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公开(公告)号：US20130096097A1
公开(公告)日：2013-04-18
申请号：US13702205
申请日：2011-06-07
申请人： Hitoshi Kasai , Hachiro Nakanishi , Koichi Baba , Hidetoshi Oikawa , Tastuya Murakami , Hiroshi Imahori , Misturu Hashida , Isamu Oh
发明人： Hitoshi Kasai , Hachiro Nakanishi , Koichi Baba , Hidetoshi Oikawa , Tastuya Murakami , Hiroshi Imahori , Misturu Hashida , Isamu Oh
IPC分类号： A61K9/10
CPC分类号： A61K9/10 , A61K9/5123 , A61K31/4745 , A61K31/573 , A61K47/55
摘要： [Problem] The purpose of the present invention is to provide organic particles containing pharmaceutical particles of which the particles are small and the particle size distribution is narrow, and a manufacturing method for the same.[Solution] Provided are pharmaceutical multimeric particles of which the particles are small and the particle size distribution is narrow and which are characterized in being obtained by pouring into water a solution of a pharmaceutical multimer dissolved in a water-miscible organic solvent, and a manufacturing method for the pharmaceutical multimeric particles. Pharmaceutical dimeric particles thereof are characterized in being obtained by pouring into water a solution of a compound represented by general formula (I) dissolved in a water-miscible organic solvent.
摘要翻译： 本发明的目的是提供含有粒子小，粒径分布狭窄的药物粒子的有机粒子及其制造方法。 [解决方案]提供了颗粒小且粒度分布窄的药物多聚体颗粒，其特征在于通过将溶解在水混溶性有机溶剂中的药物多聚体的溶液倒入水中而获得， 药物多聚体颗粒的方法。 其特征在于通过将溶解在与水可混溶的有机溶剂中的通式（I）表示的化合物的溶液倒入水中而获得的药物二聚体颗粒。
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公开(公告)号：US20060076298A1
公开(公告)日：2006-04-13
申请号：US10525228
申请日：2003-04-02
申请人： Hachiro Nakanishi , Koichi Baba , Hitoshi Kasai , Hidetoshi Oikawa , Shuji Okada
发明人： Hachiro Nakanishi , Koichi Baba , Hitoshi Kasai , Hidetoshi Oikawa , Shuji Okada
CPC分类号： B01D9/0054 , B01J3/008 , C09B67/0014 , C09B67/0096 , C09B67/0097 , Y02P20/544
摘要： The process for producing highly concentrated nanometer-size fine particles of an organic pigment, which comprises dissolving the organic pigment in an amide solvent, especially an organic solvent comprising at least 50 vol % 1-methyl-2-pyrrodinone, and pouring the resultant organic pigment solution with stirring into a poor solvent which is not compatible with the organic pigment. The pigment may be a quinacridone pigment, phthalocyanine pigment etc. Any atmospheric pressure to a sub-critical and/or supercritical state can be employed as the production conditions.
摘要翻译： 用于生产有机颜料的高度浓缩的纳米尺寸微粒的方法，其包括将有机颜料溶解在酰胺溶剂中，特别是包含至少50体积％1-甲基-2-吡咯烷酮的有机溶剂中，并将所得有机颜料 颜料溶液搅拌成与有机颜料不相容的不良溶剂。 颜料可以是喹吖啶酮颜料，酞菁颜料等。作为生产条件，可以使用亚临界和/或超临界状态的任何大气压。
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公开(公告)号：US07396560B2
公开(公告)日：2008-07-08
申请号：US10487093
申请日：2002-03-18
CPC分类号： C30B7/00
摘要： A method for preparation of inorganic fine particle-organic crystal hybrid fine particle comprising; pouring an organic material having π-conjugated bond as a water soluble solution into aqueous dispersion in which inorganic fine particles of 50 nm or less selected from the compound group consisting of metal fine particles, semi-conductor fine particles, fine particles of inorganic fluorescent material and fine particle of inorganic luminescent material, are dispersed, co-precipitating said inorganic fine particle which forms a core into said organic material which forms a shell in said dispersion and forming shell of fine crystal of said organic material on the surface of the core of said inorganic fine particles of 50 nm or less by controlling the size of said inorganic fine particle and by controlling the adding amount of said organic material.
