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公开(公告)号：US11713327B2
公开(公告)日：2023-08-01
申请号：US17251494
申请日：2019-06-11
Applicant: Hoffmann-La Roche Inc.
Inventor： Fabian Dey , Buyu Kou , Haixia Liu , Hong Shen , Xiaoqing Wang , Weixing Zhang , Zhisen Zhang , Zhiwei Zhang , Wei Zhu
IPC: C07D519/00 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/10
CPC classification number: C07D519/00 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/10
Abstract: The present invention relates to compounds of formula (I), ab (I), wherein R1 to R3 and L are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
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公开(公告)号：US11168086B2
公开(公告)日：2021-11-09
申请号：US15846910
申请日：2017-12-19
Applicant: Hoffmann-La Roche Inc.
Inventor： Taishan Hu , Xingchun Han , Buyu Kou , Hong Shen , Shixiang Yan , Zhisen Zhang
IPC: C07D487/04 , C07D519/00
Abstract: The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R4 are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.
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公开(公告)号：US11098080B2
公开(公告)日：2021-08-24
申请号：US16006564
申请日：2018-06-12
Applicant: Hoffmann-La Roche Inc.
Inventor： Alexander Alanine , Julien Beignet , Konrad Bleicher , Bernhard Fasching , Hans Hilpert , Taishan Hu , Dwight MacDonald , Stephen Jackson , Sabine Kolczewski , Carsten Kroll , Adrian Schaeublin , Hong Shen , Theodor Stoll , Helmut Thomas , Amal Wahhab , Claudia Zampaloni
Abstract: The present invention provides compounds of formula (I) wherein X1 to X8 and R1 to R8 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by Acinetobacter baumannii.
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公开(公告)号：US20210253575A1
公开(公告)日：2021-08-19
申请号：US17274415
申请日：2018-09-07
Applicant: Hoffmann-La Roche Inc.
Inventor： Fabian Dey , Haixia Liu , Hong Shen , Guolong Wu , Weixing Zhang , Wei Zhu
IPC: C07D471/10 , C07D403/10 , C07D487/10 , C07D401/14 , C07D401/10 , C07D487/04 , C07D403/14 , C07D498/10 , C07D471/08
Abstract: The present invention relates to compounds of formula (I), wherein R1, R2, R3 and R4 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
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公开(公告)号：US10781206B2
公开(公告)日：2020-09-22
申请号：US16247132
申请日：2019-01-14
Applicant: Hoffmann-La Roche Inc.
Inventor： Taishan Hu , Hong Shen , Xingchun Han
IPC: C07D471/04 , A61P31/20
Abstract: The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R5 are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.
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公开(公告)号：US10683299B2
公开(公告)日：2020-06-16
申请号：US16247170
申请日：2019-01-14
Applicant: Hoffmann-La Roche Inc.
Inventor： Xingchun Han , Xianfeng Lin , Hong Shen , Taishan Hu , Zhisen Zhang
IPC: C07D487/04 , C07D513/04 , A61P31/20 , C07D519/00
Abstract: The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R4 and Q are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.
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公开(公告)号：US20190185444A1
公开(公告)日：2019-06-20
申请号：US16199534
申请日：2018-11-26
Applicant: Hoffmann-La Roche Inc.
Inventor： Dongdong Chen , Wenming Chen , Song Feng , Lu Gao , Hong Shen , Xuefei Tan , Li Wang
IPC: C07D311/86 , A61P31/20 , C07D493/04
CPC classification number: C07D311/86 , A61P31/20 , C07D311/82 , C07D405/04 , C07D405/14 , C07D407/04 , C07D409/04 , C07D487/10 , C07D491/052 , C07D493/04 , C07D493/10 , C07D495/04
Abstract: The present invention provides novel compounds having the general formula: wherein R1 to R6, X, Y, A1 and A2 are as described herein, compositions including the compounds and methods of using the compounds.
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8.发明申请
公开(公告)号：US20180370969A1
公开(公告)日：2018-12-27
申请号：US16103198
申请日：2018-08-14
Applicant: Hoffmann-La Roche Inc.
Inventor： Lei Guo , Taishan Hu , Buyu Kou , Xianfeng Lin , Hong Shen , Houguang Shi , Shixiang Yan , Weixing Zhang , Zhisen Zhang , Mingwei Zhou , Wei Zhu
IPC: C07D471/04
CPC classification number: C07D471/04 , A61K31/4985 , A61K31/517 , A61K31/519 , C07D487/04 , C07D498/04 , C07D513/04
Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US20180250301A1
公开(公告)日：2018-09-06
申请号：US15970128
申请日：2018-05-03
Applicant: Hoffmann-La Roche Inc.
Inventor： Lu Gao , Isabel Najera , Hong Shen , Fang Shen , Liping Shi , Steffen Wildum , Guang Yang
IPC: A61K31/506 , A61K31/5377 , A61P31/12
CPC classification number: A61K31/506 , A61K31/5377 , A61K38/212 , A61K2300/00 , A61P31/12
Abstract: The present invention is directed to compositions and methods for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of an HBV capsid assembly inhibitor and an interferon for use in the treatment of hepatitis B virus infections.
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公开(公告)号：US09890167B2
公开(公告)日：2018-02-13
申请号：US14997346
申请日：2016-01-15
Applicant: Hoffmann-La Roche Inc.
Inventor： Taishan Hu , Xingchun Han , Buyu Kou , Hong Shen , Shixiang Yan , Zhisen Zhang
IPC: C07D487/04 , C07D519/00
CPC classification number: C07D487/04 , C07D519/00
Abstract: The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R4 are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.
