公开(公告)号：US08128959B2

公开(公告)日：2012-03-06

申请号：US11918651

申请日：2006-04-13

申请人： Hiroshi Maeda ,  Khaled Greish

发明人： Hiroshi Maeda ,  Khaled Greish

IPC分类号： A61K47/48 ,  A61K33/30 ,  A61K31/555 ,  B01F3/00

CPC分类号： A61K41/0071 ,  A61K9/0019 ,  A61K9/107 ,  A61K31/409 ,  A61K31/704 ,  A61K31/7048 ,  A61K47/58 ,  A61K47/60 ,  C08K5/0091 ,  C08L35/06

摘要： The present invention provides a polymeric agent which can incorporate a large amount of a drug, accumulate selectively in a tumor site, and has a molecular size of more than that for renal excretion. A metalloporphyrin derivative (such as zinc protoporphyrin) is associated with a styrene-maleic acid copolymer via non-covalent bond to give a SMA micelle complex, allowing provision of a polymeric pharmaceutical agent for treatment of cancer with a large amount of the drug incorporated. The SMA micelle complex can be produced by a method, wherein the metalloporphyrin derivative reacts with the styrene-maleic acid copolymer in the absence of a condensation agent under an alkaline condition, solubilized, adjusted to have a pH of 6-8, and subjected to a procedure for separating a polymer component to recover the micelle complex component for the polymeric pharmaceutical agent.

摘要翻译： 本发明提供了可以掺入大量药物的聚合物，其选择性地积聚在肿瘤部位，并且具有比肾排泄量更大的分子大小。 金属卟啉衍生物（例如锌原卟啉锌）通过非共价键与苯乙烯 - 马来酸共聚物缔合，得到SMA胶束复合物，允许提供用于治疗癌症的大量药物的聚合物药剂。 SMA胶束复合物可以通过一种方法制备，其中金属卟啉衍生物在碱性条件下在不存在缩合剂的情况下与苯乙烯 - 马来酸共聚物反应，溶解，调节至pH为6-8，并进行 用于分离聚合物组分以回收聚合物药剂的胶束复合物组分的方法。

公开(公告)号：US20090062476A1

公开(公告)日：2009-03-05

申请号：US11918651

申请日：2006-04-13

申请人： Hiroshi Maeda ,  Khaled Greish

发明人： Hiroshi Maeda ,  Khaled Greish

IPC分类号： C08F8/30

CPC分类号： A61K41/0071 ,  A61K9/0019 ,  A61K9/107 ,  A61K31/409 ,  A61K31/704 ,  A61K31/7048 ,  A61K47/58 ,  A61K47/60 ,  C08K5/0091 ,  C08L35/06

摘要： The present invention provides a polymeric agent which can incorporate a large amount of a drug, accumulate selectively in a tumor site, and has a molecular size of more than that for renal excretion.A metalloporphyrin derivative (such as zinc protoporphyrin) is associated with a styrene-maleic acid copolymer via non-covalent bond to give a SMA micelle complex, allowing provision of a polymeric pharmaceutical agent for treatment of cancer with a large amount of the drug incorporated. The SMA micelle complex can be produced by a method, wherein the metalloporphyrin derivative reacts with the styrene-maleic acid copolymer in the absence of a condensation agent under an alkaline condition, solubilized, adjusted to have a pH of 6-8, and subjected to a procedure for separating a polymer component to recover the micelle complex component for the polymeric pharmaceutical agent.

摘要翻译： 本发明提供了可以掺入大量药物的聚合物，其选择性地积聚在肿瘤部位，并且具有比肾排泄量更大的分子大小。 金属卟啉衍生物（例如锌原卟啉锌）通过非共价键与苯乙烯 - 马来酸共聚物缔合，得到SMA胶束复合物，允许提供用于治疗癌症的大量药物的聚合物药剂。 SMA胶束复合物可以通过一种方法制备，其中金属卟啉衍生物在碱性条件下在不存在缩合剂的情况下与苯乙烯 - 马来酸共聚物反应，溶解，调节至pH为6-8，并进行 用于分离聚合物组分以回收聚合物药剂的胶束复合物组分的方法。

