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公开(公告)号：US20230119360A1
公开(公告)日：2023-04-20
申请号：US17843740
申请日：2022-06-17
发明人： Lu GAO , Yonghong ZHU , Søren OTTOSEN , Henrik MUELLER , Xue ZHOU , Julie Elisabeth Françoise BLAISING , Yuyan JIN , Qingyan BO , Gaurav TYAGI
IPC分类号： A61K31/519 , A61K48/00 , A61P31/20
摘要： The present invention is directed to compositions and methods for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of a therapeutic oligonucleotide targeting HBV and a TLR7 agonist for use in the treatment of a chronic hepatitis B patient.
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公开(公告)号：US20230123601A1
公开(公告)日：2023-04-20
申请号：US17843774
申请日：2022-06-17
发明人： Søren OTTOSEN , Henrik MUELLER
IPC分类号： A61K31/522 , A61P31/18
摘要： The present invention is directed to compositions and methods for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of certain antiviral compounds and immune modulator compounds.
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3.发明申请公开(公告)号：US20190216846A1
公开(公告)日：2019-07-18
申请号：US16310789
申请日：2017-06-19
IPC分类号： A61K31/7125 , C12N15/113 , A61P31/20
CPC分类号： C12Q1/706 , A61K31/4745 , A61K31/519 , A61K31/7125 , A61P31/14 , A61P31/20 , C07K16/40 , C07K2317/732 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12Q1/6883
摘要： The present invention relates to a method for identifying a compound that prevents, ameliorates and/or inhibits a hepatitis B virus (HBV) infection, wherein a compound that reduces the expression and/or activity of PAP associated domain containing 5 (PAPD5) and/or PAP associated domain containing 7 (PAPD7) is identified as a compound that prevents, ameliorates and/or inhibits a HBV infection. The invention also provides for inhibitors of PAPD5 or PAPD7 for use in treating and/or preventing a HBV infection; as well as a combined preparation comprising an inhibitor of PAPD5 and an inhibitor of PAPD7 for simultaneous or sequential use in the treatment or prevention of a HBV infection. Also comprised in the present invention is a pharmaceutical composition for use in the treatment and/or prevention of a HBV infection, and a method for monitoring the therapeutic success during the treatment of a HBV infection.
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公开(公告)号：US20220096527A1
公开(公告)日：2022-03-31
申请号：US17542358
申请日：2021-12-03
发明人： Xingchun HAN , Hassan JAVANBAKHT , Henrik MUELLER , Yongguang WANG , Song YANG
IPC分类号： A61K31/7125 , C12Q1/6883 , C12N15/113 , C12Q1/70 , A61P31/14 , A61K31/4745 , A61K31/519 , C07K16/40 , A61P31/20
摘要： The present invention relates to a method for identifying a compound that prevents, ameliorates and/or inhibits hepatitis B virus (HBV) infections. The compound (i) reduces the expression and/or activity of PAP associated domain containing 5 (PAPD5) and/or PAP associated domain containing 7 (PAPD7); and/or (ii) binds to PAPD5 and/or PAPD7 and inhibits 5 propagation of HBV; and is identified as a compound that prevents, ameliorates and/or inhibits HBV infections. An inhibitor of PAPD5 and/or PAPD7 for use in treating and/or preventing HBV infections; as well as a combined preparation comprising an inhibitor of PAPD5 and an inhibitor of PAPD7 for simultaneous or sequential use in the treatment or prevention of HBV infections is also provided. The present invention includes a 10-pharmaceutical composition for use in treatment and/or prevention of HBV infections, and a method for monitoring therapeutic success during treatment of HBV infections.
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公开(公告)号：US20190194768A1
公开(公告)日：2019-06-27
申请号：US16310765
申请日：2017-06-19
发明人： Xingchun HAN , Hassan JAVANBAKHT , Henrik MUELLER , Yongguang WANG , Song YANG
IPC分类号： C12Q1/70 , C07K16/40 , A61K31/4745 , A61K31/519 , C12N15/113 , A61P31/14 , C12Q1/6883
CPC分类号： C12Q1/706 , A61K31/4745 , A61K31/519 , A61P31/14 , C07K16/40 , C07K2317/732 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12Q1/6883
摘要： The present invention relates to a method for identifying a compound that prevents, ameliorates and/or inhibits a hepatitis B virus (HBV) infection, wherein a compound that (i) reduces the expression and/or activity of PAP associated domain containing 5 (PAPD5) and/or PAP associated domain containing 7 (PAPD7); and/or (ii) binds to PAPD5 and/or PAPD7 and inhibits 5 propagation of HBV; is identified as a compound that prevents, ameliorates and/or inhibits a HBV infection. The invention also provides for an inhibitor of PAPD5 and/or PAPD7 for use in treating and/or preventing a HBV infection; as well as a combined preparation comprising an inhibitor of PAPD5 and an inhibitor of PAPD7 for simultaneous or sequential use in the treatment or prevention of a HBV infection. Also comprised in the present invention is a 10 pharmaceutical composition for use in the treatment and/or prevention of a HBV infection, and a method for monitoring the therapeutic success during the treatment of a HBV infection.
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