公开(公告)号：US06180801B2

公开(公告)日：2001-01-30

申请号：US09277941

申请日：1999-03-29

申请人： Hiroyuki Monzen ,  Hideo Miyata ,  Kimitaka Ooshiro ,  Kohei Morikawa

发明人： Hiroyuki Monzen ,  Hideo Miyata ,  Kimitaka Ooshiro ,  Kohei Morikawa

IPC分类号： C07D31102

CPC分类号： C07D311/76

摘要： The present invention intends to provide a method for producing 3-isochromanones represented by formula (II) useful as a synthetic starting material of medicals or agricultural chemicals and the cyano compound represented by formula (I) by an industrially advantageous method in a high yield. Disclosed herein is a method for manufacturing a 3-isochromanone represented by the following formula (II): (wherein R2, R3, R4 and R5 each independently represents a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group), said method is characterized by comprising the steps of: hydrolyzing a cyano compound represented by formula (I): (wherein R1 represents a hydrogen atom, an alkyl group or an aryl group, and R2, R3, R4 and R5 have the same meanings as defined above) and subjecting the hydrolyzate to intra-molecular cyclization.

摘要翻译： 本发明意在提供一种由工业上有利的方法以高产率制备可用作医药或农药合成原料的式（II）表示的3-异色满酮和由式（I）表示的氰基化合物的方法。 本文公开了一种制备由下式（II）表示的3-异色满酮的方法：其中R2，R3，R4和R5各自独立地表示氢原子，卤原子，烷基或烷氧基），所述 方法的特征在于包括以下步骤：水解由式（I）表示的氰基化合物:(其中R1表示氢原子，烷基或芳基，R2，R3，R4和R5具有与定义相同的含义） 并使水解产物进行分子内环化。