摘要翻译： 一种制备无机细颗粒 - 有机晶体杂化微粒的方法，包括： 将具有π-共轭键的有机材料作为水溶性溶液浇注到水分散体中，其中选自由金属微粒，半导体细颗粒，无机荧光材料的微粒组成的化合物组中的50nm或更小的无机细颗粒 和无机发光材料的微粒分散，将形成芯的无机细颗粒共沉淀到所述分散体中形成壳的所述有机材料中，并在所述芯的表面上形成所述有机材料的细晶的壳 通过控制所述无机细颗粒的尺寸并控制所述有机材料的添加量，所述无机细颗粒为50nm以下。
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公开(公告)号：US20060039984A1
公开(公告)日：2006-02-23
申请号：US10537497
申请日：2003-07-09
CPC分类号： C08J9/28 , C08J2201/0543 , C08J2201/0546 , C08J2379/08 , C08L79/08
摘要： A method for preparation of porous polyimide microparticles comprising, forming polyamide acid microparticles by pouring polymer solution prepared by dissolving polyamide acid containing 0.5 to 80 weight % of alkali metal salt to polyamide acid by 0.1 to 15 weight % concentration into a poor solvent selected from the group consisting of aliphatic solvents, alicyclic solvents, aromatic solvents, CS2 and mixture of two or more these solvents and the temperature of which is adjusted to the range from −20° C. to 60° C., wherein particle size of said polyamide acid microparticles is adjusted to 50 nm to 10000 nm by controlling the temperature of said poor solvent, pore size of said polyamide acid microparticles is adjusted to the range from 20 nm to 500 nm and porosity of said polyamide acid microparticles is adjusted to the range from 0.1% to 30% by controlling a content or a kind of said alkali metal salt, then treating said polyamide acid microparticles by chemical imidation or thermal imidation, or by thermal imidation after chemical imidation so that the particle size distribution, pore size and porosity of said polyamide acid microparticles can be maintained.
摘要翻译： 一种多孔聚酰亚胺微粒的制备方法，其特征在于，包括：将聚合物溶液倒入聚酰胺酸性微粒中形成聚酰胺酸微粒，所述聚合物溶液是将含有0.5〜80重量％的碱金属盐的聚酰胺酸溶解在0.1〜15重量％浓度的聚酰胺酸中， 由脂族溶剂，脂环族溶剂，芳族溶剂，CS 2和两种或更多种这些溶剂的混合物组成的组，其温度调节至-20℃至60℃。 通过控制所述不良溶剂的温度将所述聚酰胺酸微粒的粒径调整为50nm〜10000nm，将所述聚酰胺酸微粒的孔径调整为20nm〜500nm，将所述聚酰胺酸的孔隙率 通过控制所述碱金属盐的含量或种类将微粒调节至0.1％至30％的范围，然后通过化学酰亚胺化处理所述聚酰胺酸微粒 或热酰亚胺化，或通过化学酰亚胺化后的热酰亚胺化，使得可以维持所述聚酰胺酸微粒的粒度分布，孔径和孔隙率。
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公开(公告)号：US08025930B2
公开(公告)日：2011-09-27
申请号：US12067078
申请日：2006-03-10
IPC分类号： B05D3/00
摘要： A method for fabricating metal-coated organic crystal wherein a reaction of an organic crystal with transition metal salt in alkaline aqueous solution under visible light irradiation, wherein, when energy at the top of valence band of the organic crystal is defined as A (eV) and energy at the bottom of conduction band of the organic crystal is defined as B (eV), redox potential C (V) of transition metal ion or transition metal complex ion, when said transition metal salt is dissolved in the alkaline aqueous solution, these three parameters should satisfy the following relation (1): −A−4.5≧C≧−B−4.5. (1)
摘要翻译： 一种金属包覆的有机晶体的制造方法，其中在可见光照射下，碱性水溶液中的有机晶体与过渡金属盐的反应，其中当有机晶体的价带顶部的能量定义为A（eV） 并且有机晶体的导带底部的能量定义为过渡金属离子或过渡金属配合物离子的B（eV），氧化还原电位C（V），当所述过渡金属盐溶解在碱性水溶液中时，这些 三个参数应满足以下关系式（1）：-A-4.5≥C≥B-4.5。 （1）
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公开(公告)号：US07192477B2
公开(公告)日：2007-03-20
申请号：US10525228
申请日：2003-04-02
