公开(公告)号：US20110065095A1

公开(公告)日：2011-03-17

申请号：US12934908

申请日：2009-03-26

申请人： Hiroshi Kida ,  Yoshihiro Sakoda ,  Eiji Miyagawa ,  Nobuyuki Fujii ,  Yoshiaki Uchida ,  Takashi Shirakawa ,  Hiroyuki Kogaki

发明人： Hiroshi Kida ,  Yoshihiro Sakoda ,  Eiji Miyagawa ,  Nobuyuki Fujii ,  Yoshiaki Uchida ,  Takashi Shirakawa ,  Hiroyuki Kogaki

IPC分类号： C12Q1/70 ,  C07K16/10

CPC分类号： G01N33/56983 ,  C07K16/1018 ,  C07K2317/34 ,  G01N2333/11

摘要： A method of immunoassay of H5 subtype influenza A virus by which the virus can be accurately assayed even in cases where a certain level of mutation has occurred in the H5 subtype influenza A virus, and a kit therefor, and a novel anti-H5 subtype influenza A virus monoclonal antibody which can be used for the immunoassay are disclosed. The antibody or an antigen-binding fragment thereof of the present invention undergoes antigen-antibody reaction with hemagglutinin of H5 subtype influenza A virus, and the corresponding epitope of the antibody or an antigen-binding fragment thereof is located in a region other than the receptor subdomain (excluding C-terminal region thereof consisting of 11 amino acids), which antibody or an antigen-binding fragment thereof does not have neutralizing activity against the influenza A virus.

摘要翻译： 一种H5亚型甲型流感病毒的免疫测定方法，即使在H5亚型甲型流感病毒中发生一定程度的突变的情况下也能够准确测定病毒，以及其用于该药物的试剂盒，以及新的抗H5亚型流感 公开了可用于免疫测定的病毒单克隆抗体。 本发明的抗体或其抗原结合片段与H5亚型甲型流感病毒的血凝素进行抗原抗体反应，抗体或其抗原结合片段的相应表位位于受体以外的区域 子结构域（不包括由11个氨基酸组成的C末端区域），该抗体或其抗原结合片段不具有针对甲型流感病毒的中和活性。

公开(公告)号：US08658354B2

公开(公告)日：2014-02-25

申请号：US12934908

申请日：2009-03-26

申请人： Hiroshi Kida ,  Yoshihiro Sakoda ,  Eiji Miyagawa ,  Nobuyuki Fujii ,  Yoshiaki Uchida ,  Takashi Shirakawa ,  Hiroyuki Kogaki

发明人： Hiroshi Kida ,  Yoshihiro Sakoda ,  Eiji Miyagawa ,  Nobuyuki Fujii ,  Yoshiaki Uchida ,  Takashi Shirakawa ,  Hiroyuki Kogaki

IPC分类号： C12Q1/70

CPC分类号： G01N33/56983 ,  C07K16/1018 ,  C07K2317/34 ,  G01N2333/11

摘要： A method of immunoassay of H5 subtype influenza A virus by which the virus can be accurately assayed even in cases where a certain level of mutation has occurred in the H5 subtype influenza A virus, and a kit therefor, and a novel anti-H5 subtype influenza A virus monoclonal antibody which can be used for the immunoassay are disclosed. The antibody or an antigen-binding fragment thereof of the present invention undergoes antigen-antibody reaction with hemagglutinin of H5 subtype influenza A virus, and the corresponding epitope of the antibody or an antigen-binding fragment thereof is located in a region other than the receptor subdomain (excluding C-terminal region thereof consisting of 11 amino acids), which antibody or an antigen-binding fragment thereof does not have neutralizing activity against the influenza A virus.

摘要翻译： 一种H5亚型甲型流感病毒的免疫测定方法，即使在H5亚型甲型流感病毒中发生一定程度的突变的情况下，也能够准确测定病毒，以及其用途，以及新的抗H5亚型流感 公开了可用于免疫测定的病毒单克隆抗体。 本发明的抗体或其抗原结合片段与H5亚型甲型流感病毒的血凝素进行抗原抗体反应，抗体或其抗原结合片段的相应表位位于受体以外的区域 子结构域（不包括由11个氨基酸组成的C末端区域），该抗体或其抗原结合片段不具有针对甲型流感病毒的中和活性。

公开(公告)号：US4463091A

公开(公告)日：1984-07-31

申请号：US267828

申请日：1981-05-28

申请人： Takahiro Harada ,  Eiji Miyagawa ,  Junko Umemoto ,  Tsutomu Yoshida ,  Toshinari Hamakado

发明人： Takahiro Harada ,  Eiji Miyagawa ,  Junko Umemoto ,  Tsutomu Yoshida ,  Toshinari Hamakado

IPC分类号： A61K35/74 ,  A61K38/55 ,  A61P3/06 ,  A61P3/08 ,  C07G99/00 ,  C12P1/06 ,  C12R1/465 ,  C12P21/00 ,  C12P21/02 ,  C12P21/04

CPC分类号： C12R1/465 ,  C12P1/06 ,  Y10S435/886

摘要： A method of producing amylase inhibitor AI-B by cultivating an amylase inhibitor AI-B producing strain which belongs to the genus Streptomyces and isolating the amylase inhibitor AI-B from the culture.

摘要翻译： 通过培养属于链霉菌属的淀粉酶抑制剂AI-B产生菌株并从培养物中分离淀粉酶抑制剂AI-B来生产淀粉酶抑制剂AI-B的方法。