or hypodermically at a respective daily dosage of 0.1-2 mg/kg, 0.005-0.1 mg/kg, or 0.02-0.4 mg/kg.

摘要翻译： 高度安全的新利尿剂，即1,4-苯并二氧杂环己烷和1,4-苯并二恶英衍生物，其具有有效的抗高血压活性，但没有或少量的尿素活性，其可以以各自的日剂量0.1-口服，静脉内或皮下给药 2mg / kg，0.005-0.1mg / kg或0.02-0.4mg / kg。

公开(公告)号：US5268386A

公开(公告)日：1993-12-07

申请号：US558242

申请日：1990-07-26

申请人： Hiroshi Harada ,  Eiichi Ohsugi ,  Yukio Yonetani ,  Toshihiro Shinosaki

发明人： Hiroshi Harada ,  Eiichi Ohsugi ,  Yukio Yonetani ,  Toshihiro Shinosaki

IPC分类号： C12N9/99 ,  A61K31/35 ,  A61K31/352 ,  A61K31/38 ,  A61K31/382 ,  A61K31/39 ,  A61K31/47 ,  A61P19/06 ,  A61P43/00 ,  C07D215/20 ,  C07D215/22 ,  C07D215/36 ,  C07D215/38 ,  C07D221/20 ,  C07D311/22 ,  C07D311/36 ,  C07D311/96 ,  C07D335/06 ,  C07D407/12 ,  C07D487/04 ,  C07D495/10 ,  C07D497/10 ,  A61K31/385 ,  C07D339/02

CPC分类号： C07D221/20 ,  C07D311/22 ,  C07D311/96 ,  C07D335/06 ,  C07D487/04 ,  C07D495/10

摘要： A novel heterocyclic compound capable of lowering the uric acid levels in plasma and urine having the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are independently hydrogen, lower alkyl, phenyl or substituted phenyl, or R.sup.1 and R.sup.2 may form a four- to eight-membered carbon ring together with the carbon atom to which they are attached; R.sup.3 is hydrogen or lower alkyl; R.sup.4 is one or two radicals selected from a group consisting of hydrogen, halogen, nitro, lower alkyl, phenyl, substituted phenyl, --OR.sup.5 and --SO.sub.2 NR.sup.6 R.sup.6' ; R.sup.5 is hydrogen, lower alkyl, phenyl-substituted lower alkyl, carboxymethyl or ester thereof, hydroxyethyl or ether thereof, or allyl; R.sup.6 and R.sup.6' are independently hydrogen or lower alkyl; R.sup.7 is hydrogen or a pharmaceutically active ester-forming group; A is a straight or branched hydrocarbon radical having one to five carbon atoms; B is halogen, oxygen, or dithiolane; Y is oxygen, sulfur, nitrogen or substituted nitrogen; Z is oxygen, nitrogen or substituted nitrogen; dotted line represents the presence or absence of a single bond.

公开(公告)号：US4063894A

公开(公告)日：1977-12-20

申请号：US733913

申请日：1976-10-19

申请人： Yasunao Ogawa ,  Yukio Yonetani

发明人： Yasunao Ogawa ,  Yukio Yonetani

IPC分类号： G01N33/50 ,  C12Q1/28 ,  G01N33/72 ,  C09K3/00 ,  G01N31/22 ,  G01N33/16

CPC分类号： C12Q1/28 ,  G01N33/725 ,  Y10S436/904

摘要： A test strip for detecting the presence of occult blood in excreta such as urine or feces or body fluid, which strip comprises a bibulous or porous material impregnated with a chromogen, a hydroperoxide and, as a sensitizer, a thiazole compound of the formula: ##STR1## wherein R.sub.1 is a lower alkyl; a substituted or unsubstituted aralkenyl, or a substituted or unsubstituted aralkyl; R.sub.2 and R.sub.3 are each a hydrogen or a lower alkyl; and R.sub.2 and R.sub.3, when taken together with the adjacent carbon atoms, may form a benzene ring.

摘要翻译： 用于检测排泄物（例如尿液或粪便或体液）中潜血的存在的测试条，该条带包括浸渍有色原体，氢过氧化物和作为敏化剂的下式的噻唑化合物的吸水或多孔材料： IMAGE>其中R1是低级烷基; 取代或未取代的芳烯基或取代或未取代的芳烷基; R2和R3各自为氢或低级烷基; 当R 2和R 3与相邻的碳原子一起时可以形成苯环。

公开(公告)号：US3954412A

公开(公告)日：1976-05-04

申请号：US480308

申请日：1974-06-17

申请人： Yasunao Ogawa ,  Yukio Yonetani

发明人： Yasunao Ogawa ,  Yukio Yonetani

IPC分类号： G01N33/52 ,  G01N33/64 ,  G01N33/16

CPC分类号： G01N33/64 ,  Y10T436/200833

摘要： A test strip for the detection of phenylketone bodies in the body fluids, especially in the urine, comprising an absorbing material, a ferric salt and an iron-chelating agent. The test strip is useful in early diagnosis of phenylketonuria, inborn disorder of phenylalanine metabolism.

摘要翻译： 用于检测体液（特别是尿液）中苯基酮体的测试条，包括吸收材料，铁盐和铁螯合剂。 测试条可用于早期诊断苯丙酮尿症，苯丙氨酸代谢的先天性失调。