申请人： Hachiro Nakanishi , Koich Baba , Hitoshi Kasai , Hidetoshi Oikawa , Shuji Oikawa
发明人： Hachiro Nakanishi , Koich Baba , Hitoshi Kasai , Hidetoshi Oikawa , Shuji Oikawa
CPC分类号： B01D9/0054 , B01J3/008 , C09B67/0014 , C09B67/0096 , C09B67/0097 , Y02P20/544
摘要： The process for producing highly concentrated nanometer-size fine particles of an organic pigment, which comprises dissolving the organic pigment in an amide solvent, especially an organic solvent comprising at least 50 vol % 1-methyl-2-pyrrodinone, and pouring the resultant organic pigment solution with stirring into a poor solvent which is not compatible with the organic pigment. The pigment may be a quinacridone pigment, phthalocyanine pigment etc. Any atmospheric pressure to a sub-critical and/or supercritical state can be employed as the production conditions.
摘要翻译： 用于生产有机颜料的高度浓缩的纳米尺寸微粒的方法，其包括将有机颜料溶解在酰胺溶剂中，特别是包含至少50体积％1-甲基-2-吡咯烷酮的有机溶剂中，并将所得有机颜料 颜料溶液搅拌成与有机颜料不相容的不良溶剂。 颜料可以是喹吖啶酮颜料，酞菁颜料等。作为生产条件，可以使用亚临界和/或超临界状态的任何大气压。
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公开(公告)号：US20090130329A1
公开(公告)日：2009-05-21
申请号：US12067078
申请日：2006-03-10
IPC分类号： C08F2/48
摘要： A method for fabricating metal-coated organic crystal wherein a reaction of an organic crystal with transition metal salt in alkaline aqueous solution under visible light irradiation, wherein, when energy at the top of valence band of the organic crystal is defined as A (eV) and energy at the bottom of conduction band of the organic crystal is defined as B (eV), redox potential C (V) of transition metal ion or transition metal complex ion, when said transition metal salt is dissolved in the alkaline aqueous solution, these three parameters should satisfy the following relation (1): −A−4.5≧C≧−B−4.5 (1)
摘要翻译： 一种金属包覆的有机晶体的制造方法，其中在可见光照射下，碱性水溶液中的有机晶体与过渡金属盐的反应，其中当有机晶体的价带顶部的能量定义为A（eV） 并且有机晶体的导带底部的能量定义为过渡金属离子或过渡金属配合物离子的B（eV），氧化还原电位C（V），当所述过渡金属盐溶解在碱性水溶液中时，这些 三个参数应满足以下关系（1）：<？in-line-formula description =“In-line formula”end =“lead”？> - A-4.5> = C> = - B-4.5（1） ？in-line-formula description =“In-line Formulas”end =“tail”？>
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公开(公告)号：US20070086949A1
公开(公告)日：2007-04-19
申请号：US11471390
申请日：2006-06-20
申请人： Paras Prasad , Koichi Baba , Haridas Pudavar , Indrajit Roy , Tymish Ohulchanskyy , Hachiro Nakanishi , Akito Masuhara , Hitoshi Kasai
发明人： Paras Prasad , Koichi Baba , Haridas Pudavar , Indrajit Roy , Tymish Ohulchanskyy , Hachiro Nakanishi , Akito Masuhara , Hitoshi Kasai
IPC分类号： A61K49/00 , A61K31/555 , A61K31/4745 , A61K31/409
CPC分类号： A61K9/14 , A61K9/146 , A61K31/409 , A61K31/4745 , A61K31/555 , A61K49/0021 , A61K49/0032 , A61K49/0036 , A61K49/0054 , A61K49/0067 , G01N33/5005 , G01N33/52
摘要： This invention provides nanocrystals or polymer doped nanocrystals of hydrophobic organic fluorescent dyes as stable dispersions in an aqueous system. The dispersions can be prepared without stabilizers such as surfactants and the like. The aqueous dispersions of the nanocrystals or the polymer doped nanocrystals can be used for bioimaging.
