公开(公告)号：US5066582A

公开(公告)日：1991-11-19

申请号：US311779

申请日：1989-02-17

申请人： Hitoshi Tsuruta ,  Hideaki Yamada ,  Michihiro Nakamura

发明人： Hitoshi Tsuruta ,  Hideaki Yamada ,  Michihiro Nakamura

IPC分类号： G01N27/416 ,  G01N33/543

CPC分类号： G01N33/5438

摘要： A method for measuring trace amounts of analyte substance(s), which utilize a pH electrode is disclosed. This method is by far simpler than conventional optical detecting systems. The apparatus for practicing the method is also disclosed. By the use of pH electrode, the apparatus is compact, inexpensive and easy to operate, and hence usable in small-size and medium-size hospitals or clinical laboratories and by patient's bedside.

公开(公告)号：US5674696A

公开(公告)日：1997-10-07

申请号：US328057

申请日：1994-10-24

申请人： Michihiro Nakamura ,  Satomi Matsui ,  Keiko Oka ,  Hitoshi Tsuruta

发明人： Michihiro Nakamura ,  Satomi Matsui ,  Keiko Oka ,  Hitoshi Tsuruta

IPC分类号： G01N33/53 ,  G01N27/416 ,  G01N33/543 ,  G01N27/327 ,  G01N33/569

CPC分类号： G01N27/4145 ,  Y10S435/817 ,  Y10S436/806

摘要： There is disclosed an apparatus for the determination of a trace amount of an analyte substance or organism. A substrate solution is brought into contact with a small diameter tube which has captured, at least on its inner surface, a trace amount of an analyte substance or organism. The trace amount has the ability to change the pH of the substrate solution. A pH change following a reaction of a substrate in the substrate solution in the small diameter tube is measured; the apparatus has a cuvette having an inlet and an outlet for the substrate solution, a pH electrode accomodated in the cuvette, a pump for supplying the substrate solution in the cuvette, a positioning structure for positioning, in the cuvette, the small diameter tube with the pH sensitive plane of the pH electrode and spacing the surface and the plane at 1 mm or below from each other, and a sealing structure for maintaining a formed by the outer surface of the small diameter tube accommodated in the cuvette and the inner surface of the cuvette at liquid tight condition.

摘要翻译： 公开了一种用于分析物物质或生物体的痕迹量的测定的装置。 将底物溶液与小直径管接触，其至少在其内表面捕获痕量的被分析物质或生物体。 痕量具有改变的底物溶液的pH的能力。 测量小直径管中底物溶液中底物反应后的pH变化; 该装置具有一个具有用于底物溶液的入口和出口的比色杯，一个容纳在该比色皿中的pH电极，一个用于将该基质溶液供应到该比色杯中的泵，一个定位结构，用于在该小杯中定位该小直径管， pH电极的pH敏感平面，并将表面和平面彼此间隔1mm或1mm以下，并且保持由容纳在反应杯中的小直径管的外表面形成的密封结构， 液体条件下的比色杯。

公开(公告)号：US5556760A

公开(公告)日：1996-09-17

申请号：US381000

申请日：1995-01-31

申请人： Michihiro Nakamura ,  Satomi Matsui ,  Keiko Oka ,  Hitoshi Tsuruta ,  Yoshihiro Koori ,  Takuji Kato ,  Shigeji Ito

发明人： Michihiro Nakamura ,  Satomi Matsui ,  Keiko Oka ,  Hitoshi Tsuruta ,  Yoshihiro Koori ,  Takuji Kato ,  Shigeji Ito

IPC分类号： G01N27/416 ,  A61B10/00 ,  C12M1/34 ,  C12Q1/00 ,  C12Q1/58 ,  A61B5/04

CPC分类号： A61B5/14539 ,  C12Q1/00 ,  C12Q1/58

摘要： A method for assaying an enzyme on a targeted solid body surface, including the steps of contacting an end opening of a thin tube with a targeted solid body surface to form a space between the targeted solid body surface and inner wall surface of the thin tube, supplying a substrate solution into the space to bring the substrate solution in contact with the targeted solid body surface, and determining a pH change of the substrate solution in the space by using a pH electrode; and an apparatus therefor.