公开(公告)号：US07682630B2

公开(公告)日：2010-03-23

申请号：US10514892

申请日：2004-02-02

申请人： Hiroshi Maeda ,  Khaled Greish

发明人： Hiroshi Maeda ,  Khaled Greish

IPC分类号： A61K47/48 ,  A61K33/24 ,  A61K9/51

CPC分类号： A61K33/24 ,  A61K9/1075 ,  A61K47/58 ,  A61K47/6907

摘要： The present invention relates to polymeric antitumor agent which is formed in polymeric micelle complex by intermolecular bonding or mutual interaction between styrene maleic acid copolymer (SMA) and low molecule antitumor agent which is anthracyclins drug such as pirarubicin, doxorubicm, epirbicin, daunorbicin, acralbicin, or alkaloid antitumor agent such as cis-platinum, and taxol These polymeric antitumor agents may improve specificity to cancer cells so that it improves antitumor effect, while it may not be concentrated at normal organ or tissue, so that adverse effect may be diminished. These polymeric antitumor agents may be prepared by dissolving SMA and low molecule antitumor agent in aqueous solution, then in the presence of aqueous soluble carbodiimide, amino acids, or polyamine, adjusting pH to form micelle complex and recovering polymer fraction.

摘要翻译： 本发明涉及通过苯乙烯马来酸共聚物（SMA）和低分子抗肿瘤剂之间的分子间键合或相互作用形成聚合物胶束复合物的聚合物抗肿瘤剂，其是蒽环类药物，例如吡柔比星，多柔比星，表赤霉素，柔红霉素， 或生物碱抗肿瘤剂如顺铂和紫杉醇这些聚合抗肿瘤剂可以改善对癌细胞的特异性，从而提高抗肿瘤作用，而不会将其集中在正常的器官或组织，从而可能减少不良反应。 这些聚合抗肿瘤剂可以通过将SMA和低分子抗肿瘤剂溶解在水溶液中，然后在水溶性碳二亚胺，氨基酸或多胺的存在下，调节pH以形成胶束复合物并回收聚合物级分来制备。

公开(公告)号：US20050208136A1

公开(公告)日：2005-09-22

申请号：US10514892

申请日：2004-02-02

申请人： Hiroshi Maeda ,  Khaled Greish

发明人： Hiroshi Maeda ,  Khaled Greish

IPC分类号： A61K9/51 ,  A61K33/24 ,  A61K47/48 ,  A61P35/00 ,  A61K31/704 ,  A61K9/14

CPC分类号： A61K33/24 ,  A61K9/1075 ,  A61K47/58 ,  A61K47/6907

摘要： The present invention relates to polymeric antitumor agent which is formed in polymeric micelle complex by intermolecular bonding or mutual interaction between styrene maleic acid copolymer (SMA) and low molecule antitumor agent which is anthracyclins drug such as pirarubicin, doxorubicin, epirbicin, daunorbicin, acralbicin, or alkaloid antitumor agent such as cis-platinum, and taxol These polymeric antitumor agents may improve specificity to cancer cells so that it improves antitumor effect, while it may not be concentrated at normal organ or tissue, so that adverse effect may be diminished. These polymeric antitumor agents may be prepared by dissolving SMA and low molecule antitumor agent in aqueous solution, then in the presence of aqueous soluble carbodiimide, amino acids, or polyamine, adjusting pH to form micelle complex and recovering polymer fraction.

摘要翻译： 本发明涉及通过苯乙烯马来酸共聚物（SMA）和低分子抗肿瘤剂之间的分子间键合或相互作用在聚合物胶束复合物中形成的聚合物抗肿瘤剂，其是蒽环类药物，例如吡柔比星，多柔比星，表赤霉素，柔红霉素， 或生物碱抗肿瘤剂如顺铂和紫杉醇这些聚合抗肿瘤剂可以改善对癌细胞的特异性，从而提高抗肿瘤作用，而不会将其集中在正常的器官或组织，从而可能减少不良反应。 这些聚合抗肿瘤剂可以通过将SMA和低分子抗肿瘤剂溶解在水溶液中，然后在水溶性碳二亚胺，氨基酸或多胺的存在下，调节pH以形成胶束复合物并回收聚合物级分来制备。

公开(公告)号：US09489984B2

公开(公告)日：2016-11-08

申请号：US14503710

申请日：2014-10-01

申请人： Hiroshi Maeda

发明人： Hiroshi Maeda

IPC分类号： G09G5/00 ,  G11B27/10 ,  G11B27/11 ,  H04N21/414 ,  H04N21/431 ,  G06F3/14

CPC分类号： G11B27/105 ,  G06F3/1454 ,  G11B27/11 ,  H04N21/41415 ,  H04N21/4312

摘要： A display apparatus which can communicate with an information terminal via a network is disclosed. The display apparatus includes a receiving unit which receives content data which are caused to be displayed on the display apparatus and reproduction control information on reproduction of the content data from the information terminal, an execution information generation unit which causes the reproduction control information to be execution information corresponding to the display apparatus, and a display unit which causes the content data to be displayed on the display apparatus based on the execution information.

