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公开(公告)号：US09938340B2
公开(公告)日：2018-04-10
申请号：US14877475
申请日：2015-10-07
发明人： Herbert Andres , David Casagolda Vallribera , Hartmut Duefel , Michael Gerg , Christian Scholz , Michael Schraeml
IPC分类号： C07K16/22 , C12N9/90 , C07K16/12 , G01N33/74 , C07K16/40 , G01N33/573 , C07K14/475 , C07K14/65
CPC分类号： C07K16/22 , C07K14/475 , C07K14/65 , C07K16/1203 , C07K16/40 , C07K2317/34 , C07K2317/565 , C07K2317/92 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/23 , C07K2319/24 , C07K2319/35 , C07K2319/41 , C07K2319/43 , C12N9/90 , C12Y502/01008 , G01N33/573 , G01N33/74 , G01N2333/99
摘要： Herein is reported a fusion polypeptide according to formula I NH2—S2—X1—S1—COOH (formula I) wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and — denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide.
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公开(公告)号：US20140186358A1
公开(公告)日：2014-07-03
申请号：US14073149
申请日：2013-11-06
发明人： Birgit Bossenmaier , David Casagolda Vallribera , Guy Georges , Michael Gerg , Gerhard Niederfellner , Christian Scholz , Michael Schraeml
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6855 , C07K14/195 , C07K14/71 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/70 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00 , C07K2319/55 , C07K2319/70
摘要： The invention relates to anti-HER3 antigen binding proteins, e.g. anti-HER3 antibodies, that bind to the beta-hairpin of HER3, methods for selecting these antigen binding proteins, their preparation and use as medicament.
摘要翻译： 本发明涉及抗HER3抗原结合蛋白，例如， 抗HER3抗体，其结合HER3的β-发夹，选择这些抗原结合蛋白的方法，其制备和用作药物。
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3.发明申请ANTI-HER3/HER4 ANTIBODIES BINDING TO THE BETA-HAIRPIN OF HER3 AND THE BETA-HAIRPIN OF HER4 有权抗HER3 / HER4抗体与HER3的BETA-HAIRPIN和HER4的BETA-HAIRPIN结合公开(公告)号：US20140186354A1
公开(公告)日：2014-07-03
申请号：US14073137
申请日：2013-11-06
发明人： Birgit Bossenmaier , Guy Georges , Michael Gerg , Gerhard Niederfellner , Christian Scholz , Michael Schraeml
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K47/6803 , A61K47/6829 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/75 , C07K2317/77
摘要： The invention relates to anti-HER3/HER4 antigen binding proteins, e.g. anti-HER3/HER4 antibodies, that bind to the beta-hairpin of HER3 and the beta-hairpin of HER4, methods for selecting these antigen binding proteins, their preparation and use as medicament.
摘要翻译： 本发明涉及抗HER3 / HER4抗原结合蛋白，例如 抗HER3 / HER4抗体，其结合HER3的β发夹和HER4的β-发夹，选择这些抗原结合蛋白的方法，其制备和用作药物。
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4.发明授权公开(公告)号：US10364290B2
公开(公告)日：2019-07-30
申请号：US15668396
申请日：2017-08-03
发明人： Birgit Bossenmaier , Guy Georges , Michael Gerg , Gerhard Niederfellner , Christian Scholz , Michael Schraeml
摘要： The invention relates to anti-HER3/HER4 antigen binding proteins, e.g. anti-HER3/HER4 antibodies, that bind to the beta-hairpin of HER3 and the beta-hairpin of HER4, methods for selecting these antigen binding proteins, their preparation and use as medicament.
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5.发明申请公开(公告)号：US20180118837A1
公开(公告)日：2018-05-03
申请号：US15668396
申请日：2017-08-03
发明人： Birgit Bossenmaier , Guy Georges , Michael Gerg , Gerhard Niederfellner , Christian Scholz , Michael Schraeml
CPC分类号： C07K16/2863 , A61K47/6803 , A61K47/6829 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/75 , C07K2317/77
摘要： The invention relates to anti-HER3/HER4 antigen binding proteins, e.g. anti-HER3/HER4 antibodies, that bind to the beta-hairpin of HER3 and the beta-hairpin of HER4, methods for selecting these antigen binding proteins, their preparation and use as medicament.