摘要翻译： 一种用于测定目标实体表面上的酶的方法，包括以下步骤：使细管的端部开口与目标实体表面接触，以在目标实体表面和细管的内壁表面之间形成空间， 将基材溶液供给到所述空间中，使所述基材溶液与所述目标固体表面接触，并且使用pH电极确定所述空间中的所述基材溶液的pH变化; 及其装置。

公开(公告)号：US20120145563A1

公开(公告)日：2012-06-14

申请号：US13391746

申请日：2010-08-24

申请人： Akira Yamada ,  Michihiro Nakamura ,  Satoshi Mohri ,  Keiji Naruse

发明人： Akira Yamada ,  Michihiro Nakamura ,  Satoshi Mohri ,  Keiji Naruse

IPC分类号： G01N27/414

CPC分类号： G01N27/4167 ,  G01N27/414 ,  H01L2924/13073

摘要： Disclosed are a pH or concentration measuring device and a pH or concentration measuring method which enable measurement in the shortest possible time even in an object to be measured having low buffer capacity. Specifically disclosed are a pH or concentration measuring device and measuring method for measuring the pH or concentration of a sample solution that is an object to be measured, the device being provided with first and second sensors that each output a signal corresponding to the pH or concentration of a solution, an inspection tube that is provided with a first room in which the first sensor is disposed and a second room in which the second sensor is disposed, a feeding means that feeds a baseline solution into the inspection tube, and an injecting means which injects the sample solution into the first room of the inspection tube and brings the sample solution into contact with the first sensor, wherein a vibration means which vibrates the interface between the sample solution stored in the first room and the baseline solution is provided.

摘要翻译： 公开了一种pH或浓度测量装置和pH或浓度测量方法，即使在具有低缓冲容量的被测量物体中也能够在最短的时间内进行测量。 具体公开的是用于测量作为被测量对象物的样品溶液的pH或浓度的pH或浓度测量装置和测量方法，该装置设置有第一和第二传感器，每个传感器输出对应于pH或浓度的信号 解决方案的检查管，设置有设置有第一传感器的第一房间和设置有第二传感器的第二房间的检查管，将基线溶液供给到检查管中的供给单元，以及注入单元 其将样品溶液注入检查管的第一房间，并使样品溶液与第一传感器接触，其中提供振动装置，其振动存储在第一房间中的样品溶液与基线溶液之间的界面。

公开(公告)号：US4568444A

公开(公告)日：1986-02-04

申请号：US724641

申请日：1985-04-18

申请人： Michihiro Nakamura ,  Makoto Yano ,  Hidehiko Ikeya ,  Hiroshi Tsurumi ,  Osamu Kusudo ,  Yoshito Hamamoto

发明人： Michihiro Nakamura ,  Makoto Yano ,  Hidehiko Ikeya ,  Hiroshi Tsurumi ,  Osamu Kusudo ,  Yoshito Hamamoto

IPC分类号： G01N27/401 ,  G01N27/30 ,  G01N27/403 ,  G01N27/50

CPC分类号： G01N27/4035

摘要： An apparatus for measuring the quantities of chemical substances contained in a solution to be assayed by using a chemical-substance sensitive sensor consists of a potentiometric electrode which responds selectively to chemical substances, and a liquid-junction type reference electrode including a tube, a porous thread member housed in the front end opening of the tube and having a pore capacity of 0.2 cc/g or more and at least the surface of which is hydrophilic, a silver-silver chloride wire is provided and housed in the tube so that at one end of the wire is in contact with the thread member and the wire which extends along the tube. The wire is connected to a connector at the other end opening of the tube, an electrical insulating resin fills said tube, at least at the front end portion thereof, for fixing both the silver-silver chloride wire and the thread member by contact therewith and for stopping said tube. An internal solution is retained by suction in said porous thread member. This apparatus is advantageously used for monitoring the living body and may be thermally sterilized.