摘要翻译： 公开了能够经由网络与信息终端进行通信的显示装置。 显示装置包括接收单元，其接收在显示装置上显示的内容数据和关于来自信息终端的内容数据的再现的再现控制信息;使再现控制信息执行的执行信息生成单元 与显示装置相对应的信息，以及基于执行信息使内容数据显示在显示装置上的显示单元。

公开(公告)号：US20160267878A1

公开(公告)日：2016-09-15

申请号：US15064547

申请日：2016-03-08

申请人： Hiroshi Maeda ,  Sachiko Abe

发明人： Hiroshi Maeda ,  Sachiko Abe

IPC分类号： G09G5/12 ,  G06F3/14

CPC分类号： G09G5/12 ,  G06F3/1446 ,  G09G2370/025 ,  H04N9/3147 ,  H04W4/80

摘要： A display control apparatus is connected to another display control apparatus. The display control apparatus includes a display unit configured to display a content; a request reception unit configured to receive a request about the content; a display request generation unit configured to generate a plurality of display requests for controlling display statuses of contents displayed by the display control apparatus and the other display control apparatus synchronously in response to the request, the display requests including a first display request for controlling the display status of the content of the other display control apparatus and a second display request for controlling the display status of the content of the display control apparatus; a communication unit configured to transmit the first display request to the other display control apparatus; and a display control unit configured to control the display status of the content based on the second display request.

摘要翻译： 显示控制装置连接到另一显示控制装置。 显示控制装置包括：显示单元，被配置为显示内容; 被配置为接收关于内容的请求的请求接收单元; 显示请求生成单元，其被配置为响应于该请求，同步地生成用于控制由显示控制装置和其他显示控制装置显示的内容的显示状态的多个显示请求，显示请求包括用于控制显示的第一显示请求 另一显示控制装置的内容的状态和用于控制显示控制装置的内容的显示状态的第二显示请求; 通信单元，被配置为将所述第一显示请求发送到所述另一显示控制装置; 以及显示控制单元，被配置为基于所述第二显示请求来控制所述内容的显示状态。

公开(公告)号：US09360919B2

公开(公告)日：2016-06-07

申请号：US13730098

申请日：2012-12-28

申请人： Ryo Iwasaki ,  Reiji Yukumoto ,  Yoshifumi Kawai ,  Hiroshi Maeda ,  Daigo Uchiyama

发明人： Ryo Iwasaki ,  Reiji Yukumoto ,  Yoshifumi Kawai ,  Hiroshi Maeda ,  Daigo Uchiyama

IPC分类号： G06F1/32

CPC分类号： G06F1/3234 ,  G06F1/3203

摘要： A processing device includes a plurality of input units configured to input a process request; a plurality of processing units configured to execute a process corresponding to the process request input by the plurality of input units; a power control unit configured to transfer the processing device into a power saving state and to transfer the processing device back to a regular state from the power saving state; and an operation suppression control unit configured to send an operation suppression request to the plurality of input units and the plurality of processing units before the power control unit transfers the processing device into the power saving state, and to send an operation suppression release request to the plurality of input units and the plurality of processing units when the power control unit transfers the processing device back to the regular state from the power saving state.

摘要翻译： 处理装置包括：多个输入单元，被配置为输入处理请求; 多个处理单元，被配置为执行与由所述多个输入单元输入的处理请求对应的处理; 功率控制单元，被配置为将所述处理装置传送到省电状态，并将所述处理装置从所述省电状态返回到规则状态; 以及操作抑制控制单元，被配置为在所述电源控制单元将所述处理设备传送到省电状态之前向所述多个输入单元和所述多个处理单元发送操作抑制请求，并且向所述操作抑制控制单元发送操作抑制解除请求 多个输入单元和多个处理单元，当功率控制单元从处于省电状态的状态转移到正常状态时。

公开(公告)号：US09055235B2

公开(公告)日：2015-06-09

申请号：US14268389

申请日：2014-05-02

申请人： Hiroshi Maeda

发明人： Hiroshi Maeda

IPC分类号： H04N5/268 ,  H04N5/64

CPC分类号： H04N5/268 ,  H04N5/64 ,  H04N21/4122 ,  H04N21/4184

摘要： A video output apparatus outputs one of image information items received from external storage units. The video output apparatus includes input interfaces, an image information acquisition unit that acquires the image information items from the external storage units through the input interfaces, an output object management unit that manages one of the image information items as an output object among the image information items, an image information presence determination unit that sends a notification of presence or absence of image information to the output object management unit for each of the input interfaces based on whether image acquisition information for acquiring image information has been acquired, and an output unit that outputs an image information item acquired through one of the input interfaces associated with the notification of the presence of image information received from the image information presence determination unit.

