摘要:
Pyrimidine-5-carboxamide derivatives represented by a general formula (I) or salts thereof [wherein each symbol has the following meaning; X: O, S, NR1, CO, NR1CO, CONR1, C═N—OR1 or a bond, Y: a lower alkylene group which may be substituted by OR1 or —NHR1, or a bond, Z: O, NR2 or a bond, A: H, or a lower alkyl which may have a substituent, a —CO-lower alkyl which may have a substituent, an aryl which may have a substituent, a heteroaryl which may have a substituent, a cycloalkyl which may have a substituent or a nitrogen-containing saturated heterocyclic group which may have a substituent, B: an aryl which may have a substituent or a heteroaryl group which may have a substituent, R1, R2: H, a lower alkyl or a —CO-lower alkyl group].
摘要:
A nitrogen-containing six-membered heterocyclic compound having substituents —X—A—R3, —N(R1)-(Ph substituted by R2), and —CONH2, a salt thereof, a prodrug thereof, and a Syk inhibitor containing the same as an active ingredient. (In the formula, A: a (substituted) lower alkylene, a (substituted) arylene, or the like; X: NR4, CONR4, NR4CO, O, or S; R1, R4: H, a lower alkyl, —CO-lower alkyl, or —SO2-lower alkyl; R2: H, a (substituted) lower alkyl, —O-lower alkyl, —S-lower alkyl, —O-aryl, nitro, cyano, or the like; R3: —CO2H, —CO2-lower alkyl, -lower alkylene-CO2H, —NH2, -alkylene-NH2 or the like.
摘要翻译:具有取代基-XAR 3,-N(R 1) - (Ph被R 2取代的)的含氮六元杂环化合物和-CONH 2,其盐,其前药和 含有与活性成分相同的Syk抑制剂。 (式中,A:(取代的)低级亚烷基,(取代的)亚芳基等; X:NR 4,CONR 4,NR 4 CO,O或S; R 1 R 4:H,低级烷基,-CO-低级烷基或-SO 2 - 低级烷基; R 2:H,(取代的)低级烷基,-O-低级烷基,-S-低级 烷基,-O-芳基,硝基,氰基等; R 3:-CO 2 H,-CO 2 - 低级烷基, - 低级亚烷基-CO 2 H,-NH 2, - 亚烷基-NH 2等。
摘要:
A neural network type of apparatus is provided to detect an internal state of a secondary battery implemented in a battery system. The apparatus comprises a detecting unit, producing unit and estimating unit. The detecting unit detects electric signals indicating an operating state of the battery. The producing unit produces, using the electric signals, an input parameter required for estimating the internal state of the battery. The input parameter reflects calibration of a present charged state of the battery which is attributable to at least one of a present degraded state of the battery and a difference in types of the battery. The estimating unit estimates an output parameter indicating the charged state of the battery by applying the input parameter to neural network calculation.
摘要:
An optical head for a recording device in which data are recorded on a recording surface of an optical memory disk, comprises, a head body which is substantially prevented from moving perpendicularly to the recording surface and is movable to be positioned roughly along the recording surface, an object lens for focussing a light beam on the recording surface, a carriage on which the object lens is mounted and which is movable to be positioned precisely along the recording surface, a drive base member for generating a force substantially parallel to the recording surface between the drive base member and the carriage to position precisely the carriage along the recording surface, and an elastic member for connecting the drive base member to the head body to support the drive base member relative to the head body elastically in a direction substantially parallel to the recording surface, joining areas between the elastic member and the drive base member and between the elastic member and the head body are aligned substantially straightly.
摘要:
A flexible branching apparatus in a superconducting magnetically levitated railway having a U-shaped guideway includes a flexible main beam, which is integrally disposed along the guideway at the center thereof and has cross-sectional rigidity that gradually decreases from a fixed end to a distal end thereof, the main beam consisting of paramagnetic steel; cross beams integrated with the main beam and consisting of paramagnetic steel; runway concrete panels laid between the cross beams and supported so as not to possess transverse rigidity; short-span concrete panels connected to vertical portions of the cross beams by hinge support means, the short-span concrete panels having ground coils mounted thereon and constructing side walls for guidance; a driving device for driving the distal end of the main beam so as to be capable of forming the main beam into an alignment that does not fall below a minimum radius of curvature decided from an acceleration level for riding comfort; and a stopping device and locking device for restraining movement of the main beam upon completion of movement of the distal end thereof. Despite the fact that the guideway is U-shaped, bending into a planned alignment can be performed merely by driving a single location, namely the distal end portion.
摘要:
A paper coating composition comprising (A) a pigment as a main ingredient and (B) a binder for said pigment which is either (a) an alkali decomposition product of a yeast or (b) a mixture of said alkali decomposition product of a yeast and an emulsion of a synthetic polymer and/or an aqueous solution of a natural or snythetic polymer and the paper coating composition coated paper product are disclosed.
摘要:
There is provided a two-dimensional position control method which carries out two-dimensional position control fast at a minimum wobbling frequency. The method includes a step of oscillating at least either a space propagation energy distributed in a substantially limited range on a predetermined two-dimensional plane or energy input system to which the energy is input such that a locus of a relative movement thereof forms an ellipse on the two-dimensional plane, a step of detecting energies at least two pairs of points on the elliptic locus on both sides of the center of the ellipse, and a step of calculating differences between the detected energies at the respective pairs of points, thereby detecting a displacement between the energy and the energy input system on the two-dimensional plane.
摘要:
A simple and inexpensive method of forming a film on a wire or strip material by immersing it in a solution bath containing a film-treating component, and then draining liquid off, and an apparatus thereof are disclosed. The time from taking out the material from the solution bath to completing liquid draining is not less than 4 times the immersion time in the solution bath to thereby improve drawability.
摘要:
The invention relates to a tape transport mechanism in which two reels are respectively driven by different motors, thereby transporting a magnetic tape from one reel to another reel by passing through the portion of a read/write head without any variation in tension. At the initial stage to transport the magnetic tape, an acceleration time from a stop state of the tape until a tape speed reaches a reference speed and an average tension deviation to be applied to the magnetic tape during this time are obtained. Correction values to correct variations in run characteristics of two reel drive systems are calculated by use of the acceleration time and the average tension deviation. Upon next and the subsequent magnetic tape transport, currents to be supplied to the motors to drive two reels are controlled by use of the drive current command values corrected by those correction values.
摘要:
Novel compounds having the general formula: ##STR1## wherein R is selected from hydrogen and methyl, effectively inhibit the growth of cancerous cells. These compounds are useful as carcinostatic agents.