摘要翻译： 本发明提供疏水性有机荧光染料的纳米晶体或聚合物掺杂的纳米晶体作为水系统中的稳定分散体。 可以在没有稳定剂如表面活性剂等的情况下制备分散体。 纳米晶体或聚合物掺杂纳米晶体的水分散体可用于生物成像。
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9.发明授权Method of concentrating nanoparticles and method of deaggregating aggregated nanoparticles 有权浓缩纳米颗粒的方法和聚集纳米粒子的聚集方法公开(公告)号：US08679341B2
公开(公告)日：2014-03-25
申请号：US11919076
申请日：2006-05-08
IPC分类号： B01D11/02 , B01D17/02 , B01D17/025
CPC分类号： C09B67/0091 , B01D11/0288 , C09B67/0065
摘要： A method of concentrating nanoparticles, having the steps of: adding and mixing an extraction solvent with a nanoparticles-dispersion liquid that nanoparticles are dispersed in a dispersion solvent, thereby concentrating and extracting the nanoparticles into a phase of the extraction solvent, and removing the dispersion solvent by filter-filtrating a liquid of concentrated extract, in which the extraction solvent is substantially incompatible with the dispersion solvent, and the extract solvent can form an interface after the extraction solvent is mixed with the dispersion solvent and left the mixture still; further a method of deaggregating aggregated nanoparticles, having the steps of: applying two or more ultrasonic waves different in frequency to a liquid containing aggregated nanoparticles, and thereby fining and dispersing the aggregated nanoparticles.
摘要翻译： 一种浓缩纳米颗粒的方法，具有以下步骤：将提取溶剂与纳米颗粒分散在分散溶剂中的纳米颗粒分散液相加并混合，从而将纳米颗粒浓缩并萃取到萃取溶剂的相中，并除去分散体 溶剂，其中提取溶剂与分散溶剂基本上不相容，并且萃取溶剂可以在萃取溶剂与分散溶剂混合后形成界面，并将混合物静置; 进一步解聚聚集的纳米颗粒的方法，具有以下步骤：将不同频率的两个或更多个超声波施加到含有聚集的纳米颗粒的液体上，从而使聚集的纳米颗粒澄清和分散。
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10.发明授权Method of concentrating fine particle dispersion and method of recovering fine particle 失效浓缩微粒分散体的方法和回收细粒的方法公开(公告)号：US07732494B2
公开(公告)日：2010-06-08
申请号：US10548407
申请日：2003-08-04
CPC分类号： B01D43/00
摘要： A method for concentration of fine particles dispersed in a dispersion into an ionic liquid comprising, adding an ionic liquid, especially an organic ionic liquid at ordinary temperature, e.g., a salt of 1-butyl-3-methylimidazolium with PF6− to a dilute dispersion of fine particles so as to concentrate the fine particles into the ionic liquid.
摘要翻译： 将分散在分散体中的细颗粒浓缩成离子液体的方法，包括在常温下将离子液体，特别是有机离子液体，例如1-丁基-3-甲基咪唑与PF6-的盐相加至稀的分散体 的细颗粒，以将细颗粒浓缩到离子液体中。
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