摘要翻译： 视频输出装置输出从外部存储单元接收的图像信息项之一。 视频输出装置包括输入接口，图像信息获取单元，通过输入接口从外部存储单元获取图像信息项;输出对象管理单元，其在图像信息中管理作为输出对象的图像信息项之一 项目，图像信息存在确定单元，其基于是否已经获取了用于获取图像信息的图像获取信息，将每个输入界面的图像信息的存在或不存在通知发送到输出对象管理单元;以及输出单元， 输出通过与从图像信息存在确定单元接收到的图像信息的存在的通知相关联的输入接口之一获取的图像信息项。

公开(公告)号：US08866577B2

公开(公告)日：2014-10-21

申请号：US13467759

申请日：2012-05-09

申请人： Hiroshi Maeda ,  Katsumi Kobayashi ,  Nobuo Kitajima ,  Kiho Hwang

发明人： Hiroshi Maeda ,  Katsumi Kobayashi ,  Nobuo Kitajima ,  Kiho Hwang

IPC分类号： H01F27/30

CPC分类号： H01F5/02 ,  H01F27/2823 ,  H01F27/30 ,  H01F27/325

摘要： The present invention provides a coil component which is possible to be thinner with less leakage flux toward upward and downward directions, and to sustain a good insulation. The coil component comprises a core including two opposing parts mutually opposing, two side legs mutually connect both ends of the two opposing parts, and a middle leg placed between the two side legs and mutually connect central parts of the two opposing parts, a primary coil, which goes around outer circumference of the middle leg, and a secondary coil, which goes around outer circumference of the primary coil, wherein; a distance between outer perimeter edge of the primary coil and inner perimeter edge of the secondary coil varies along circumferential direction.

摘要翻译： 本发明提供一种线圈部件，其可以以较小的漏磁通向上下方向变薄，并且能够维持良好的绝缘。 线圈部件包括：芯部，其包括相互相对的两个相对部分，两个侧腿相互连接两个相对部分的两端;以及中间腿，放置在两个侧腿之间并相互连接两个相对部分的中心部分，初级线圈 ，其绕着中间腿的外周;以及绕过初级线圈的外周的次级线圈，其中： 初级线圈的外周边缘与次级线圈的内周缘之间的距离沿圆周方向变化。

公开(公告)号：US08691125B2

公开(公告)日：2014-04-08

申请号：US13206096

申请日：2011-08-09

申请人： Hiroshi Maeda

发明人： Hiroshi Maeda

IPC分类号： B29C45/73

CPC分类号： B29C45/73 ,  B29C2045/7343

摘要： An injection molding apparatus includes a first mold and a second mold, a cavity formed by clamping the first mold and the second mold, and includes a portion where the ratio of a first dimension and a second dimension changes continuously such that a portion where the ratio of the first dimension of a pair of first surfaces, and the second dimension of a pair of second surfaces becomes 1 locates in an intermediate portion of the cavity in a longitudinal direction of the long shape; and a first temperature adjusting circuit that is provided at the first mold and the second mold to adjust a temperature within a range where the second dimension of the second surfaces is greater than the first dimension of the first surfaces such that the temperature of the pair of first surfaces becomes higher than the temperature of the pair of second surfaces.

摘要翻译： 注射成型装置包括第一模具和第二模具，通过夹持第一模具和第二模具而形成的空腔，并且包括第一尺寸和第二尺寸的比例连续变化的部分，使得比例 一对第一表面的第一尺寸，一对第二表面的第二尺寸变为1，沿着长形状的纵向方向位于空腔的中间部分; 以及第一温度调节电路，其设置在所述第一模具和所述第二模具处，以将所述第二表面的所述第二尺寸的尺寸大于所述第一表面的所述第一尺寸的范围内的温度调节， 第一表面变得高于一对第二表面的温度。