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公开(公告)号：US10647765B2
公开(公告)日：2020-05-12
申请号：US15924110
申请日：2018-03-16
发明人： Herbert Andres , David Casagolda Vallribera , Hartmut Duefel , Michael Gerg , Christian Scholz , Michael Schraeml
IPC分类号： A61K39/00 , C07K16/22 , C07K16/12 , C12N9/90 , G01N33/74 , C07K16/40 , G01N33/573 , C07K14/475 , C07K14/65
摘要： Herein is reported a fusion polypeptide according to formula I NH2—S2—X1—S1—COOH (formula I) wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and — denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide.
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公开(公告)号：US20180094062A1
公开(公告)日：2018-04-05
申请号：US15668405
申请日：2017-08-03
发明人： Birgit Bossenmaier , David Casagolda Vallribera , Guy Georges , Michael Gerg , Gerhard Niederfellner , Christian Scholz , Michael Schraeml
IPC分类号： C07K16/28 , A61K47/68 , C07K14/71 , C07K14/195 , C07K16/32
CPC分类号： C07K16/2863 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6855 , C07K14/195 , C07K14/71 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/70 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00 , C07K2319/55 , C07K2319/70
摘要： The invention relates to anti-HER3 antigen binding proteins, e.g. anti-HER3 antibodies, that bind to the beta-hairpin of HER3, methods for selecting these antigen binding proteins, their preparation and use as medicament.
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公开(公告)号：US09725512B2
公开(公告)日：2017-08-08
申请号：US14073149
申请日：2013-11-06
发明人： Birgit Bossenmaier , David Casagolda Vallribera , Guy Georges , Michael Gerg , Gerhard Niederfellner , Christian Scholz , Michael Schraeml
IPC分类号： A61K39/395 , C07K16/28 , C07K16/32 , C07K14/195 , A61K47/48 , C07K14/71
CPC分类号： C07K16/2863 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6855 , C07K14/195 , C07K14/71 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/70 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00 , C07K2319/55 , C07K2319/70
摘要： The invention relates to anti-HER3 antigen binding proteins, e.g. anti-HER3 antibodies, that bind to the beta-hairpin of HER3, methods for selecting these antigen binding proteins, their preparation and use as medicament.
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9.发明授权公开(公告)号：US09725511B2
公开(公告)日：2017-08-08
申请号：US14073137
申请日：2013-11-06
发明人： Birgit Bossenmaier , Guy Georges , Michael Gerg , Gerhard Niederfellner , Christian Scholz , Michael Schraeml
IPC分类号： A61K39/395 , C07K16/28 , C07K16/32 , A61K47/48 , A61K39/00
CPC分类号： C07K16/2863 , A61K47/6803 , A61K47/6829 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/75 , C07K2317/77
摘要： The invention relates to anti-HER3/HER4 antigen binding proteins, e.g. anti-HER3/HER4 antibodies, that bind to the beta-hairpin of HER3 and the beta-hairpin of HER4, methods for selecting these antigen binding proteins, their preparation and use as medicament.
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公开(公告)号：US20160138004A1
公开(公告)日：2016-05-19
申请号：US14877475
申请日：2015-10-07
发明人： Herbert Andres , David Casagolda Vallribera , Hartmut Duefel , Michael Gerg , Christian Scholz , Michael Schraeml
IPC分类号： C12N9/90 , G01N33/573 , C07K14/65 , C07K14/475 , C07K16/40 , C07K16/22
CPC分类号： C07K16/22 , C07K14/475 , C07K14/65 , C07K16/1203 , C07K16/40 , C07K2317/34 , C07K2317/565 , C07K2317/92 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/23 , C07K2319/24 , C07K2319/35 , C07K2319/41 , C07K2319/43 , C12N9/90 , C12Y502/01008 , G01N33/573 , G01N33/74 , G01N2333/99
摘要： Herein is reported a fusion polypeptide according to formula I NH2—S2—X1—S1—COOH (formula I) wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and — denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide.
摘要翻译： 本文报道了根据式I的融合多肽，NH2-S2-X1-S1-COOH（式I），其中X1包含随机氨基酸序列或衍生自第一多肽的氨基酸序列，S2和S1不重叠 衍生自第二多肽的氨基酸序列和 - 表示肽键，其中第二多肽是具有肽基 - 脯氨酰顺/反异构酶活性（PPIase活性）或衍生自FKBP-折叠域家族的多肽，其中X1 被插入代替第二多肽的插入片段结构域。
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