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    SYSTEM FOR SIMULATING LUNG FUNCTION
    1.
    发明申请
    SYSTEM FOR SIMULATING LUNG FUNCTION 审中-公开
    模拟肺功能的系统

    公开(公告)号：US20140315175A1

    公开(公告)日：2014-10-23

    申请号：US13748346

    申请日：2013-01-23

    申请人： Hoang Nguyen ,  Ryan Olivera ,  Alex Yang ,  Sri Radhakrishnan ,  Steve Wallace ,  Surag Mantri ,  Greg Pulido ,  Ramon Estrada

    发明人： Hoang Nguyen ,  Ryan Olivera ,  Alex Yang ,  Sri Radhakrishnan ,  Steve Wallace ,  Surag Mantri ,  Greg Pulido ,  Ramon Estrada

    IPC分类号： G09B23/32

    CPC分类号： G09B23/32 ,  G09B23/30

    摘要： A system for simulating a breathing lung is disclosed. The system comprises a lung model contained within an enclosure, wherein a main bronchus of the lung model is open to ambient air. In one embodiment, the system also comprises a vacuum pump connected to the enclosure, a first normally closed 2-way valve connected to the enclosure, a flow controller connected to both the vacuum pump and the enclosure, and a timer connected to the first normally closed 2-way valve. In alternative embodiments, the system comprises a first pump connected to the enclosure and a second pump connected to the enclosure, wherein the first and second pumps work independently of each other, and wherein the first pump is a vacuum pump, and the second pump is either a peristaltic pump or a piston pump.

    摘要翻译： 公开了一种用于模拟呼吸肺的系统。 该系统包括包含在外壳内的肺模型，其中肺模型的主支气管对环境空气开放。 在一个实施例中，系统还包括连接到外壳的真空泵，连接到外壳的第一常闭二通阀，连接到真空泵和外壳的流量控制器以及连接到第一正常的定时器 关闭二通阀。 在替代实施例中，系统包括连接到外壳的第一泵和连接到外壳的第二泵，其中第一和第二泵彼此独立地工作，并且其中第一泵是真空泵，第二泵是 蠕动泵或活塞泵。

    METHODS AND SYSTEMS FOR ENDOBRONCHIAL DIAGNOSTICS
    4.
    发明申请
    METHODS AND SYSTEMS FOR ENDOBRONCHIAL DIAGNOSTICS 审中-公开
    内分泌诊断的方法与系统

    公开(公告)号：US20110295141A1

    公开(公告)日：2011-12-01

    申请号：US12954499

    申请日：2010-11-24

    申请人： Srikanth Radhakrishnan ,  Ryan Olivera ,  Niyazi Beyhan ,  Surag Mantri ,  Lutz Freitag

    发明人： Srikanth Radhakrishnan ,  Ryan Olivera ,  Niyazi Beyhan ,  Surag Mantri ,  Lutz Freitag

    IPC分类号： A61B5/08

    CPC分类号： A61B5/082

    摘要： A method for assessing lung function in a patient is disclosed. The method comprises isolating a lung compartment. Thereafter, in one embodiment, an inhaled gas of known composition is introduced into the lung and compared to the composition of the exhaled gas. Alternatively, accumulated CO2 content is measured within the isolated lung compartment over time, and compared to a baseline CO2 content. Alternatively, a change in pressure of an isolated lung compartment may be monitored. Alternatively, the magnitude of the range of CO2 values in an isolated lung compartment can be compared to a predetermined threshold. Any of the results obtained via these alternative embodiments may be used to determine lung function.

    摘要翻译： 公开了一种用于评估患者的肺功能的方法。 该方法包括分离肺隔室。 此后，在一个实施方案中，将已知组合物的吸入气体引入肺中并与呼出气体的组成进行比较。 或者，随着时间的推移在隔离的肺隔室内测量累积的CO 2含量，并与基线CO 2含量进行比较。 或者，可以监测隔离的肺隔室的压力变化。 或者，可以将隔离的肺隔室中的CO 2值的范围的大小与预定阈值进行比较。 通过这些替代实施方案获得的任何结果可用于确定肺功能。

    MEASURING LUNG FUNCTION AND LUNG DISEASE PROGRESSION AT A LOBAR/SEGMENTAL LEVEL
    6.
    发明申请
    MEASURING LUNG FUNCTION AND LUNG DISEASE PROGRESSION AT A LOBAR/SEGMENTAL LEVEL 有权
    测量肺功能和肺功能障碍进展

    公开(公告)号：US20110313307A1

    公开(公告)日：2011-12-22

    申请号：US12964515

    申请日：2010-12-09

    申请人： Srikanth Radhakrishnan ,  Surag Mantri ,  Ryan Olivera

    发明人： Srikanth Radhakrishnan ,  Surag Mantri ,  Ryan Olivera

    IPC分类号： A61B5/085

    CPC分类号： A61B5/085 ,  A61B5/087 ,  A61B5/097 ,  A61B5/6853 ,  A61B5/7278 ,  A61B2562/0247

    摘要： A method for determining lung function in a patient is disclosed, in which a multi-lumen catheter with an expandable occluding element at its end is used to isolate a targeted lung compartment, and respiratory characteristics at the targeted lung compartment are measured over multiple respiratory cycles. The relation between various characteristics of the respiratory cycle is used to determine compliance of lung tissue within the targeted lung compartment.

