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![PROCESS FOR THE PREPARATION OF (9S)-2-BROMO-9-(2,3,4-TRIFLUOROPHENYL)-6,7,8,9-TETRAHYDRO-5H-[1,2,4]TRIAZOLO[1,5-A]AZEPINE](/abs-image/US/2023/02/16/US20230048657A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230048657A1
公开(公告)日：2023-02-16
申请号：US17780127
申请日：2020-11-27
发明人： Weichun CHEN , Christian JENNY , Hasane RATNI , Guocai ZHANG , Fugui ZHANG
IPC分类号： C07D487/04 , C07C213/08 , C07C215/34 , C07C57/58 , C07C51/353 , C07C51/41 , C07C51/60 , C07C277/08
摘要： The present invention relates to a process for synthesizing large scale a compound of formula (I), or pharmacuetically acceptable salt thereof, which is useful as the key intermediate for the synthesis of compounds for prophylaxis and treatment of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.
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公开(公告)号：US20190321440A1
公开(公告)日：2019-10-24
申请号：US16389292
申请日：2019-04-19
发明人： Konrad BLEICHER , Daniella CHEANG , Patrick DI GIORGIO , Taishan HU , Christian JENNY , Patrizio MATTEI , Petra SCHMITZ , Theodor STOLL
摘要： The present invention provides compounds of formula (I) wherein X1, X2, R1 to R6 and A are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by bacteria.
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