摘要翻译： 用于测量通过使用化学物质敏感传感器测定的溶液中所含的化学物质的量的装置由选择性地对化学物质作出响应的电位电极和包括管的液体接合型参比电极，多孔 螺纹构件容纳在管的前端开口中，孔容量为0.2cc / g以上，至少其表面为亲水性，银 - 氯化银线被提供并容纳在管中，使得在一个 线的端部与螺纹构件和沿着管延伸的线接触。 导线连接到管的另一端开口处的连接器，电绝缘树脂至少在其前端部填充所述管，用于通过与其接触固定银 - 氯化银线和线构件， 用于停止所述管。 内部溶液通过吸力保持在所述多孔螺纹构件中。 该装置有利地用于监测生物体并且可以被热灭菌。

公开(公告)号：US20100310872A1

公开(公告)日：2010-12-09

申请号：US12734968

申请日：2008-12-08

申请人： Michihiro Nakamura

发明人： Michihiro Nakamura

IPC分类号： B32B5/00 ,  A61K49/00 ,  H01F1/00

CPC分类号： A61K9/1676 ,  C08G77/06 ,  C08G77/20 ,  C08G77/26 ,  C08G77/28 ,  Y10T428/2995

摘要： Provided are nanofunctional silica particles having excellent functionality and quality, and capable of being mass-produced at low costs. According to the present invention, there are provided nanofunctional silica particles including a coating layer containing one or more silica compounds selected from the group consisting of mercaptopropyl trimethoxysilane (MPS), mercaptopropyl triethoxysilane (MPES), mercaptopropyl methyldimethoxysilane (MPDMS), trimethoxy[2-(7-oxabicyclo[4.1.0]-hept-3-yl)ethyl]silane (EpoPS), thiocyanatopropyl triethoxysilane (TCPS), acryloxypropyl trimethoxysilane (ACPS), and aminopropyl trimethoxysilane (APS); and functional particles in the coating layer, and being used in imaging, assay, diagnosis, treatment or the like, medicine or bioresearch.

摘要翻译： 提供具有优异的功能性和质量的纳米官能二氧化硅颗粒，并且能够以低成本批量生产。 根据本发明，提供了纳米官能二氧化硅颗粒，其包括含有一种或多种选自巯基丙基三甲氧基硅烷（MPS），巯基丙基三乙氧基硅烷（MPES），巯基丙基甲基二甲氧基硅烷（MPDMS），三甲氧基[2- （7-氧杂双环[4.1.0]庚基-3-基）乙基]硅烷（EpoPS），硫氰酰丙基三乙氧基硅烷（TCPS），丙烯酰氧基丙基三甲氧基硅烷（ACPS）和氨基丙基三甲氧基硅烷（APS）; 和涂层中的功能性颗粒，用于成像，测定，诊断，治疗等，药物或生物研究。

公开(公告)号：US07826102B2

公开(公告)日：2010-11-02

申请号：US11065005

申请日：2005-02-25

申请人： Michihiro Nakamura

发明人： Michihiro Nakamura

IPC分类号： H04N1/00

CPC分类号： H04N1/00212 ,  H04N1/00209 ,  H04N2201/0017 ,  H04N2201/0018

摘要： A network facsimile system has a communication terminal and relaying server. The network facsimile system is configured such that the communication terminal can transmit an image, through the relaying server, to a destination terminal outside the network facsimile system, that the communication terminal transmits an image to the relaying server in accordance with a predetermined communication protocol. The relaying server transmits an image to the destination terminal in accordance with a facsimile communication protocol. The communication terminal includes a notification system that notifies a user of the communication terminal of an operation status information indicating an operation status of the network facsimile system during a relaying server side operation period.

摘要翻译： 网络传真系统具有通信终端和中继服务器。 网络传真系统被配置为使得通信终端可以通过中继服务器将图像发送到网络传真系统外部的目的地终端，通信终端根据预定的通信协议向中继服务器发送图像。 中继服务器根据传真通信协议将图像发送到目的地终端。 通信终端包括通知系统，其在中继服务器侧操作时段期间通知通信终端的用户指示网络传真系统的操作状态的操作状态信息。

公开(公告)号：US20050190404A1

公开(公告)日：2005-09-01

申请号：US11065005

申请日：2005-02-25

申请人： Michihiro Nakamura

发明人： Michihiro Nakamura

IPC分类号： G06F13/00 ,  H04M11/00 ,  H04N1/00 ,  H04N1/32 ,  G06F15/16

CPC分类号： H04N1/00212 ,  H04N1/00209 ,  H04N2201/0017 ,  H04N2201/0018

摘要： A network facsimile system has a communication terminal and relaying server. The network facsimile system is configured such that the communication terminal can transmit an image, through the relaying server, to a destination terminal outside the network facsimile system, that the communication terminal transmits an image to the relaying server in accordance with a predetermined communication protocol. The relaying server transmits an image to the destination terminal in accordance with a facsimile communication protocol. The communication terminal includes a notification system that notifies a user of the communication terminal of an operation status information indicating an operation status of the network facsimile system during a relaying server side operation period.