    摘要翻译： 公开了一种用于确定患者的肺功能的方法，其中使用其末端具有可扩张闭塞元件的多腔导管来分离靶向的肺隔室，并且在多个呼吸循环中测量目标肺隔室处的呼吸特征 。 呼吸周期的各种特征之间的关系用于确定目标肺隔室内肺组织的依从性。

    Double balloon catheter and methods for homogeneous drug delivery using the same
    9.
    发明授权
    Double balloon catheter and methods for homogeneous drug delivery using the same 有权
    双气囊导管和使用其同质药物递送的方法

    公开(公告)号：US08603064B2

    公开(公告)日：2013-12-10

    申请号：US13446400

    申请日：2012-04-13

    申请人： Neil Hattangadi ,  Daniel Lerner ,  Ryan Olivera

    发明人： Neil Hattangadi ,  Daniel Lerner ,  Ryan Olivera

    IPC分类号： A61M31/00

    CPC分类号： A61M25/1011 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61M25/007 ,  A61M2025/1052

    摘要： The present disclosure is directed to a catheter for site-specific delivery of a therapeutic agent to a blood vessel of a patient. The catheter further includes an elongated shaft having at least one inner lumen, a distal end and a proximal end and proximal and distal vessel-conforming balloons where each is separately positionable and inflatable, and when inflated, substantially restricts blood flow in the vessel and creates a treatment window of a defined but variable length for delivery of the therapeutic agent. The catheter optionally includes at least one marker band adjacent to the proximal balloon and at least one marker band adjacent to the distal balloon. At least one lateral aperture positioned in the window is in fluid communication with a drug delivery conduit located within either the inner shaft or the outer shaft to provide a homogeneous concentration of the therapeutic agent to the window.

    摘要翻译： 本公开涉及用于将治疗剂的位点特异性递送给患者的血管的导管。 导管还包括细长轴，其具有至少一个内腔，远端和近端以及近端和远侧容器构造的气囊，其中每个气囊均可分开定位和充气，并且当充气时，基本上限制血管中的血流并产生 用于递送治疗剂的具有限定但可变长度的治疗窗。 导管可选地包括与近端球囊相邻的至少一个标记带和与远端球囊相邻的至少一个标记带。 定位在窗口中的至少一个侧向孔与位于内轴或外轴内的药物输送导管流体连通，以提供治疗剂到窗口的均匀浓度。

    DOUBLE BALLOON CATHETER AND METHODS FOR HOMOGENEOUS DRUG DELIVERY USING THE SAME
    10.
    发明申请
    DOUBLE BALLOON CATHETER AND METHODS FOR HOMOGENEOUS DRUG DELIVERY USING THE SAME 有权
    双重气泡导管及使用其的均质药物递送方法

    公开(公告)号：US20100082012A1

    公开(公告)日：2010-04-01

    申请号：US12564771

    申请日：2009-09-22

    申请人： Neil Hattangadi ,  Daniel Lerner ,  Ryan Olivera

    发明人： Neil Hattangadi ,  Daniel Lerner ,  Ryan Olivera

    IPC分类号： A61M25/10

    CPC分类号： A61M25/1011 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61M25/007 ,  A61M2025/1052

    摘要： The invention, in one embodiment, is directed to a catheter for site-specific delivery of a therapeutic agent to a blood vessel of a patient. The catheter further includes an elongated shaft having at least one inner lumen, a distal end and a proximal end and proximal and distal vessel-conforming balloons where each is separately positionable and inflatable, and when inflated, substantially restricts blood flow in the vessel and creates a treatment window of a defined but variable length for delivery of the therapeutic agent. The catheter optionally includes at least one marker band adjacent to the proximal balloon and at least one marker band adjacent to the distal balloon. At least one lateral aperture positioned in the window is in fluid communication with a drug delivery conduit located within either the inner shaft or the outer shaft to provide a homogeneous concentration of the therapeutic agent to the window.

    摘要翻译： 在一个实施方案中，本发明涉及用于将治疗剂的位点特异性递送给患者的血管的导管。 导管还包括细长轴，其具有至少一个内腔，远端和近端以及近端和远侧容器构造的气囊，其中每个气囊均可分开定位和充气，并且当充气时，基本上限制血管中的血流并产生 用于递送治疗剂的具有限定但可变长度的治疗窗。 导管可选地包括与近端球囊相邻的至少一个标记带和与远端球囊相邻的至少一个标记带。 定位在窗口中的至少一个侧向孔与位于内轴或外轴内的药物输送导管流体连通，以提供治疗剂到窗口的均匀浓度。