摘要翻译： 网络传真系统具有通信终端和中继服务器。 网络传真系统被配置为使得通信终端可以通过中继服务器将图像发送到网络传真系统外部的目的地终端，通信终端根据预定的通信协议向中继服务器发送图像。 中继服务器根据传真通信协议将图像发送到目的地终端。 通信终端包括通知系统，其在中继服务器侧操作时段期间通知通信终端的用户指示网络传真系统的操作状态的操作状态信息。

公开(公告)号：US20050190403A1

公开(公告)日：2005-09-01

申请号：US11064972

申请日：2005-02-25

申请人： Michihiro Nakamura

发明人： Michihiro Nakamura

IPC分类号： G06F13/00 ,  H04M11/00 ,  H04N1/00 ,  H04N1/32 ,  G06F15/16

CPC分类号： H04N1/324 ,  H04N1/00209 ,  H04N1/00212 ,  H04N1/32406 ,  H04N2201/0017 ,  H04N2201/0024

摘要： A network facsimile system including a relaying server and a communication terminal connected through a network. The relaying server has a facsimile communication system, an image data creating system, an information obtaining system, and a relaying server side data communication system. Further, the communication terminal includes a communication terminal side data communication system and an image data processing system. The relaying server includes a status setting system that sets an operational status of the network facsimile system to a receivable state where the communication terminal can receive the image through the relaying server when the communication terminal has become usable by a user of the communication terminal.

摘要翻译： 一种网络传真系统，包括中继服务器和通过网络连接的通信终端。 中继服务器具有传真通信系统，图像数据创建系统，信息获取系统和中继服务器端数据通信系统。 此外，通信终端包括通信终端侧数据通信系统和图像数据处理系统。 中继服务器包括状态设置系统，其将网络传真系统的操作状态设置为可通信状态，其中当通信终端已经被通信终端的用户使用时，通信终端可以通过中继服务器接收图像。

公开(公告)号：US4736748A

公开(公告)日：1988-04-12

申请号：US034026

申请日：1987-04-03

申请人： Michihiro Nakamura ,  Makoto Yano

发明人： Michihiro Nakamura ,  Makoto Yano

IPC分类号： G01N33/49 ,  A61B5/145 ,  G01N27/28 ,  G01N33/487 ,  A61B5/00

CPC分类号： G01N33/4925

摘要： A blood component monitoring system for monitoring chemical substances of interest in blood, which includes a transfusion circuit including a flow-through cell adapted to be fluid-connected with a blood vessel through an indwelling catheter, a reservoir for accommodating a quantity of physiologically compatible sensor correcting solution, a connecting tubing extending between the reservoir and the flow-through cell and a transfusion pump; a detector unit including a temperature sensor and a chemical sensitive sensor device both incorporated inside the flow-through cell. A transfusion pump drive circuit is provided for controlling operation of the transfusion pump, a sensor drive circuit is provided for driving the temperature sensor and the chemical sensitive sensor device, a processing unit is provided for controlling both of the transfusion pump drive circuit and the sensor drive circuit and for reading respective outputs from the temperature sensor and the chemical sensitive sensor device and converting the outputs into respective measured values, and an output device is provided for externally outputting the measured values.

摘要翻译： 一种血液成分监测系统，用于监测血液中感兴趣的化学物质，其包括输血回路，其包括适于通过留置导管与血管流体连接的流通细胞，用于容纳一定数量的生理学上相容的传感器 校正溶液，在储存器和流通池之间延伸的连接管和输血泵; 包括温度传感器和化学敏感传感器装置的检测器单元，两者都并入流通池内。 提供输液泵驱动电路，用于控制输液泵的运行，设置传感器驱动电路用于驱动温度传感器和化学敏感传感器装置，提供一个处理单元，用于控制输血泵驱动电路和传感器 并且用于从温度传感器和化学敏感传感器装置读取各个输出，并将输出转换成各自的测量值，并且输出装置用于从外部输出测量值。